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Author Nora D Volkow

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Identifying functionally relevant candidate genes for inflexible ethanol intake in mice and humans using a guilt-by-association approach.

Luana Martins de Carvalho, Pablo A S Fonseca, Isadora M Paiva, Samara Damasceno, Agatha S B Pedersen, Daniel da Silva E Silva, Corinde E Wiers, Nora D Volkow, Ana L Brunialti Godard,

Gene prioritization approaches are useful tools to explore and select candidate genes in transcriptome studies. Knowing the importance of processes such as neuronal activity, intracellular signal transduction, and synapse plasticity to the development and maintenance of compulsive ethanol drinking, the aim of the present study was to explore and identify ... Read more >>

Brain Behav (Brain and behavior)
[2020, :e01879]

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Epistatic evidence for gender-dependant slow neurotransmission signalling in substance use disorders: PPP1R12B versus PPP1R1B.

Kefu Liu, Juan Zhao, Chunnuan Chen, Jie Xu, Richard L Bell, Frank S Hall, George F Koob, Nora D Volkow, Hong Qing, Zhicheng Lin,

BACKGROUND:Slow neurotransmission including DARPP-32 signalling is implicated in substance use disorders (SUDs) by experimental systems but not yet in the human aetiology. PPP1R12B, encoding another protein in the DARPP-32 family, hasn't been studied in the brain. METHODS:Brain-regional gene activity was assessed in three different animal models of SUDs for mRNA ... Read more >>

EBioMedicine (EBioMedicine)
[2020, 61:103066]

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Resting activity of the hippocampus and amygdala in obese individuals predicts their response to food cues.

Guanya Li, Yang Hu, Wenchao Zhang, Yueyan Ding, Yuanyuan Wang, Jia Wang, Yang He, Ganggang Lv, Karen M von Deneen, Yu Zhao, Antao Chen, Yu Han, Guangbin Cui, Gang Ji, Peter Manza, Dardo Tomasi, Nora D Volkow, Yongzhan Nie, Gene-Jack Wang, Yi Zhang,

Obese individuals exhibit brain functional abnormalities in multiple regions implicated in reward/motivation, emotion/memory, homeostatic regulation, and executive control when exposed to food cues and during rest. However, it remains unclear whether abnormal brain responses to food cues might account for or relate to their abnormal activity in resting state. This ... Read more >>

Addict Biol (Addiction biology)
[2020, :e12974]

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Brain Connectivity, and Hormonal and Behavioral Correlates of Sustained Weight Loss in Obese Patients after Laparoscopic Sleeve Gastrectomy.

Yang Hu, Gang Ji, Guanya Li, Peter Manza, Wenchao Zhang, Jia Wang, Ganggang Lv, Yang He, Zhida Zhang, Kai Yuan, Karen M von Deneen, Antao Chen, Guangbin Cui, Huaning Wang, Corinde E Wiers, Nora D Volkow, Yongzhan Nie, Yi Zhang, Gene-Jack Wang,

The biological mediators that support cognitive-control and long-term weight-loss after laparoscopic sleeve gastrectomy (LSG) remain unclear. We measured peripheral appetitive hormones and brain functional-connectivity (FC) using magnetic-resonance-imaging with food cue-reactivity task in 25 obese participants at pre, 1 month, and 6 month after LSG, and compared with 30 normal weight ... Read more >>

Cereb Cortex (Cerebral cortex (New York, N.Y. : 1991))
[2020, :]

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Managing dual disorders: a statement by the Informal Scientific Network, UN Commission on Narcotic Drugs.

Nora D Volkow, Marta Torrens, Vladimir Poznyak, Elizabeth Sáenz, Anja Busse, Wataru Kashino, Dzmitry Krupchanka, Devora Kestel, Giovanna Campello, Gilberto Gerra,

World Psychiatry (World psychiatry : official journal of the World Psychiatric Association (WPA))
[2020, 19(3):396-397]

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Brain Network Segregation and Glucose Energy Utilization: Relevance for Age-Related Differences in Cognitive Function.

Peter Manza, Corinde E Wiers, Ehsan Shokri-Kojori, Danielle Kroll, Dana Feldman, Melanie Schwandt, Gene-Jack Wang, Dardo Tomasi, Nora D Volkow,

The human brain is organized into segregated networks with strong within-network connections and relatively weaker between-network connections. This "small-world" organization may be essential for maintaining an energetically efficient system, crucial to the brain which consumes 20% of the body's energy. Brain network segregation and glucose energy utilization both change throughout ... Read more >>

Cereb Cortex (Cerebral cortex (New York, N.Y. : 1991))
[2020, 30(11):5930-5942]

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Increased risk of COVID-19 infection and mortality in people with mental disorders: analysis from electronic health records in the United States.

