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Author Ottavia Dipasquale

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Differences in social brain function in autism spectrum disorder are linked to the serotonin transporter

Nichol M.L. Wong, Ottavia Dipasquale, Federico Turkheimer, James Findon, Robert Wichers, Mihail Dimitrov, Clodagh Murphy, Vladimira Stoencheva, Dene Robertson, Declan Murphy, Eileen Daly, Grainne McAlonan,

Alterations in the serotonergic control of brain pathways responsible for facial-emotion processing in people with autism spectrum disorder (ASD) may be a target for intervention. However, the molecular underpinnings of autistic-neurotypical serotonergic differences are challenging to access in vivo. Receptor-Enriched Analysis of functional Connectivity by Targets (REACT) has helped define ... Read more >>

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Imaging transcriptomics: Convergent cellular, transcriptomic, and molecular neuroimaging signatures in the healthy adult human brain

Daniel Martins, Alessio Giacomel, Steven CR Williams, Federico Turkheimer, Ottavia Dipasquale, Mattia Veronese, ,

The expansion of neuroimaging techniques over the last decades has opened a wide range of new possibilities to characterize brain dysfunction in several neurological and psychiatric disorders. However, the lack of specificity of most of these techniques, such as magnetic resonance imaging (MRI)-derived measures, to the underlying molecular and cellular ... Read more >>

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A candidate neuroimaging biomarker for detection of neurotransmission-related functional alterations and prediction of pharmacological analgesic response in chronic pain

Daniel Martins, Mattia Veronese, Federico Turkheimer, Matthew Howard, Steven CR Williams, Ottavia Dipasquale,

<h4>Background</h4> Chronic pain is a world-wide clinical challenge. Response to analgesic treatment is limited and difficult to predict. Functional MRI (fMRI) has been suggested as a potential solution. However, while most analgesics target specific neurotransmission pathways, fMRI-based biomarkers are not specific for any neurotransmitter system, limiting our understanding of how ... Read more >>

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Transcriptional and cellular signatures of cortical morphometric similarity remodelling in chronic pain

Daniel Martins, Ottavia Dipasquale, Mattia Veronese, Federico Turkheimer, Marco Loggia, Stephen McMahon, Matthew Howard, Steven CR Williams,

Chronic pain is a highly debilitating and poorly understood condition. Here, we attempt to advance our understanding of the brain mechanisms driving chronic pain by investigating alterations in morphometric similarity (MS) and corresponding transcriptomic and cellular signatures, in three cohorts of patients with distinct chronic pain syndromes (knee osteoarthritis, low ... Read more >>

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“Less is more”: a dose-response account of intranasal oxytocin pharmacodynamics in the human brain

Daniel Martins, Katja Broadmann, Mattia Veronese, Ottavia Dipasquale, Ndaba Mazibuko, Uwe Schuschnig, Fernando Zelaya, Aikaterini Fotopoulou, Yannis Paloyelis,

Intranasal oxytocin is receiving increasing research attention as a potential treatment for several brain disorders due to promising preclinical results. However, translating these findings to humans has been hampered by remaining uncertainties about its pharmacodynamics and the methods used to probe its effects in the human brain. Using a dose-response ... Read more >>

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Cognitive fatigue in multiple sclerosis is associated with alterations in the functional connectivity of monoamine circuits.

Mara Cercignani, Ottavia Dipasquale, Iulia Bogdan, Tiziana Carandini, James Scott, Waqar Rashid, Osama Sabri, Swen Hesse, Michael Rullmann, Leonardo Lopiano, Mattia Veronese, Daniel Martins, Marco Bozzali,

Fatigue is a highly prevalent and debilitating symptom in multiple sclerosis, but currently the available treatment options have limited efficacy. The development of innovative and efficacious targeted treatments for fatigue in multiple sclerosis has been marred by the limited knowledge of the underlying mechanisms. One of the hypotheses postulates that ... Read more >>

Brain Commun (Brain communications)
[2021, 3(2):fcab023]

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A Complex Systems Perspective on Neuroimaging Studies of Behavior and Its Disorders.

Federico E Turkheimer, Fernando E Rosas, Ottavia Dipasquale, Daniel Martins, Erik D Fagerholm, Paul Expert, František Váša, Louis-David Lord, Robert Leech,

The study of complex systems deals with emergent behavior that arises as a result of nonlinear spatiotemporal interactions between a large number of components both within the system, as well as between the system and its environment. There is a strong case to be made that neural systems as well ... Read more >>

Neuroscientist (The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry)
[2021, :1073858421994784]

Cited: 1 time

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Oxytocin modulates local topography of human functional connectome in healthy men at rest.

