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Author Norbert Weiss

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Trigeminal neuropathic pain is alleviated by inhibition of Cav3.3 T-type calcium channels in mice.

Marena Montera, Aleyah Goins, Leos Cmarko, Norbert Weiss, Karin N Westlund, Sascha R A Alles,

In this brief report, we demonstrate that the Ca<sub>v</sub>3.3 T-type voltage-gated calcium channel subtype is involved in our FRICT-ION model of chronic trigeminal neuropathic pain. We first showed that the <i>Cacna1i</i> gene encoding Ca<sub>v</sub>3.3 is significantly upregulated in whole trigeminal ganglia of FRICT-ION mice compared to controls at week 10 post-injury. ... Read more >>

Channels (Austin) (Channels (Austin, Tex.))
[2021, 15(1):31-37]

Cited: 1 time

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Overexpression of dimethylarginine dimethylaminohydrolase 1 protects from angiotensin II - induced cardiac hypertrophy and vascular remodeling.

Irakli Kopaliani, Natalia Jarzebska, Silke Brilloff, Anne Kolouschek, Jens Martens-Lobenhoffer, Stefan R Bornstein, Stefanie M Bode-Böger, Vinitha N Ragavan, Norbert Weiss, Arduino A Mangoni, Andreas Deussen, Roman N Rodionov,

<h4>Background</h4>Cardiovascular complications are the leading cause of death and elevated levels of asymmetric dimethyarginine (ADMA), an endogenous inhibitor of nitric oxide synthase, are implicated in their pathophysiology. We investigated the role of DDAH1 (dimethylarginine dimethylaminohydrolase 1), an enzyme hydrolyzing ADMA, in prevention of cardiovascular remodeling during hypertension. We hypothesized that ... Read more >>

Am J Physiol Heart Circ Physiol (American journal of physiology. Heart and circulatory physiology)
[2021, :]

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Second asymptomatic carotid surgery trial (ACST-2): a randomised comparison of carotid artery stenting versus carotid endarterectomy.

Alison Halliday, Richard Bulbulia, Leo H Bonati, Johanna Chester, Andrea Cradduck-Bamford, Richard Peto, Hongchao Pan, ,

<h4>Background</h4>Among asymptomatic patients with severe carotid artery stenosis but no recent stroke or transient cerebral ischaemia, either carotid artery stenting (CAS) or carotid endarterectomy (CEA) can restore patency and reduce long-term stroke risks. However, from recent national registry data, each option causes about 1% procedural risk of disabling stroke or ... Read more >>

Lancet (Lancet (London, England))
[2021, 398(10305):1065-1073]

Cited: 1 time

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4PEPS - a new pretest probability score to reduce imaging testing for suspected pulmonary embolism?

Anne Kolouschek, Norbert Weiss,

Vasa (VASA. Zeitschrift fur Gefasskrankheiten)
[2021, 50(5):398-399]

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De novo SCN8A and inherited rare CACNA1H variants associated with severe developmental and epileptic encephalopathy.

Robin N Stringer, Bohumila Jurkovicova-Tarabova, Ivana A Souza, Judy Ibrahim, Tomas Vacik, Waseem Mahmoud Fathalla, Jozef Hertecant, Gerald W Zamponi, Lubica Lacinova, Norbert Weiss,

Developmental and epileptic encephalopathies (DEEs) are a group of severe epilepsies that are characterized by seizures and developmental delay. DEEs are primarily attributed to genetic causes and an increasing number of cases have been correlated with variants in ion channel genes. In this study, we report a child with an ... Read more >>

Mol Brain (Molecular brain)
[2021, 14(1):126]

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Divergent Dimethylarginine Dimethylaminohydrolase Isoenzyme Expression in the Central Nervous System.

Alena A Kozlova, Vinitha N Ragavan, Natalia Jarzebska, Iana V Lukianova, Anastasia E Bikmurzina, Elena Rubets, Toshiko Suzuki-Yamamoto, Masumi Kimoto, Arduino A Mangoni, Raul R Gainetdinov, Norbert Weiss, Michael Bauer, Alexander G Markov, Roman N Rodionov, Nadine Bernhardt,

The endogenous methylated derivative of ʟ-arginine, N<sup>ω</sup>,N<sup>ω'</sup>-dimethyl-ʟ-arginine (asymmetric dimethylarginine, ADMA), an independent risk factor in many diseases, inhibits the activity of nitric oxide synthases and, consequently, modulates the availability of nitric oxide. While most studies on the biological role of ADMA have focused on endothelial and inducible nitric oxide synthases ... Read more >>

Cell Mol Neurobiol (Cellular and molecular neurobiology)
[2021, :]

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Ultrasonography Grading of Internal Carotid Artery Disease: Multiparametric German Society of Ultrasound in Medicine (DEGUM) versus Society of Radiologists in Ultrasound (SRU) Consensus Criteria.

