Full Text Journal Articles by
Author Nuzhat Ahmed

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TIMP-2 regulates proliferation, invasion and STAT3-mediated cancer stem cell-dependent chemoresistance in ovarian cancer cells.

Ruth M Escalona, Maree Bilandzic, Patrick Western, Elif Kadife, George Kannourakis, Jock K Findlay, Nuzhat Ahmed,

BACKGROUND:The metzincin family of metalloproteinases and the tissue inhibitors of metalloproteinases (TIMPs) are essential proteins required for biological processes during cancer progression. This study aimed to determine the role of TIMP-2 in ovarian cancer progression and chemoresistance by reducing TIMP-2 expression in vitro in Fallopian tube secretory epithelial (FT282) and ... Read more >>

BMC Cancer (BMC cancer)
[2020, 20(1):960]

Cited: 0 times

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Ovarian Cancer, Cancer Stem Cells and Current Treatment Strategies: A Potential Role of Magmas in the Current Treatment Methods.

Nuzhat Ahmed, Elif Kadife, Ali Raza, Mary Short, Paul T Jubinsky, George Kannourakis,

Epithelial ovarian cancer (EOC) constitutes 90% of ovarian cancers (OC) and is the eighth most common cause of cancer-related death in women. The cancer histologically and genetically is very complex having a high degree of tumour heterogeneity. The pathogenic variability in OC causes significant impediments in effectively treating patients, resulting ... Read more >>

Cells (Cells)
[2020, 9(3):]

Cited: 1 time

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Early Detection of Atrial Fibrillation Based on ECG Signals.

Nuzhat Ahmed, Yong Zhu,

Atrial fibrillation, often called AF is considered to be the most common type of cardiac arrhythmia, which is a major healthcare challenge. Early detection of AF and the appropriate treatment is crucial if the symptoms seem to be consistent and persistent. This research work focused on the development of a ... Read more >>

Bioengineering (Basel) (Bioengineering (Basel, Switzerland))
[2020, 7(1):]

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TIMP-2 regulates proliferation, invasion and STAT3-mediated cancer stem cell-dependent chemoresistance in ovarian cancer cells

Ruth M. Escalona, Maree Bilandzic, Patrick Western, Elif Kadife, George Kannourakis, Jock K. Findlay, Nuzhat Ahmed,

Background The metzincin family of metalloproteinases and the tissue inhibitors of metalloproteinases (TIMPs) are essential proteins required for biological processes during cancer progression. This study aimed to determine the role of TIMP-2 in ovarian cancer progression and chemoresistance by reducing TIMP-2 expression in vitro in Fallopian tube secretory epithelial (FT282) ... Read more >>

BMC Cancer (BMC cancer)
[2020, 20(1):]

Cited: 0 times

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Paclitaxel-Induced Src Activation Is Inhibited by Dasatinib Treatment, Independently of Cancer Stem Cell Properties, in a Mouse Model of Ovarian Cancer.

Elif Kadife, Emily Chan, Rodney Luwor, George Kannourakis, Jock Findlay, Nuzhat Ahmed,

Approximately seventy percent of ovarian cancer patients succumb to the disease within the first 5 years of diagnosis, even after successful surgery and effective chemotherapy treatment. A small subset of chemotherapy resistant cancer stem cells (CSCs) cause relapse of ovarian cancers. This study investigated the association between paclitaxel-mediated Src activation ... Read more >>

(Cancers)
[2019, 11(2):]

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Tumour microenvironment and metabolic plasticity in cancer and cancer stem cells: Perspectives on metabolic and immune regulatory signatures in chemoresistant ovarian cancer stem cells.

Nuzhat Ahmed, Ruth Escalona, Dilys Leung, Emily Chan, George Kannourakis,

Cancer stem cells (CSCs) are a sub-population of tumour cells, which are responsible to drive tumour growth, metastasis and therapy resistance. It has recently been proposed that enhanced glucose metabolism and immune evasion by tumour cells are linked, and are modulated by the changing tumour microenvironment (TME) that creates a ... Read more >>

Semin. Cancer Biol. (Seminars in cancer biology)
[2018, 53:265-281]

Cited: 13 times

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Paclitaxel-Loaded Self-Assembled Lipid Nanoparticles as Targeted Drug Delivery Systems for the Treatment of Aggressive Ovarian Cancer.

