Full Text Journal Articles by
Author Norbert Suttorp

Advertisement

Find full text journal articles






COVID-19 severity correlates with airway epithelium-immune cell interactions identified by single-cell analysis.

Robert Lorenz Chua, Soeren Lukassen, Saskia Trump, Bianca P Hennig, Daniel Wendisch, Fabian Pott, Olivia Debnath, Loreen Thürmann, Florian Kurth, Maria Theresa Völker, Julia Kazmierski, Bernd Timmermann, Sven Twardziok, Stefan Schneider, Felix Machleidt, Holger Müller-Redetzky, Melanie Maier, Alexander Krannich, Sein Schmidt, Felix Balzer, Johannes Liebig, Jennifer Loske, Norbert Suttorp, Jürgen Eils, Naveed Ishaque, Uwe Gerd Liebert, Christof von Kalle, Andreas Hocke, Martin Witzenrath, Christine Goffinet, Christian Drosten, Sven Laudi, Irina Lehmann, Christian Conrad, Leif-Erik Sander, Roland Eils,

To investigate the immune response and mechanisms associated with severe coronavirus disease 2019 (COVID-19), we performed single-cell RNA sequencing on nasopharyngeal and bronchial samples from 19 clinically well-characterized patients with moderate or critical disease and from five healthy controls. We identified airway epithelial cell types and states vulnerable to severe ... Read more >>

Nat. Biotechnol. (Nature biotechnology)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Suppressive myeloid cells are a hallmark of severe COVID-19

Jonas Schulte-Schrepping, Nico Reusch, Daniela Paclik, Kevin Baßler, Stephan Schlickeiser, Bowen Zhang, Benjamin Krämer, Tobias Krammer, Sophia Brumhard, Lorenzo Bonaguro, Elena De Domenico, Daniel Wendisch, Martin Grasshoff, Theodore Kapellos, Michael Beckstette, Tal Pecht, Adem Saglam, Oliver Dietrich, Henrik Mei, Axel Schulz, Claudia Conrad, Désirée Kunkel, Ehsan Vafadarnejad, Cheng-Jian Xu, Arik Horne, Miriam Herbert, Anna Drews, Charlotte Thibeault, Moritz Pfeiffer, Stefan Hippenstiel, Andreas Hocke, Holger Müller-Redetzky, Katrin-Moira Heim, Felix Machleidt, Alexander Uhrig, Laure Bousquillon de Jarcy, Linda Jürgens, Miriam Stegemann, Christoph Glösenkamp, Hans-Dieter Volk, Christine Goffinet, Jan Raabe, Kim Melanie Kaiser, Michael To Vinh, Gereon Rieke, Christian Meisel, Thomas Ulas, Matthias Becker, Robert Geffers, Martin Witzenrath, Christian Drosten, Norbert Suttorp, Christof von Kalle, Florian Kurth, Kristian Händler, Joachim Schultze, Anna Aschenbrenner, Yang Li, Jacob Nattermann, Birgit Sawitzki, Antoine-Emmanuel Saliba, Leif Erik Sander, ,

'Severe Acute Respiratory Syndrome - Coronavirus-2' (SARS-CoV-2) infection causes Coronavirus Disease 2019 (COVID-19), a mild to moderate respiratory tract infection in the majority of patients. A subset of patients, however, progresses to severe disease and respiratory failure with acute respiratory distress syndrome (ARDS). Severe COVID-19 has been associated with increased ... Read more >>

()
[, :]

Cited: 0 times

View full text PDF listing >>



Advertisement

Studying the pathophysiology of coronavirus disease 2019: a protocol for the Berlin prospective COVID-19 patient cohort (Pa-COVID-19).

