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Author Nuno Mendonca

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Safety and efficacy of tilavonemab in progressive supranuclear palsy: a phase 2, randomised, placebo-controlled trial.

Günter U Höglinger, Irene Litvan, Nuno Mendonca, Deli Wang, Hui Zheng, Beatrice Rendenbach-Mueller, Hoi-Kei Lon, Ziyi Jin, Nahome Fisseha, Kumar Budur, Michael Gold, Davis Ryman, Hana Florian, ,

<h4>Background</h4>Progressive supranuclear palsy is a neurodegenerative disorder associated with tau protein aggregation. Tilavonemab (ABBV-8E12) is a monoclonal antibody that binds to the N-terminus of human tau. We assessed the safety and efficacy of tilavonemab for the treatment of progressive supranuclear palsy.<h4>Methods</h4>We did a phase 2, multicentre, randomised, placebo-controlled, double-blind study ... Read more >>

Lancet Neurol (The Lancet. Neurology)
[2021, 20(3):182-192]

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Correction to: Tea consumption and measures of attention and psychomotor speed in the very old: the Newcastle 85+ longitudinal study

Edward Jonathan Okello, Nuno Mendonça, Blossom Stephan, Graciela Muniz-Terrera, Keith Wesnes, Mario Siervo,

BMC Nutr (BMC nutrition)
[2021, 7(1):]

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Transitions between frailty states in the very old: the influence of socioeconomic status and multi-morbidity in the Newcastle 85+ cohort study.

Nuno Mendonça, Andrew Kingston, Mohammad Yadegarfar, Helen Hanson, Rachel Duncan, Carol Jagger, Louise Robinson,

<h4>Background</h4>Using Newcastle 85+ Study data, we investigated transitions between frailty states from age 85 to 90 years and whether multi-morbidities and socioeconomic status (SES) modify transitions.<h4>Methods</h4>The Newcastle 85+ Study is a prospective, longitudinal cohort study of all people born in 1921 in Newcastle and North Tyneside. Data included: a multidimensional health ... Read more >>

Age Ageing (Age and ageing)
[2020, 49(6):974-981]

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Tea consumption and measures of attention and psychomotor speed in the very old: the Newcastle 85+ longitudinal study.

Edward Jonathan Okello, Nuno Mendonça, Blossom Stephan, Graciela Muniz-Terrera, Keith Wesnes, Mario Siervo,

<h4>Background</h4>A number of studies have indicated a beneficial effect of tea consumption on the reduction of risk of cognitive impairment and dementia in older aged populations. However, there is a paucity of data on these associations in the very old, defined as individuals aged 85 years and over. We investigated the ... Read more >>

BMC Nutr (BMC nutrition)
[2020, 6(1):57]

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The Association between 25-Hydroxyvitamin D Concentration and Disability Trajectories in Very Old Adults: The Newcastle 85+ Study.

Sarah Hakeem, Nuno Mendonca, Terry Aspray, Andrew Kingston, Carmen Ruiz-Martin, Carol Jagger, John C Mathers, Rachel Duncan, Tom R Hill,

<i>Background</i>: Low vitamin D status is common in very old adults which may have adverse consequences for muscle function, a major predictor of disability. <i>Aims</i>: To explore the association between 25-hydroxyvitamin D [25(OH)D] concentrations and disability trajectories in very old adults and to determine whether there is an 'adequate' 25(OH)D ... Read more >>

Nutrients (Nutrients)
[2020, 12(9):]

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Tea consumption and measures of attention and psychomotor speed in the very old: the Newcastle 85+ longitudinal study.

Edward Jonathan Okello, Nuno Mendonça, Blossom Stephan, Graciela Muniz-Terrera, Keith Wesnes, Mario Siervo,

<h4>Background</h4>A number of studies have indicated a beneficial effect of tea consumption on the reduction of risk of cognitive impairment and dementia in older aged populations. However, there is a paucity of data on these associations in the very old, defined as individuals aged 85 years and over. We investigated the ... Read more >>

BMC Nutr (BMC nutrition)
[2020, 6:57]

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Tea consumption and measures of attention and psychomotor speed in the very old: The Newcastle 85+ Longitudinal Study

Edward Jonathan Okello, Nuno Mendonça, Blossom Stephan, Graciela Muniz-Terrera, Keith Wesnes, Mario Siervo,

<h4>Background: </h4> A number of studies have indicated a beneficial effect of tea consumption on the reduction of risk of cognitive impairment and dementia in older aged populations. However, there is a paucity of data on these associations in the very old, defined as individuals aged 85 years and over. ... Read more >>

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Prevalence of protein intake below recommended in community-dwelling older adults: a meta-analysis across cohorts from the PROMISS consortium.