Jiali Zhai, Rodney B Luwor, Nuzhat Ahmed, Ruth Escalona, Fiona H Tan, Celesta Fong, Julian Ratcliffe, Judith A Scoble, Calum J Drummond, Nhiem Tran,

Chemotherapy using cytotoxic agents, such as paclitaxel (PTX), is one of the most effective treatments for advanced ovarian cancer. However, due to nonspecific targeting of the drug and the presence of toxic solvents required for dissolving PTX prior to injection, there are several serious side effects associated with this treatment. ... Read more >>

ACS Appl Mater Interfaces (ACS applied materials & interfaces)
[2018, 10(30):25174-25185]

Cited: 4 times

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Momelotinib decreased cancer stem cell associated tumor burden and prolonged disease-free remission period in a mouse model of human ovarian cancer.

Emily Chan, Rodney Luwor, Christopher Burns, George Kannourakis, Jock K Findlay, Nuzhat Ahmed,

Despite a good initial response to front-line chemotherapy, majority of the ovarian cancer patients relapse with consecutive phases of recurrences; and nearly 60% die within 5 years due to the development of a chemoresistant disease. This study investigated whether inhibition of the Janus kinase 2 (JAK2)-signal transducer and activator of ... Read more >>

Oncotarget (Oncotarget)
[2018, 9(24):16599-16618]

Cited: 4 times

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The Many Facets of Metzincins and Their Endogenous Inhibitors: Perspectives on Ovarian Cancer Progression.

Ruth M Escalona, Emily Chan, George Kannourakis, Jock K Findlay, Nuzhat Ahmed,

Approximately sixty per cent of ovarian cancer patients die within the first five years of diagnosis due to recurrence associated with chemoresistance. The metzincin family of metalloproteinases is enzymes involved in matrix remodeling in response to normal physiological changes and diseased states. Recently, there has been a mounting awareness of ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2018, 19(2):]

Cited: 1 time

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Surface Profiling of Extracellular Vesicles from Plasma or Ascites Fluid Using DotScan Antibody Microarrays.

Larissa Belov, Susannah Hallal, Kieran Matic, Jerry Zhou, Sandra Wissmueller, Nuzhat Ahmed, Sumaiya Tanjil, Stephen P Mulligan, O Giles Best, Richard J Simpson, Richard I Christopherson,

DotScan antibody microarrays were initially developed for the extensive surface profiling of live leukemia and lymphoma cells. DotScan's diagnostic capability was validated with an extensive clinical trial using mononuclear cells from the blood or bone marrow of leukemia or lymphoma patients. DotScan has also been used for the profiling of ... Read more >>

Methods Mol. Biol. (Methods in molecular biology (Clifton, N.J.))
[2017, 1619:263-301]

Cited: 2 times

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Coalition of Oct4A and β1 integrins in facilitating metastasis in ovarian cancer.

Chantel Samardzija, Rodney B Luwor, Michael A Quinn, George Kannourakis, Jock K Findlay, Nuzhat Ahmed,

Ovarian cancer is a metastatic disease and one of the leading causes of gynaecology malignancy-related deaths in women. Cancer stem cells (CSCs) are key contributors of cancer metastasis and relapse. Integrins are a family of cell surface receptors which allow interactions between cells and their surrounding microenvironment and play a ... Read more >>

BMC Cancer (BMC cancer)
[2016, 16:432]

Cited: 1 time

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Unique proteome signature of post-chemotherapy ovarian cancer ascites-derived tumor cells.

Nuzhat Ahmed, David Greening, Chantel Samardzija, Ruth M Escalona, Maoshan Chen, Jock K Findlay, George Kannourakis,

Eighty % of ovarian cancer patients diagnosed at an advanced-stage have complete remission after initial surgery and chemotherapy. However, most patients die within <5 years due to episodes of recurrences resulting from the growth of residual chemoresistant cells. In an effort to identify mechanisms associated with chemoresistance and recurrence, we ... Read more >>

Sci Rep (Scientific reports)
[2016, 6:30061]

Cited: 10 times

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Coexisting JAK2V617F and CALR Exon 9 Mutations in Myeloproliferative Neoplasms - Do They Designate a New Subtype?