Florian Kurth, Maria Roennefarth, Charlotte Thibeault, Victor M Corman, Holger Müller-Redetzky, Mirja Mittermaier, Christoph Ruwwe-Glösenkamp, Katrin M Heim, Alexander Krannich, Saskia Zvorc, Sein Schmidt, Lucie Kretzler, Chantip Dang-Heine, Matthias Rose, Michael Hummel, Andreas Hocke, Ralf H Hübner, Bastian Opitz, Marcus A Mall, Jobst Röhmel, Ulf Landmesser, Burkert Pieske, Samuel Knauss, Matthias Endres, Joachim Spranger, Frank P Mockenhaupt, Frank Tacke, Sascha Treskatsch, Stefan Angermair, Britta Siegmund, Claudia Spies, Steffen Weber-Carstens, Kai-Uwe Eckardt, Dirk Schürmann, Alexander Uhrig, Miriam S Stegemann, Thomas Zoller, Christian Drosten, Norbert Suttorp, Martin Witzenrath, Stefan Hippenstiel, Christof von Kalle, Leif Erik Sander,

PURPOSE:Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread worldwide causing a global health emergency. Pa-COVID-19 aims to provide comprehensive data on clinical course, pathophysiology, immunology and outcome of COVID-19, to identify prognostic biomarkers, clinical scores, and therapeutic targets for improved clinical management and preventive interventions. METHODS:Pa-COVID-19 is a prospective ... Read more >>

Infection (Infection)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Pemetrexed-Based Chemotherapy Is Inferior to Pemetrexed-Free Regimens in Thyroid Transcription Factor 1 (TTF-1)-Negative, EGFR/ALK-Negative Lung Adenocarcinoma: A Propensity Score Matched Pairs Analysis.

Nikolaj Frost, Tamar Zhamurashvili, Maximilian von Laffert, Frederick Klauschen, Christoph Ruwwe-Glösenkamp, Matthias Raspe, Matthias Brunn, Sebastian Ochsenreither, Bettina Temmesfeld-Wollbrück, Norbert Suttorp, Christian Grohé, Martin Witzenrath,

INTRODUCTION:Thyroid transcription factor 1 (TTF-1) is a prognostic biomarker in lung adenocarcinoma; however, TTF-1-positive patients also display more favorable factors like actionable target mutations. In contrast, TTF-1-negative cancer is a poorly described entity. We performed a retrospective study to characterize a TTF-1-negative phenotype and to evaluate outcome depending on the ... Read more >>

Clin Lung Cancer (Clinical lung cancer)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Studying the pathophysiology of coronavirus disease 2019 - a protocol for the Berlin prospective COVID-19 patient cohort (Pa- COVID-19)

Florian Kurth, Maria Roennefarth, Charlotte Thibeault, Victor Corman, Holger Mueller-Redetzky, Mirja Mittermaier, Christoph Ruwwe-Gloesenkamp, Alexander Krannich, Sein Schmidt, Lucie Kretzler, Chantip Dang-Heine, Matthias Rose, Michael Hummel, Andreas Hocke, Ralf Huebner, Marcus Mall, Jobst Roehmel, Ulf Landmesser, Burkert Pieske, Samuel Knauss, Matthias Endres, Joachim Spranger, Frank Mockenhaupt, Frank Tacke, Sascha Treskatsch, Stefan Angermair, Britta Siegmund, Claudia Spies, Steffen Weber-Carstens, Kai-Uwe Eckardt, Alexander Uhrig, Thomas Zoller, Christian Drosten, Norbert Suttorp, Martin Witzenrath, Stefan Hippenstiel, Christoph von Kalle, Leif Erik Sander,

Purpose Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread worldwide causing a global health emergency. Pa-COVID-19 aims to provide comprehensive data on clinical course, pathophysiology, immunology and outcome of COVID-19, in order to identify prognostic biomarkers, clinical scores, and therapeutic targets for improved clinical management and preventive interventions. Methods ... Read more >>

()
[, :]

Cited: 0 times

View full text PDF listing >>



Results of intensified source finding efforts among community-acquired cases of Legionnaires' disease - First results of the German LeTriWa study; Berlin, 2016-2019