Linda M Hengeveld, Jolanda M A Boer, Pierrette Gaudreau, Martijn W Heymans, Carol Jagger, Nuno Mendonça, Marga C Ocké, Nancy Presse, Stefania Sette, Eleanor M Simonsick, Heli Tapanainen, Aida Turrini, Suvi M Virtanen, Hanneke A H Wijnhoven, Marjolein Visser,

<h4>Background</h4>Lower protein intake in older adults is associated with loss of muscle mass and strength. The present study aimed to provide a pooled estimate of the overall prevalence of protein intake below recommended (according to different cut-off values) among community-dwelling older adults, both within the general older population and within ... Read more >>

J Cachexia Sarcopenia Muscle (Journal of cachexia, sarcopenia and muscle)
[2020, 11(5):1212-1222]

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Dietary Selenium Intakes and Musculoskeletal Function in Very Old Adults: Analysis of the Newcastle 85+ Study.

Giorgia Perri, Nuno Mendonça, Carol Jagger, Jennifer Walsh, Richard Eastell, John C Mathers, Tom R Hill,

<b>Background</b>: Selenium is a trace element essential for health. Severe selenium deficiencies are associated with poor musculoskeletal (MSK) function. However, the effects of moderate deficiency on MSK function, especially in older adults, is unclear. <b>Objectives</b>: To determine the associations between selenium intake and MSK function in very old adults. <b>Methods</b>: ... Read more >>

Nutrients (Nutrients)
[2020, 12(7):]

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Protocol for the Characterization of the Cytosine-Adenine-Guanine Tract and Flanking Polymorphisms in Machado-Joseph Disease: Impact on Diagnosis and Development of Gene-Based Therapies.

Sara M Lopes, Rosário Faro, Miguel M Lopes, Isabel Onofre, Nuno Mendonça, Joana Ribeiro, Cristina Januário, Rui Jorge Nobre, Luís Pereira de Almeida,

Polyglutamine spinocerebellar ataxias (SCAs) constitute a group of autosomal dominantly inherited neurodegenerative disorders with considerable phenotypic overlap. Definitive diagnoses rely on the detection of a mutation in each associated locus, comprising the abnormal expansion of the trinucleotide cytosine-adenine-guanine (CAG) in coding exons. Assessment of single nucleotide polymorphisms associated with the ... Read more >>

J Mol Diagn (The Journal of molecular diagnostics : JMD)
[2020, 22(6):782-793]

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Dietary Protein and Transitions Between Frailty States and to Death in Advanced Age: LiLACS NZ

Ruth Teh, Ngaire Kerse, Nuno Mendonca, Oliver Menzies, Tom Hill, Carol Jagger,

Abstract Modifiable factors delaying frailty progression are important in demographic ageing; health disparities for indigenous people require specific strategies. Does dietary protein intake impact transitions in frailty in Maori (indigenous) and non-Maori aged 80+ in New Zealand? LiLACS NZ is population based longitudinal cohorts of Maori aged 80-90 years and ... Read more >>

Innov Aging (Innovation in aging)
[2020, 4(Suppl 1):239-240]

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SOCIOECONOMIC INEQUALITIES IN TRANSITIONS BETWEEN FRAILTY STATES IN THE VERY OLD: THE NEWCASTLE 85+ STUDY.

Carol Jagger, Nuno Mendonca, Andrew Kingston, Louise Robinson, Mohammad E Yadegarfar, Helen Hanson, Rachel Duncan,

AbstractEarly-life socio-economic position (SEP), defined by education, remains a significant factor in disability progression in Innovation in Aging, 2019, Vol. 3, No. S1 225 GSA 2019 Annual Scientific Meeting very old age, but there is less evidence for its effect on frailty progression. We used the Newcastle 85+ Study, a ... Read more >>

Innov Aging (Innovation in aging)
[2019, 3(Suppl 1):S225-S226]

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Protein intake and transitions between frailty states and to death in very old adults: the Newcastle 85+ study.

