Full Text Journal Articles by
Author Omar Saadah

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Exploring celiac disease candidate pathways by global gene expression profiling and gene network cluster analysis.

Babajan Banaganapalli, Haifa Mansour, Arif Mohammed, Arwa Mastoor Alharthi, Nada Mohammed Aljuaid, Khalidah Khalid Nasser, Aftab Ahmad, Omar I Saadah, Jumana Yousuf Al-Aama, Ramu Elango, Noor Ahmad Shaik,

Celiac disease (CeD) is a gastrointestinal autoimmune disorder, whose specific molecular basis is not yet fully interpreted. Therefore, in this study, we compared the global gene expression profile of duodenum tissues from CeD patients, both at the time of disease diagnosis and after two years of the gluten-free diet. A series ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):16290]

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The Efficacy of Anti-Tumor Necrosis Factor Alpha for Symptomatic Stricturing Small Bowel Crohn's Disease.

Mansour Alourfi, Mahmoud Mosli, Omar I Saadah,

Introduction Crohn's disease (CD) is a chronic inflammatory disease. Current treatment aims to prevent complications and the need for surgical intervention. In patients with symptomatic complications, such as strictures, the possible benefits of anti-tumor necrosis factor-alpha (anti-TNF-α) therapy are currently the subject of considerable debate. This study aims to determine ... Read more >>

Cureus (Cureus)
[2020, 12(9):e10315]

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Dysbiosis of gut microbiota in inflammatory bowel disease: Current therapies and potential for microbiota-modulating therapeutic approaches.

Dikhnah Alshehri, Omar Saadah, Mahmoud Mosli, Sherif Edris, Rashad Alhindi, Ahmed Bahieldin,

There is a growing body of evidence reinforcing the unique connections between the host microbiome, health and diseases. Due to the extreme importance of the symbiotic relationship between the intestinal microbiome and the host, it is not surprising that any alteration in the gut microbiota would result in various diseases, ... Read more >>

Bosn J Basic Med Sci (Bosnian journal of basic medical sciences)
[2020, :]

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A cross-sectional survey on the psychological impact of the COVID-19 pandemic on inflammatory bowel disease patients in Saudi Arabia.

Mahmoud Mosli, Mansour Alourfi, Amani Alamoudi, Almoutaz Hashim, Omar Saadah, Eman Al Sulais, Turki AlAmeel, Othman Alharbi, Shakir Bakari, Yaser Meeralam, Seigha Alshobai, Majid Alsahafi, Hani Jawa, Yousif Qari,

Background/Aims:The coronavirus (COVID-19) pandemic has caused significant disruption to patients with chronic illnesses. We explored the emotional state, perception, and concerns of Saudi patients with inflammatory bowel disease (IBD) during the crisis. Materials and Methods:We conducted a cross-sectional survey from 30 March to 5 April, 2020 using a pre-designed questionnaire ... Read more >>

Saudi J Gastroenterol (Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association)
[2020, 26(5):263-271]

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Patterns of Complementary and Alternative Medicine Use in Saudi Arabian Patients With Inflammatory Bowel Disease: A Cross-Sectional Study.

Albaraa Altunisi, Mahmoud Mosli, Mazen Banweer, Yousif Qari, Faris O Arif, Omar I Saadah,

Background Inflammatory bowel disease (IBD) concerns a group of chronic autoimmune diseases that results in uncontrolled inflammation of the gastrointestinal (GI) tract, which can lead to long-term complications. Conventional treatments for IBD usually target inflammation and include biologics and immunosuppressants, which have been associated with significant adverse effects. Also, non-response ... Read more >>

Cureus (Cureus)
[2020, 12(8):e9687]

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Saudi children with celiac disease: are they at risk of developing type-1 diabetes mellitus?

Omar I Saadah, Ameera S ALsaiari, Jamil A Al-Mughales,

Objectives Patients with type-1 diabetes mellitus (T1DM) and celiac disease (CeD) share the same genetic susceptibility alleles. The diabetes-associated autoantibodies (DAA) may be detected in CeD patients. The aim of this study is to describe the prevalence of DAA in children with CeD. Methods This is a cross-sectional study of ... Read more >>

J. Pediatr. Endocrinol. Metab. (Journal of pediatric endocrinology & metabolism : JPEM)
[2020, :]

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Prevalence of Celiac Disease in Children and Adolescents With Inflammatory Bowel Disease.