Simon Winzer, Henning Rickmann, Hagen Kitzler, Andrij Abramyuk, Christos Krogias, Henning Strohm, Jessica Barlinn, Lars-Peder Pallesen, Timo Siepmann, Sebastian Arnold, Peter Moennings, Harald Mudra, Jennifer Linn, Heinz Reichmann, Norbert Weiss, Georg Gahn, Andrei Alexandrov, Volker Puetz, Kristian Barlinn,

<h4>Purpose</h4> We sought to determine the diagnostic agreement between the revised ultrasonography approach by the German Society of Ultrasound in Medicine (DEGUM) and the established Society of Radiologists in Ultrasound (SRU) consensus criteria for the grading of carotid artery disease.<h4>Materials and methods</h4> Post-hoc analysis of a prospective multicenter study, in which patients ... Read more >>

Ultraschall Med (Ultraschall in der Medizin (Stuttgart, Germany : 1980))
[2021, :]

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Pearls & Oy-sters: Primary Cerebral Buerger Disease: A Rare Differential Diagnosis of Stroke in Young Adults.

Daniel Kaiser, Georg K Leonhardt, Norbert Weiss, Christoph G Radosa, Jennifer Linn, Johannes C Gerber, Volker Puetz,

Neurology (Neurology)
[2021, 97(11):551-554]

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Divergent dimethylarginine dimethylaminohydrolase isoenzyme expression in the central nervous system

Alena Kozlova, Vinitha Ragavan, Natalia Jarzebska, Iana Lukianova, Anastasia Bikmurzina, Elena Rubets, Toshiko Suzuki-Yamamoto, Masumi Kimoto, Arduino Mangoni, Raul Gainetdinov, Norbert Weiss, Michael Bauer, Alexander Markov, Roman Rodionov, Nadine Bernhardt,

The endogenous methylated derivative of L-arginine, N G -N G -dimethyl-ʟ-arginine (asymmetric dimethylarginine, ADMA), an independent risk factor in many diseases, inhibits the activity of nitric oxide synthases and, consequently, modulates the availability of nitric oxide. While most studies on the biological role of ADMA have focused on endothelial and ... Read more >>

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Overexpression of Alanine-glyoxylate aminotransferase 2 Protects from Asymmetric Dimethylarginine-induced Endothelial Dysfunction and Aortic Remodeling

Roman Rodionov, Natalia Jarzebska, Dmitrii Burdin, Vladimir Todorov, Jens Martens-Lobenhoffer, Anja Hofmann, Anne Kolouschek, Nada Cordasic, Johannes Jacobi, Elena Rubets, Henning Morawietz, John O’Sullivan, Alexander Markov, Stefan Bornstein, Karl Hilgers, Renke Maas, Christian Pfluecke, YingJie Chen, Stefanie Bode-Böger, Christian Hugo, Bernd Hohenstein, Norbert Weiss,

<h4>Objective: </h4> Elevated plasma concentrations of asymmetric dimethylarginine (ADMA) are associated with an increased risk of mortality and adverse cardiovascular outcomes. ADMA can be metabolized by dimethylarginine dimethylaminohydrolases (DDAHs) and by alanine-glyoxylate aminotransferase 2 (AGXT2). Deletion of DDAH1 in mice leads to elevation of ADMA in plasma and blood pressure, ... Read more >>

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Divergent dimethylarginine dimethylaminohydrolase isoenzyme expression in the central nervous system

Alena Alekseevna Kozlova, Vinitha Nair Ragavan, Natalia Jarzebska, Iana Vadimovna Lukianova, Anastasia Evgenievna Bikmurzina, Elena Rubets, Toshiko Suzuki-Yamamoto, Masumi Kimoto, Arduino Mangoni, Raul Radikovich Gainetdinov, Norbert Weiss, Michael Bauer, Alexander Georgievich Markov, Roman Nikolaevich Rodionov, Nadine Bernhardt,

The endogenous methylated derivative of L-arginine, N G -N G -dimethyl-ʟ-arginine (asymmetric dimethylarginine, ADMA), an independent risk factor in many diseases, inhibits the activity of nitric oxide synthases and, consequently, modulates the availability of nitric oxide. While most studies on the biological role of ADMA have focused on endothelial and ... Read more >>

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T-type channels in neuropathic pain - Villain or victim?

Norbert Weiss,

Channels (Austin) (Channels (Austin, Tex.))
[2020, 14(1):98-100]

Cited: 1 time

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Transcriptomic analysis of glycan-processing genes in the dorsal root ganglia of diabetic mice and functional characterization on Cav3.2 channels.