QuanQiu Wang, Rong Xu, Nora D Volkow,

Concerns have been expressed that persons with a pre-existing mental disorder may represent a population at increased risk for COVID-19 infection and with a higher likelihood of adverse outcomes of the infection, but there is no systematic research evidence in this respect. This study assessed the impact of a recent ... Read more >>

World Psychiatry (World psychiatry : official journal of the World Psychiatric Association (WPA))
[2020, :]

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Correction: COVID-19 risk and outcomes in patients with substance use disorders: analyses from electronic health records in the United States.

Quan Qiu Wang, David C Kaelber, Rong Xu, Nora D Volkow,

An amendment to this paper has been published and can be accessed via a link at the top of the paper. ... Read more >>

Mol Psychiatry (Molecular psychiatry)
[2020, :]

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Opportunities for Research on the Treatment of Substance Use Disorders in the Context of COVID-19.

Carlos Blanco, Wilson M Compton, Nora D Volkow,

JAMA Psychiatry (JAMA psychiatry)
[2020, :]

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Elevated thalamic glutamate levels and reduced water diffusivity in alcohol use disorder: Association with impulsivity.

Corinde E Wiers, Samantha I Cunningham, Dardo G Tomasi, Thomas Ernst, Linda Chang, Ehsan Shokri-Kojori, Gene-Jack Wang, Nora D Volkow,

Alcohol induces neuroinflammation but its role in cognitive impairment and impulsivity in alcohol use disorder (AUD) has been poorly investigated. We used proton magnetic resonance spectroscopy to measure brain glutamate (Glu) levels and diffusion-weighted imaging to measure functional anisotropy (FA) in the thalamus and ventral anterior cingulate cortex (vACC) in ... Read more >>

Psychiatry Res Neuroimaging (Psychiatry research. Neuroimaging)
[2020, 305:111185]

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PET Radiotracers for CNS-Adrenergic Receptors: Developments and Perspectives.

Santosh Reddy Alluri, Sung Won Kim, Nora D Volkow, Kun-Eek Kil,

Epinephrine (E) and norepinephrine (NE) play diverse roles in our body's physiology. In addition to their role in the peripheral nervous system (PNS), E/NE systems including their receptors are critical to the central nervous system (CNS) and to mental health. Various antipsychotics, antidepressants, and psychostimulants exert their influence partially through ... Read more >>

Molecules (Molecules (Basel, Switzerland))
[2020, 25(17):]

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The associations of comorbid substance use disorders and psychiatric conditions with adolescent brain structure and function: A review.

Danielle S Kroll, Dana E Feldman, Szu-Yung Ariel Wang, Rui Zhang, Peter Manza, Corinde E Wiers, Nora D Volkow, Gene-Jack Wang,

Adolescence is a period of rapid neural and behavioral development that often precipitates substance use, substance use disorders (SUDs), and other psychopathology. While externalizing disorders have been closely linked to SUD epidemiologically, the comorbidity of internalizing disorders and SUD is less well understood. Neuroimaging studies can be used to measure ... Read more >>

J Neurol Sci (Journal of the neurological sciences)
[2020, 418:117099]

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Ethical Imperatives to Overcome Stigma Against People With Substance Use Disorders.

Jerome M Adams, Nora D Volkow,

Responding to the public health crisis in the United States resulting from untreated opioid use disorder (OUD) requires expanding delivery of effective treatments, including medications, and eliminating stigma against people with OUD and people seeking OUD treatment. Stigma discourages people with substance use disorders from seeking care and compromises the ... Read more >>

AMA J Ethics (AMA journal of ethics)
[2020, 22(1):E702-708]

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Opioid Research: Past and Future.

Rita J Valentino, Nora D Volkow,

The International Narcotics Research Conference (INRC) has a rich history of uniting the most creative minds across the fields of chemistry, pharmacology, physiology, and behavior in the study of opioids. The Conference has been a forum for sharing knowledge, discussing controversies, introducing innovative research, and announcing landmark discoveries. In this ... Read more >>

Mol Pharmacol (Molecular pharmacology)
[2020, 98(4):389-391]

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A deep-learning-based approach for noise reduction in high-speed optical coherence Doppler tomography.

Ang Li, Congwu Du, Nora D Volkow, Yingtian Pan,

Optical coherence Doppler tomography (ODT) increasingly attracts attention because of its unprecedented advantages with respect to high contrast, capillary-level resolution and flow speed quantification. However, the trade-off between the signal-to-noise ratio of ODT images and A-scan sampling density significantly slows down the imaging speed, constraining its clinical applications. To accelerate ... Read more >>

J Biophotonics (Journal of biophotonics)
[2020, :e202000084]

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Neuroimaging of Sex/Gender Differences in Obesity: A Review of Structure, Function, and Neurotransmission.

Danielle S Kroll, Dana E Feldman, Catherine L Biesecker, Katherine L McPherson, Peter Manza, Paule Valery Joseph, Nora D Volkow, Gene-Jack Wang,

While the global prevalence of obesity has risen among both men and women over the past 40 years, obesity has consistently been more prevalent among women relative to men. Neuroimaging studies have highlighted several potential mechanisms underlying an individual's propensity to become obese, including sex/gender differences. Obesity has been associated ... Read more >>

Nutrients (Nutrients)
[2020, 12(7):]

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Decreased Neuronal Excitability in Medial Prefrontal Cortex during Morphine Withdrawal is associated with enhanced SK channel activity and upregulation of small GTPase Rac1.

