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Author Nobuyuki Takahashi

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Metabolomics of a mouse model of preeclampsia induced by overexpressing soluble fms-like tyrosine kinase 1.

Emiko Sato, Yukako Tsunokuni, Manami Kaneko, Daisuke Saigusa, Ritsumi Saito, Shuichi Shimma, Akiyo Sekimoto, Yoshiko Kawana, Yuji Oe, Sadayoshi Ito, Hiroshi Sato, Nobuyuki Takahashi,

Preeclampsia (PE) is a leading cause of maternal morbidity and mortality. Nicotinamide has beneficial effects on PE. In this study, we evaluated the effect of nicotinamide on placental development using a PE mouse model. To generate the PE model, a recombinant adenovirus to overproduce soluble fms-like tyrosine kinase 1 (sFlt-1) ... Read more >>

Biochem. Biophys. Res. Commun. (Biochemical and biophysical research communications)
[2020, :]

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Dual blockade of protease-activated receptor 1 and 2 additively ameliorates diabetic kidney disease.

Shohei Mitsui, Yuji Oe, Akiyo Sekimoto, Emiko Sato, Yamato Hashizume, Shu Yamakage, Satoshi Kumakura, Hiroshi Sato, Sadayoshi Ito, Nobuyuki Takahashi,

Protease-activated receptors (PARs) are coagulation protease targets, and they increase expression of inflammatory cytokines and chemokines in various diseases. Of all PARs, previous reports have shown that PAR1 or PAR2 inhibition is protective against diabetic glomerular injury. However, how PAR1 and PAR2 cooperatively contribute to diabetic kidney disease (DKD) pathogenesis ... Read more >>

Am. J. Physiol. Renal Physiol. (American journal of physiology. Renal physiology)
[2020, 318(5):F1067-F1073]

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Oral high dose vitamin B12 decreases renal superoxide and post-ischemia/reperfusion injury in mice.

Feng Li, Edward M Bahnson, Jennifer Wilder, Robin Siletzky, John Hagaman, Volker Nickekeit, Sylvia Hiller, Azraa Ayesha, Lanfei Feng, Jerrold S Levine, Nobuyuki Takahashi, Nobuyo Maeda-Smithies,

Renal ischemia/reperfusion injury (IRI) is a leading cause of acute kidney injury (AKI), a potentially fatal syndrome characterized by a rapid decline in kidney function. Excess production of superoxide contributes to the injury. We hypothesized that oral administration of a high dose of vitamin B12 (B12 - cyanocobalamin), which possesses ... Read more >>

Redox Biol (Redox biology)
[2020, 32:101504]

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Effects of the oral adsorbent AST-120 on fecal p-cresol and indole levels and on the gut microbiota composition.

Emiko Sato, Koji Hosomi, Akiyo Sekimoto, Eikan Mishima, Yuji Oe, Daisuke Saigusa, Sadayoshi Ito, Takaaki Abe, Hiroshi Sato, Jun Kunisawa, Toshimitsu Niwa, Nobuyuki Takahashi,

In chronic kidney disease, elevated levels of circulating uremic toxins are associated with a variety of symptoms and organ dysfunction. Indoxyl sulfate (IS) and p-cresyl sulfate (pCS) are microbiota-derived metabolites and representative uremic toxins. We have previously shown that the oral adsorbent AST-120 profoundly reduced pCS compared to IS in ... Read more >>

Biochem. Biophys. Res. Commun. (Biochemical and biophysical research communications)
[2020, 525(3):773-779]

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Comparative Study of Dorsal and Volar Plating for Ulnar Shortening Osteotomy.

Yasuhiro Ozasa, Kousuke Iba, Nobuyuki Takahashi, Takuro Wada, Toshihiko Yamashita,

Background: Postoperative results of ulnar shortening osteotomy for ulnar abutment syndrome were compared between groups of patients in whom the plate was placed on the volar side and those in whom the plate was placed on the dorsal side. Methods: A total of 35 wrists of 14 males and 21 ... Read more >>

J Hand Surg Asian Pac Vol (The journal of hand surgery Asian-Pacific volume)
[2020, 25(1):54-58]

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Recovery and stable persistence of chloroquine sensitivity in Plasmodium falciparum parasites after its discontinued use in Northern Uganda.