Udo Buchholz, Heiko Juergen Jahn, Bonita Brodhun, Ann-Sophie Lehfeld, Marina Lewandowsky, Franziska Reber, Kristin Adler, Jacqueline Bochmann, Christina Foerster, Madlen Koch, Yvonne Schreiner, Fabian Stemmler, Corinna Gaggel, Edith Harbich, Sina Baerwolff, Andreas Beyer, Ute Geuss-Fosu, Martina Haenel, Patrick Larscheid, Lukas Murajda, Klaus Morawski, Uwe Peters, Raimund Pitzing, Andreas von Welczeck, Gudrun Widders, Nicoletta Wischnewski, Inas Abdelgawad, Anke Hinzmann, Denis Aguilar Pineda, Birte Schilling, Silvia Schmidt, Jakob Schumacher, Irina Zuschneid, Iskandar Atmowihardjo, Keikawus Arasteh, Steffen Behrens, Petra Creutz, Johannes Elias, Martina Gregor, Stefan Kahl, Henning Kahnert, Viktor Kimmel, Josefa Lehmke, Pascal Migaud, Agata Mikolajewska, Verena Moos, Maria-Barbara Naumann, Wulf Pankow, Hans Scheruebl, Bernd Schmidt, Thomas Schneider, Hartmut Stocker, Norbert Suttorp, Dorina Thiemig, Walter Haas, Benedikt Schaefer, Christian Lueck,

Introduction: Sources of infection of most cases of community-acquired Legionnaires' disease (CALD) are unknown. Objective: Identification of sources of infection of CALD. Setting: Berlin; December 2016-May 2019. Participants: Adult cases of CALD reported to district health authorities and consenting to the study; age and hospital matched controls. Main outcome measure: ... Read more >>

()
[, :]

Cited: 0 times

View full text PDF listing >>



Presence of SARS-CoV-2 reactive T cells in COVID-19 patients and healthy donors

Julian Braun, Lucie Loyal, Marco Frentsch, Daniel Wendisch, Philipp Georg, Florian Kurth, Stefan Hippenstiel, Manuela Dingeldey, Beate Kruse, Florent Fauchere, Emre Baysal, Maike Mangold, Larissa Henze, Roland Lauster, Marcus Mall, Kirsten Beyer, Jobst Roehmel, Juergen Schmitz, Stefan Miltenyi, Marcel Mueller, Martin Witzenrath, Norbert Suttorp, Florian Kern, Ulf Reimer, Holger Wenschuh, Christian Drosten, Victor Corman, Claudia Giesecke-Thiel, Leif-Erik Sander, Andreas Thiel,

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a rapidly unfolding pandemic, overwhelming health care systems worldwide1. Clinical manifestations of Corona-virus-disease 2019 (COVID-19) vary broadly, ranging from asymptomatic infection to acute respiratory failure and death2, yet the underlying physiological conditions and mechanisms for this high variability are still ... Read more >>

()
[, :]

Cited: 0 times

View full text PDF listing >>



Neutralizing Complement C5a Protects Mice with Pneumococcal Pulmonary Sepsis.

Holger Müller-Redetzky, Ute Kellermann, Sandra-Maria Wienhold, Birgitt Gutbier, Jasmin Lienau, Katharina Hellwig, Katrin Reppe, Eleftheria Letsiou, Thomas Tschernig, Markus Scholz, Peter Ahnert, Christian Maasch, Kai Hoehlig, Sven Klussmann, Axel Vater, Theresa C Firsching, Judith Hoppe, Norbert Suttorp, Martin Witzenrath,

BACKGROUND:Community-acquired pneumonia and associated sepsis cause high mortality despite antibiotic treatment. Uncontrolled inflammatory host responses contribute to the unfavorable outcome by driving lung and extrapulmonary organ failure. The complement fragment C5a holds significant proinflammatory functions and is associated with tissue damage in various inflammatory conditions. The authors hypothesized that C5a ... Read more >>

Anesthesiology (Anesthesiology)
[2020, 132(4):795-807]

Cited: 0 times

View full text PDF listing >>



Update on the "Choosing Wisely" initiative in infectious diseases in Germany.

