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Author Nobuo Yaegashi

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The trend and outcome of postsurgical therapy for high-risk early-stage cervical cancer with lymph node metastasis in Japan: a report from the Japan Society of Gynecologic Oncology (JSGO) guidelines evaluation committee.

Masae Ikeda, Masako Shida, Shogo Shigeta, Satoru Nagase, Fumiaki Takahashi, Wataru Yamagami, Hidetaka Katabuchi, Nobuo Yaegashi, Daisuke Aoki, Mikio Mikami,

<h4>Objective</h4>The Japan Society of Gynecologic Oncology published the first guidelines for the treatment of cervical cancer in 2007. The aim of this research was to evaluate the influence of the introduction of the first guideline on clinical trends and outcomes of patients with early-stage cervical cancer who underwent surgery.<h4>Methods</h4>This analysis ... Read more >>

J Gynecol Oncol (Journal of gynecologic oncology)
[2021, 32(3):e44]

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Influence of physical activity before and during pregnancy on infant's sleep and neurodevelopment at 1-year-old.

Kazushige Nakahara, Takehiro Michikawa, Seiichi Morokuma, Masanobu Ogawa, Kiyoko Kato, Masafumi Sanefuji, Eiji Shibata, Mayumi Tsuji, Masayuki Shimono, Toshihiro Kawamoto, Shouichi Ohga, Koichi Kusuhara, ,

The aim of this study was to investigate the association between maternal physical activity (PA) before and during pregnancy and sleep and developmental problems in 1-year-old infants. We used data from a nationwide cohort study in Japan that registered 103,062 pregnancies between 2011 and 2014. Participants were asked about their ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):8099]

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Maternal sleep duration and neonatal birth weight: the Japan Environment and Children's Study.

Tsuyoshi Murata, Hyo Kyozuka, Toma Fukuda, Shun Yasuda, Akiko Yamaguchi, Seiichi Morokuma, Akiko Sato, Yuka Ogata, Kosei Shinoki, Mitsuaki Hosoya, Seiji Yasumura, Koichi Hashimoto, Hidekazu Nishigori, Keiya Fujimori, ,

<h4>Background</h4>The adequate maternal sleep duration required for favorable obstetric outcomes is unknown. We evaluated the association between maternal sleep duration and low birth weight infants, small for gestational age infants, and macrosomia.<h4>Methods</h4>Participants enrolled in the Japan Environment and Children's Study, a nationwide birth cohort study, with singleton pregnancies after 22 weeks, ... Read more >>

BMC Pregnancy Childbirth (BMC pregnancy and childbirth)
[2021, 21(1):295]

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Abnormal early folliculogenesis due to impeded pyruvate metabolism in mouse oocytes.

Keiko Tanaka, Yohei Hayashi, Asuka Takehara, Yumi Ito-Matsuoka, Masahito Tachibana, Nobuo Yaegashi, Yasuhisa Matsui,

Fetal ovarian germ cells show characteristic energy metabolism status, such as enhanced mitochondrial metabolism as well as glycolysis, but their roles in early folliculogenesis are unclear. We show here that inhibition of pyruvate uptake to mitochondria by UK5099 in organ cultures of fetal mouse ovaries resulted in repressed early folliculogenesis ... Read more >>

Biol Reprod (Biology of reproduction)
[2021, :]

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Effect of RBD mutations in spike glycoprotein of SARS-CoV-2 on neutralizing IgG affinity

Takuma Hayashi, Nobuo Yaegashi, Ikuo Konishi,

<h4>Background: </h4> Certain mutant strains of SARS-CoV-2 are known to spread widely among humans, including the receptor binding domain (RBD) mutant, Y453F, from farmed minks, and the RBD mutant, N501Y, a mutation common to three major SARS-CoV-2 subspecies (B.1.1.7, B.1.351, and B.1.1.248). <h4>Methods:</h4> We investigated the characteristics of the RBD ... Read more >>

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Involvement of small extracellular vesicle-derived TIE-1 in the chemoresistance of ovarian cancer cells.