Rifat Zubair Ahmed, Munazza Rashid, Nuzhat Ahmed, Muhammad Nadeem, Tahir Sultan Shamsi,

The classic BCR-ABL1-negative myeloproliferative neoplasm is an operational sub-category of MPNs that includes polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF). The JAK2V617F mutation is found in ~ 95% of PV and 50-60% of ET or PMF. In most of the remaining JAK2V617F- negative PV cases, JAK2 exon ... Read more >>

Asian Pac. J. Cancer Prev. (Asian Pacific journal of cancer prevention : APJCP)
[2016, 17(3):923-926]

Cited: 2 times

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Coexisting JAK2V617F and CALR Exon 9 Mutation in Essential Thrombocythemia.

Munazza Rashid, Rifat Zubair Ahmed, Shariq Ahmed, Muhammad Nadeem, Nuzhat Ahmed, Tahir Sultan Shamsi,

Classic "BCR-ABL1-negative" MPN is an operational sub-category of MPN that includes polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF) harboring JAK2V617F as the most common mutation. JAK2V617F can be detected in about 95 % of patients with PV while remaining 5 % of PV patients carry a somatic mutation of ... Read more >>

(Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion)
[2016, 32(Suppl 1):112-116]

Cited: 1 time

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Outcome of Inversion 16 in TKD Positive and Negative Acute Myeloid Leukemia Patients.

Sadaf Shahab, Danish Zahid, Shariq Ahmed, Muhammad Nadeem, Tasneem Farzana, Mehwesh Taj, Nuzhat Ahmed, Tahir S Shamsi,

abstract. ... Read more >>

Asian Pac. J. Cancer Prev. (Asian Pacific journal of cancer prevention : APJCP)
[2016, 17(4):2343-2344]

Cited: 0 times

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A critical role of Oct4A in mediating metastasis and disease-free survival in a mouse model of ovarian cancer.

Chantel Samardzija, Rodney B Luwor, Mila Volchek, Michael A Quinn, Jock K Findlay, Nuzhat Ahmed,

High grade epithelial ovarian cancer (EOC) is commonly characterised by widespread peritoneal dissemination and ascites. Metastatic EOC tumour cells can attach directly to neighbouring organs or alternatively, maintain long term tumourigenicity and chemoresistance by forming cellular aggregates (spheroids). Cancer stem-like cells are proposed to facilitate this mechanism. This study aimed ... Read more >>

Mol. Cancer (Molecular cancer)
[2015, 14:152]

Cited: 12 times

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Chronic Myeloid Leukemia--Prognostic Value of Mutations.

Bushra Kaleem, Sadaf Shahab, Nuzhat Ahmed, Tahir Sultan Shamsi,

Chronic myeloid leukemia (CML) is a stem cell disorder characterized by unrestricted proliferation of the myeloid series that occurs due to the BCR-ABL fusion oncogene as a result of reciprocal translocation t(9;22) (q34;q11). This discovery has made this particular domain a target for future efforts to cure CML. Imatinib revolutionized ... Read more >>

Asian Pac. J. Cancer Prev. (Asian Pacific journal of cancer prevention : APJCP)
[2015, 16(17):7415-7423]

Cited: 9 times

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Betaglycan blocks metastatic behaviors in human granulosa cell tumors by suppressing NFκB-mediated induction of MMP2.

Maree Bilandzic, Yao Wang, Nuzhat Ahmed, Rodney B Luwor, Hong Jian Zhu, Jock K Findlay, Kaye L Stenvers,

Metastatic ovarian granulosa cell tumors (GCT) exhibit loss of betaglycan. Here we test the hypothesis that betaglycan blocks GCT metastasis by suppressing NFκB/TGFβ2-induced matrix metalloprotinease-2 (MMP2). Human GCT and a human GCT cell model demonstrated prominent MMP2 expression, which was dependent on NFκB activity and stimulated by TGFβ2 in an ... Read more >>

Cancer Lett (Cancer letters)
[2014, 354(1):107-114]

Cited: 14 times

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Overall survival in acute myeloid leukaemia patients with and without internal tandem duplication.

