Full Text Journal Articles by
Author Noreen Akhtar

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Secretory Carcinoma Of Salivary Gland: A Clincopathological Analysis.

Noreen Akhtar, Aribah Atiq, Asif Loya, Usman Hassan, Mudassir Hussain, Muhammad Abu-Bakar, Sajid Mushtaq,

BACKGROUND:Secretory carcinoma of the salivary gland (SC) is a new entity that harbours a specific ETV6 gene rearrangement. The clinical behaviour of this tumour is not well-known as it is a relatively new entity but it is generally considered as a tumour of low malignant potential. The objective of the ... Read more >>

J Ayub Med Coll Abbottabad (Journal of Ayub Medical College, Abbottabad : JAMC)
[2020, 32(4):481-486]

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Androgen Receptor Expression In Endometrial Carcinoma And Its Correlation With Estrogen Receptor And Progesterone Receptor And Clinicopathological Findings.

Maryam Nisar, Sajid Mushtaq, Usman Hassan, Noreen Akhtar, Muhammad Azma,

BACKGROUND:The objective of the study is to analyze the expression of androgen, estrogen and progesterone receptor in different types of endometrial carcinomas and to correlate the androgen receptor expression with estrogen and progesterone receptor and the clinicopathological parameters like lymphovascular invasion, grade of the tumour, size of tumour and extent ... Read more >>

J Ayub Med Coll Abbottabad (Journal of Ayub Medical College, Abbottabad : JAMC)
[2020, 32(2):160-164]

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Absence of the TRIP13 c.1060C>T Mutation in Wilms Tumor Patients From Pakistan.

Muhammad U Rashid, Humaira Naeemi, Abid Q Qazi, Noor Muhammad, Mansoor Ahmad, Noreen Akhtar, Nazneen Rahman,

BACKGROUND AND AIM:Wilms tumor (WT) is the most common childhood malignant renal tumor. Germline mutations in several WT predisposition genes have been identified. However, the fundamental cause of most WT patients remains unexplained. Recently, a founder mutation, c.1060C>T (p. Arg254X) in a mitotic spindle checkpoint gene, TRIP13, was reported in ... Read more >>

J Pediatr Hematol Oncol (Journal of pediatric hematology/oncology)
[2020, 42(3):e128-e131]

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The Hot Pleura: Isolated Pleural Metastases From Renal Cell Carcinoma.

Pir Abdul Ahad Aziz Qureshi, Namra Asghar, Humayun Bashir, Imran Khalid Niazi, Noreen Akhtar,

Renal cell carcinoma (RCC) is the most common solid renal malignancy that metastasizes typically to lungs, bones, liver, adrenals, and lymph nodes. Isolated pleural metastases of RCC are extremely rare, with only few cases reported in the literature. We report one such case of a 60-year-old woman, a known case ... Read more >>

Clin Nucl Med (Clinical nuclear medicine)
[2020, 45(3):211-213]

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Diagnostic Utility of BCOR Antibody in Clear Cell Sarcomas of Kidney.

Muhammad Zeeshan Khan, Noreen Akhtar, Usman Hassan, Sajid Mushtaq,

Purpose. Clear cell sarcoma of the kidney (CCSK) is an uncommon malignant renal tumor. It is the second most common renal pediatric renal malignancy after Wilms tumor. It exhibits a heterogeneous morphology, with overlapping features with its close differentials, which results in diagnostic challenges. There was no specific immunohistochemical marker ... Read more >>

Int. J. Surg. Pathol. (International journal of surgical pathology)
[2020, 28(5):477-481]

Cited: 1 time

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Effect of Autologous Platelet-rich Plasma on Appearance of Tenocytes at Injured Achilles Tendon Entheses in Rabbits.

Tayyaba Faisal, Rafia Asjid, Khadija Qamar, Noreen Akhtar, Khalida Moeed, Tassaduq Hussain,

OBJECTIVE:To determine the effects of autologous platelet-rich plasma on appearance of tenocytes at injured Achilles tendon entheses in rabbits. STUDY DESIGN:Laboratory-based experimental study. PLACE AND DURATION OF STUDY:Department of Anatomy and Pathology, Army Medical College, Rawalpindi, in collaboration with National Institute of Health, Islamabad, from March to May, 2018. METHODOLOGY:Forty ... Read more >>

J Coll Physicians Surg Pak (Journal of the College of Physicians and Surgeons--Pakistan : JCPSP)
[2019, 29(11):1029-1033]

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Assessment of Cucumber Genotypes for Salt Tolerance Based on Germination and Physiological Indices.