Nuno Mendonça, Andrew Kingston, Antoneta Granic, Carol Jagger,

<h4>Objectives</h4>To examine the association of protein intake with frailty progression in very old adults.<h4>Design</h4>The Newcastle 85+ study, a prospective longitudinal study of people aged 85 years old in Northeast England and followed over 5 years.<h4>Setting and participants</h4>668 community-dwelling older adults (59% women) at baseline, with complete dietary assessment and Fried frailty status ... Read more >>

Age Ageing (Age and ageing)
[2019, 49(1):32-38]

Cited: 3 times

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Contribution of protein intake and its interaction with physical activity to transitions between disability states and to death in very old adults: the Newcastle 85+ Study.

Nuno Mendonça, Andrew Kingston, Antoneta Granic, Tom R Hill, John C Mathers, Carol Jagger,

<h4>Introduction</h4>Growth in the number of very old (≥ 85 years) adults will likely lead to increased prevalence of disability. Our aim was to determine the contribution of protein intake, and the interaction between protein intake and physical activity (PA), to the transition between disability states and to death in the very old ... Read more >>

Eur J Nutr (European journal of nutrition)
[2020, 59(5):1909-1918]

Cited: 2 times

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Effects of dietary patterns and low protein intake on sarcopenia risk in the very old: The Newcastle 85+ study.

Antoneta Granic, Nuno Mendonça, Avan A Sayer, Tom R Hill, Karen Davies, Mario Siervo, John C Mathers, Carol Jagger,

<h4>Background</h4>Sarcopenia, a progressive age-related loss of skeletal muscle mass and strength, leads to disability, falls, and hospitalisation. Individual variation in sarcopenia onset may be partly explained by lifestyle factors such as physical activity and diet. Healthy dietary patterns (DPs) have been linked to better physical functioning in older adults, but ... Read more >>

Clin Nutr (Clinical nutrition (Edinburgh, Scotland))
[2020, 39(1):166-173]

Cited: 3 times

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Plasma Vitamin B12, Supplementation and Mortality.

Nuno Mendonça, Carol Jagger, Antoneta Granic, Carmen Martin-Ruiz, John C Mathers, Chris J Seal, Tom R Hill,

J Gerontol A Biol Sci Med Sci (The journals of gerontology. Series A, Biological sciences and medical sciences)
[2019, 74(1):138]

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Malnutrition among older adults living in Portuguese nursing homes: the PEN-3S study.

Teresa Madeira, Catarina Peixoto-Plácido, Nuno Sousa-Santos, Osvaldo Santos, Violeta Alarcão, Beatriz Goulão, Nuno Mendonça, Paulo Jorge Nicola, Agneta Yngve, Asta Bye, Astrid Bergland, Teresa F Amaral, Carla Lopes, João Gorjão Clara,

<h4>Objective</h4>To characterise the nutritional status and to identify malnutrition-associated variables of older adults living in Portuguese nursing homes.<h4>Design</h4>Cross-sectional study. Data on demographic and socio-economic characteristics, self-reported morbidity, eating-related problems, nutritional status, cognitive function, depression symptoms, loneliness feelings and functional status were collected by trained nutritionists through a computer-assisted face-to-face structured ... Read more >>

Public Health Nutr (Public health nutrition)
[2018, :1-12]

Cited: 2 times

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Multidrug-Resistant Salmonella enterica Isolated from Food Animal and Foodstuff May Also Be Less Susceptible to Heavy Metals.

Rui Figueiredo, Roderick M Card, Javier Nunez-Garcia, Nuno Mendonça, Gabriela Jorge da Silva, Muna F Anjum,

Salmonella enterica is a foodborne pathogen showing increasing multidrug resistance (MDR). We characterized the antimicrobial resistance (AMR) genotype using microarrays in a panel of 105 nontyphoidal S. enterica isolated from food animals and foodstuff. Nineteen isolates were chosen on the basis of their MDR and virulence for determination of heavy ... Read more >>

Foodborne Pathog Dis (Foodborne pathogens and disease)
[2019, 16(3):166-172]

Cited: 3 times

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Protein Intake and Disability Trajectories in Very Old Adults: The Newcastle 85+ Study.

Nuno Mendonça, Antoneta Granic, Tom R Hill, Mario Siervo, John C Mathers, Andrew Kingston, Carol Jagger,

<h4>Objectives</h4>To determine whether protein intake is associated with better disability trajectories in the oldest adults (≥85) and whether muscle mass and muscle strength would partially mediate this.<h4>Design</h4>Prospective cohort study.<h4>Setting</h4>Newcastle-upon-Tyne and North Tyneside, United Kingdom.<h4>Participants</h4>Community-dwelling older adults aged 85 at baseline (N=722).<h4>Methods</h4>Protein intake was estimated using two 24-hour multiple-pass recalls at ... Read more >>

J Am Geriatr Soc (Journal of the American Geriatrics Society)
[2019, 67(1):50-56]

Cited: 9 times

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Pharmacokinetics, Safety, Tolerability, and Pharmacodynamics of Alicapistat, a Selective Inhibitor of Human Calpains 1 and 2 for the Treatment of Alzheimer Disease: An Overview of Phase 1 Studies.