Ayman Eskander, Omar I Saadah, Abdelrahman A Abdelrazek, Mahmoud Mosli, Hadeel A Alsufyani, Safa Meshaal, Amera M Hasnoon, Sara Tarek, Abobakr Abdelgalil,

Introduction The association between inflammatory bowel disease (IBD) - particularly its two main subtypes, ulcerative colitis (UC) and Crohn's disease (CD) - and celiac disease (CeD) has been attributed to an overlap in the mechanism of immune dysregulation that characterizes these conditions. Owing to the paucity of studies that have ... Read more >>

Cureus (Cureus)
[2020, 12(8):e9977]

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Deamidated gliadin peptide and tissue transglutaminase antibodies in children with coeliac disease: A correlation study.

Omar I Saadah, Aisha M Alamri, Jamil A Al-Mughales,

BACKGROUND AND STUDY AIMS:Serological tests for coeliac disease (CD) are important in the clinical diagnosis and monitoring of response to a gluten free diet (GFD). The tests differ in their sensitivity, specificity, and diagnostic accuracy. In this study, tissue transglutaminase (IgA) (tTG-IgA) antibody was compared with the deamidated gliadin peptide ... Read more >>

Arab J Gastroenterol (Arab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology)
[2020, 21(3):174-178]

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The effects of ursodeoxycholic acid on sepsis-induced cholestasis management in an animal model.

Randa H Ainosah, Magda M Hagras, Sameer E Alharthi, Omar I Saadah,

Objectives:Cholestasis refers to a reduction in bile flow from the liver into the biliary system. Ursodeoxycholic acid (UDCA) is commonly used for the treatment of hepatic cholestasis. This study aimed to explore the role of UDCA in the treatment and prevention of lipopolysaccharide (LPS)-induced cholestasis. Methods:Sixty male albino rats were ... Read more >>

(Journal of Taibah University Medical Sciences)
[2020, 15(4):312-320]

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Prevalence and Predictors of Reduced Bone Density in Child and Adolescent Patients With Crohn's Disease.

Omar I Saadah, Vito Annese, Mahmoud H Mosli,

Reduced bone mineral density (BMD) has broadly been found to be associated with inflammatory bowel disease across a number of geographical locations and cultures. We aimed to estimate the prevalence of reduced BMD and identify clinical predictors in a cohort of Crohn's disease patients (CD) in Saudi Arabia. We conducted ... Read more >>

J Clin Densitom (Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry)
[2020, :]

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Extraintestinal Manifestations of Inflammatory Bowel Disease in Middle Eastern Patients.

Heba Adam, Maryam Alqassas, Omar I Saadah, Mahmoud Mosli,

BACKGROUND AND AIMS:The Inflammatory Bowel Diseases (IBDs), Crohn's Disease (CD) and Ulcerative Colitis (UC), are gastrointestinal autoimmune disorders with many Extraintestinal Manifestations (EIMs). Previously reported incidences of EIMs in IBD patients have ranged from 10% to 50%. The large variation in occurrence of EIMs has been linked to genetic predisposition. ... Read more >>

J Epidemiol Glob Health (Journal of epidemiology and global health)
[2020, :]

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Metabolic bone disease in children and adolescent patients with ulcerative colitis.

Mahmoud Hisham Mosli, Omar Ibrahim Saadah,

OBJECTIVE:Metabolic bone disease concerns a broad spectrum of conditions related to reduced bone density. Metabolic bone disease has been linked to chronic inflammatory diseases, such as ulcerative colitis. This study examines the prevalence of metabolic bone disease in ulcerative colitis patients and explores possible clinical predictors. METHOD:The authors performed a ... Read more >>

J Pediatr (Rio J) (Jornal de pediatria)
[2020, :]

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Whole exome sequencing of a Saudi family and systems biology analysis identifies CPED1 as a putative causative gene to Celiac Disease.

