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Author Norbert Nass

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Relationship of micro-RNA, mRNA and eIF Expression in Tamoxifen-Adapted MCF-7 Breast Cancer Cells: Impact of miR-1972 on Gene Expression, Proliferation and Migration.

Akhil Behringer, Darko Stoimenovski, Martin Porsch, Katrin Hoffmann, Gerhard Behre, Ivo Grosse, Thomas Kalinski, Johannes Haybaeck, Norbert Nass,

<h4>Background</h4>Tamoxifen-adapted MCF-7-Tam cells represent an in-vitro model for acquired tamoxifen resistance, which is still a problem in clinics. We here investigated the correlation of microRNA-, mRNA- and eukaryotic initiation factors (eIFs) expression in this model.<h4>Methods</h4>MicroRNA- and gene expression were analyzed by nCounter and qRT-PCR technology; eIFs by Western blotting. Protein ... Read more >>

Biomolecules (Biomolecules)
[2022, 12(7):916]

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BCL3 expression is strongly associated with the occurrence of breast cancer relapse under tamoxifen treatment in a retrospective cohort study.

Piotr Czapiewski, Maximilian Cornelius, Roland Hartig, Thomas Kalinski, Johannes Haybaeck, Angela Dittmer, J├╝rgen Dittmer, Atanas Ignatov, Norbert Nass,

Patients with estrogen receptor positive breast cancer are usually receiving an anti-estrogen therapy by either aromatase inhibitors or selective estrogen receptor mediators such as tamoxifen. Nevertheless, acquired resistance to tamoxifen under treatment frequently hampers therapy. One proposed explanation for this phenomenon is the interaction of the tumor cells with cells ... Read more >>

Virchows Arch (Virchows Archiv : an international journal of pathology)
[2022, 480(3):529-541]

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