Liang Qu, Yuan Wang, Yang Li, Xin Wang, Nan Li, Shunnan Ge, Jing Wang, Gene-Jack Wang, Nora D Volkow, Bing Lang, Ping Wang, Hao Wu, Jie Zeng, Jian Fu, Jiaming Li, Yue Zhang, Xuelian Wang,

Rationale: Neuroadaptations in the medial prefrontal cortex (mPFC) and Nucleus Accumbens (NAc) play a role in the disruption of control-reward circuits in opioid addiction. Small Conductance Calcium-Activated Potassium (SK) channels in the mPFC have been implicated in neuronal excitability changes during morphine withdrawal. However, the mechanism that modulates SK channels ... Read more >>

Theranostics (Theranostics)
[2020, 10(16):7369-7383]

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America's opioid crisis: the need for an integrated public health approach.

Carlos Blanco, Tisha R A Wiley, Jacqueline J Lloyd, Marsha F Lopez, Nora D Volkow,

Continued increases in overdose deaths and recent declines in life expectancy call for need to adopt comprehensive public health approaches to the United States opioid crisis and to establish an infrastructure to avert future crises. Successfully addressing the challenges posed by the crisis requires a translational, integrated approach that combines ... Read more >>

Transl Psychiatry (Translational psychiatry)
[2020, 10(1):167]

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Neuropsychosocial markers of binge drinking in young adults.

Joshua L Gowin, Peter Manza, Vijay A Ramchandani, Nora D Volkow,

Binge drinking is associated with disease and death, and developing tools to identify risky drinkers could mitigate its damage. Brain processes underlie risky drinking, so we examined whether neural and psychosocial markers could identify binge drinkers. Reward is the most widely studied neural process in addiction, but processes such as ... Read more >>

Mol. Psychiatry (Molecular psychiatry)
[2020, :]

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Network connectivity predicts language processing in healthy adults.

Dardo Tomasi, Nora D Volkow,

Brain imaging has been used to predict language skills during development and neuropathology but its accuracy in predicting language performance in healthy adults has been poorly investigated. To address this shortcoming, we studied the ability to predict reading accuracy and single-word comprehension scores from rest- and task-based functional magnetic resonance ... Read more >>

Hum Brain Mapp (Human brain mapping)
[2020, 41(13):3696-3708]

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Personality traits in substance use disorders and obesity when compared to healthy controls.

Veronica Ramirez, Corinde E Wiers, Gene-Jack Wang, Nora D Volkow,

BACKGROUND AND AIMS:Although personality traits are implicated in substance use disorders (SUDs) and obesity, differences and similarities between them have not been assessed. Our main aim was to compare personality traits between people with different SUDs, obese people and healthy controls. DESIGN:This was a secondary analysis of personality scores obtained ... Read more >>

Addiction (Addiction (Abingdon, England))
[2020, 115(11):2130-2139]

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Stigma and the Toll of Addiction.

Nora D Volkow,

N. Engl. J. Med. (The New England journal of medicine)
[2020, 382(14):1289-1290]

Cited: 2 times

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Sleep inconsistency between weekends and weekdays is associated with changes in brain function during task and rest.

Rui Zhang, Dardo Tomasi, Ehsan Shokri-Kojori, Corinde E Wiers, Gene-Jack Wang, Nora D Volkow,

STUDY OBJECTIVES:Sleep deprivation and circadian disruptions impair brain function and cognitive performance, but few studies have examined the effect of sleep inconsistency. Here, we investigated how inconsistent sleep duration and sleep timing between weekends (WE) and weekdays (WD) correlated with changes in behavior and brain function during task and at ... Read more >>

Sleep (Sleep)
[2020, :]

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Altered Interactions Among Resting-State Networks in Individuals with Obesity.

Yueyan Ding, Gang Ji, Guanya Li, Wenchao Zhang, Yang Hu, Lei Liu, Yuanyuan Wang, Chunxin Hu, Karen M von Deneen, Yu Han, Guangbin Cui, Huaning Wang, Corinde E Wiers, Peter Manza, Dardo Tomasi, Nora D Volkow, Yongzhan Nie, Gene-Jack Wang, Yi Zhang,

OBJECTIVE:The aim of this study was to investigate alterations in functional connectivity (FC) within and interactions between resting-state networks involved in salience, executive control, and interoception in participants with obesity (OB). METHODS:Using resting-state functional magnetic resonance imaging with independent component analysis and FC, alterations within and interactions between resting-state networks ... Read more >>

Obesity (Silver Spring) (Obesity (Silver Spring, Md.))
[2020, 28(3):601-608]

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Importance of a standard unit dose for cannabis research.

Nora D Volkow, Susan R B Weiss,

Addiction (Addiction (Abingdon, England))
[2020, 115(7):1219-1221]

Cited: 1 time

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