Robin N Stringer, Joanna Lazniewska, Norbert Weiss,

Ca<sub>v</sub>3.2 T-type calcium channels play an essential role in the transmission of peripheral nociception in the dorsal root ganglia (DRG) and alteration of Ca<sub>v</sub>3.2 expression is associated with the development of peripheral painful diabetic neuropathy (PDN). Several studies have previously documented the role of glycosylation in the expression and functioning of ... Read more >>

Channels (Austin) (Channels (Austin, Tex.))
[2020, 14(1):132-140]

Cited: 1 time

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Functional identification of potential non-canonical N-glycosylation sites within Cav3.2 T-type calcium channels.

Vendula Ficelova, Ivana A Souza, Leos Cmarko, Maria A Gandini, Robin N Stringer, Gerald W Zamponi, Norbert Weiss,

Low-voltage-activated T-type calcium channels are important contributors to nervous system function. Post-translational modification of these channels has emerged as an important mechanism to control channel activity. Previous studies have documented the importance of asparagine (N)-linked glycosylation and identified several asparagine residues within the canonical consensus sequence N-X-S/T that is essential ... Read more >>

Mol Brain (Molecular brain)
[2020, 13(1):149]

Cited: 2 times

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The role of alanine glyoxylate transaminase-2 (agxt2) in β-alanine and carnosine metabolism of healthy mice and humans.

Jan Stautemas, Natalia Jarzebska, Zhou Xiang Shan, Laura Blancquaert, Inge Everaert, Sarah de Jager, Siegrid De Baere, Arne Hautekiet, Anneke Volkaert, Filip B D Lefevere, Jens Martens-Lobenhoffer, Stefanie M Bode-Böger, Chang Keun Kim, James Leiper, Norbert Weiss, Siska Croubels, Roman N Rodionov, Wim Derave,

<h4>Purpose</h4>Chronic β-alanine supplementation leads to increased levels of muscle histidine-containing dipeptides. However, the majority of ingested β-alanine is, most likely, degraded by two transaminases: GABA-T and AGXT2. In contrast to GABA-T, the in vivo role of AGXT2 with respect to β-alanine metabolism is unknown. The purpose of the present work ... Read more >>

Eur J Appl Physiol (European journal of applied physiology)
[2020, 120(12):2749-2759]

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Endovascular interventions for peripheral arterial disease have to be integrated in a concept of total cardiovascular care by angiologists to improve patients and limbs prognosis.

Norbert Weiss,

Vasa (VASA. Zeitschrift fur Gefasskrankheiten)
[2020, 49(5):345-347]

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Opioid Receptor Regulation of Neuronal Voltage-Gated Calcium Channels.

Norbert Weiss, Gerald W Zamponi,

Neuronal voltage-gated calcium channels play a pivotal role in the conversion of electrical signals into calcium entry into nerve endings that is required for the release of neurotransmitters. They are under the control of a number of cellular signaling pathways that serve to fine tune synaptic activities, including G-protein coupled ... Read more >>

Cell Mol Neurobiol (Cellular and molecular neurobiology)
[2021, 41(5):839-847]

Cited: 1 time

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COMPARE: prospective, randomized, non-inferiority trial of high- vs. low-dose paclitaxel drug-coated balloons for femoropopliteal interventions.

Sabine Steiner, Andrej Schmidt, Thomas Zeller, Gunnar Tepe, Marcus Thieme, Lars Maiwald, Henrik Schröder, Wulf Euringer, Matthias Ulrich, Klaus Brechtel, Steffen Brucks, Erwin Blessing, Johannes Schuster, Ralf Langhoff, Sebastian Schellong, Norbert Weiss, Dierk Scheinert,

<h4>Aims</h4>Drug-coated balloons (DCBs) for femoropopliteal interventions have not been tested against each other. We aimed to directly compare efficacy and safety of a high-dose (In.Pact™) vs. low-dose (Ranger™) DCB with nominal paclitaxel densities of 3.5 vs. 2.0 μg/mm2.<h4>Methods and results</h4>Within a prospective, multicentre, non-inferiority, clinical trial 414 patients with symptomatic femoropopliteal ... Read more >>

Eur Heart J (European heart journal)
[2020, 41(27):2541-2552]

Cited: 1 time

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Selective inhibition of neuronal Cav3.3 T-type calcium channels by TAT-based channel peptide.

Leos Cmarko, Norbert Weiss,

Low-voltage-activated Ca<sub>v</sub>3 calcium channels (T-type) play an essential role in the functioning of the nervous system where they support oscillatory activities that relie on several channel molecular determinants that shape their unique gating properties. In a previous study, we documented the important role of the carboxy proximal region in the ... Read more >>

Mol Brain (Molecular brain)
[2020, 13(1):95]

Cited: 1 time

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Aortic stiffness and related complications after endovascular repair of blunt thoracic aortic injury in young patients.