Hifaa A Bokhari, Noor Ahmad Shaik, Babajan Banaganapalli, Khalidah Khalid Nasser, Hossain Ibrahim Ageel, Ali Saad Al Shamrani, Omran M Rashidi, Omar Yaseen Al Ghubayshi, Jilani Shaik, Aftab Ahmad, Nuha Mohammad Alrayes, Jumana Yousuf Al-Aama, Ramu Elango, Omar Ibrahim Saadah,

Celiac disease (CD) is a gastrointestinal disorder whose genetic basis is not fully understood. Therefore, we studied a Saudi family with two CD affected siblings to discover the causal genetic defect. Through whole exome sequencing (WES), we identified that both siblings have inherited an extremely rare and deleterious CPED1 genetic ... Read more >>

Saudi J Biol Sci (Saudi journal of biological sciences)
[2020, 27(6):1494-1502]

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Prevalence of combined growth hormone deficiency and celiac disease among Saudi Arabian children with short stature: a tertiary care center experience.

Lujain M Qutub, Omar I Saadah,

Chin. Med. J. (Chinese medical journal)
[2020, (6):729-731]

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Environmental exposures and the risk of inflammatory bowel disease: a case-control study from Saudi Arabia.

Wafaa Algethmi, Cedric Baumann, Wed Alnajjar, Aaliah Sroji, Majid Alsahafi, Hani Jawa, Yousef Qari, Laurent Peyrin-Biroulet, Omar I Saadah, Mahmoud Mosli,

BACKGROUND AND AIMS:Environmental exposures play a key role in inflammatory bowel disease pathogenesis. The incidence of IBD has increased in the Arabic Peninsula with a disease phenotype that seems to differ from that of Western countries. We aimed to examine the association between environmental exposures and the risk of IBD ... Read more >>

Eur J Gastroenterol Hepatol (European journal of gastroenterology & hepatology)
[2020, 32(3):358-364]

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Health related quality of life among Saudi children and adolescents with celiac disease.

Norah D Al Nofaie, Jawaher R Al Ahmadi, Omar I Saadah,

Background/Aims:Celiac disease (CD) is an immune-mediated enteropathy triggered by gluten ingestion in genetically susceptible individuals. This study reports on the quality of life (QOL) of Saudi children and adolescents with CD. Patients and Methods:This is a case control study that included Saudi patients with CD, aged 9-18 years, who attended ... Read more >>

Saudi J Gastroenterol (Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association)
[2020, 26(1):26-31]

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Short children with impaired growth hormone secretion. Do they have celiac disease?

Omar I Saadah,

OBJECTIVES:To determine the prevalence of celiac disease (CeD) in children with short stature (SS) and growth hormone deficiency (GHD). METHODS:This is a retrospective study of patients with isolated SS and GHD, diagnosed during the period 2002 to 2016. Their medical records were reviewed and serum tissue transglutaminase (tTG) antibody results ... Read more >>

Saudi Med J (Saudi medical journal)
[2020, 41(1):68-72]

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Histologically confirmed upper gastrointestinal Crohn's disease: is it rare or are we just not searching hard enough?

Omar Ibrahim Saadah, Kholoud Bakur Fallatah, Cedric Baumann, Abdulrahman Ahmed Elbaradie, Fatimah Talat Howladar, Motaz Tariq Daiwali, Omar Hamad Alshuaibi, Majid Abdulaziz Alsahafi, Rana Yaqoob Bokhary, Yousef Abdulfattah Qari, Laurent Peyrin-Biroulet, Mahmoud Hisham Mosli,

BACKGROUND/AIMS:Crohn's disease (CD) may involve the upper parts of the gastrointestinal (GI) tract including the esophagus, stomach, and duodenum. Clinical features of upper GI CD (UGICD) are not well characterized in the Gulf region. We therefore aimed to assess the prevalence and clinical characteristics of patients diagnosed with UGICD. METHODS:We ... Read more >>

Intest Res (Intestinal research)
[2020, 18(2):210-218]

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Celiac disease in Saudi children with isolated short stature: is it rare or are we not screening rigorously enough?