Daniel Martins, Ottavia Dipasquale, Yannis Paloyelis,

Oxytocin has recently received remarkable attention for its role as a modulator of human behaviour. Here, we aimed to expand our knowledge of the neural circuits engaged by oxytocin by investigating the effects of intranasal and intravenous oxytocin on the functional connectome at rest in 16 healthy men. Oxytocin modulates ... Read more >>

Commun Biol (Communications biology)
[2021, 4(1):68]

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The association between pain-induced autonomic reactivity and descending pain control is mediated by the periaqueductal grey

Elena Makovac, Alessandra Venezia, David Hohenschurz-Schmidt, Ottavia Dipasquale, Jade Jackson, Sonia Medina, Owen O’Daly, Steve CR Williams, Stephen McMahon, Matthew Howard,

There is a strict interaction between the autonomic nervous system (ANS) and pain, which might involve descending pain modulatory mechanisms. The periaqueductal grey (PAG) is involved both in descending pain modulation and ANS, but its role in mediating this relationship has not yet been explored. Here, we sought to determine ... Read more >>

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Sustained perturbation in functional connectivity induced by cold pain.

Elena Makovac, Ottavia Dipasquale, Jade B Jackson, Sonia Medina, Owen O'Daly, Jonathan O'Muircheartaigh, Alfonso de Lara Rubio, Steven C R Williams, Stephen B McMahon, Matthew A Howard,

<h4>Background</h4>Functional connectivity (FC) perturbations have been reported in multiple chronic pain phenotypes, but the nature of reported changes varies between cohorts and may relate to the consequences of living with chronic-pain related comorbidities, such as anxiety and depression. Healthy volunteer studies provide opportunities to study the effects of tonic noxious ... Read more >>

Eur J Pain (European journal of pain (London, England))
[2020, 24(9):1850-1861]

Cited: 1 time

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Unravelling the effects of methylphenidate on the dopaminergic and noradrenergic functional circuits.

Ottavia Dipasquale, Daniel Martins, Arjun Sethi, Mattia Veronese, Swen Hesse, Michael Rullmann, Osama Sabri, Federico Turkheimer, Neil A Harrison, Mitul A Mehta, Mara Cercignani,

Functional magnetic resonance imaging (fMRI) can be combined with drugs to investigate the system-level functional responses in the brain to such challenges. However, most psychoactive agents act on multiple neurotransmitters, limiting the ability of fMRI to identify functional effects related to actions on discrete pharmacological targets. We recently introduced a ... Read more >>

Neuropsychopharmacology (Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology)
[2020, 45(9):1482-1489]

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Unravelling the effects of methylphenidate on the dopaminergic and noradrenergic functional circuits

Ottavia Dipasquale, Daniel Martins, Arjun Sethi, Mattia Veronese, Swen Hesse, Michael Rullmann, Osama Sabri, Federico Turkheimer, Neil Harrison, Mitul Mehta, Mara Cercignani,

<h4>ABSTRACT</h4> Functional magnetic resonance imaging (fMRI) can be combined with drugs to investigate the system-level functional responses in the brain to such challenges. However, most psychoactive agents act on multiple neurotransmitters, limiting the ability of fMRI to identify functional effects related to actions on discrete pharmacological targets. We recently introduced ... Read more >>

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Linking Pain Sensation to the Autonomic Nervous System: The Role of the Anterior Cingulate and Periaqueductal Gray Resting-State Networks.

David Johannes Hohenschurz-Schmidt, Giovanni Calcagnini, Ottavia Dipasquale, Jade B Jackson, Sonia Medina, Owen O'Daly, Jonathan O'Muircheartaigh, Alfonso de Lara Rubio, Steven C R Williams, Stephen B McMahon, Elena Makovac, Matthew A Howard,

There are bi-directional interactions between the autonomic nervous system (ANS) and pain. This is likely underpinned by a substantial overlap between brain areas of the central autonomic network and areas involved in pain processing and modulation. To date, however, relatively little is known about the neuronal substrates of the ANS-pain ... Read more >>

Front Neurosci (Frontiers in neuroscience)
[2020, 14:147]

Cited: 3 times

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Sustained perturbation in functional connectivity induced by cold pain

Elena Makovac, Ottavia Dipasquale, Jade Jackson, Sonia Medina, Owen O’Daly, Jonathan O’Muircheartaigh, Alfonso de Lara Rubio, Steven CR Williams, Stephen McMahon, Matthew Howard,

Functional connectivity (FC) perturbations have been reported in multiple chronic pain phenotypes, but the nature of reported changes is varied and inconsistent between cohorts. Increases and decreases in connectivity strength in task negative and positive networks, for example, the default mode and salience networks (DMN/SN), respectively, have been described, but ... Read more >>

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Topological gene expression networks recapitulate brain anatomy and function.