Tomoka Misawa, Masafumi Toyoshima, Kazuyuki Kitatani, Masumi Ishibashi, Junko Hasegawa-Minato, Shogo Shigeta, Nobuo Yaegashi,

<h4>Background</h4>Ovarian cancer is the most lethal gynecologic malignancy due to the tumor's acquisition of chemoresistance to platinum-based chemotherapy. To solve this problem, we conducted RNAi-based large-scale screening and determined that tyrosine kinase with immunoglobulin-like and EGF-like domains 1 (TIE-1) is a key molecule involved in the platinum resistance of ovarian ... Read more >>

Cancer Treat Res Commun (Cancer treatment and research communications)
[2021, 27:100364]

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Prospective evaluation of sentinel node navigation surgery in Japanese patients with low-risk endometrial cancer-safety and occurrence of lymphedema.

Hitoshi Niikura, Asami Toki, Tomoyuki Nagai, Satoshi Okamoto, Shogo Shigeta, Hideki Tokunaga, Muneaki Shimada, Mika Watanabe, Nobuo Yaegashi,

<h4>Objective</h4>The present study aimed to clarify the occurrence rate of lymphedema and prognosis in patients with endometrial cancer according to sentinel lymph node biopsy alone with intraoperative histopathological examination.<h4>Methods</h4>The study included 45 consecutive patients with endometrial cancer treated at Tohoku University Hospital between October 2014 and August 2017. All patients ... Read more >>

Jpn J Clin Oncol (Japanese journal of clinical oncology)
[2021, 51(4):584-589]

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Factors influencing exclusive breastfeeding rates until 6 months postpartum: the Japan Environment and Children's Study.

Hitomi Inano, Mariko Kameya, Kyoko Sasano, Kenta Matsumura, Akiko Tsuchida, Kei Hamazaki, Hidekuni Inadera, Tomomi Hasegawa, ,

This research aimed to examine the efficacy of the early initiation of breastfeeding within 1 h of birth, early skin-to-skin contact, and rooming-in for the continuation of exclusive breastfeeding until 6 months postpartum. The research used data from the Japan Environment and Children's Study (JECS), a nationwide government-funded birth cohort study. A ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):6841]

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Prospective Association between Maternal Bonding Disorders and Child Toothbrushing Frequency: a cross-sectional study of the Japan Environment and Children's Study.

Shinobu Tsuchiya, Masahiro Tsuchiya, Haruki Momma, Ryoichi Nagatomi, Takahiro Arima, Nobuo Yaegashi, Kaoru Igarashi, ,

<h4>Background</h4>Daily toothbrushing effectively prevents early childhood caries, but it depends on facilitative parenting behaviours. Mother-to-infant bonding, the maternal affection toward the infant, is an environmental factor that strongly influences parenting.<h4>Aim</h4>This study examined the association between maternal bonding and children's daily toothbrushing frequency.<h4>Design</h4>The sample consisted of 83,954 mother-infant pairs at two ... Read more >>

Int J Paediatr Dent (International journal of paediatric dentistry)
[2021, :]

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Survey of the clinical practice pattern of using sentinel lymph node biopsy in patients with gynecological cancers in Japan: the Japan Society of Gynecologic Oncology study.

Shinichi Togami, Hiroaki Kobayashi, Hitoshi Niikura, Muneaki Shimada, Nobuyuki Susumu, Tomohito Tanaka, Yoshito Terai, Tomoyuki Nagai, Tsukasa Baba, Hideaki Yahata, Wataru Yamagami, Ken Yamaguchi, Tsuyoshi Yamashita, Nobuo Yaegashi, Hidetaka Katabuchi, Daisuke Aoki,

<h4>Background</h4>Sentinel lymph node (SN) biopsy is essential for evaluating survival and minimal treatment-related morbidity associated with cervical, endometrial, and vulvar cancer in Japan. As such, our aim in this study was to evaluate the current practice pattern of using SN biopsy for cervical, endometrial, and vulvar cancer in Japan.<h4>Methods</h4>We deployed ... Read more >>

Int J Clin Oncol (International journal of clinical oncology)
[2021, :]

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Annual report of the Committee on Gynecologic Oncology, the Japan Society of Obstetrics and Gynecology: Annual patient report for 2017 and annual treatment report for 2012.