Sadaf Shahab, Zeeshanul Qadar, Muhammad Nadeem, Danish Zahid, Saqib Ansari, Tasneem Farzana, Mehwesh Taj, Munira Borhany, Nuzhat Ahmed, Tahir S Shamsi,

Asian Pac. J. Cancer Prev. (Asian Pacific journal of cancer prevention : APJCP)
[2015, 16(1):393]

Cited: 0 times

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Isolation and partial characterization of phosphate solubilizing bacteria isolated from soil and marine samples.

Talat Yasmeen Mujahid, Khaizran Siddiqui, Rifat Ahmed, Shahana U Kazmi, Nuzhat Ahmed,

In the present study the potential of indigenous bacterial isolates from soil rhizosphere and marine environment to promote plant growth was determined. Eight bacterial strains isolated from soil and marine samples were characterized for the phosphate solubilizing activity. Qualitative and quantitative estimation of phosphate solubilization is done. MIC of antibiotic ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2014, 27(5 Spec no):1483-1490]

Cited: 1 time

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Targeted Disruption of the JAK2/STAT3 Pathway in Combination with Systemic Administration of Paclitaxel Inhibits the Priming of Ovarian Cancer Stem Cells Leading to a Reduced Tumor Burden.

Khalid Abubaker, Rodney B Luwor, Ruth Escalona, Orla McNally, Michael A Quinn, Erik W Thompson, Jock K Findlay, Nuzhat Ahmed,

Chemotherapy resistance associated with recurrent disease is the major cause of poor survival of ovarian cancer patients. We have recently demonstrated activation of the JAK2/STAT3 pathway and the enhancement of a cancer stem cell (CSC)-like phenotype in ovarian cancer cells treated in vitro with chemotherapeutic agents. To elucidate further these ... Read more >>

(Frontiers in oncology)
[2014, 4:75]

Cited: 26 times

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Inhibition of the JAK2/STAT3 pathway in ovarian cancer results in the loss of cancer stem cell-like characteristics and a reduced tumor burden.

Khalid Abubaker, Rodney B Luwor, Hongjian Zhu, Orla McNally, Michael A Quinn, Christopher J Burns, Erik W Thompson, Jock K Findlay, Nuzhat Ahmed,

BACKGROUND: Current treatment of ovarian cancer patients with chemotherapy leaves behind a residual tumor which results in recurrent ovarian cancer within a short time frame. We have previously demonstrated that a single short-term treatment of ovarian cancer cells with chemotherapy in vitro resulted in a cancer stem cell (CSC)-like enriched ... Read more >>

BMC Cancer (BMC cancer)
[2014, 14:317]

Cited: 48 times

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Survival outcome of AML patients with and without TKD mutations.

Sadaf Shahab, Khaleeq Un Nisa, Muhammad Nadeem, Danish Zahid, Saqib Ansari, Tasneem Farzana, Mehwesh Taj, Munira Borhany, Nuzhat Ahmed, Tahir S Shamsi,

Asian Pac. J. Cancer Prev. (Asian Pacific journal of cancer prevention : APJCP)
[2014, 15(24):10995]

Cited: 0 times

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Ovarian cancer stem cells: Molecular concepts and relevance as therapeutic targets.

Nuzhat Ahmed, Khalid Abubaker, Jock K Findlay,

In spite of recent progress in cancer therapeutics and increased knowledge about the cellular and molecular biology of cancer, ovarian cancer still remains a clinical challenge. Chemoresistance followed by tumor recurrence are major causes of poor survival rates of ovarian cancer patients. In recent years, ovarian cancer has been described ... Read more >>

Mol. Aspects Med. (Molecular aspects of medicine)
[2014, 39:110-125]

Cited: 36 times

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Optimization of growth conditions for the isolation of dextran producing Leuconostoc spp. from indigenous food sources.

Farwa Sarwat, Nuzhat Ahmed, Afsheen Aman, Shah Ali Ul Qader,

Leuconostoc are known to produce dextran, which have great commercial importance in chemical, medical and food industry. The present study is an attempt to select the best medium for the isolation of indigenous dextran producing Leuconostoc, measuring their enzyme activities for dextransucrase, production of dextran and identification of dextran producing ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2013, 26(4):793-797]

Cited: 2 times

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