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Author Omer Akyol

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Accuracy and uniformity of the nomenclature of biogenic amines and polyamines in metabolomics studies: A preliminary study.

Omer Akyol, Kylie Tessier, Sumeyya Akyol,

Metabolomics is one of the newest areas in biochemistry dedicated to investigating small biomolecules in biofluids, tissues, and cells. Cutting edge instruments used in metabolomics studies make it possible to identify thousands of biomolecules and determine their interactions with biological networks. This tremendous area has increased the significance of accurate ... Read more >>

Biochem Mol Biol Educ (Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology)
[2021, 49(3):441-445]

Cited: 0 times

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Why are cardiovascular diseases more common among patients with severe mental illness? The potential involvement of electronegative low-density lipoprotein (LDL) L5.

Omer Akyol, Imtihan Chowdhury, Hafsa Rana Akyol, Kylie Tessier, Huseyin Vural, Sumeyya Akyol,

Despite tremendous efforts of experimental and clinical studies and knowledge, the pathophysiology of severe mental illness (SMI), including bipolar disorder (BD), unipolar depression (mood disorders, MD), and schizophrenia (SCZ), remains poorly understood. Besides their chronic course and high prevalence in society, mental and somatic comorbidities are really serious problems; patients ... Read more >>

Med Hypotheses (Medical hypotheses)
[2020, 142:109821]

Cited: 1 time

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Genetic Polymorphism of Manganese Superoxide Dismutase in Behçet's Disease.

Efkan Uz, H Ramazan Yilmaz, Ramazan Yağci, İsmail Akyol, Tuğba Ersoy, Gülten Sungur, Ayşe Yiğit, Sunay Duman, Ömer Akyol,

Objectives:This study aims to investigate the genetic association between single nucleotide mutation in mitochondrial manganese superoxide dismutase and a Behçet's disease (BD) population by using molecular techniques. Patients and methods:Ninety-three BD patients (45 males, 48 females; mean age 33.15±8.99 years; range 17 to 65 years) and 125 controls (58 males, ... Read more >>

Arch Rheumatol (Archives of rheumatology)
[2016, 31(1):48-54]

Cited: 0 times

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The role of electronegative low-density lipoprotein in cardiovascular diseases and its therapeutic implications.

Sumeyya Akyol, Jonathan Lu, Omer Akyol, Fatih Akcay, Ferah Armutcu, Liang-Yin Ke, Chu-Huang Chen,

Cardiovascular disease (CVD) is a health problem of great concern to both the public and medical authorities. Low-density lipoprotein (LDL) has been reported to play an important role in both the development and progression of CVD, but studies are underway to determine how LDL exerts its effects. In recent years, ... Read more >>

Trends Cardiovasc Med (Trends in cardiovascular medicine)
[2017, 27(4):239-246]

Cited: 5 times

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Update on ADAMTS13 and VWF in cardiovascular and hematological disorders.

Omer Akyol, Sumeyya Akyol, Chu-Huang Chen,

Endothelial cells (EC) respond to injury by releasing numerous factors, including von Willebrand factor (VWF). High circulating levels of unusually large VWF multimers (UL-VWFM) have strong procoagulant activity and facilitate platelet adhesion and aggregation by interacting with platelets after an acute event superimposed on peripheral arterial disease and coronary artery ... Read more >>

Clin Chim Acta (Clinica chimica acta; international journal of clinical chemistry)
[2016, 463:109-118]

Cited: 12 times

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The Role of ADAMTS1 and Versican in Human Myocardial Infarction: A Postmortem Study.

Sultan Pehlivan, Murat Serdar Gurses, Mustafa Numan Ural, Sumeyya Akyol, Filiz Eren, Nursel Turkmen Inanir, Mehmet Akif Gulec, Bulent Eren, Recep Fedakar, Kadir Demircan, Omer Akyol,

<h4>Objective</h4>To determine the role of a disintegrin and metalloproteinase with thrombospondin type 1 motif (ADAMTS1) and fragmented versican in the myocardial infarction (MI) process in humans and to evaluate the diagnostic efficacy of ADAMTS1 for postmortem diagnosis of MI.<h4>Methods</h4>Thirty autopsied individuals were allocated into 2 groups, namely, a study group ... Read more >>

Lab Med (Laboratory medicine)
[2016, 47(3):205-212]

Cited: 2 times

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Possible role of antioxidants and nitric oxide inhibitors against carbon monoxide poisoning: Having a clear conscience because of their potential benefits.

Sumeyya Akyol, Sevda Yuksel, Sultan Pehlivan, Haci Kemal Erdemli, Mehmet Akif Gulec, Bahattin Adam, Omer Akyol,

Carbon monoxide poisoning is one of the important emergency situations manifested by primarily acute and chronic anoxic central nervous system (CNS) injuries and other organ damages. Current descriptions and therapeutic approaches have been focused on the anoxic pathophysiology. However, this point of view incompletely explains some of the outcomes and ... Read more >>

Med Hypotheses (Medical hypotheses)
[2016, 92:3-6]

Cited: 3 times

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Melatonin and caffeic acid phenethyl ester in the regulation of mitochondrial function and apoptosis: The basis for future medical approaches.