Satoru Nagase, Tsuyoshi Ohta, Fumiaki Takahashi, Nobuo Yaegashi, ,

<h4>Aim</h4>To provide information including the trend of gynecological malignancies in Japan, we hereby present the Annual Patient Report for 2017 and the Annual Treatment Report for 2012, on the outcomes of patients who started treatment in 2012.<h4>Methods</h4>The Japan Society of Obstetrics and Gynecology maintains an annual tumor registry, where information ... Read more >>

J Obstet Gynaecol Res (The journal of obstetrics and gynaecology research)
[2021, :]

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The prevalence of psychological distress during pregnancy in Miyagi Prefecture for 3 years after the Great Eas t Japan Earthquake.

Kaou Tanoue, Zen Watanabe, Hidekazu Nishigori, Noriyuki Iwama, Michihiro Satoh, Takahisa Murakami, Kousuke Tanaka, Satomi Sasaki, Kasumi Sakurai, Mami Ishikuro, Taku Obara, Masatoshi Saito, Junichi Sugawara, Nozomi Tatsuta, Shinichi Kuriyama, Takahiro Arima, Kunihiko Nakai, Nobuo Yaegashi, Hirohito Metoki, ,

<h4>Background</h4>To examine changes in psychological distress prevalence among pregnant women in Miyagi Prefecture, which was directly affected by the Great East Japan Earthquake and tsunami, and compare it with the other, less damaged areas of Japan.<h4>Methods</h4>This study was conducted in conjunction with the Japan Environment and Children`s Study. We examined ... Read more >>

Environ Health Prev Med (Environmental health and preventive medicine)
[2021, 26(1):27]

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Maternal pre-pregnancy body mass index and foetal acidosis in vaginal and caesarean deliveries: The Japan Environment and Children's Study.

Tsuyoshi Murata, Hyo Kyozuka, Akiko Yamaguchi, Toma Fukuda, Shun Yasuda, Akiko Sato, Yuka Ogata, Kosei Shinoki, Mitsuaki Hosoya, Seiji Yasumura, Koichi Hashimoto, Hidekazu Nishigori, Keiya Fujimori, ,

A high maternal body mass index (BMI) is associated with increased risks of asphyxia-related neonatal morbidity. We evaluated the association between maternal pre-pregnancy BMI and foetal acidosis while accounting for the mode of delivery. Participants from the Japan Environment and Children's Study with singleton pregnancies after 22 weeks of gestation who ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):4350]

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The validity of the subsequent pregnancy index score for fertility-sparing trachelectomy in early-stage cervical cancer.

Takashi Iwata, Hiroko Machida, Koji Matsuo, Kaoru Okugawa, Tsuyoshi Saito, Kyoko Tanaka, Kenichiro Morishige, Hiroaki Kobayashi, Kiyoshi Yoshino, Hideki Tokunaga, Tomoaki Ikeda, Makio Shozu, Nobuo Yaegashi, Takayuki Enomoto, Mikio Mikami,

<h4>Objective</h4>To evaluate timing and a prediction model for pregnancy in early-stage cervical cancer patients who underwent fertility-sparing trachelectomy.<h4>Design</h4>Retrospective cohort.<h4>Setting</h4>Academic multicenter.<h4>Patient(s)</h4>Women ages <45 years with clinical stage I-II cervical cancer were enrolled between 2009 and 2013 (n = 393).<h4>Intervention(s)</h4>Planned fertility-sparing trachelectomy.<h4>Main outcome measure(s)</h4>Cumulative incidences and clinicopathological characteristics of those who developed ... Read more >>

Fertil Steril (Fertility and sterility)
[2021, :]

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Effect of RBD mutations in spike glycoprotein of SARS-CoV-2 on neutralizing IgG affinity

Takuma Hayashi, Nobuo Yaegashi, Ikuo Konishi,

<h4>Background</h4> Certain mutant strains of SARS-CoV-2 are known to spread widely among humans, including the receptor binding domain (RBD) mutant, Y453F, from farmed minks, and the RBD mutant, N501Y, a mutation common to three major SARS-CoV-2 subspecies (B.1.1.7, B.1.351, and B.1.1.248). <h4>Methods</h4> We investigated the characteristics of the RBD mutants, ... Read more >>

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Ceramide synthase 2-C24:1 -ceramide axis limits the metastatic potential of ovarian cancer cells.

