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Author Noriko Hirakawa

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Synergistic tumor suppression by a Perilla frutescens-derived methoxyflavanone and anti-cancer tyrosine kinase inhibitors in A549 human lung adenocarcinoma.

Amer Ali Abd El-Hafeez, Takashi Fujimura, Rikiya Kamei, Noriko Hirakawa, Kenji Baba, Kazuhisa Ono, Seiji Kawamoto,

Anti-cancer tyrosine kinase inhibitors (TKIs) are effective in many types of cancers including non-small cell lung cancer, while appearance of TKI-resistant tumors suggests a need for the development of their potentiation strategies. We have previously shown that a methoxyflavanone derivative from the Asian medicinal herb Perilla frutescens (Perilla-derived methoxyflavanone; PDMF) ... Read more >>

Cytotechnology (Cytotechnology)
[2018, 70(3):913-919]

Cited: 3 times

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A methoxyflavanone derivative from the Asian medicinal herb (Perilla frutescens) induces p53-mediated G2/M cell cycle arrest and apoptosis in A549 human lung adenocarcinoma.

Amer Ali Abd El-Hafeez, Takashi Fujimura, Rikiya Kamei, Noriko Hirakawa, Kenji Baba, Kazuhisa Ono, Seiji Kawamoto,

Perilla frutescens is an Asian dietary herb consumed as an essential seasoning in Japanese cuisine as well as used for a Chinese medicine. Here, we report that a newly found methoxyflavanone derivative from P. frutescens (Perilla-derived methoxyflavanone, PDMF; 8-hydroxy-5,7-dimethoxyflavanone) shows carcinostatic activity on human lung adenocarcinoma, A549. We found that ... Read more >>

Cytotechnology (Cytotechnology)
[2018, 70(3):899-912]

Cited: 2 times

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12. Influence of Wound Dressing on the Fracture Healing Effect of Low-Intensity Pulsed Ultrasound (LIPUS).

Koji Naruse, Masataka Uchino, Noriko Hirakawa, Masahiro Toyama, Genyo Miyajima, Manabu Mukai, Ken Urabe, Kentaro Uchida, Moritoshi Itoman,

<h4>Objective</h4>We have conducted a basic study on the influences on ultrasonic properties when LIPUS is applied through wound dressing. According to the results of ex vivo experiments conducted to date, LIPUS showed ultrasonic properties such as transmittance, coefficient of transmission, and a non-uniformity ratio through film wound dressing better than ... Read more >>

J Orthop Trauma (Journal of orthopaedic trauma)
[2016, 30(8):S5]

Cited: 0 times

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A flavanone derivative from the Asian medicinal herb (Perilla frutescens) potently suppresses IgE-mediated immediate hypersensitivity reactions.

Rikiya Kamei, Takashi Fujimura, Miki Matsuda, Kotaro Kakihara, Noriko Hirakawa, Kenji Baba, Kazuhisa Ono, Kenji Arakawa, Seiji Kawamoto,

Perilla frutescens is a dietary leafy herb consumed as a traditional Japanese condiment as well as used for Chinese medicine with anti-inflammatory activity. Here we report a hitherto-unrecognized P. frutescens phytochemical that potently suppresses IgE-mediated type I hypersensitivity reactions. Structural analysis reveals that the purified anti-allergic compound (Perilla-derived methoxyflavanone, PDMF) is ... Read more >>

Biochem Biophys Res Commun (Biochemical and biophysical research communications)
[2017, 483(1):674-679]

Cited: 8 times

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4. The Low-Intensity Pulsed Ultrasound (LIPUS) Mechanism and the Effect of Teriparatide on Fracture Healing.

Koji Naruse, Masataka Uchino, Noriko Hirakawa, Masahiro Toyama, Genyo Miyajima, Manabu Mukai, Ken Urabe, Kentaro Uchida, Moritoshi Itoman,

Low-Intensity Pulsed Ultrasound (LIPUS) provided a mechanical stimulus, and was thought to promote fracture healing by signal transduction through integrin, a cytoskeletal protein. Meanwhile, teriparatide, a drug for osteoporosis treatment, showed efficacy in promoting bone metabolism. This drug also appeared to prevent fractures in patients with serious osteoporosis by improving ... Read more >>

J Orthop Trauma (Journal of orthopaedic trauma)
[2016, 30(8):S3]

Cited: 0 times

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Angiotensin receptor blocker improves coronary flow velocity reserve in hypertensive patients: comparison with calcium channel blocker.