Betty Balikagala, Miki Sakurai-Yatsushiro, Shin-Ichiro Tachibana, Mie Ikeda, Masato Yamauchi, Osbert T Katuro, Edward H Ntege, Makoto Sekihara, Naoyuki Fukuda, Nobuyuki Takahashi, Shouki Yatsushiro, Toshiyuki Mori, Makoto Hirai, Walter Opio, Paul S Obwoya, Denis A Anywar, Mary A Auma, Nirianne M Q Palacpac, Takafumi Tsuboi, Emmanuel I Odongo-Aginya, Eisaku Kimura, Martin Ogwang, Toshihiro Horii, Toshihiro Mita,

BACKGROUND:Usage of chloroquine was discontinued from the treatment of Plasmodium falciparum infection in almost all endemic regions because of global spread of resistant parasites. Since the first report in Malawi, numerous epidemiological studies have demonstrated that the discontinuance led to re-emergence of chloroquine-susceptible P. falciparum, suggesting a possible role in ... Read more >>

Malar. J. (Malaria journal)
[2020, 19(1):76]

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Targeting DNA Repair to Drive Immune Responses: It's Time to Reconsider the Strategy for Clinical Translation.

Nobuyuki Takahashi, Ira Surolia, Anish Thomas,

PARP inhibition induces robust local and systemic antitumor immune responses and curative responses when combined with immune checkpoint blockade in many preclinical studies. However, the combination has not markedly improved antitumor effect compared with individual agents in clinical trials to date. We propose that the data from these trials indicate ... Read more >>

Clin. Cancer Res. (Clinical cancer research : an official journal of the American Association for Cancer Research)
[2020, :]

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Recovery and stable persistence of chloroquine sensitivity in Plasmodium falciparum parasites after its discontinued use in Northern Uganda.

Betty Balikagala, Miki Sakurai Yatsushiro, Shin-Ichiro Tachibana, Mie Ikeda, Masato Yamauchi, Osbert Katuro, Edward Hosea Ntege, Makoto Sekihara, Naoyuki Fukuda, Nobuyuki Takahashi, Shouki Yatsushiro, Toshiyuki Mori, Makoto Hirai, Walter Opio, Paul Obwoya, Denis Arony Anywar, Mary Alai Auma, Nirianne Marie Querijero Palacpac, Takafumi Tsuboi, Emmanuel Igwaro Odongo-Aginya, Eisaku Kimura, Martin David Ogwang, Toshihiro Horii, Toshihiro Mita,

Abstract Background Usage of chloroquine was discontinued from the treatment of Plasmodium falciparum infection in almost all endemic regions because of global spread of resistant parasites. Since the first report in Malawi, numerous epidemiological studies have demonstrated that the discontinuance led to re-emergence of chloroquine-susceptible P. falciparum parasites, suggesting a ... Read more >>

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Exploratory clinical characterization of experimentally-induced ulcerative colitis nonhuman primates.

Nobuyuki Takahashi, Chinatsu Kitazawa, Yoshitaka Itani, Yuji Awaga, Aldric Hama, Ikuo Hayashi, Hiroyuki Takamatsu,

A limitation of currently used preclinical models of colitis is that disease and treatment assessment methods differ from clinically used methods. Thus, a modified Mayo score and an endoscopic index (EI) were developed for use in cynomolgus macaques with 0.25% dextran sulfate sodium (DSS)-induced ulcerative colitis. Macaques were treated with ... Read more >>

Heliyon (Heliyon)
[2020, 6(1):e03178]

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Uremic toxins alter coagulation and fibrinolysis-related genes expression in human endothelial cells.

Yuji Oe, Emiko Sato, Hiroshi Sato, Mariko Miyazaki, Sadayoshi Ito, Nobuyuki Takahashi,

Thromb. Res. (Thrombosis research)
[2020, 186:75-77]

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Food-Derived Compounds Apigenin and Luteolin Modulate mRNA Splicing of Introns with Weak Splice Sites.