Alice Patania, Pierluigi Selvaggi, Mattia Veronese, Ottavia Dipasquale, Paul Expert, Giovanni Petri,

Understanding how gene expression translates to and affects human behavior is one of the ultimate goals of neuroscience. In this paper, we present a pipeline based on Mapper, a topological simplification tool, to analyze gene co-expression data. We first validate the method by reproducing key results from the literature on ... Read more >>

Netw Neurosci (Network neuroscience (Cambridge, Mass.))
[2019, 3(3):744-762]

Cited: 2 times

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Dissociative identity as a continuum from healthy mind to psychiatric disorders: Epistemological and neurophenomenological implications approached through hypnosis.

Enrico Facco, Laura Mendozzi, Angelo Bona, Achille Motta, Massimo Garegnani, Isa Costantini, Ottavia Dipasquale, Pietro Cecconi, Roberta Menotti, Elisa Coscioli, Susanna Lipari,

The topic of multiple personality, redefined as Dissociative Identity Disorders (DIDs) in the DSM-5, is an intriguing and still debated disorder with a long history and deep cultural and epistemological implications, extending up to the idea of possession. Hypnosis is an appealing and valuable model to manipulate subjective experience and ... Read more >>

Med Hypotheses (Medical hypotheses)
[2019, 130:109274]

Cited: 1 time

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Receptor-Enriched Analysis of functional connectivity by targets (REACT): A novel, multimodal analytical approach informed by PET to study the pharmacodynamic response of the brain under MDMA.

Ottavia Dipasquale, Pierluigi Selvaggi, Mattia Veronese, Anthony S Gabay, Federico Turkheimer, Mitul A Mehta,

One of the main limitations of pharmacological fMRI is its inability to provide a molecular insight into the main effect of compounds, leaving an open question about the relationship between drug effects and haemodynamic response. The aim of this study is to investigate the acute effects of 3,4-methylenedioxymethamphetamine (MDMA) on ... Read more >>

Neuroimage (NeuroImage)
[2019, 195:252-260]

Cited: 4 times

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Increased cerebral blood flow after single dose of antipsychotics in healthy volunteers depends on dopamine D2 receptor density profiles.

Pierluigi Selvaggi, Peter C T Hawkins, Ottavia Dipasquale, Gaia Rizzo, Alessandro Bertolino, Juergen Dukart, Fabio Sambataro, Giulio Pergola, Steven C R Williams, Federico Turkheimer, Fernando Zelaya, Mattia Veronese, Mitul A Mehta,

As a result of neuro-vascular coupling, the functional effects of antipsychotics in human brain have been investigated in both healthy and clinical populations using haemodynamic markers such as regional Cerebral Blood Flow (rCBF). However, the relationship between observed haemodynamic effects and the pharmacological action of these drugs has not been ... Read more >>

Neuroimage (NeuroImage)
[2019, 188:774-784]

Cited: 5 times

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Covariance statistics and network analysis of brain PET imaging studies.

Mattia Veronese, Lucia Moro, Marco Arcolin, Ottavia Dipasquale, Gaia Rizzo, Paul Expert, Wasim Khan, Patrick M Fisher, Claus Svarer, Alessandra Bertoldo, Oliver Howes, Federico E Turkheimer,

The analysis of structural and functional neuroimaging data using graph theory has increasingly become a popular approach for visualising and understanding anatomical and functional relationships between different cerebral areas. In this work we applied a network-based approach for brain PET studies using population-based covariance matrices, with the aim to explore ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):2496]

Cited: 8 times

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Topological gene-expression networks recapitulate brain anatomy and function

Alice Patania, Pierluigi Selvaggi, Mattia Veronese, Ottavia Dipasquale, Paul Expert, Giovanni Petri,

Understanding how gene expression translates to and affects human behaviour is one of the ultimate aims of neuroscience. In this paper, we present a pipeline based on Mapper, a topological simplification tool, to produce and analyze genes co-expression data. We first validate the method by reproducing key results from the ... Read more >>

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Exploring resting-state functional connectivity invariants across the lifespan in healthy people by means of a recently proposed graph theoretical model.