Rika Draenert, Norma Jung, ,

PURPOSE:The Choosing Wisely® initiative is an international campaign addressing over- and underuse of diagnostic and therapeutic measures in infectious diseases among others. Since 2016, the German Society for Infectious Diseases (DGI) has constantly designed new items in this regard. Here we report the most recent recommendations. METHODS:The recommendations of the ... Read more >>

Infection (Infection)
[2020, 48(3):317-321]

Cited: 0 times

View full text PDF listing >>



Markov State Modelling of Disease Courses and Mortality Risks of Patients with Community-Acquired Pneumonia.

Jens Przybilla, Peter Ahnert, Holger Bogatsch, Frank Bloos, Frank M Brunkhorst, SepNet Critical Care Trials Group, Progress Study Group, Michael Bauer, Markus Loeffler, Martin Witzenrath, Norbert Suttorp, Markus Scholz,

Community-acquired pneumonia (CAP) is one of the most frequent infectious diseases worldwide, with high lethality. Risk evaluation is well established at hospital admission, and re-evaluation is advised for patients at higher risk. However, severe disease courses may develop from all levels of severity. We propose a stochastic continuous-time Markov model ... Read more >>

J Clin Med (Journal of clinical medicine)
[2020, 9(2):]

Cited: 0 times

View full text PDF listing >>



Association of proteome and metabolome signatures with severity in patients with community-acquired pneumonia.

Manuela Gesell Salazar, Sophie Neugebauer, Tim Kacprowski, Stephan Michalik, Peter Ahnert, Petra Creutz, Maciej Rosolowski, , Markus Löffler, Michael Bauer, Norbert Suttorp, Michael Kiehntopf, Uwe Völker,

A combined OMICS screening approach of human plasma and serum was used to characterize protein and metabolome signatures displaying association to severity of Community-acquired pneumonia (CAP). 240 serum and BD P100 EDTA plasma samples from patients diagnosed with CAP, collected during the day of enrolment to the hospital, were analyzed ... Read more >>

J Proteomics (Journal of proteomics)
[2020, 214:103627]

Cited: 0 times

View full text PDF listing >>



Surface Proteome of Plasma Extracellular Vesicles as Biomarkers for Pneumonia and Acute Exacerbation of Chronic Obstructive Pulmonary Disease.

Anna Lena Jung, Malene Møller Jørgensen, Rikke Bæk, Kathrin Griss, Maria Han, Kristina Auf Dem Brinke, Nina Timmesfeld, Wilhelm Bertrams, Timm Greulich, Rembert Koczulla, Stefan Hippenstiel, Norbert Suttorp, Bernd Schmeck,

BACKGROUND:Community-acquired pneumonia (CAP) and acute exacerbation of chronic obstructive pulmonary disease (AECOPD) represent a major burden of disease and death and their differential diagnosis is critical. A potential source of relevant accessible biomarkers are blood-borne small extracellular vesicles (sEVs). METHODS:We performed an extracellular vesicle array to find proteins on plasma ... Read more >>

J. Infect. Dis. (The Journal of infectious diseases)
[2020, 221(2):325-335]

Cited: 0 times

View full text PDF listing >>



Indwelling pleural catheters for malignancy-associated pleural effusion: report on a single centre's ten years of experience.

Nikolaj Frost, Martin Brünger, Christoph Ruwwe-Glösenkamp, Matthias Raspe, Antje Tessmer, Bettina Temmesfeld-Wollbrück, Dirk Schürmann, Norbert Suttorp, Martin Witzenrath,

INTRODUCTION:Recurrent pleural effusion is a common cause of dyspnoea, cough and chest pain during the course of malignant diseases. Chemical pleurodesis had been the only definitive treatment option until two decades ago. Indwelling pleural catheters (IPC) emerged as an alternative, not only assuring immediate symptom relief but also potentially leading ... Read more >>

BMC Pulm Med (BMC pulmonary medicine)
[2019, 19(1):232]

Cited: 0 times

View full text PDF listing >>



Indwelling pleural catheters for non-malignant pleural effusions: report on a single centre's 10 years of experience.

