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One Year of Procarbazine Lomustine and Vincristine is Poorly Tolerated in Low Grade Glioma: A Real World Experience in a National Neuro-Oncology Centre

Rachel Keogh, Razia Aslam, Maeve Hennessy, Zac Coyne, Bryan Hennessy, Oscar Breathnach, Liam Grogan, Patrick Morris,

<h4>Background: </h4> Following optimal local therapy, adjuvant Procarbazine, Lomustine and Vincristine (PCV) improves overall survival (OS) in low-grade glioma (LGG). However, one year of PCV is associated with significant toxicities. In the pivotal RTOG 9802 randomised control trial, approximately half of the patients discontinued treatment after six months. As patients ... Read more >>

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Chemotherapy in the Covid-19 era: the patient's perception.

Maeve A Hennessy, Anna Linehan, Darren Cowzer, Zachary L Coyne, Orla Fitzpatrick, Fiona Barrett, Roisin Ni Dhonaill, Bryan T Hennessy, Liam Grogan, Patrick G Morris, Oscar S Breathnach,

<h4>Background</h4>The Covid-19 pandemic poses significant challenges for the management of patients with cancer. In our institution, we adapted our delivery of outpatient systemic anti-cancer therapy (SACT) by introducing a number of 'risk-reducing' measures including pre-assessment screening.<h4>Aims</h4>We sought to evaluate the experience and perceptions of patients with cancer undergoing SACT during ... Read more >>

Ir J Med Sci (Irish journal of medical science)
[2021, :]

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Prevalence of tumor BRCA1 and BRCA2 dysfunction in unselected patients with ovarian cancer.

Roshni D Kalachand, Ciaran O'Riain, Sinead Toomey, Aoife Carr, Kirsten M Timms, Sharon O'Toole, Stephen Madden, Mark Bates, John J O'Leary, Noreen Gleeson, Dearbhaile O'Donnell, Liam Grogan, Oscar Breathnach, Angela Farrelly, Britta Stordal, Bryan T Hennessy,

<h4>Objective</h4>The therapeutic benefits of poly(ADP-ribose) polymerase inhibitors highlight the need to evaluate BRCA1/2 defects in tubal/ovarian cancer (OC). We sought to determine the pattern and disease characteristics associated with tumor BRCA1/2 mutations and BRCA1 methylation in women with OC.<h4>Methods</h4>We obtained 111 OC specimens from 2 university hospitals and assessed BRCA1/2 ... Read more >>

Obstet Gynecol Sci (Obstetrics & gynecology science)
[2020, 63(5):643-654]

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Use of exhaled breath condensate (EBC) in the diagnosis of SARS-COV-2 (COVID-19).

Daniel J Ryan, Sinead Toomey, Stephen F Madden, Michelle Casey, Oscar S Breathnach, Patrick G Morris, Liam Grogan, Peter Branagan, Richard W Costello, Eoghan De Barra, Killian Hurley, Cedric Gunaratnam, Noel G McElvaney, Michael Emmet OBrien, Imran Sulaiman, Ross K Morgan, Bryan T Hennessy,

False negatives from nasopharyngeal swabs (NPS) using reverse transcriptase PCR (RT-PCR) in SARS-CoV-2 are high. Exhaled breath condensate (EBC) contains lower respiratory droplets that may improve detection. We performed EBC RT-PCR for SARS-CoV-2 genes (E, S, N, ORF1ab) on NPS-positive (n=16) and NPS-negative/clinically positive COVID-19 patients (n=15) using two commercial ... Read more >>

Thorax (Thorax)
[2021, 76(1):86-88]

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1732P Prognostic indicators for COVID-19 related deaths in patients with cancer

A. Linehan, D. Cowzer, M. Hennessy, Z. Coyne, O. Fitzpatrick, A. Nolan, L. Judge, N. Cooley, D. O'Doherty, C. Matassa, T. Doyle, B.T. Hennessy, L. Grogan, P.G. Morris, O.S. Breathnach,

Ann Oncol (Annals of oncology : official journal of the European Society for Medical Oncology)
[2020, 31(9):S1014-S1014]

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1571P Chemotherapy in the COVID-19 era: The patient’s perception

M. Hennessy, A. Linehan, D. Cowzer, Z. Coyne, O. Fitzpatrick, R. Ní Dhonaill, B.T. Hennessy, L. Grogan, P.G. Morris, O.S. Breathnach,

Ann Oncol (Annals of oncology : official journal of the European Society for Medical Oncology)
[2020, 31(9):S957-S957]

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Genomic and Transcriptomic Characterisation of Response to Neoadjuvant Chemoradiotherapy in Locally Advanced Rectal Cancer.