Paolo Finotelli, Ottavia Dipasquale, Isa Costantini, Alessia Pini, Francesca Baglio, Giuseppe Baselli, Paolo Dulio, Mara Cercignani,

In this paper we investigate the changes in the functional connectivity intensity, and some related properties, in healthy people, across the life span and at resting state. For the explicit computation of the functional connectivity we exploit a recently proposed model, that bases not only on the correlations data provided ... Read more >>

PLoS One (PloS one)
[2018, 13(11):e0206567]

Cited: 3 times

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In vivo mapping of brainstem nuclei functional connectivity disruption in Alzheimer's disease.

Laura Serra, Marcello D'Amelio, Carlotta Di Domenico, Ottavia Dipasquale, Camillo Marra, Nicola Biagio Mercuri, Carlo Caltagirone, Mara Cercignani, Marco Bozzali,

We assessed here functional connectivity changes in the locus coeruleus (LC) and ventral tegmental area (VTA) of patients with Alzheimer's disease (AD). We recruited 169 patients with either AD or amnestic mild cognitive impairment due to AD and 37 elderly controls who underwent cognitive and neuropsychiatric assessments and resting-state functional ... Read more >>

Neurobiol Aging (Neurobiology of aging)
[2018, 72:72-82]

Cited: 9 times

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O4.3. INCREASED CEREBRAL BLOOD FLOW AFTER SINGLE DOSE OF ANTIPSYCHOTICS IN HEALTHY SUBJECTS DEPENDS ON DOPAMINE D2 RECEPTOR DENSITY PROFILES EVALUATED WITH PET AND MRNA EXPRESSION DATA.

Pierluigi Selvaggi, Mattia Veronese, Peter CT Hawkins, Ottavia Dipasquale, Gaia Rizzo, Alessandro Bertolino, Juergen Dukart, Fabio Sambataro, Steven CR Williams, Federico Turkheimer, Mitul Mehta,

Abstract <h4>Background</h4> Previous studies measuring cerebral blood flow (CBF) with magnetic resonance sequences like Arterial Spin Labelling (ASL) showed that patients with schizophrenia (SCZ) have increased CBF in basal ganglia and reduced blood flow in cortical areas like the prefrontal cortex. It is still not clear whether these abnormalities are ... Read more >>

Schizophr Bull (Schizophrenia bulletin)
[2018, 44(Suppl 1):S83-S84]

Cited: 0 times

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Increased Cerebral Blood Flow after single dose of antipsychotics in healthy volunteers depends on dopamine D2 receptor density profiles

Pierluigi Selvaggi, Peter C.T. Hawkins, Ottavia Dipasquale, Gaia Rizzo, Alessandro Bertolino, Juergen Dukart, Fabio Sambataro, Giulio Pergola, Steven C.R. Williams, Federico Turkheimer, Fernando Zelaya, Mattia Veronese, Mitul Mehta,

As a result of neuro-vascular coupling, the functional effects of antipsychotics in human brain have been investigated in both healthy and clinical populations using haemodynamic markers such as regional Cerebral Blood Flow (rCBF). However, the relationship between observed haemodynamic effects and the pharmacological action of these drugs has not been ... Read more >>

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Effects of motor rehabilitation on mobility and brain plasticity in multiple sclerosis: a structural and functional MRI study.

Eleonora Tavazzi, Niels Bergsland, Davide Cattaneo, Elisa Gervasoni, Maria Marcella Laganà, Ottavia Dipasquale, Cristina Grosso, Francesca Lea Saibene, Francesca Baglio, Marco Rovaris,

<h4>Background</h4>Rehabilitation seems to promote brain plasticity, but objective measures of efficacy are lacking and there is a limited understanding of the mechanisms underlying functional recovery.<h4>Objective</h4>To study functional and structural brain changes induced by gait rehabilitation.<h4>Methods</h4>We enrolled MS inpatients (EDSS 4.5-6.5) undergoing a 4-week neurorehabilitation. Several clinical measures were obtained, including: ... Read more >>

J Neurol (Journal of neurology)
[2018, 265(6):1393-1401]

Cited: 11 times

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