Omar I Saadah, Nouf M ALNosani,

Background Celiac disease (CeD) is an immune-mediated enteropathy induced by gluten exposure in individuals with genetic susceptibility. Short stature (SS) can be the sole clinical manifestation of CeD, in the absence of gastrointestinal (GI) symptoms. This study aimed to determine the prevalence of CeD in Saudi Arabian children with SS. ... Read more >>

J. Pediatr. Endocrinol. Metab. (Journal of pediatric endocrinology & metabolism : JPEM)
[2020, 33(1):89-93]

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The effects of ursodeoxycholic acid in the management of sepsis-induced cholestasis in rodents

Randa Ainosah, Magda Hagras, Sameer Alharthi, Omar Saadah,

Abstract The authors have withdrawn this preprint from Research Square ... Read more >>

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Reflective learning conversations as an approach for clinical learning and teaching in critical care.

Emad Almomani, Tawfiq Alraoush, Omar Saadah, Ahmed Al Nsour, Megha Kamble, Jisha Samuel, Karim Atallah, Emad Mustafa,

Background: Reflective practice has become an integral element in healthcare and education.1,2 Hamad Medical Corporation (HMC) is the largest healthcare organization in Qatar and it aims to: develop highly competent healthcare practitioners, promote nurses’ critical thinking, enhance the implementation of evidence-based practice, encourage deep learning approaches, create positive learning environments, ... Read more >>

(Qatar medical journal)
[2019, 2019(2):]

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Whole exome sequencing identifies rare biallelic ALMS1 missense and stop gain mutations in familial Alström syndrome patients.

Naglaa M Kamal, Ahmed N Sahly, Babajan Banaganapalli, Omran M Rashidi, Preetha J Shetty, Jumana Y Al-Aama, Noor A Shaik, Ramu Elango, Omar I Saadah,

Alström syndrome (AS, OMIM ID 203800) is a rare childhood multiorgan disorder, which is widely studied in non-Arab ethnic patients. The clinical and molecular basis of AS and the mode of disease inheritance in consanguineous Arab populations is not well investigated. Therefore, to identify the molecular basis of AS in ... Read more >>

Saudi J Biol Sci (Saudi journal of biological sciences)
[2020, 27(1):271-278]

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Diagnostic delay of pediatric inflammatory bowel disease in Saudi Arabia.

Mohammad I El Mouzan, Badr I AlSaleem, Mohammed Y Hasosah, Abdulrahman A Al-Hussaini, Aziz H Al Anazi, Omar I Saadah, Ahmed A Al Sarkhy, Mohammad A Al Mofarreh, Asaad A Assiri,

Background/Aim:Delay in the diagnosis of inflammatory bowel disease (IBD) is associated with complications. Our aim was to describe the pattern and risk factors associated with delay in the diagnosis of IBD in Saudi children. Patients and Methods:This was a multicenter study with a retrospective/prospective design. Data on diagnostic delay in ... Read more >>

Saudi J Gastroenterol (Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association)
[2019, 25(4):257-261]

Cited: 1 time

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An explanatory mixed methods study on the validity and validation of students' assessment results in the undergraduate surgery course.

Omayma Hamed, Husain Hamza Jabbad, Omar I Saadah, Mahmoud S Al Ahwal, Fatin M Al-Sayes,

BACKGROUND/PURPOSE:There is inadequate evidence of reported validity of the results of assessment instruments used to assess clinical competence. This study aimed at combining multiple lines of quantitative and qualitative evidence to support interpretation and use of assessment results. METHOD:This study is a mixed methods explanatory research set in two stages ... Read more >>

Med Teach (Medical teacher)
[2018, 40(sup1):S56-S67]

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A cross-sectional survey of Saudi gastroenterologists: Transition strategies for adolescents with inflammatory bowel disease.

Elaf Al-Jahdali, Mahmoud Mosli, Omar Saadah,

The transition of adolescents with inflammatory bowel disease (IBD) from pediatric to adult care requires a well-structured standardized protocol to ensure the delivery of optimal healthcare and decrease the risk of nonadherence, hospitalizations, and complications. The aims of this survey are to evaluate current IBD transition practices adopted by gastroenterology ... Read more >>

Saudi J Gastroenterol (Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association)
[2017, 23(4):233-237]

Cited: 3 times

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