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Author Ola Forslund

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Equal prevalence of severe cervical dysplasia by HPV self-sampling and by midwife-collected samples for primary HPV screening: a randomised controlled trial.

Caroline Hellsten, Avalon Ernstson, Gunilla Bodelsson, Ola Forslund, Christer Borgfeldt,

<h4>Objectives</h4>HPV self-sampling is an option for cervical screening. The aim of this randomised study was to investigate the compliance, prevalence of HPV, and prevalence of severe dysplasia in a vaginal self-sampling group in comparison to cervical samples collected by midwives (control arm). The hypothesis was that there would be no ... Read more >>

Eur J Cancer Prev (European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP))
[2021, 30(4):334-340]

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The 2019 HPV Labnet international proficiency study: Need of global Human Papillomavirus Proficiency Testing.

Carina Eklund, Laila Sara Arroyo Mühr, Camilla Lagheden, Ola Forslund, Karin Dahlin Robertsson, Joakim Dillner,

<h4>Background</h4>Accurate and internationally comparable human papillomavirus (HPV) testing services are essential for cervical cancer elimination programs. The WHO HPV Laboratory Network started issuing international HPV testing proficiency panels in 2008.<h4>Objectives</h4>We report the results of the 2019 global proficiency study and evaluate the proficiency over time.<h4>Study design</h4>The proficiency panel contained 40 ... Read more >>

J Clin Virol (Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology)
[2021, 141:104902]

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HPV73 in cervical cancer and distribution of HPV73 variants in cervical dysplasia.

Christer Borgfeldt, Anna Söderlund-Strand, Lotten Darlin Flygh, Ola Forslund,

HPV73 is classified as possibly oncogenic and is not recognized by most commercial primary HPV screening platforms. The aim was to determine the prevalence of HPV73 among invasive cervical cancers, formalin-fixed paraffin embedded (FFPE) samples (N = 69), from southern Sweden during 2009 to 2010. Another aim was to determine ... Read more >>

Int J Cancer (International journal of cancer)
[2021, :]

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Promotion of Cervical Screening among Long-term Non-attendees by Human Papillomavirus Self-sampling.

Avalon Ernstson, Ola Forslund, Christer Borgfeldt,

Cervical cancer is preventable through gynecological screening. To promote participation among non-attending women, self-collected vaginal samples for detection of high-risk human papillomavirus (hr-HPV) is an option. The aims of this study were to investigate the response of self-collected vaginal samples for hr-HPV testing among long-term non-attendees, to explore the attendance ... Read more >>

J Cancer Prev (Journal of cancer prevention)
[2021, 26(1):25-31]

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14-type HPV mRNA test in triage of HPV DNA-positive postmenopausal women with normal cytology.

Katrin Christine Asciutto, Christer Borgfeldt, Ola Forslund,

<h4>Background</h4>During 2013 and 2016 the region of Skåne, Sweden started to analyse human papillomavirus (HPV) and cytology in postmenopausal women 60-65 years of age. Our aim was to evaluate high-risk (HR) HPV mRNA testing for the triage of HPV DNA-positive postmenopausal women with normal cytology.<h4>Methods</h4>A total of 271 women, 60-65 years of ... Read more >>

BMC Cancer (BMC cancer)
[2020, 20(1):1025]

Cited: 1 time

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Immune Phenotypes of Nasopharyngeal Cancer.

Johan S Nilsson, Aastha Sobti, Sabine Swoboda, Jonas S Erjefält, Ola Forslund, Malin Lindstedt, Lennart Greiff,

Nasopharyngeal cancer (NPC) features intralesional immune cells, but data are lacking on presence/distribution of T-cells and dendritic cells (DCs). Based on intralesional distribution of lymphocytes, a series of NPC biopsies (<i>n</i> = 48) were classified into "inflamed", "excluded", and "deserted" phenotypes. In addition, CD8+ T-cells and CD207+ DCs were quantified. ... Read more >>

Cancers (Basel) (Cancers)
[2020, 12(11):]

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14-type HPV mRNA test in triage of HPV DNA positive postmenopausal women with normal cytology

Katrin Christine Asciutto, Christer Borgfeldt, Ola Forslund,

<h4>Background: </h4> During 2013 and 2016 the Region of Skåne, Sweden, started to analyse human papillomavirus (HPV) and cytology in postmenopausal women 60-65 years of age. Our aim was to evaluate high-risk (HR) HPV mRNA testing for the triage of HPV DNA positive postmenopausal women with normal cytology. <h4>Methods:</h4> A ... Read more >>

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Penile intraepithelial neoplasia, penile cancer precursors and human papillomavirus prevalence in symptomatic preputium: a cross-sectional study of 351 circumcised men in Sweden.