Nikolaj Frost, Christoph Ruwwe-Glösenkamp, Matthias Raspe, Martin Brünger, Bettina Temmesfeld-Wollbrück, Norbert Suttorp, Martin Witzenrath,

BACKGROUND:Recurrent pleural effusion is a common cause of dyspnoea, cough and chest pain during the course of infectious pleurisy and non-malignant diseases like congestive heart failure (CHF) or liver cirrhosis with hepatic hydrothorax (HH). With regard to the chronic character of the underlying diseases, indwelling pleural catheters (IPC) are increasingly ... Read more >>

BMJ Open Respir Res (BMJ open respiratory research)
[2020, 7(1):]

Cited: 0 times

View full text PDF listing >>



Intravenous Artesunate for Imported Severe Malaria in Children Treated in Four Tertiary Care Centers in Germany: A Retrospective Study.

Sabine Bélard, Judith Brand, Ulf Schulze-Sturm, Ales Janda, Ulrich von Both, Costanza Tacoli, Martin Alberer, Caroline Kempf, Miriam S Stegemann, Renate Krüger, Verena Varnholt, Martin Blohm, Karl Reiter, Thomas Zoller, Norbert Suttorp, Marcus Mall, Horst von Bernuth, Alexander Gratopp, Johannes Hübner, Markus Hufnagel, Robin Kobbe, Florian Kurth,

BACKGROUND:Intravenous artesunate (ivA) is the standard treatment for severe malaria. Data systematically evaluating the use of ivA in pediatric patients outside malaria-endemic regions are limited. The aim of this case series was to summarize efficacy and safety of ivA for imported severe malaria in children in Germany. METHODS:Our retrospective case ... Read more >>

Pediatr. Infect. Dis. J. (The Pediatric infectious disease journal)
[2019, 38(11):e295-e300]

Cited: 0 times

View full text PDF listing >>



Microbiota-Dependent Regulation of Antimicrobial Immunity in the Lung.

Laura Maschirow, Norbert Suttorp, Bastian Opitz,

Several body sites, including the intestinal and respiratory tracts, are colonized with a myriad of bacteria, archaea, fungi, and viruses, which are collectively referred to as the "microbiota." The bacterial component of the microbiota in particular has been recognized to influence a multitude of physiological functions, including innate and adaptive ... Read more >>

Am. J. Respir. Cell Mol. Biol. (American journal of respiratory cell and molecular biology)
[2019, 61(3):284-289]

Cited: 0 times

View full text PDF listing >>



[Hemophagocytic lymphohistiocytosis in unspecific virus infection].

Gunnar Lachmann, Cornelia Knaak, Paul La Rosée, Claudia Spies, Peter Nyvlt, Christian Oberender, Leif Erik Sander, Norbert Suttorp, Holger Müller-Redetzky,

Hemophagocytic lymphohistiocytosis (HLH), also known as hemophagocytic syndrome or macrophage activation syndrome within a pre-existing rheumatological disease, remains undiagnosed in over 70% of all cases in intensive care units (ICU) due to the sepsis-like clinical presentation. This report describes the case of a 30-year-old previously healthy male patient who was admitted ... Read more >>

Anaesthesist (Der Anaesthesist)
[2019, 68(9):626-632]

Cited: 0 times

View full text PDF listing >>



Sequential organ failure assessment score is an excellent operationalization of disease severity of adult patients with hospitalized community acquired pneumonia - results from the prospective observational PROGRESS study.