Haci Kemal Erdemli, Sumeyya Akyol, Ferah Armutcu, Mehmet Akif Gulec, Metin Canbal, Omer Akyol,

The aim of this review article is to summarize and compare the effects of melatonin and caffeic acid phenethyl ester (CAPE) on the relationship between mitochondrial functioning and apoptosis. References in this article were selected with an approach based on a comprehensive literature review by using MEDLINE/PubMed and Google Scholar ... Read more >>

Life Sci (Life sciences)
[2016, 148:305-312]

Cited: 3 times

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Is Serum Caveolin-1 a Useful Biomarker for Progression in Patients with Colorectal Cancer?.

Haci Kemal Erdemli, Ramazan Kocabas, Osman Salis, Fatma Sen, Sumeyya Akyol, Fatih Eskin, Omer Akyol, Abdulkerim Bedir, Abdullah Fahri Sahin,

<h4>Background</h4>Colorectal cancer (CRC) is the third most common cause of cancer diagnosed in males and the second in females. Survival is strongly related to stage at diagnosis. There is an urgent need to find a noninvasive biomarker that can be commonly applied for screening diagnosis, early detection of recurrence, and ... Read more >>

Clin Lab (Clinical laboratory)
[2016, 62(3):401-408]

Cited: 3 times

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Can propolis and caffeic acid phenethyl ester be promising agents against cyclophosphamide toxicity?

Sumeyya Akyol, Mehmet Akif Gulec, Haci Kemal Erdemli, Omer Akyol,

Propolis is a mixture having hundreds of polyphenols including caffeic acid phenethyl ester (CAPE). They have been using in several medical conditions/diseases in both in vitro and in vivo experimental setup. Cyclophosphamide (CP) has been used to treat a broad of malignancies including Hodgkin's and non-Hodgkin's lymphoma, Burkitt's lymphoma, chronic ... Read more >>

J Intercult Ethnopharmacol (Journal of intercultural ethnopharmacology)
[2016, 5(1):105-107]

Cited: 3 times

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The comparison of caffeic acid and caffeic acid phenethyl ester against cisplatin-induced hair cell damage.

Sumeyya Akyol, Haci Kemal Erdemli, Ferah Armutcu, Omer Akyol,

Int J Pediatr Otorhinolaryngol (International journal of pediatric otorhinolaryngology)
[2016, 81:103-104]

Cited: 0 times

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Pathophysiological Function of ADAMTS Enzymes on Molecular Mechanism of Alzheimer's Disease.

Murat Serdar Gurses, Mustafa Numan Ural, Mehmet Akif Gulec, Omer Akyol, Sumeyya Akyol,

The extracellular matrix (ECM) is an environment that has various enzymes attended in regeneration and restoration processes which is very important to sustain physiological and biological functions of central nervous system (CNS). One of the participating enzyme systems in ECM turnover is matrix metalloproteinases. A disintegrin-like and metalloproteinase with thrombospondin ... Read more >>

Aging Dis (Aging and disease)
[2016, 7(4):479-490]

Cited: 5 times

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Antiviral properties of caffeic acid phenethyl ester and its potential application.

Hacı Kemal Erdemli, Sumeyya Akyol, Ferah Armutcu, Omer Akyol,

Caffeic acid phenethyl ester (CAPE) is found in a variety of plants and well-known the active ingredient of the honeybee propolis. CAPE showed anti-inflammatory, anticarcinogenic, antimitogenic, antiviral, and immunomodulatory properties in several studies. The beneficial effects of CAPE on different health issues attracted scientists to make more studies on CAPE. ... Read more >>

J Intercult Ethnopharmacol (Journal of intercultural ethnopharmacology)
[2015, 4(4):344-347]

Cited: 9 times

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Multifaceted impact of caffeic acid phenethyl ester (CAPE) in experimental myocardial injuries.

Sümeyya Akyol, Ömer Akyol,

Anatol J Cardiol (Anatolian journal of cardiology)
[2015, 15(10):848]

Cited: 0 times

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A new therapeutic approach for carbon monoxide poisoning: Antioxidants.

Sumeyya Akyol, Mehmet Akif Gulec, Haci Kemal Erdemli, Omer Akyol,

Toxicology (Toxicology)
[2015, 336:34-35]

Cited: 2 times

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A commentary on "The effectiveness of oxygen therapy in carbon monoxide poisoning is pressure- and time-dependent: A study on cultured astrocytes".