Sinead Toomey, Jillian Gunther, Aoife Carr, David C Weksberg, Valentina Thomas, Manuela Salvucci, Orna Bacon, El-Masry Sherif, Joanna Fay, Elaine W Kay, Katherine M Sheehan, Deborah A McNamara, Keith L Sanders, Geena Mathew, Oscar S Breathnach, Liam Grogan, Patrick G Morris, Wai C Foo, Yi-Qian N You, Jochen H Prehn, Brian O'Neill, Sunil Krishnan, Bryan T Hennessy, Simon J Furney,

Standard treatment for locally advanced rectal cancer (LARC) is neoadjuvant chemoradiotherapy (NACRT), followed by surgical resection. However, >70% of patients do not achieve a complete pathological response and have higher rates of relapse and death. There are no validated pre- or on-treatment factors that predict response to NACRT besides tumour ... Read more >>

Cancers (Basel) (Cancers)
[2020, 12(7):]

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1762P Delivery of systemic anti-cancer therapy during the COVID-19 pandemic

O. Fitzpatrick, R. Ní Dhonaill, A. Linehan, Z. Coyne, M. Hennessy, M. Clarke, E. McGee, F. Barrett, C. Matassa, D. O'Doherty, T. Doyle, A. Christie, B.T. Hennessy, L. Grogan, P.G. Morris, O.S. Breathnach, D. Cowzer,

Ann Oncol (Annals of oncology : official journal of the European Society for Medical Oncology)
[2020, 31(9):S1024-S1025]

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Challenges associated with systemic therapy for older patients with inoperable non-small cell lung cancer.

Connor O'Leary, Lynda McSorley, Bryan Hennessy, Liam Grogan, Oscar Breathnach, Patrick Morris,

<h4>Introduction</h4>Lung cancer is the most common cancer diagnosed worldwide. Data from several studies fall short to make appropriate conclusions on the management for elderly patients. The discovery of targeted therapy and immunotherapy has allowed these patients access to a wider array of options.<h4>Areas covered</h4>The authors review research for treating older ... Read more >>

Expert Opin Pharmacother (Expert opinion on pharmacotherapy)
[2020, 21(17):2185-2194]

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Lack of familiarity with genetic testing among patients in Ireland with Cancer.

William J Mullally, Fergus Keane, Amy Nolan, Liam Grogan, Oscar S Breathnach, Bryan T Hennessy, Dearbhaile C Collins, Patrick G Morris,

BACKGROUND:Cancer gene panel testing is available in Ireland. The need for a clear strategy to deal with patient information generated from tumour genomic testing is recognised as a challenge in the National Cancer Strategy. However, the public's attitude and opinions regarding these results is not known in Ireland. AIMS:This prospective ... Read more >>

Ir J Med Sci (Irish journal of medical science)
[2020, :]

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Patient demographics and management challenges in an Irish symptomatic breast cancer unit.

Zac L Coyne, Maeve Hennessy, Deirdre Duke, Arnold Hill, Liam Grogan, Oscar Breathnach, Bryan Hennessy, Patrick G Morris,

<h4>Background</h4>Breast cancer is the most common cancer in women. Beaumont Hospital is a nationally designated symptomatic breast cancer unit, independent of the national screening programme, BreastCheck.<h4>Aims</h4>We hypothesised that patients attending symptomatic breast cancer units differ from national registry data and aimed to characterise this in a retrospective study.<h4>Methods</h4>A prospective database ... Read more >>

Ir J Med Sci (Irish journal of medical science)
[2020, 189(4):1237-1241]

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Identification and clinical impact of potentially actionable somatic oncogenic mutations in solid tumor samples.

Sinead Toomey, Aoife Carr, Mateusz Janusz Mezynski, Yasir Elamin, Shereen Rafee, Mattia Cremona, Clare Morgan, Stephen Madden, Khairun I Abdul-Jalil, Kathy Gately, Angela Farrelly, Elaine W Kay, Susan Kennedy, Kenneth O'Byrne, Liam Grogan, Oscar Breathnach, Patrick G Morris, Alexander J Eustace, Joanna Fay, Robert Cummins, Anthony O'Grady, Roshni Kalachand, Norma O'Donovan, Fergal Kelleher, Aine O'Reilly, Mark Doherty, John Crown, Bryan T Hennessy,

BACKGROUND:An increasing number of anti-cancer therapeutic agents target specific mutant proteins that are expressed by many different tumor types. Successful use of these therapies is dependent on the presence or absence of somatic mutations within the patient's tumor that can confer clinical efficacy or drug resistance. METHODS:The aim of our ... Read more >>

J Transl Med (Journal of translational medicine)
[2020, 18(1):99]

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Similar overall survival with reduced vs. standard dose bevacizumab monotherapy in progressive glioblastoma.