Peter Ahnert, Petra Creutz, Katrin Horn, Fabian Schwarzenberger, Michael Kiehntopf, Hamid Hossain, Michael Bauer, Frank Martin Brunkhorst, Konrad Reinhart, Uwe Völker, Trinad Chakraborty, Martin Witzenrath, Markus Löffler, Norbert Suttorp, Markus Scholz, ,

BACKGROUND:CAP (Community acquired pneumonia) is frequent, with a high mortality rate and a high burden on health care systems. Development of predictive biomarkers, new therapeutic concepts, and epidemiologic research require a valid, reproducible, and quantitative measure describing CAP severity. METHODS:Using time series data of 1532 patients enrolled in the PROGRESS ... Read more >>

Crit Care (Critical care (London, England))
[2019, 23(1):110]

Cited: 0 times

View full text PDF listing >>



Delay in antibiotic therapy results in fatal disease outcome in murine pneumococcal pneumonia.

Sarah Berger, Cengiz Goekeri, Shishir K Gupta, Julio Vera, Kristina Dietert, Ulrike Behrendt, Jasmin Lienau, Sandra-Maria Wienhold, Achim D Gruber, Norbert Suttorp, Martin Witzenrath, Geraldine Nouailles,

BACKGROUND:Community-acquired pneumonia (CAP) remains a major cause of death worldwide. Mechanisms underlying the detrimental outcome despite adequate antibiotic therapy and comorbidity management are still not fully understood. METHODS:To model timely versus delayed antibiotic therapy in patients, mice with pneumococcal pneumonia received ampicillin twice a day starting early (24 h) or late ... Read more >>

Crit Care (Critical care (London, England))
[2018, 22(1):287]

Cited: 0 times

View full text PDF listing >>



Ventilator-induced lung injury is aggravated by antibiotic mediated microbiota depletion in mice.

Sandra-Maria Wienhold, Mario Macrì, Geraldine Nouailles, Kristina Dietert, Corinne Gurtner, Achim D Gruber, Markus M Heimesaat, Jasmin Lienau, Fabian Schumacher, Burkhard Kleuser, Bastian Opitz, Norbert Suttorp, Martin Witzenrath, Holger C Müller-Redetzky,

BACKGROUND:Antibiotic exposure alters the microbiota, which can impact the inflammatory immune responses. Critically ill patients frequently receive antibiotic treatment and are often subjected to mechanical ventilation, which may induce local and systemic inflammatory responses and development of ventilator-induced lung injury (VILI). The aim of this study was to investigate whether ... Read more >>

Crit Care (Critical care (London, England))
[2018, 22(1):282]

Cited: 1 time

View full text PDF listing >>



Local ablative treatment for synchronous single organ oligometastatic lung cancer-A propensity score analysis of 180 patients.

Nikolaj Frost, Antje Tessmer, Alexander Schmittel, Vincent van Laak, Matthias Raspe, Christoph Ruwwe-Glösenkamp, Matthias Brunn, Carolin Senger, Dirk Böhmer, Sebastian Ochsenreither, Bettina Temmesfeld-Wollbrück, Christian Furth, Bernd Schmidt, Jens Neudecker, Jens-Carsten Rückert, Norbert Suttorp, Martin Witzenrath, Christian Grohé,

INTRODUCTION:Local ablative treatment (LAT) improves outcome in lung cancer with oligometastatic disease (OMD) and potentially leads to long term survival. The aim of this retrospective study was to evaluate and quantify the additional benefit of LAT in synchronous OMD and to further identify prognostic factors for survival. PATIENTS AND METHODS:A ... Read more >>

Lung Cancer (Lung cancer (Amsterdam, Netherlands))
[2018, 125:164-173]

Cited: 1 time

View full text PDF listing >>



Prognostic and Pathogenic Role of Angiopoietin-1 and -2 in Pneumonia.