Asma Marium, Abida Kausar, Syed Muhammad Ali Shah, Syed Muhammad Ali Shah, Muhammad Yasin Ashraf, Noreen Akhtar, Muhammad Akram, Muhammad Riaz,

Soil salinity is one of the primary problem for agricultural crops which causes a great loss in crop production in Pakistan and worldwide. Various approaches have been implemented to overcome salinity problem. Assembly of crops for the enhancement of salt tolerance is a good strategy to achieve cost-effective yields. Cucumber ... Read more >>

Dose Response (Dose-response : a publication of International Hormesis Society)
[2019, 17(4):1559325819889809]

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Ex-vivo antihypertensive and calcium channel blocking activity of Androsace foliosa n-hexane leaves fraction on isolated rabbit aorta.

Jawad Zaheer, Abida Kausar, Hina Kanwal, Noreen Akhtar, Aisha Ilyas, Zil-I-Huma Nazlli, Ayesha Riaz, Syed Muhammad Ali Shah, Muhammad Akram, Muhammad Usman Sarwar, Abdul Hamid Khan, Fahad Said Khan, Farhan Asad, Hina Anwar, Madeeha Anwar,

Hypertension is persistent elevation in blood pressure for 3-4 weeks. Estimated global prevalence of hypertension suggested that by the Year 2025 (29%) of adult worldwide are suffering from hypertension (1.56 billion). Hypertension complications are hemorrhage, atherosclerosis, renal artery stenosis, angina pectoris end organ damage, cardiomyopathy, myocardial infarction and retinopathy. Along ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2019, 32(6(Supplementary)):2893-2898]

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Long term tapering versus standard prednisolone treatment for first episode of childhood nephrotic syndrome: phase III randomised controlled trial and economic evaluation.

Nicholas J A Webb, Rebecca L Woolley, Tosin Lambe, Emma Frew, Elizabeth A Brettell, Emma N Barsoum, Richard S Trompeter, Carole Cummins, Jonathan J Deeks, Keith Wheatley, Natalie J Ives, ,

OBJECTIVE:To determine whether extending initial prednisolone treatment from eight to 16 weeks in children with idiopathic steroid sensitive nephrotic syndrome improves the pattern of disease relapse. DESIGN:Double blind, parallel group, phase III randomised placebo controlled trial, including a cost effectiveness analysis. SETTING:125 UK National Health Service district general hospitals and ... Read more >>

BMJ (BMJ (Clinical research ed.))
[2019, 365:l1800]

Cited: 1 time

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Structural weakening of the colonic mucus barrier is an early event in ulcerative colitis pathogenesis.

Sjoerd van der Post, Karolina S Jabbar, George Birchenough, Liisa Arike, Noreen Akhtar, Henrik Sjovall, Malin E V Johansson, Gunnar C Hansson,

OBJECTIVE:The colonic inner mucus layer protects us from pathogens and commensal-induced inflammation, and has been shown to be defective in active UC. The aim of this study was to determine the underlying compositional alterations, their molecular background and potential contribution to UC pathogenesis. DESIGN:In this single-centre case-control study, sigmoid colon ... Read more >>

Gut (Gut)
[2019, 68(12):2142-2151]

Cited: 7 times

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Structure-based pharmacophore models to probe anticancer activity of inhibitors of protein kinase B-beta (PKB β).

Noreen Akhtar, Ishrat Jabeen, Nasir Jalal, Jon Antilla,

Protein kinase B-beta (PKBβ/Akt2) is a non-receptor kinase that has attracted a great deal of attention as a promising cancer therapy drug target. In mammalian cells, hyperactivation of Akt2 exclusively facilitates the survival of solid tumors by interfering with cell cycle progression. This definite function of Akt2 in tumor survival/maintenance ... Read more >>

Chem Biol Drug Des (Chemical biology & drug design)
[2019, 93(3):325-336]

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Granulomatous Interstitial Nephritis: A Rare Cause of Acute Kidney Injury.

Sajad Ahmad, Muhammad Anees, Hina Akbar, Noreen Akhtar,

Acute granulomatous interstitial nephritis (GIN) is a rare cause of acute kidney injury (AKI) but treatable. It is present in 0.5 to 0.9% of native renal biopsies. Treatment with moderate dosage of steroids is associated with good prognosis. We herein review a case of a 48-year lady having AKI following ... Read more >>

J Coll Physicians Surg Pak (Journal of the College of Physicians and Surgeons--Pakistan : JCPSP)
[2018, 28(11):885-887]

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Diagnostic accuracy of glypican-3 in differentiating hepatocellular carcinoma from metastatic liver tumours.