Xuewei Zhang, Wataru Sakamoto, Daniel Canals, Masumi Ishibashi, Masaya Matsuda, Kentaro Nishida, Masafumi Toyoshima, Shogo Shigeta, Makoto Taniguchi, Can E Senkal, Toshiro Okazaki, Nobuo Yaegashi, Yusuf A Hannun, Takeshi Nabe, Kazuyuki Kitatani,

Regulation of sphingolipid metabolism plays a role in cellular homeostasis, and dysregulation of these pathways is involved in cancer progression. Previously, our reports identified ceramide as an anti-metastatic lipid. In the present study, we investigated the biochemical alterations in ceramide-centered metabolism of sphingolipids that were associated with metastatic potential. We ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(2):e21287]

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Estimation of the carrier frequencies and proportions of potential patients by detecting causative gene variants associated with autosomal recessive bone dysplasia using a whole-genome reference panel of Japanese individuals.

Shinichi Nagaoka, Yumi Yamaguchi-Kabata, Naomi Shiga, Masahito Tachibana, Jun Yasuda, Shu Tadaka, Gen Tamiya, Nobuo Fuse, Kengo Kinoshita, Shigeo Kure, Jun Murotsuki, Masayuki Yamamoto, Nobuo Yaegashi, Junichi Sugawara,

Bone dysplasias are a group of rare hereditary diseases, with up to 436 disease types. Perinatal diagnosis is clinically important for adequate personalized management and counseling. There are no reports focused on pathogenic variants of bone dysplasias in the general population. In this study, we focused on autosomal recessive bone ... Read more >>

Hum Genome Var (Human genome variation)
[2021, 8(1):2]

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Novel candidates of pathogenic variants of the BRCA1 and BRCA2 genes from a dataset of 3,552 Japanese whole genomes (3.5KJPNv2).

Hideki Tokunaga, Keita Iida, Atsushi Hozawa, Soichi Ogishima, Yoh Watanabe, Shogo Shigeta, Muneaki Shimada, Yumi Yamaguchi-Kabata, Shu Tadaka, Fumiki Katsuoka, Shin Ito, Kazuki Kumada, Yohei Hamanaka, Nobuo Fuse, Kengo Kinoshita, Masayuki Yamamoto, Nobuo Yaegashi, Jun Yasuda,

Identification of the population frequencies of definitely pathogenic germline variants in two major hereditary breast and ovarian cancer syndrome (HBOC) genes, BRCA1/2, is essential to estimate the number of HBOC patients. In addition, the identification of moderately penetrant HBOC gene variants that contribute to increasing the risk of breast and ... Read more >>

PLoS One (PloS one)
[2021, 16(1):e0236907]

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Lymphadenectomy issues in endometrial cancer.

Yosuke Konno, Hiroshi Asano, Ayumi Shikama, Daisuke Aoki, Michihiro Tanikawa, Akinori Oki, Koji Horie, Akira Mitsuhashi, Akira Kikuchi, Hideki Tokunaga, Yasuhisa Terao, Toyomi Satoh, Kimio Ushijima, Mitsuya Ishikawa, Nobuo Yaegashi, Hidemichi Watari,

<h4>Objectives</h4>This review aims to introduce preoperative scoring systems to predict lymph node metastasis (LNM) and ongoing clinical trials to investigate the therapeutic role of lymphadenectomy for endometrial cancer.<h4>Methods</h4>We summarized previous reports on the preoperative prediction models for LNM and evaluated their validity to omit lymphadenectomy in our recent cohorts. Next, ... Read more >>

J Gynecol Oncol (Journal of gynecologic oncology)
[2021, 32(2):e25]

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Associations of umbilical cord fatty acid profiles and desaturase enzyme indices with birth weight for gestational age in Japanese infants.

Azusa Matsumoto, Terue Kawabata, Yasuo Kagawa, Kumiko Shoji, Fumiko Kimura, Teruo Miyazawa, Nozomi Tatsuta, Takahiro Arima, Nobuo Yaegashi, Kunihiko Nakai,

Long-chain polyunsaturated fatty acids (LCPUFAs) required for infant development are produced by Δ6 desaturase (D6D) and Δ5 desaturase (D5D). The D6D index and D5D index are calculated based on their respective precursor/product ratios. The D5D and D6D indices are related to obesity and lifestyle-related diseases. The aim of the present ... Read more >>

Prostaglandins Leukot Essent Fatty Acids (Prostaglandins, leukotrienes, and essential fatty acids)
[2021, 165:102233]

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The delivery of a placenta/fetus with high gonadal steroid production contributes to postpartum depressive symptoms.