Hoi-Kei Lon, Nuno Mendonca, Sandra Goss, Ahmed A Othman, Ahmed A Othman, Charles Locke, Ziyi Jin, Beatrice Rendenbach-Mueller,

Alicapistat is an orally active selective inhibitor of calpain 1 and 2 whose overactivation has been linked to Alzheimer disease (AD). Three studies were conducted in healthy subjects (18-55 years), 1 in healthy elderly subjects (≥65 years), and 1 in patients with mild to moderate AD. Four studies assessed pharmacokinetics, 1 study ... Read more >>

Clin Pharmacol Drug Dev (Clinical pharmacology in drug development)
[2019, 8(3):290-303]

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Elevated Total Homocysteine in All Participants and Plasma Vitamin B12 Concentrations in Women Are Associated With All-Cause and Cardiovascular Mortality in the Very Old: The Newcastle 85+ Study.

Nuno Mendonça, Carol Jagger, Antoneta Granic, Carmen Martin-Ruiz, John C Mathers, Chris J Seal, Tom R Hill,

<h4>Background</h4>Folate and vitamin B12 are keys to the correct functioning of one-carbon (1-C) metabolism. The current evidence on associations between 1-C metabolism biomarkers and mortality is inconclusive and generally based on younger or institutionalized populations. This study aimed to determine the associations between biomarkers of 1-C metabolism and all-cause and ... Read more >>

J Gerontol A Biol Sci Med Sci (The journals of gerontology. Series A, Biological sciences and medical sciences)
[2018, 73(9):1258-1264]

Cited: 8 times

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Nutrition in the Very Old.

Antoneta Granic, Nuno Mendonça, Tom R Hill, Carol Jagger, Emma J Stevenson, John C Mathers, Avan A Sayer,

The population of older adults aged 85 years and over (the very old) is growing rapidly in many societies because of increases in life expectancy and reduced mortality at older ages. In 2016, 27.3 million very old adults were living in the European Union, and in the UK, 2.4% of ... Read more >>

Nutrients (Nutrients)
[2018, 10(3):]

Cited: 14 times

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Clinical Features of Machado-Joseph Disease.

Nuno Mendonça, Marcondes C França, António Freire Gonçalves, Cristina Januário,

Machado-Joseph disease (MJD) also known as Spinocerebellar ataxia type 3, is a hereditary neurodegenerative disease associated with severe clinical manifestations and premature death. Although rare, it is the most common autosomal dominant spinocerebellar ataxia worldwide and has a distinct geographic distribution, reaching peak prevalence in certain regions of Brazil, Portugal ... Read more >>

Adv Exp Med Biol (Advances in experimental medicine and biology)
[2018, 1049:255-273]

Cited: 2 times

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Prevalence and determinants of low protein intake in very old adults: insights from the Newcastle 85+ Study.

Nuno Mendonça, Antoneta Granic, John C Mathers, Tom R Hill, Mario Siervo, Ashley J Adamson, Carol Jagger,

<h4>Purpose</h4>The very old (aged ≥ 85 years), fastest growing age group in most western societies, are at especially high risk of muscle mass and strength loss. The amount, sources and timing of protein intake may play important roles in the aetiology and management of sarcopenia. This study investigated the prevalence and determinants of ... Read more >>

Eur J Nutr (European journal of nutrition)
[2018, 57(8):2713-2722]

Cited: 13 times

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Low protein intake, muscle strength and physical performance in the very old: The Newcastle 85+ Study.

Antoneta Granic, Nuno Mendonça, Avan Aihie Sayer, Tom R Hill, Karen Davies, Ashley Adamson, Mario Siervo, John C Mathers, Carol Jagger,

BACKGROUND:Low protein intake has been linked to reduced muscle strength and physical performance in older adults but little is known about how it may affect muscle health and subsequent functional decline in the very old (aged 85+), who are at enhanced risk of malnutrition and loss of muscle mass and ... Read more >>

Clin Nutr (Clinical nutrition (Edinburgh, Scotland))
[2018, 37(6 Pt A):2260-2270]

Cited: 14 times

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