Fumihiko Kamezaki, Hiromi Tasaki, Kazuhito Yamashita, Kiyoko Shibata, Noriko Hirakawa, Masato Tsutsui, Ryouji Kouzuma, Toshihisa Nagatomo, Tetsuo Adachi, Yutaka Otsuji,

Large-scale clinical studies have indicated that angiotensin receptor blockers (ARBs) have beneficial effects against cardiovascular diseases. We designed this study to compare the effects of an ARB and a calcium channel blocker (CCB) on coronary flow velocity reserve (CFVR), a predictor of cardiovascular events, as estimated using transthoracic Doppler echocardiography. ... Read more >>

Hypertens Res (Hypertension research : official journal of the Japanese Society of Hypertension)
[2007, 30(8):699-706]

Cited: 18 times

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Detection of patency of internal mammary artery grafts to the left anterior descending artery by transthoracic Doppler echocardiography.

Hiromi Tasaki, Kazuhito Yamashita, Noriko Hirakawa, Hiroshi Suzuka, Tsuyoshi Morishita, Masahiro Okazaki, Yasuhide Nakashima, Ichiro Nagano,

<h4>Background</h4>To determine whether a coronary artery bypass graft (CABG) is patent, we examined the flow of the left internal mammary artery (LIMA) to the left anterior descending artery (LAD) by transthoracic Doppler echocardiography (TTDE).<h4>Patients and methods</h4>Eighty-seven patients with CABG (LIMA to distal LAD) were enrolled in the study. The flows ... Read more >>

Echocardiography (Echocardiography (Mount Kisco, N.Y.))
[2006, 23(9):741-749]

Cited: 1 time

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Prolonged survival in a female with untreated tetralogy of Fallot.

Seiya Tanaka, Noriko Kikuchi, Noriko Hirakawa, Kazuhito Yamashita, Ryouji Kouzuma, Masahiro Okazaki, Hiromi Tasaki, Yasuhide Nakashima,

It has been reported that most patients with untreated tetralogy of Fallot (TOF) die by the time they reach adulthood. We report the case of a 72-year-old female diagnosed by echocardiography and cardiac cathetherization as having TOF and diagnosed at birth with a ventricular septal defect (VSD). During childhood, she ... Read more >>

J UOEH (Journal of UOEH)
[2005, 27(2):189-195]

Cited: 2 times

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Infective tricuspid valve endocarditis due to abscess of an endogenous arteriovenous fistula in a chronic hemodialysis patient.

Noriko Hirakawa, Hiromi Tasaki, Seiya Tanaka, Kazuhito Yamashita, Masahiro Okazaki, Yasuhide Nakashima, Narutoshi Kabashima, Masahito Tamura,

Patients on chronic hemodialysis are at high risk for endocarditis due to prosthetic access devices. Right-sided endocarditis without any predisposing factors is rare in dialysis patients. A 76-year-old female, who had chronic renal failure had been treated by hemodialysis and had a permanent pacemaker implanted, was admitted to our hospital ... Read more >>

J UOEH (Journal of UOEH)
[2004, 26(4):451-460]

Cited: 0 times

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The CAP-Gly domain of CYLD associates with the proline-rich sequence in NEMO/IKKgamma.

Kohei Saito, Takanori Kigawa, Seizo Koshiba, Kazuo Sato, Yo Matsuo, Ayako Sakamoto, Tetsuo Takagi, Mikako Shirouzu, Takashi Yabuki, Emi Nunokawa, Eiko Seki, Takayoshi Matsuda, Masaaki Aoki, Yukako Miyata, Noriko Hirakawa, Makoto Inoue, Takaho Terada, Takahiro Nagase, Reiko Kikuno, Manabu Nakayama, Osamu Ohara, Akiko Tanaka, Shigeyuki Yokoyama,

CYLD was originally identified as the human familial cylindromatosis tumor suppressor. Recently, it was reported that CYLD directly interacts with NEMO/IKKgamma and TRAF2 in the NF-kappaB signaling pathway. The two proteins bind to a region of CYLD that contains a Cys-box motif and the third cytoskeleton-associated protein-glycine conserved (CAP-Gly) domain. ... Read more >>

Structure (Structure (London, England : 1993))
[2004, 12(9):1719-1728]

Cited: 53 times

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Successful thromboendarterectomy for severe chronic thromboembolic pulmonary hypertension caused by primary antiphospholipid syndrome.

Fumihiko Kamezaki, Hiromi Tasaki, Asuka Yamanaka, Tsuyoshi Morishita, Noriko Hirakawa, Kazuhito Yamashita, Masahiro Okazaki, Yasuhide Nakashima, Norifumi Nakanishi, Hitoshi Ogino,

Pulmonary hypertension is one of the lethal complications in the antiphospholipid syndrome due to chronic recurrence of embolism or thrombosis. We experienced a 19-year-old man suffering from severe chronic thromboembolic pulmonary hypertension (CTEPH) caused by primary antiphospholipid syndrome. According to the guideline, pulmonary thromboendarterectomy was decided on after combined therapy ... Read more >>

J UOEH (Journal of UOEH)
[2004, 26(3):287-294]

Cited: 1 time

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