Jack Patrick Gleeson, Fergus Keane, Niamh M Keegan, Emin Mammadov, Emily Harrold, Abdullah Alhusaini, Jeffrey Harte, Austin Eakin-Love, Philip J O'Halloran, Stephen MacNally, Bryan T Hennessy, Oscar S Breathnach, Liam Grogan, Patrick G Morris,

<h4>Introduction</h4>Bevacizumab has demonstrated activity in glioblastoma (GBM), but the true benefits and optimal dose-schedule are debated. A lower dose-schedule than standard-dose bevacizumab (10 mg/kg 2-weekly) might offer similar benefits with lower costs. At our Institution, patients are randomly assigned at time of primary diagnosis to Neuro-Oncologists, who have varying practices in ... Read more >>

Cancer Med (Cancer medicine)
[2020, 9(2):469-475]

Cited: 2 times

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An uncommon complication of vertebroplasty: the role of anticoagulation.

Niamh O'Connor-Byrne, Caitriona Logan, Niamh Keegan, Paul Brennan, Oscar S Breathnach, Liam Grogan, Bryan Hennessy, Patrick G Morris,

Vertebroplasty is a well-established treatment for both pathological and painful osteoporotic fractures. It is a frequently performed and generally low risk, but severe complications can occur. We report on a patient with metastatic breast cancer requiring vertebroplasty for pain relief who suffered an unusual complication: a pulmonary cement embolism. We ... Read more >>

Anticancer Drugs (Anti-cancer drugs)
[2019, 30(6):646-648]

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Trauma assessment clinic: Virtually a safe and smarter way of managing trauma care in Ireland.

M O' Reilly, O Breathnach, B Conlon, C Kiernan, E Sheehan,

<h4>Introduction</h4>The Trauma Assessment Clinic [TAC], also referred to as Virtual Fracture Clinic, offers a novel care pathway for patients and is being increasingly utilised across the Irish and UK health care systems. The provision of safe, patient centred, efficient and cost-effective treatment via a multidisciplinary team [MDT] approach is the ... Read more >>

Injury (Injury)
[2019, 50(4):898-902]

Cited: 5 times

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Electronic referrals for virtual fracture clinic service using the National Integrated Medical Imaging System (NIMIS).

Oisin Breathnach, Marc O'Reilly, Keith Morrissey, Breda Conlon, Eoin Sheehan,

<h4>Introduction</h4>Virtual fracture clinics (VFC) are now prevalent across many orthopaedic services in the UK and Ireland. The management of a variety of musculoskeletal injuries using the VFC model has been demonstrated to be safe, cost-effective and associated with high levels of patient satisfaction. Referrals were made available through the National ... Read more >>

Ir J Med Sci (Irish journal of medical science)
[2019, 188(2):371-377]

Cited: 1 time

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Absence of thyroid transcription factor-1 expression is associated with poor survival in patients with advanced pulmonary adenocarcinoma treated with pemetrexed-based chemotherapy.

Mark K Doherty, Emer O'Connor, David Hannon, Aine O'Reilly, Daphne Yen, Maeve Redmond, Liam M Grogan, Bryan T Hennessy, Oscar S Breathnach, Patrick G Morris,

<h4>Introduction</h4>Adenocarcinoma is the commonest histologic subtype of lung cancer and is often identified by immunohistochemical staining for thyroid transcription factor-1 (TTF-1). However, up to 20% of lung adenocarcinomas do not express TTF-1, and there is uncertainty regarding the significance of this. We aimed to evaluate the prognostic effect of TTF-1 ... Read more >>

Ir J Med Sci (Irish journal of medical science)
[2019, 188(1):69-74]

Cited: 1 time

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The "National Integrated Medical Imaging System" [NIMIS]-friend, not nimesis!

Marc F O' Reilly, Oisin P Breathnach, Khalid M Mohamed, Eoin C Sheehan,

<h4>Introduction</h4>The "National Integrated Medical Imaging System" or NIMIS went live in 2011 and allows the movement of patient radiology imaging throughout the Irish health system. At the time of its launch, NIMIS was not only going to allow the filmless passage of patient radiology imaging but it was also envisaged ... Read more >>

Ir J Med Sci (Irish journal of medical science)
[2019, 188(2):365-369]

Cited: 1 time

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Brief Report on the Detection of the EGFR T790M Mutation in Exhaled Breath Condensate from Lung Cancer Patients.

Robert J Smyth, Sinead M Toomey, Alexander Sartori, Emer O'Hanrahan, Sinead D Cuffe, Oscar S Breathnach, Ross K Morgan, Bryan T Hennessy,

The EGFR T790M somatic mutation is the most common mechanism of resistance to tyrosine kinase inhibitors in NSCLC. Patients with advanced disease are not always amenable to repeat biopsy for further molecular analysis. Developing noninvasive methods to detect T790M in cell-free DNA in the absence of tissue is being actively ... Read more >>

J Thorac Oncol (Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer)
[2018, 13(8):1213-1216]

Cited: 6 times

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Impact of somatic PI3K pathway and ERBB family mutations on pathological complete response (pCR) in HER2-positive breast cancer patients who received neoadjuvant HER2-targeted therapies.

