Full Text Journal Articles by
Author Olivia Molinar Inglis

Advertisement

Find full text journal articles








aPC/PAR1 confers endothelial anti-apoptotic activity via a discrete, β-arrestin-2-mediated SphK1-S1PR1-Akt signaling axis.

Olivia Molinar-Inglis, Cierra A Birch, Dequina Nicholas, Lennis Orduña-Castillo, Metztli Cisneros-Aguirre, Anand Patwardhan, Buxin Chen, Neil J Grimsey, Luisa J Coronel, Huilan Lin, Patrick K Gomez Menzies, Mark A Lawson, Hemal H Patel, JoAnn Trejo,

Endothelial dysfunction is associated with vascular disease and results in disruption of endothelial barrier function and increased sensitivity to apoptosis. Currently, there are limited treatments for improving endothelial dysfunction. Activated protein C (aPC), a promising therapeutic, signals via protease-activated receptor-1 (PAR1) and mediates several cytoprotective responses, including endothelial barrier stabilization ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2021, 118(49):]

Cited: 0 times

View full text PDF listing >>



aPC/PAR1 confers endothelial anti-apoptotic activity via a discrete β-arrestin-2 mediated SphK1-S1PR1-Akt signaling axis

Olivia Molinar-Inglis, Cierra Birch, Dequina Nicholas, Metzli Cisneros-Aguirre, Anand Patwardhan, Buxin Chen, Neil Grimsey, Patrick Gomez-Menzies, Huilan Lin, Luisa Coronel, Mark Lawson, Hemal Patel, JoAnn Trejo,

Endothelial dysfunction is associated with multiple vascular diseases and lacks effective treatments. Activated Protein C (aPC) is a promising biotherapeutic that signals via protease-activated receptor-1 (PAR1) to promote diverse cytoprotective responses, including endothelial barrier stabilization, anti-inflammatory and anti-apoptotic activities, which is facilitated by co-receptors. We showed that aPC-activated PAR1 signals ... Read more >>

()
[, :]

Cited: 0 times

View full text PDF listing >>



Advertisement

Subcellular hot spots of GPCR signaling promote vascular inflammation.

Cierra A Birch, Olivia Molinar-Inglis, JoAnn Trejo,

G-coupled protein receptors (GPCRs) comprise the largest class of druggable targets. Signaling by GPCRs is initiated from subcellular hot spots including the plasma membrane, signalosomes, and endosomes to contribute to vascular inflammation. GPCR-G protein signaling at the plasma membrane causes endothelial barrier disruption and also cross-talks with growth factor receptors ... Read more >>

Curr Opin Endocr Metab Res (Current opinion in endocrine and metabolic research)
[2021, 16:37-42]

Cited: 8 times

View full text PDF listing >>



Signaling diversity enabled by Rap1-regulated plasma membrane ERK with distinct temporal dynamics.

Jeremiah Keyes, Ambhighainath Ganesan, Olivia Molinar-Inglis, Archer Hamidzadeh, Jinfan Zhang, Megan Ling, JoAnn Trejo, Andre Levchenko, Jin Zhang,

A variety of different signals induce specific responses through a common, extracellular-signal regulated kinase (ERK)-dependent cascade. It has been suggested that signaling specificity can be achieved through precise temporal regulation of ERK activity. Given the wide distrubtion of ERK susbtrates across different subcellular compartments, it is important to understand how ... Read more >>

Elife (eLife)
[2020, 9:]

Cited: 9 times

View full text PDF listing >>



MON-009 GLUT1-Mediated Glycolysis Facilitates GnRH-Induced Secretion of Luteinizing Hormone

Dequina Nicholas, Vashti Knight, Karen Tonsfeldt, Tomohiro Terasaka, Olivia Molinar-Inglis, Shannon Brooke Zoe Stephens, Joann Trejo, Alexander S Kauffman, Pamela L Mellon, Mark A Lawson,

Abstract Reproduction requires intensive energy expenditure, and energy availability impacts the function of the reproductive endocrine HPG-axis. Accordingly, the reproductive axis is suppressed during hypoglycemia. Circulating blood glucose can directly interact with gonadotropes within the highly vascular pituitary. Therefore, it is possible that gonadotropes may sense energy availability via the ... Read more >>

J Endocr Soc (Journal of the Endocrine Society)
[2020, 4(Suppl 1):]

Cited: 0 times

View full text PDF listing >>



Phosphoproteomic analysis of protease-activated receptor-1 biased signaling reveals unique modulators of endothelial barrier function.

Ying Lin, Jacob M Wozniak, Neil J Grimsey, Sravan Girada, Anand Patwardhan, Olivia Molinar-Inglis, Thomas H Smith, John D Lapek, David J Gonzalez, JoAnn Trejo,

Thrombin, a procoagulant protease, cleaves and activates protease-activated receptor-1 (PAR1) to promote inflammatory responses and endothelial dysfunction. In contrast, activated protein C (APC), an anticoagulant protease, activates PAR1 through a distinct cleavage site and promotes anti-inflammatory responses, prosurvival, and endothelial barrier stabilization. The distinct tethered ligands formed through cleavage of ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2020, 117(9):5039-5048]

Cited: 7 times

View full text PDF listing >>



Signaling Diversity Enabled by Rap1-Regulated Plasma Membrane ERK with Distinct Temporal Dynamics

Jeremiah Keyes, Ambhighainath Ganesan, Olivia Molinar-Inglis, Archer Hamidzadeh, Megan Ling, JoAnn Trejo, Andre Levchenko, Jin Zhang,

A variety of different signals induce specific responses through a common, ERK-dependent kinase cascade. It has been suggested that signaling specificity can be achieved through precise temporal regulation of ERK activity. Given the wide distrubtion of ERK susbtrates across different subcellular compartments, it is important to understand how ERK activity ... Read more >>

()
[, :]

Cited: 0 times

View full text PDF listing >>



APC2 associates with the actin cortex through a multipart mechanism to regulate cortical actin organization and dynamics in the Drosophila ovary.

Olivia Molinar-Inglis, Stacie L Oliver, Paige Rudich, Ezgi Kunttas, Brooke M McCartney,

The actin cortex that lines the plasma membrane of most eukaryotic cells resists external mechanical forces and plays critical roles in a variety of cellular processes including morphogenesis, cytokinesis, and cell migration. Despite its ubiquity and significance, we understand relatively little about the composition, dynamics, and structure of the actin ... Read more >>

Cytoskeleton (Hoboken) (Cytoskeleton (Hoboken, N.J.))
[2018, 75(7):323-335]

Cited: 3 times

View full text PDF listing >>





Advertisement


Disclaimer

0.6339 s