Masashi Kurata, Naoko Fujiwara, Ken-Ichi Fujita, Yasutaka Yamanaka, Shigeto Seno, Hisato Kobayashi, Yusaku Miyamae, Nobuyuki Takahashi, Yasuyuki Shibuya, Seiji Masuda,

Cancer cells often exhibit extreme sensitivity to splicing inhibitors. We identified food-derived flavonoids, apigenin and luteolin, as compounds that modulate mRNA splicing at the genome-wide level, followed by proliferation inhibition. They bind to mRNA splicing-related proteins to induce a widespread change of splicing patterns in treated cells. Their inhibitory activity ... Read more >>

iScience (iScience)
[2019, 22:336-352]

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Tadalafil alleviates preeclampsia and fetal growth restriction in RUPP model of preeclampsia in mice.

Akiyo Sekimoto, Kayo Tanaka, Yamato Hashizume, Emiko Sato, Hiroshi Sato, Tomoaki Ikeda, Nobuyuki Takahashi,

BACKGROUND:- Tadalafil, a long-acting phosphodiesterase 5 (PDE5) inhibitor, alleviates preeclampsia (PE), and decreases the fetal and infant deaths associated with fetal growth restriction (FGR) in phase II clinical trial. Recently, we demonstrated that tadalafil alleviates FGR and hypertension in the dams with PE induced by l-NAME. OBJECTIVE:-The aim of present ... Read more >>

Biochem. Biophys. Res. Commun. (Biochemical and biophysical research communications)
[2020, 521(3):769-774]

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Relationship between Streptococcus mutans expressing Cnm in the oral cavity and non-alcoholic steatohepatitis: a pilot study.

Shuichi Tonomura, Shuhei Naka, Keiko Tabata, Tasuku Hara, Kojiro Mori, Saiyu Tanaka, Yoshio Sumida, Kazuyuki Kanemasa, Ryota Nomura, Michiyo Matsumoto-Nakano, Masafumi Ihara, Nobuyuki Takahashi, Kazuhiko Nakano,

Background:Non-alcoholic steatohepatitis (NASH) is a severe state of non-alcoholic fatty liver disease (NAFLD), which is pathologically characterised by steatosis, hepatocyte ballooning, and lobular inflammation. Host-microbial interaction has gained attention as one of the risk factors for NASH. Recently, cnm-gene positive Streptococcus mutans expressing cell surface collagen-binding protein, Cnm (cnm-positive S. ... Read more >>

BMJ Open Gastroenterol (BMJ open gastroenterology)
[2019, 6(1):e000329]

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Glomerular Injury Is Exacerbated in Lupus-Prone MRL/lpr Mice Treated with a Protease-Activated Receptor 2 Antagonist.

Rina Itto, Yuji Oe, Kenta Imaruoka, Emiko Sato, Akiyo Sekimoto, Shu Yamakage, Satoshi Kumakura, Hiroshi Sato, Sadayoshi Ito, Nobuyuki Takahashi,

Systemic lupus erythematosus (SLE) is characterized by the production of autoantibodies, which causes multi-organ injury such as lupus nephritis. SLE is associated with hypercoagulability. Activated coagulation factors such as tissue factor and VIIa complex and factor Xa activate protease-activated receptor 2 (PAR2). PAR2 promotes cytokine production through mitogen-activated protein kinase ... Read more >>

Tohoku J. Exp. Med. (The Tohoku journal of experimental medicine)
[2019, 249(2):127-133]

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β-Cryptoxanthin Induces UCP-1 Expression via a RAR Pathway in Adipose Tissue.

Hideyuki Hara, Haruya Takahashi, Shinsuke Mohri, Hiroki Murakami, Satoko Kawarasaki, Mari Iwase, Nobuyuki Takahashi, Minoru Sugiura, Tsuyoshi Goto, Teruo Kawada,

While β-cryptoxanthin is hypothesized to have a preventive effect on lifestyle-related diseases, its underlying mechanisms are unknown. We investigated the effect of β-cryptoxanthin on energy metabolism in adipose tissues and its underlying mechanism. C57BL/6J mice were fed a high-fat diet (60% kcal fat) containing 0 or 0.05% β-cryptoxanthin for 12 ... Read more >>

J. Agric. Food Chem. (Journal of agricultural and food chemistry)
[2019, 67(38):10595-10603]

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Relationship between the induced-fit loop and the activity of Klebsiella pneumoniae pullulanase.