Birgitt Gutbier, Anne-Kathrin Neuhauß, Katrin Reppe, Carolin Ehrler, Ansgar Santel, Jörg Kaufmann, Markus Scholz, Norbert Weissmann, Lars Morawietz, Timothy J Mitchell, Stefano Aliberti, Stefan Hippenstiel, Norbert Suttorp, Martin Witzenrath, ,

RATIONALE:During pneumonia, pathogen-host interaction evokes inflammation and lung barrier dysfunction. Tie2 activation by angiopoietin-1 reduces, whereas Tie2 blockade by angiopoietin-2 increases, inflammation and permeability during sepsis. The role of angiopoietin-1/-2 in pneumonia remains unidentified. OBJECTIVES:To investigate the prognostic and pathogenic impact of angiopoietins in regulating pulmonary vascular barrier function and ... Read more >>

Am. J. Respir. Crit. Care Med. (American journal of respiratory and critical care medicine)
[2018, 198(2):220-231]

Cited: 6 times

View full text PDF listing >>



Antibiotic treatment-induced secondary IgA deficiency enhances susceptibility to Pseudomonas aeruginosa pneumonia.

Oliver H Robak, Markus M Heimesaat, Andrey A Kruglov, Sandra Prepens, Justus Ninnemann, Birgitt Gutbier, Katrin Reppe, Hubertus Hochrein, Mark Suter, Carsten J Kirschning, Veena Marathe, Jan Buer, Mathias W Hornef, Markus Schnare, Pascal Schneider, Martin Witzenrath, Stefan Bereswill, Ulrich Steinhoff, Norbert Suttorp, Leif E Sander, Catherine Chaput, Bastian Opitz,

Broad-spectrum antibiotics are widely used with patients in intensive care units (ICUs), many of whom develop hospital-acquired infections with Pseudomonas aeruginosa. Although preceding antimicrobial therapy is known as a major risk factor for P. aeruginosa-induced pneumonia, the underlying mechanisms remain incompletely understood. Here we demonstrate that depletion of the resident ... Read more >>

J. Clin. Invest. (The Journal of clinical investigation)
[2018, 128(8):3535-3545]

Cited: 10 times

View full text PDF listing >>



DNA-release by Streptococcus pneumoniae autolysin LytA induced Krueppel-like factor 4 expression in macrophages.

Toni Herta, Aritra Bhattacharyya, Christian Bollensdorf, Christin Kabus, Pedro García, Norbert Suttorp, Stefan Hippenstiel, Janine Zahlten,

The recruitment of myeloid cells to the lung is of utmost importance for the elimination of invading pathogens. We investigated the Streptococcus pneumoniae-dependent induction mechanism of KLF4 in macrophages as a potential regulator of the macrophage immune response. We demonstrated that only viable pneumococci, which have direct contact to the ... Read more >>

Sci Rep (Scientific reports)
[2018, 8(1):5723]

Cited: 1 time

View full text PDF listing >>



Recognition of microbial viability via TLR8 drives TFH cell differentiation and vaccine responses.

Matteo Ugolini, Jenny Gerhard, Sanne Burkert, Kristoffer Jarlov Jensen, Philipp Georg, Friederike Ebner, Sarah M Volkers, Shruthi Thada, Kristina Dietert, Laura Bauer, Alexander Schäfer, Elisa T Helbig, Bastian Opitz, Florian Kurth, Saubashya Sur, Nickel Dittrich, Sumanlatha Gaddam, Melanie L Conrad, Christine S Benn, Ulrike Blohm, Achim D Gruber, Andreas Hutloff, Susanne Hartmann, Mark V Boekschoten, Michael Müller, Gregers Jungersen, Ralf R Schumann, Norbert Suttorp, Leif E Sander,

Live attenuated vaccines are generally highly efficacious and often superior to inactivated vaccines, yet the underlying mechanisms of this remain largely unclear. Here we identify recognition of microbial viability as a potent stimulus for follicular helper T cell (TFH cell) differentiation and vaccine responses. Antigen-presenting cells (APCs) distinguished viable bacteria ... Read more >>

Nat. Immunol. (Nature immunology)
[2018, 19(4):386-396]

Cited: 26 times

View full text PDF listing >>



Advertisement

Disclaimer
1.3142 s