Sinead Toomey, Alexander J Eustace, Joanna Fay, Katherine M Sheehan, Aoife Carr, Malgorzata Milewska, Stephen F Madden, Ausra Teiserskiene, Elaine W Kay, Norma O'Donovan, William Gallagher, Liam Grogan, Oscar Breathnach, Janice Walshe, Catherine Kelly, Brian Moulton, M John Kennedy, Guiseppe Gullo, Arnold D Hill, Colm Power, Deirdre Duke, Niamh Hambly, John Crown, Bryan T Hennessy,

<h4>Background</h4>The Cancer Genome Atlas analysis revealed that somatic EGFR, receptor tyrosine-protein kinase erbB-2 (ERBB2), Erb-B2 receptor tyrosine kinase 3 (ERBB3) and Erb-B2 receptor tyrosine kinase 4 (ERBB4) gene mutations (ERBB family mutations) occur alone or co-occur with somatic mutations in the gene encoding the phosphatidylinositol 3-kinase (PI3K) catalytic subunit (PIK3CA) ... Read more >>

Breast Cancer Res (Breast cancer research : BCR)
[2017, 19(1):87]

Cited: 10 times

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Bilateral Adrenalectomy for Metastatic Esophageal Adenocarcinoma: A Case Report.

Ciara S McNevin, Jack P Gleeson, Darragh B Herlihy, John J Aird, William B Robb, Elaine W Kay, Patrick G Morris, Liam Grogan, Oscar S Breathnach,

J Oncol Pract (Journal of oncology practice)
[2018, 14(1):47-48]

Cited: 0 times

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Emergency Aeromedical Services in Ireland: A Single-Centre Study in 2014.

G A Sheridan, D Cooper, J P Gibbons, O Breathnach, J F Quinlan,

This retrospective analysis includes patients requiring Emergency Aeromedical Services (EAS) in 2014. The aim of this paper is to evaluate the HEMS service in a single centre and to accurately assess whether certain internationally validated criteria can predict admission rates better than the currently used criteria. Using the American College ... Read more >>

Ir Med J (Irish medical journal)
[2017, 110(3):531]

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Adjuvant Sunitinib in High-Risk Renal-Cell Carcinoma after Nephrectomy.

Alain Ravaud, Robert J Motzer, Hardev S Pandha, Daniel J George, Allan J Pantuck, Anup Patel, Yen-Hwa Chang, Bernard Escudier, Frede Donskov, Ahmed Magheli, Giacomo Carteni, Brigitte Laguerre, Piotr Tomczak, Jan Breza, Paola Gerletti, Mariajose Lechuga, Xun Lin, Jean-Francois Martini, Krishnan Ramaswamy, Michelle Casey, Michael Staehler, Jean-Jacques Patard, ,

<h4>Background</h4>Sunitinib, a vascular endothelial growth factor pathway inhibitor, is an effective treatment for metastatic renal-cell carcinoma. We sought to determine the efficacy and safety of sunitinib in patients with locoregional renal-cell carcinoma at high risk for tumor recurrence after nephrectomy.<h4>Methods</h4>In this randomized, double-blind, phase 3 trial, we assigned 615 patients ... Read more >>

N Engl J Med (The New England journal of medicine)
[2016, 375(23):2246-2254]

Cited: 178 times

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The impact of outpatient systemic anti-cancer treatment on patient costs and work practices.

D C Collins, M Coghlan, B T Hennessy, L Grogan, P G Morris, O S Breathnach,

<h4>Background</h4>There is extensive focus on the rising costs of healthcare. However, for patients undergoing cancer treatment, there are additional personal costs, which are poorly characterised.<h4>Aim</h4>To qualify indirect costs during anti-cancer therapy in a designated Irish cancer centre.<h4>Methods</h4>An anonymous questionnaire collected demographic data, current work practice, and personal expenditure on regular ... Read more >>

Ir J Med Sci (Irish journal of medical science)
[2017, 186(1):81-87]

Cited: 0 times

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Emergency aeromedical services in Ireland: a retrospective study for "MEDEVAC112".

J P Gibbons, O Breathnach, J F Quinlan,

<h4>Aim</h4>This is a retrospective analysis of all consecutive patients requiring emergency aeromedical services (EAS) to a level II trauma centre. This analysis was performed to evaluate the new service to Tallaght Hospital in terms of: the criteria used for dispatch, an estimate of baseline efficiency of time critical management of ... Read more >>

Ir J Med Sci (Irish journal of medical science)
[2017, 186(1):33-39]

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