Naoki Saka, Dominggus Malle, Hiroyuki Iwamoto, Nobuyuki Takahashi, Kimihiko Mizutani, Bunzo Mikami,

Klebsiella pneumoniae pullulanase (KPP) belongs to glycoside hydrolase family 13 subfamily 13 (GH13_13) and is the only enzyme that is reported to perform an induced-fit motion of the active-site loop (residues 706-710). Comparison of pullulanase structures indicated that only KPP has Leu680 present behind the loop, in contrast to the ... Read more >>

Acta Crystallogr D Struct Biol (Acta crystallographica. Section D, Structural biology)
[2019, 75(Pt 9):792-803]

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Dural Sinus Thrombosis with Nonsymptomatic Persistent Falcine Sinus: A Case Report.

Ayako Shioya, Ryota Mashiko, Masanari Shiigai, Yasunobu Nakai, Nobuyuki Takahashi, Hiroyuki Kobayashi, Toshiyuki Irie, Akira Tamaoka,

A 24-year-old woman was admitted to our hospital after convulsive status epilepticus. A cerebral magnetic resonance venography revealed a persistent fetal falcine sinus. Additionally, the posterior third of the superior sagittal sinus was hypoplastic and the abnormal deep venous drainage was accompanied. These abnormalities had already been detected by magnetic ... Read more >>

J Stroke Cerebrovasc Dis (Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association)
[2019, 28(11):104309]

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Reversible cerebral vasoconstriction syndrome associated with a traditional Japanese training method under a waterfall named Takigyo: a case report.

Kiyoshi Takemoto, Nobuyuki Takahashi,

Case:Takigyo is a traditional Japanese training method for psychosomatic conditions in which individuals meditate under a waterfall. A 55-year-old man presented with a mild headache and visual loss that occurred following Takigyo. On the day of admission, acute ischemic stroke was suspected based on brain magnetic resonance imaging examination. However, ... Read more >>

Acute Med Surg (Acute medicine & surgery)
[2019, 6(4):408-412]

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A new mouse model for noninvasive fluorescence-based monitoring of mitochondrial UCP1 expression.

Satoko Kawarasaki, Hidetoshi Kuwata, Honami Sawazaki, Tomoya Sakamoto, Takahiro Nitta, Chuu-Sook Kim, Huei-Fen Jheng, Haruya Takahashi, Wataru Nomura, Takeshi Ara, Nobuyuki Takahashi, Koichi Tomita, Rina Yu, Teruo Kawada, Tsuyoshi Goto,

Mitochondrial uncoupling protein 1 (UCP1) is well known for its thermogenic function in brown adipose tissue (BAT). Since UCP1 expends energy on thermogenesis, UCP1 activation has been considered an approach to ameliorate obesity. As a tool for uncovering yet unknown mechanisms of UCP1 activation, we generated a transgenic mouse model ... Read more >>

FEBS Lett. (FEBS letters)
[2019, 593(11):1201-1212]

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Gut microbiome-derived phenyl sulfate contributes to albuminuria in diabetic kidney disease.

Koichi Kikuchi, Daisuke Saigusa, Yoshitomi Kanemitsu, Yotaro Matsumoto, Paxton Thanai, Naoto Suzuki, Koki Mise, Hiroaki Yamaguchi, Tomohiro Nakamura, Kei Asaji, Chikahisa Mukawa, Hiroki Tsukamoto, Toshihiro Sato, Yoshitsugu Oikawa, Tomoyuki Iwasaki, Yuji Oe, Tomoya Tsukimi, Noriko N Fukuda, Hsin-Jung Ho, Fumika Nanto-Hara, Jiro Ogura, Ritsumi Saito, Shizuko Nagao, Yusuke Ohsaki, Satoshi Shimada, Takehiro Suzuki, Takafumi Toyohara, Eikan Mishima, Hisato Shima, Yasutoshi Akiyama, Yukako Akiyama, Mariko Ichijo, Tetsuro Matsuhashi, Akihiro Matsuo, Yoshiaki Ogata, Ching-Chin Yang, Chitose Suzuki, Matthew C Breeggemann, Jurgen Heymann, Miho Shimizu, Susumu Ogawa, Nobuyuki Takahashi, Takashi Suzuki, Yuji Owada, Shigeo Kure, Nariyasu Mano, Tomoyoshi Soga, Takashi Wada, Jeffrey B Kopp, Shinji Fukuda, Atsushi Hozawa, Masayuki Yamamoto, Sadayoshi Ito, Jun Wada, Yoshihisa Tomioka, Takaaki Abe,