Sinja Kristiansen, Carina Bjartling, Åke Svensson, Ola Forslund, Christian Torbrand,

<h4>Objectives</h4>To investigate the prevalence of pathological disease and spectrum of human papillomavirus (HPV) types among symptomatic foreskin tissue.<h4>Patients and methods</h4>Consecutively excised symptomatic foreskins from 351 men were sent for histopathological evaluation. During the surgical procedure, a fresh biopsy was taken for HPV analysis by modified general primer polymerase chain reaction. ... Read more >>

BJU Int (BJU international)
[2021, 127(4):428-434]

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Detection of HPV mRNA in Self-collected Vaginal Samples Among Urban Ethiopian Women.

Selamawit Mekuria, Mats Jerkeman, Ola Forslund, Saba Fikru, Christer Borgfeldt,

BACKGROUND/AIM:Cervical cancer is the most common cancer among women in Ethiopia. The objective was to evaluate the participation rate of a free of charge vaginal self-sample (Aptima multitest swab, Hologic) for the detection of human papillomavirus (HPV) in an Ethiopian cohort. PATIENTS AND METHODS:Specimens were collected from women employed by ... Read more >>

Anticancer Res (Anticancer research)
[2020, 40(3):1513-1517]

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Cervical cancer prevention among long-term screening non-attendees by vaginal self-collected samples for hr-HPV mRNA detection.

Avalon Ernstson, Annika Urdell, Ola Forslund, Christer Borgfeldt,

Background:The efficacy of cervical cancer screening programs is dependent on the participation rate. To increase participation among women not attending cervical cancer screening, self-collected samples for detection of high-risk human papillomavirus (hr-HPV) may be an option.The aims of this study were: to investigate the response rate to sending a self-collected ... Read more >>

Infect Agent Cancer (Infectious agents and cancer)
[2020, 15:10]

Cited: 1 time

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Detecting TP53 mutations in diagnostic and archival liquid-based Pap samples from ovarian cancer patients using an ultra-sensitive ddPCR method.

Nicolai Skovbjerg Arildsen, Laura Martin de la Fuente, Anna Måsbäck, Susanne Malander, Ola Forslund, Päivi Kannisto, Ingrid Hedenfalk,

High-grade serous ovarian cancer (HGSOC) is the most common subtype of epithelial ovarian cancer and early detection is challenging. TP53 mutations are a hallmark of HGSOC and detection of these mutations in liquid-based Pap samples could provide a method for early diagnosis. Here we evaluate the use of IBSAFE, an ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):15506]

Cited: 2 times

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Intralesional EBV-DNA load as marker of prognosis for nasopharyngeal cancer.

Johan S Nilsson, Ola Forslund, Fredrik C Andersson, Malin Lindstedt, Lennart Greiff,

Nasopharyngeal cancer (NPC) is associated with the Epstein-Barr virus (EBV). The clinical presentation and prognosis of NPC is well described, but not in relation to intralesional EBV-DNA load. In a retrospective design, 48 patients with NPC were examined. Patient history was re-evaluated, and diagnostic biopsies were re-examined. Furthermore, intralesional EBV-DNA ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):15432]

Cited: 4 times

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Increased HPV detection by the use of a pre-heating step on vaginal self-samples analysed by Aptima HPV assay.

Christer Borgfeldt, Ola Forslund,

<h4>Background</h4>We recently reported a sensitivity of 85.5% to detect high-grade squamous intraepithelial lesions (HSIL)/adenocarcinoma in situ (AIS)/cancer by the use of self-collected vaginal samples analysed by the Aptima mRNA HPV assay (AHPV).<h4>Objectives</h4>To increase detection of HPV among self-samples.<h4>Study design</h4>We used a pre-heating step at 90 °C for 1 h on our previously ... Read more >>

J Virol Methods (Journal of virological methods)
[2019, 270:18-20]

Cited: 2 times

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Linear Trimer Formation with Antiferromagnetic Ordering in 1T-CrSe2 Originating from Peierls-like Instabilities and Interlayer Se-Se Interactions.