Sadia Majeed, Sajid Mushtaq, Muhammad Azam, Noreen Akhtar, Mudassar Hussain, Asif Loya,

OBJECTIVE:To determine the diagnostic accuracy of Glypican-3 in differentiating hepatocellular carcinoma from metastatic liver tumours while taking histopathology as the gold standard.. METHODS:The cross-sectional study was conducted at Shaukat Khanum Memorial Cancer Hospital, Lahore, Pakistan, from January 1 to June 30, 2016, and comprised cases of malignant liver tumours. Samples ... Read more >>

J Pak Med Assoc (JPMA. The Journal of the Pakistan Medical Association)
[2018, 68(7):1029-1031]

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Fluorescence in Situ Hybridization (FISH) for Differential Diagnosis of Soft Tissue Sarcomas

Amna Asif, Sajid Mushtaq, Usman Hassan, Noreen Akhtar, Mudassar Hussain, Muhammad Azam, Romena Qazi,

Introduction:Soft tissue sarcomas are rare tumors comprising 1 percent of solid malignancies. The latest edition of WHO soft tissue pathology lists 94 benign and malignant soft tissue tumors. Many of these show a large degree of morphological overlap. Immunohistochemistry has been shown to be reliable in many cases for differential diagnosis of lesions, ... Read more >>

Asian Pac. J. Cancer Prev. (Asian Pacific journal of cancer prevention : APJCP)
[2018, 19(3):655-660]

Cited: 2 times

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Ethnopharmacological studies of indigenous plants in Kel village, Neelum Valley, Azad Kashmir, Pakistan.

Khawaja Shafique Ahmad, Abdul Hamid, Fahim Nawaz, Mansoor Hameed, Farooq Ahmad, Jiabin Deng, Noreen Akhtar, Ambreen Wazarat, Sehrish Mahroof,

This explorative study was undertaken for the first time in Kel village located in the Upper Neelum Valley, Azad Kashmir, Pakistan. The purpose was to document the indigenous knowledge of the native people used in the preparation of herbal medicines.To get the data on traditional uses of medicinal plants, 20 ... Read more >>

J Ethnobiol Ethnomed (Journal of ethnobiology and ethnomedicine)
[2017, 13(1):68]

Cited: 5 times

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Pharmacoinformatic Approaches to Design Novel Inhibitors of Protein Kinase B Pathways in Cancer.

Noreen Akhtar, Ishrat Jabeen,

BACKGROUND:Protein kinase B (PKB/Akt) belongs to the AGC superfamily of related serine/ threonine kinases with three structurally homologous mammalian isoforms, Akt1 (PKBα), Akt2 (PKBβ), and Akt3 (PKBγ). Besides sharing a similar structural topology, the difference in their physiological functions and tissue distribution makes Akt a cardinal node in diverse signaling ... Read more >>

Curr Cancer Drug Targets (Current cancer drug targets)
[2018, 18(9):830-846]

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A 2D-QSAR and Grid-Independent Molecular Descriptor (GRIND) Analysis of Quinoline-Type Inhibitors of Akt2: Exploration of the Binding Mode in the Pleckstrin Homology (PH) Domain.

Noreen Akhtar, Ishrat Jabeen,

Protein kinase B-β (PKBβ/Akt2) is a serine/threonine-specific protein kinase that has emerged as one of the most important regulators of cell growth, differentiation, and division. Upregulation of Akt2 in various human carcinomas, including ovarian, breast, and pancreatic, is a well-known tumorigenesis phenomenon. Early on, the concept of the simultaneous administration ... Read more >>

PLoS One (PloS one)
[2016, 11(12):e0168806]

Cited: 2 times

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A Questionnaire-Based Survey of Physical Medicine and Rehabilitation Residency Training in Pakistan.

Farooq A Rathore, Aamir W Butt, Nabila Soomro, Noreen Akhtar,

Pakistan is one of the three countries in South East Asia that has an active postgraduate physical medicine and rehabilitation (PM&R) training program. College of Physicians and Surgeons Pakistan (CPSP) offers a four-year structured training program in PM&R. It consists of clinical teaching, lectures, rotations in other specialties, and writing a research ... Read more >>

Cureus (Cureus)
[2017, 9(1):e1005]

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Right-Sided and Left-Sided Colon Cancers are Two Distinct Disease Entities: an Analysis of 200 Cases in Pakistan.

Mudassar Hussain, Omer Waqas, Usman Hassan, Asif Loya, Noreen Akhtar, Sajid Mushtaq, Muhammad Aasim Yusuf, Aamir Ali Syed,

There is growing evidence that there are differences in histological and genetic characteristics along with clinical behavior between right- and left-sided colon carcinomas. We have compared various parameters of the two types and assessed associations of the results with prognosis in patients in Pakistan.We reviewed 200 cases from our institutional ... Read more >>

Asian Pac J Cancer Prev (Asian Pacific journal of cancer prevention : APJCP)
[2016, 17(5):2545-2548]

Cited: 8 times

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A methodological evaluation and predictive in silico investigation into the multi-functionality of arginine in directly compressed tablets.