Diabetic kidney disease is a major cause of renal failure that urgently necessitates a breakthrough in disease management. Here we show using untargeted metabolomics that levels of phenyl sulfate, a gut microbiota-derived metabolite, increase with the progression of diabetes in rats overexpressing human uremic toxin transporter SLCO4C1 in the kidney, ... Read more >>

Nat Commun (Nature communications)
[2019, 10(1):1835]

Cited: 2 times

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Preventing brain embolism by using a modified isolation technique in transcatheter aortic valve implantation for a patient with shaggy and porcelain aorta.

Yoshikatsu Nomura, Motoharu Kawashima, Kanetsugu Nagao, Shota Hasegawa, Takanori Tsujimoto, So Izumi, Masamichi Matsumori, Tasuku Honda, Kenzo Uzu, Nobuyuki Takahashi, Takahiro Sawada, Tetsuari Onishi, Yoshinori Yasaka, Hirohisa Murakami, Nobuhiko Mukohara,

Transcatheter aortic valve implantation (TAVI) has become a useful and effective treatment for surgical high-risk patients with severe aortic valve stenosis (AS). Stroke is one of the most frequent complications associated with TAVI. Shaggy and porcelain aortas are a risk factor for procedure-related strokes. Preventing brain embolism is one of ... Read more >>

J Cardiol Cases (Journal of cardiology cases)
[2019, 20(2):65-68]

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WT1 as an immunotherapy target for thymic epithelial tumors: a novel method to activate anti-tumor immunity.

Nobuyuki Takahashi, Chen Zhao, Arun Rajan,

Mediastinum (Mediastinum (Hong Kong, China))
[2019, 3:]

Cited: 1 time

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Intermittent Hypoxia Up-Regulates Gene Expressions of Peptide YY (PYY), Glucagon-like Peptide-1 (GLP-1), and Neurotensin (NTS) in Enteroendocrine Cells.

Ryogo Shobatake, Asako Itaya-Hironaka, Akiyo Yamauchi, Mai Makino, Sumiyo Sakuramoto-Tsuchida, Tomoko Uchiyama, Hiroyo Ota, Nobuyuki Takahashi, Satoshi Ueno, Kazuma Sugie, Shin Takasawa,

The patients with sleep apnea syndrome are exposed to intermittent hypoxia (IH) during sleep. We previously demonstrated the IH-induced up-regulation of the mRNA levels of anorexigenic peptides proopiomelanocortin (POMC), and cocaine- and amphetamine-regulated transcript (CART) in human neuronal cells. Appetite is regulated not only by the central nervous system but ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2019, 20(8):]

Cited: 4 times

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High-resolution crystal structures of the glycoside hydrolase family 45 endoglucanase EG27II from the snail Ampullaria crossean.

Taisuke Nomura, Hisamu Iwase, Naoki Saka, Nobuyuki Takahashi, Bunzo Mikami, Kimihiko Mizutani,

Although endogenous animal cellulases have great potential for industrial applications such as bioethanol production, few investigations have focused on these enzymes. In this study, the glycoside hydrolase family 45 (GH45) subfamily B endoglucanase EG27II from the snail Ampullaria crossean was expressed using a Pichia pastoris expression system and the crystal ... Read more >>

Acta Crystallogr D Struct Biol (Acta crystallographica. Section D, Structural biology)
[2019, 75(Pt 4):426-436]

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Protease-activated receptor 2 protects against VEGF inhibitor-induced glomerular endothelial and podocyte injury.

Yuji Oe, Tomofumi Fushima, Emiko Sato, Akiyo Sekimoto, Kiyomi Kisu, Hiroshi Sato, Junichi Sugawara, Sadayoshi Ito, Nobuyuki Takahashi,

Vascular endothelial growth factor (VEGF) inhibitors cause glomerular injury. We have recently shown that activation of protease-activated receptor 2 (PAR2) by factor Xa exacerbated diabetic kidney disease. However, the role of PAR2 in glomerular injury induced by VEGF blockade is not known. Herein, we investigated the effect of the lack ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):2986]

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