Mehmet Akif Gulec, Omer Akyol, Sumeyya Akyol,

Toxicol Lett (Toxicology letters)
[2015, 238(3):83]

Cited: 1 time

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Comment on 'Caffeic acid phenethyl ester lessens disease symptoms in an experimental autoimmune uveoretinitis mouse model' by Choi J.H. et al. [Exp. Eye Res. 134 (2015) 53-62].

Haci Kemal Erdemli, Sumeyya Akyol, Ferah Armutcu, Omer Akyol,

Exp Eye Res (Experimental eye research)
[2015, 138:124-125]

Cited: 0 times

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In vitro and in vivo neuroprotective effect of caffeic acid phenethyl ester.

Sumeyya Akyol, Haci Kemal Erdemli, Ferah Armutcu, Omer Akyol,

J Intercult Ethnopharmacol (Journal of intercultural ethnopharmacology)
[2015, 4(3):192-193]

Cited: 6 times

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The possible preventive effect of caffeic acid phenethyl ester (CAPE) against myringosclerosis.

Haci Kemal Erdemli, Sumeyya Akyol, Ferah Armutcu, Omer Akyol,

Eur Arch Otorhinolaryngol (European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery)
[2016, 273(3):789-790]

Cited: 0 times

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A new remedial approach to oxidant/antioxidant imbalance-based diseases: Wet-cupping therapy.

Omer Akyol, Haci Kemal Erdemli,

Complement Ther Med (Complementary therapies in medicine)
[2015, 23(4):633]

Cited: 1 time

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Future opportunities in preventing ototoxicity: Caffeic acid phenethyl ester may be a candidate (Review).

Sumeyya Akyol, Bunyamin Isik, Aynur Altuntas, Gonul Erden, Ozlem Cakmak, S Fatih Kurşunlu, Bahattin Adam, Omer Akyol,

Caffeic acid phenethyl ester (CAPE) is an important active component of propolis, which is derived from honeybee hives. It has received increasing attention in a variety of medical and pharmaceutical research, due to its anti‑oxidant, antiproliferative, anti‑inflammatory, antiviral and antifungal activity, in addition to its antineoplastic properties. Besides the use ... Read more >>

Mol Med Rep (Molecular medicine reports)
[2015, 12(3):3231-3235]

Cited: 2 times

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Caffeic acid phenethyl ester as a remedial agent for reproductive functions and oxidative stress-based pathologies of gonads.

Sumeyya Akyol, Ali Akbas, Ilknur Butun, Muhsin Toktas, Huseyin Ozyurt, Semsettin Sahin, Omer Akyol,

In recent years, the studies on the roles of caffeic acid phenethyl ester (CAPE) in several disease models and cell cultures are tremendously growing. It is such a great molecule that was used by ancient times to ameliorate some diseases and nowadays, it is used by modern medicine to test ... Read more >>

J Intercult Ethnopharmacol (Journal of intercultural ethnopharmacology)
[2015, 4(2):187-191]

Cited: 6 times

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Preface.

Mark S Kindy, Ömer Akyol, Kumar Sambamurti,

Turk J Med Sci (Turkish journal of medical sciences)
[2015, 45(5):i-ii]

Cited: 0 times

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Caffeic acid phenethyl ester: its protective role against certain major eye diseases.

Sumeyya Akyol, Veli Ugurcu, Mehmet Balci, Ayse Gurel, Gonul Erden, Ozlem Cakmak, Omer Akyol,

As an effective compound found mainly in the honeybee product propolis, caffeic acid phenethyl ester (CAPE) has been commonly utilized as a medicine and remedial agent, in a number of countries. Specifically, it might inhibit nuclear factor kappa B at micromolar concentrations and demonstrate antioxidant, antineoplastic, antiproliferative, cytostatic, antiviral, antibacterial, ... Read more >>

J Ocul Pharmacol Ther (Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics)
[2014, 30(9):700-708]

Cited: 5 times

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ADAMTS4 and ADAMTS5 knockout mice are protected from versican but not aggrecan or brevican proteolysis during spinal cord injury.

Kadir Demircan, Vehap Topcu, Tomoyuki Takigawa, Sumeyya Akyol, Tomoko Yonezawa, Gulfer Ozturk, Veli Ugurcu, Rukiye Hasgul, M Ramazan Yigitoglu, Omer Akyol, Daniel R McCulloch, Satoshi Hirohata,

The chondroitin sulfate proteoglycans (CSPGs) aggrecan, versican, and brevican are large aggregating extracellular matrix molecules that inhibit axonal growth of the mature central nervous system (CNS). ADAMTS proteoglycanases, including ADAMTS4 and ADAMTS5, degrade CSPGs, representing potential targets for ameliorating axonal growth-inhibition by CSPG accumulation after CNS injury. We investigated the ... Read more >>

Biomed Res Int (BioMed research international)
[2014, 2014:693746]

Cited: 16 times

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