Akram Youssef, Igli Kalaja, Usama Alkomi, Tobias Abt, Ralf-Thorsten Hoffmann, Christian Reeps, Norbert Weiss, Helmut Karl Lackner, Adrian Mahlmann,

Background: This study aimed to evaluate the changes in aortic stiffness in young patients undergoing thoracic endovascular aortic repair (TEVAR) after blunt thoracic aortic injury (TBAI) and to examine the associated cardiovascular complications during follow-up. Patients and methods: We included survivors of TBAI who underwent stent graft placement between November ... Read more >>

Vasa (VASA. Zeitschrift fur Gefasskrankheiten)
[2020, 49(4):295-300]

Cited: 1 time

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A rare CACNA1H variant associated with amyotrophic lateral sclerosis causes complete loss of Cav3.2 T-type channel activity.

Robin N Stringer, Bohumila Jurkovicova-Tarabova, Sun Huang, Omid Haji-Ghassemi, Romane Idoux, Anna Liashenko, Ivana A Souza, Yuriy Rzhepetskyy, Lubica Lacinova, Filip Van Petegem, Gerald W Zamponi, Roger Pamphlett, Norbert Weiss,

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by the progressive loss of cortical, brain stem and spinal motor neurons that leads to muscle weakness and death. A previous study implicated CACNA1H encoding for Ca<sub>v</sub>3.2 calcium channels as a susceptibility gene in ALS. In the present study, two heterozygous ... Read more >>

Mol Brain (Molecular brain)
[2020, 13(1):33]

Cited: 2 times

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Webinar zur S3-Leitlinie Screening, Diagnostik, Therapie und Nachsorge des Bauchaortenaneurysmas.

Eike Sebastian Debus, Walter Gross-Fengels, Franziska Heidemann, Adrian Mahlmann, Elke Muhl, Karin Pfister, Sebastian Roth, Christian Stroszczynski, Andreas Walther, Norbert Weiss, Mathias Wilhelmi, Reinhart T Grundmann,

Chirurg (Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen)
[2020, 91(2):167-168]

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ADMA elevation does not exacerbate development of diabetic nephropathy in mice with streptozotocin-induced diabetes mellitus.

Roman N Rodionov, Natalia Jarzebska, Alfred Schneider, Annett Rexin, Jan Sradnick, Silke Brilloff, Jens Martens-Lobenhoffer, Stefanie M Bode-Böger, Vladimir Todorov, Christian Hugo, Norbert Weiss, Bernd Hohenstein,

BACKGROUND AND AIMS:Cardiovascular disease is nowadays the major cause of mortality and morbidity worldwide. The risk of developing cardiovascular disease is significantly increased in patients with diabetic nephropathy. It has been suggested that asymmetric dimethylarginine (ADMA), an endogenous inhibitor of NO synthases (NOS), may play an important role in the ... Read more >>

Atheroscler Suppl (Atherosclerosis. Supplements)
[2019, 40:100-105]

Cited: 3 times

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Compound heterozygous CACNA1H mutations associated with severe congenital amyotrophy.

Melissa T Carter, Hugh J McMillan, Andriy Tomin, Norbert Weiss,

Neuromuscular disorders encompass a wide range of conditions often associated with a genetic component. In the present study, we report a patient with severe infantile-onset amyotrophy in whom two compound heterozygous variants in the gene CACNA1H encoding for Ca<sub>v</sub>3.2 T-type calcium channels were identified. Functional analysis of Ca<sub>v</sub>3.2 variants revealed ... Read more >>

Channels (Austin) (Channels (Austin, Tex.))
[2019, 13(1):153-161]

Cited: 10 times

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Kidney and liver are the main organs of expression of a key metabolic enzyme alanine:glyoxylate aminotransferase 2 in humans.

Natalia Jarzebska, Sophia Georgi, Normund Jabs, Silke Brilloff, Renke Maas, Roman N Rodionov, Christian Zietz, Sabrina Montresor, Bernd Hohenstein, Norbert Weiss,

BACKGROUND:The metabolic syndrome is a cluster of cardiovascular risk factors and is highly predictive for development of cardiovascular diseases. An association between elevated plasma levels of the endogenous inhibitor of nitric oxide synthases asymmetric dimethylarginine (ADMA) and risk of cardiovascular diseases has been demonstrated in numerous epidemiological studies. ADMA can ... Read more >>

Atheroscler Suppl (Atherosclerosis. Supplements)
[2019, 40:106-112]

Cited: 2 times

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