Saya Kikuchi, Natsuko Kobayashi, Zen Watanabe, Chiaki Ono, Takashi Takeda, Hidekazu Nishigori, Nobuo Yaegashi, Takahiro Arima, Kunihiko Nakai, Hiroaki Tomita,

<h4>Background</h4>A correlation between gonadal steroids and depressive symptoms during the perinatal period has long been suggested; however, the underlying mechanism for this relationship remains unclear.<h4>Methods</h4>This study was designed to examine the correlation between gonadal steroid concentrations of umbilical cord blood and postpartum depressive symptoms as well as longitudinal alterations in ... Read more >>

Depress Anxiety (Depression and anxiety)
[2021, 38(4):422-430]

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Effect of RBD mutation (Y453F) in spike glycoprotein of SARS-CoV-2 on neutralizing antibody affinity

Takuma Hayashi, Nobuo Yaegashi, Ikuo Konishi,

Natural selection “adaptation” in the coronavirus can occur during coronavirus amplification in vivo in farmed minks. Natural selection in such viruses is observed by introduction of mutations in SARS- CoV-2 that are not observed during the growth process in humans. Infection with a mutant (Y453F) of SARS-CoV-2 from farmed minks ... Read more >>

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Propensity score-matched analysis of systemic chemotherapy versus salvage hysterectomy for persistent cervical cancer after definitive radiotherapy/concurrent chemoradiotherapy.

Munetaka Takekuma, Fumiaki Takahashi, Seiji Mabuchi, Wataru Kudaka, Koji Horie, Mariko Ikeda, Ayumi Shikama, Akira Mitsuhashi, Shoji Nagao, Shiro Suzuki, Mika Mizuno, Shin Nishio, Hideki Tokunaga, Yukinobu Ota, Takahiro Kasamatsu, Ryo Kitagawa, Takafumi Toita, Hiroaki Kobayashi, Mitsuya Ishikawa, Nobuo Yaegashi,

<h4>Background: </h4> The aim of the current study was to evaluate oncologic outcomes of patients who were treated with salvage hysterectomy (HT), compared to systemic chemotherapy (CT) for persistent cervical cancer after definitive radiotherapy (RT)/ concurrent chemoradiotherapy (CCRT). <h4>Methods: </h4> Patients with persistent cervical cancer treated with definitive RT/CCRT at ... Read more >>

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Propensity score-matched analysis of systemic chemotherapy versus salvage hysterectomy for persistent cervical cancer after definitive radiotherapy/concurrent chemoradiotherapy.

Munetaka Takekuma, Fumiaki Takahashi, Seiji Mabuchi, Wataru Kudaka, Koji Horie, Mariko Ikeda, Ayumi Shikama, Akira Mitsuhashi, Shoji Nagao, Shiro Suzuki, Mika Mizuno, Shin Nishio, Hideki Tokunaga, Yukinobu Ota, Takahiro Kasamatsu, Ryo Kitagawa, Takafumi Toita, Hiroaki Kobayashi, Mitsuya Ishikawa, Nobuo Yaegashi,

<h4>Background</h4>The aim of the current study was to evaluate oncologic outcomes of patients who were treated with salvage hysterectomy (HT), compared to systemic chemotherapy (CT) for persistent cervical cancer after definitive radiotherapy (RT)/ concurrent chemoradiotherapy (CCRT).<h4>Methods</h4>Patients with persistent cervical cancer treated with definitive RT/CCRT at 35 institutions from 2005 to ... Read more >>

BMC Cancer (BMC cancer)
[2020, 20(1):1169]

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Maternal alcohol consumption and risk of offspring with congenital malformation: the Japan Environment and Children's Study.

Hiroshi Kurita, Noriko Motoki, Yuji Inaba, Yuka Misawa, Satoshi Ohira, Makoto Kanai, Teruomi Tsukahara, Tetsuo Nomiyama, ,

<h4>Background</h4>The association between fetal exposure to alcohol and congenital structural disorders remains inconclusive. The present study searched for relationships between maternal alcohol consumption during pregnancy and the risk of congenital malformations.<h4>Methods</h4>We evaluated the fixed dataset of a large national birth cohort study including 73,595 mothers with a singleton live birth. ... Read more >>

Pediatr Res (Pediatric research)
[2020, :]

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