Amr ElShaer, Waseem Kaialy, Noreen Akhtar, Affiong Iyire, Tariq Hussain, Raid Alany, Afzal R Mohammed,

The acceleration of solid dosage form product development can be facilitated by the inclusion of excipients that exhibit poly-/multi-functionality with reduction of the time invested in multiple excipient optimisations. Because active pharmaceutical ingredients (APIs) and tablet excipients present diverse densification behaviours upon compaction, the involvement of these different powders during ... Read more >>

Eur J Pharm Biopharm (European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V)
[2015, 96:272-281]

Cited: 0 times

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The pattern of peripheral nerve injuries among Pakistani soldiers in the war against terror.

Sarah Razaq, Rehana Yasmeen, Aamir Waheed Butt, Noreen Akhtar, Sahibzada Nasir Mansoor,

To determine the pattern of peripheral nerve injuries in Pakistani soldiers in the War against terror.Case series.Department of Electrodiagnosis at Armed Forces Institute of Rehabilitation Medicine (AFIRM), Rawalpindi, Pakistan, from June 2008 to June 2011.All new cases of war wounded soldiers with peripheral nerve injuries were consecutively enrolled. Physical examination ... Read more >>

J Coll Physicians Surg Pak (Journal of the College of Physicians and Surgeons--Pakistan : JCPSP)
[2015, 25(5):363-366]

Cited: 2 times

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Genotypes of hepatitis C virus in relapsed and non-respondent patients and their response to anti-viral therapy in district Mardan, Khyber Pakhtunkhawa, Pakistan.

Noreen Akhtar, Muhammad Bilal, Muhammad Rizwan, Muhammad Asif Khan, Aurangzeb Khan,

Hepatitis C is a blood-borne infectious disease of liver, caused by a small enveloped, positive-single stranded RNA virus, called the hepatitis C virus (HCV). HCV belongs to the Flaviviridae family and has 6 genotypes and more than 100 subtypes. It is estimated that 185 million people are infected with HCV ... Read more >>

Asian Pac J Cancer Prev (Asian Pacific journal of cancer prevention : APJCP)
[2015, 16(3):1037-1040]

Cited: 1 time

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Endoscopic ultrasound - fine needle aspiration of 2-deoxy-2-[18F] fluoro-D-glucose avid lymph nodes seen on positron emission tomography- computed tomography -what looks like cancer may not always be so.

Anum Imran Malik, Noreen Akhtar, Asif Loya, Muhammed Aasim Yusuf,

Patients suffering from malignancies often undergo serial positron emission tomography - computed tomography (PET-CT) scans, using 2-deoxy-2-[18F] fluoro-D-glucose (FDG) for diagnosis and follow up. This principle may also be applied to benign conditions as inflammatory cells take up increased amounts of FDG as well. The aim of our study was ... Read more >>

Cancer Imaging (Cancer imaging : the official publication of the International Cancer Imaging Society)
[2014, 14:27]

Cited: 1 time

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Determination of frequency of epstein-barr virus in non- Hodgkin lymphomas Using EBV latent membrane protein 1 (EBV-LMP1) immunohistochemical staining.

Sheeba Ishtiaq, Usman Hassan, Sajid Mushtaq, Noreen Akhtar,

The presence of Epstein-Barr virus (EBV) in Non-Hodgkin's lymphoma can be identified by immunohistochemistry for detection of EBV latent membrane protein (LMP). The role of EBV as an etiologic agent in the development of non-Hodgkin lymphoma has been supported by detection of high levels of latent membrane protein 1 (LMP-1) ... Read more >>

Asian Pac J Cancer Prev (Asian Pacific journal of cancer prevention : APJCP)
[2013, 14(6):3963-3967]

Cited: 5 times

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Role of immunoflourescence in the diagnosis of glomerulonephritis.

Humaira Nasir, Sarah Chaudhry, Wajiha Raza, Ambreen Moatasim, Nadira Mamoon, Noreen Akhtar,

OBJECTIVE: To correlate the findings of immunoflorescence (IF) with morphology in renal biopsies of patients with glomerulonephritis (GN) of both primary and secondary nature. METHODS: The cross-sectional analytical study was conducted at the Shifa International Hospital's Department of Pathology form March 2007 to August 2008, during which a total of ... Read more >>

J Pak Med Assoc (JPMA. The Journal of the Pakistan Medical Association)
[2012, 62(3):240-243]

Cited: 0 times

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