Shintaro Kobayashi, Naoyuki Katayama, Taishun Manjo, Hiroaki Ueda, Chishiro Michioka, Jun Sugiyama, Yasmine Sassa, Ola Kenji Forslund, Martin Månsson, Kazuyoshi Yoshimura, Hiroshi Sawa,

Anomalous successive structural transitions in layered 1<i>T</i>-CrSe<sub>2</sub> with an unusual Cr<sup>4+</sup> valency were investigated by synchrotron X-ray diffraction. 1<i>T</i>-CrSe<sub>2</sub> exhibits dramatic structural changes in in-plane Cr-Cr and interlayer Se-Se distances, which originate from two interactions: (i) in-plane Cr-Cr interactions derived from Peierls-like trimerization instabilities on the orbitally assisted one-dimensional chains ... Read more >>

Inorg Chem (Inorganic chemistry)
[2019, 58(21):14304-14315]

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Population-based primary HPV mRNA cervical screening compared with cytology screening.

Ylva Lindroth, Christer Borgfeldt, Gunilla Thorn, Gunilla Bodelsson, Ola Forslund,

Primary HPV screening for cervical cancer by HPV mRNA testing (Aptima) was implemented in January 2017, for women ≥30 through 70 years, in the Region of Skåne, Sweden. HPV positive samples underwent cytology assessment, and women with any degree of abnormal cytology were referred for colposcopy. The aim was to audit ... Read more >>

Prev Med (Preventive medicine)
[2019, 124:61-66]

Cited: 2 times

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Risk Factors for Penile Intraepithelial Neoplasia: A Population-based Register Study in Sweden, 2000-2012.

Sinja Kristiansen, Åke Svensson, Linda Drevin, Ola Forslund, Christian Torbrand, Carina Bjartling,

Studies on risk factors for penile intraepithelial neo-plasia have been small in size, have not distinguished penile intraepithelial neoplasia from invasive cancer, and have relied on self-reported information. This study investigated risk factors for penile intraepithelial neoplasia in a cohort of 580 penile intraepithelial neoplasia cases and 3,436 controls using ... Read more >>

Acta Derm Venereol (Acta dermato-venereologica)
[2019, 99(3):315-320]

Cited: 2 times

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Detection of HPV mRNA in Self-collected Vaginal Samples Among Women at 69-70 Years of Age.

Avalon Ernstson, Katrin Christine Asciutto, Johan Sturesson, Jonas Norén, Ola Forslund, Christer Borgfeldt,

<h4>Background/aim</h4>Cervical cancer is associated with poorer diagnosis among the elderly and pap-smear screening has a lower sensitivity. Self-sampling for detection of high-risk human papillomavirus (hr-HPV) may be an alternative screening method. The aim of this study was to analyze the response rate to vaginal HPV self-sampling and the HPV mRNA ... Read more >>

Anticancer Res (Anticancer research)
[2019, 39(1):381-386]

Cited: 4 times

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HPV-mRNA and HPV-DNA detection in samples taken up to seven years before severe dysplasia of cervix uteri.

Ola Forslund, K Miriam Elfström, Helena Lamin, Joakim Dillner,

Randomized clinical trials using human papillomavirus (HPV) DNA testing have found increased protection against cervical cancer and HPV-based screening is globally recommended for women ≥30 years of age. HPV-mRNA is a promising alternative target for cervical screening tests, but assessing equivalence requires longitudinal evaluation over at least the length of ... Read more >>

Int J Cancer (International journal of cancer)
[2019, 144(5):1073-1081]

Cited: 6 times

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Prevalence of High-risk HPV in Postmenopausal Women with Benign Cervical Cytology - A Population-based Cohort Study.

Katrin Christine Asciutto, Ola Forslund, Christer Borgfeldt,

<h4>Aim</h4>To compare the clinical performance of human papillomavirus (HPV) mRNA and DNA assays in postmenopausal women.<h4>Materials and methods</h4>A total of 5,925 postmenopausal women were tested with cytology and the Luminex HPV DNA assay. High risk-HPV-positive women with benign cytology underwent a complimentary HPV mRNA assay (APTIMA). Both assays and the ... Read more >>

Anticancer Res (Anticancer research)
[2018, 38(7):4221-4228]

Cited: 3 times

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Continuing global improvement in human papillomavirus DNA genotyping services: The 2013 and 2014 HPV LabNet international proficiency studies.

Carina Eklund, Ola Forslund, Keng-Ling Wallin, Joakim Dillner,

BACKGROUND:Accurate and internationally comparable human papillomavirus (HPV) DNA detection and typing services are essential for HPV vaccine research and surveillance. OBJECTIVES:This study assessed the proficiency of different HPV typing services offered routinely in laboratories worldwide. STUDY DESIGN:The HPV Laboratory Network (LabNet) has designed international proficiency panels that can be regularly ... Read more >>

J Clin Virol (Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology)
[2018, 101:74-85]

Cited: 6 times

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Self-sampling with HPV mRNA analyses from vagina and urine compared with cervical samples.

Katrin Christine Asciutto, Avalon Ernstson, Ola Forslund, Christer Borgfeldt,

BACKGROUND:In order to increase coverage in the organized cervical screening program, self-sampling with HPV analyses has been suggested. OBJECTIVES:The aim was to compare human papillomavirus (HPV) mRNA detection in vaginal and urine self-collected samples with clinician-taken cervical samples and the corresponding clinician-taken histological specimens. STUDY DESIGN:Self-collected vaginal, urine and clinician-taken ... Read more >>

J Clin Virol (Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology)
[2018, 101:69-73]

Cited: 11 times

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Mycoplasma genitalium and Macrolide Resistance-associated Mutations in the Skåne Region of Southern Sweden 2015.

Ola Forslund, Max Hjelm, Raghd El-Ali, Annika Johnsson, Carina Bjartling,

Mycoplasma genitalium is a sexually transmitted infection ordinarily treated with azithromycin. Emerging resistance to macrolide is linked to mutations in the 23S rRNA gene. We analysed the frequency of such mutations of M. genitalium isolates from patients that were symptomatic, and from sexual partners of symptomatic individuals, from October to ... Read more >>

Acta Derm Venereol (Acta dermato-venereologica)
[2017, 97(10):1235-1238]

Cited: 1 time

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Spectrum of HPV types before and after treatment of cervical intraepithelial neoplasia grade 2 and 3.

Ylva Lindroth, Kaj Bjelkenkrantz, Ola Forslund,

BACKGROUND:To monitor residual disease after treatment of high grade cervical intraepithelial neoplasia (CIN), cytology together with human papillomavirus (HPV) testing are commonly performed. OBJECTIVES:To analyse the spectrum of HPV types before and after treatment. STUDY DESIGN:This register-based study included 446 women treated for CIN2 or 3, where cytology samples had ... Read more >>

J Clin Virol (Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology)
[2017, 97:38-43]

Cited: 1 time

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Prevalence of human papillomavirus types, viral load and physical status of HPV16 in head and neck squamous cell carcinoma from the South Swedish Health Care Region.

Helena Faust, Erika Eldenhed Alwan, Alexander Roslin, Johan Wennerberg, Ola Forslund,

Incidence of human papillomavirus (HPV)-positive head and neck squamous cell carcinoma (HNSCC) is rising in several countries. Intriguingly, large variations of HPV16 viral load and different proportions of the physical viral status among HNSCC have been reported. We analysed fresh biopsies of 275 HNSCC patients from the South Swedish Health ... Read more >>

J Gen Virol (The Journal of general virology)
[2016, 97(11):2949-2956]

Cited: 12 times

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TPL2 Is an Oncogenic Driver in Keratocanthoma and Squamous Cell Carcinoma.

Jun-Han Lee, Joo-Hyung Lee, Sang Hyuk Lee, Sung-Im Do, Sung-Dae Cho, Ola Forslund, Kyung-Soo Inn, Jeong-Sang Lee, Fang-Ming Deng, Jonathan Melamed, Jae U Jung, Joseph H Jeong,

Squamous cell carcinoma (SCC) and keratoacanthoma (KA; SCC/KA) research has been hampered mainly by our lack of understanding the underlying genetic and epigenetic alterations associated with SCC/KA development, as well as the lack of animal models that faithfully recapitulate histopathologic features of human SCC/KA. Here, we show that TPL2 overexpression ... Read more >>

Cancer Res (Cancer research)
[2016, 76(22):6712-6722]

Cited: 6 times

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