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Author Noam A Vanderwalde

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Sex-Based Disparities Among Cancer Clinical Trial Participants.

Ethan B Ludmir, C David Fuller, Shalini Moningi, Walker Mainwaring, Timothy A Lin, Austin B Miller, Amit Jethanandani, Andres F Espinoza, Vivek Verma, Benjamin D Smith, Grace L Smith, Noam A VanderWalde, Emma B Holliday, B Ashleigh Guadagnolo, Thomas E Stinchcombe, Reshma Jagsi, Daniel R Gomez, Bruce D Minsky, Claus Rödel, Emmanouil Fokas,

Landmark investigation two decades ago demonstrated sex-based disparities among participants in cancer cooperative group trials. Although federal efforts have aimed to improve representation of female patients in government-sponsored research, less is known about sex disparities in the broader landscape of modern oncologic randomized controlled trials. Using ClinicalTrials.gov, we identified randomized ... Read more >>

J. Natl. Cancer Inst. (Journal of the National Cancer Institute)
[2020, 112(2):211-213]

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The utilization and impact of adjuvant therapy following neoadjuvant therapy and resection of pancreatic adenocarcinoma: does more really matter?

Justin A Drake, Zachary E Stiles, Stephen W Behrman, Evan S Glazer, Jeremiah L Deneve, Bradley G Somer, Noam A Vanderwalde, Paxton V Dickson,

BACKGROUND:Although neoadjuvant therapy is increasingly administered to patients with pancreatic ductal adenocarcinoma (PDAC), the impact of additional adjuvant therapy (AT) following resection is not well defined. METHODS:The National Cancer Database (NCDB) was queried for patients who received neoadjuvant therapy followed by R0 or R1 resection for PDAC. Factors influencing survival, ... Read more >>

HPB (Oxford) (HPB : the official journal of the International Hepato Pancreato Biliary Association)
[2020, :]

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The Trials (and Tribulations) of Complementary and Alternative Medicine in Oncology.

Ethan B Ludmir, Amit Jethanandani, Walker Mainwaring, Austin B Miller, Timothy A Lin, Andres F Espinoza, Vivek Verma, Noam A VanderWalde, Aaron J Grossberg, B Ashleigh Guadagnolo, Albert C Koong, Reshma Jagsi, Charles R Thomas, C David Fuller,

Two decades following the creation of the Office of Cancer Complementary and Alternative Medicine at the National Cancer Institute, the status of complementary and alternative medicine (CAM) research within oncology remains opaque. To better understand the landscape of CAM studies in oncology, we identified CAM-related phase III randomized controlled trials ... Read more >>

J. Natl. Cancer Inst. (Journal of the National Cancer Institute)
[2019, 111(12):1358-1360]

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Decreasing incidence of upper age restriction enrollment criteria among cancer clinical trials.

Ethan B Ludmir, Ishwaria M Subbiah, Walker Mainwaring, Austin B Miller, Timothy A Lin, Amit Jethanandani, Andres F Espinoza, Jacob J Mandel, Penny Fang, Benjamin D Smith, Grace L Smith, Chelsea C Pinnix, Mina S Sedrak, Gretchen G Kimmick, Thomas E Stinchcombe, Reshma Jagsi, Charles R Thomas, C David Fuller, Noam A VanderWalde,

BACKGROUND:Age disparities among cancer clinical trial participants are pervasive and worsening over time. Identification of factors associated with age disparities is critical to improve enrollment of older patients on trials. The incidence and impact of trial eligibility criteria that exclude patients on the basis of age remains opaque. METHODS:ClinicalTrials.gov was ... Read more >>

J Geriatr Oncol (Journal of geriatric oncology)
[2020, 11(3):451-454]

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Factors Associated With Age Disparities Among Cancer Clinical Trial Participants.

Ethan B Ludmir, Walker Mainwaring, Timothy A Lin, Austin B Miller, Amit Jethanandani, Andres F Espinoza, Jacob J Mandel, Steven H Lin, Benjamin D Smith, Grace L Smith, Noam A VanderWalde, Bruce D Minsky, Albert C Koong, Thomas E Stinchcombe, Reshma Jagsi, Daniel R Gomez, Charles R Thomas, C David Fuller,

Importance:Seminal investigation 2 decades ago alerted the oncology community to age disparities in participation in cooperative group trials; less is known about whether these disparities persist in industry-funded research. Objective:To characterize the age disparities among trial enrollees on randomized clinical trials (RCTs) of common cancers in clinical oncology and identify ... Read more >>

JAMA Oncol (JAMA oncology)
[2019, :]

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Real-world treatment patterns among patients with unresected stage III non-small-cell lung cancer.

Kellie J Ryan, Karen E Skinner, Ancilla W Fernandes, Rajeshwari S Punekar, Melissa Pavilack, Mark S Walker, Noam A VanderWalde,

Aim: Little is known about recent treatment patterns among patients with unresected stage III NSCLC in the real world. This retrospective study used medical records from USA community oncology practices to address this knowledge gap. Materials & methods: Eligible patients were stage III NSCLC adults diagnosed between 1 January 2011 ... Read more >>

Future Oncol (Future Oncology)
[2019, 15(25):2943-2953]

Cited: 1 time

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Real-world outcomes in patients with unresected stage III non-small cell lung cancer.

Kellie J Ryan, Karen E Skinner, Ancilla W Fernandes, Rajeshwari S Punekar, Melissa Pavilack, Mark S Walker, Noam A VanderWalde,

This study examined real-world clinical outcomes such as progression-free survival (PFS), time to metastasis (TTM), overall survival (OS), and health-related quality of life (HRQOL) in patients with unresected stage III non-small cell lung cancer (NSCLC) treated in the community setting. A retrospective review of medical records extracted from 10 US ... Read more >>

Med. Oncol. (Medical oncology (Northwood, London, England))
[2019, 36(3):24]

Cited: 1 time

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Definitive Pelvic Radiotherapy and Survival of Patients With Newly Diagnosed Metastatic Anal Cancer.

Yuefeng Wang, Xinhua Yu, Nan Zhao, Jiajing Wang, Chi Lin, Enrique W Izaguirre, Michael Farmer, Gary Tian, Bradley Somer, Nilesh Dubal, David L Schwartz, Matthew T Ballo, Noam A VanderWalde,

Background: Chemotherapy with or without pelvic radiotherapy (RT) is included in the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for metastatic anal cancer (MAC), despite limited clinical evidence for RT in this setting. In addition, increasing evidence shows that local therapies, including RT, may increase patient survival for some ... Read more >>

J Natl Compr Canc Netw (Journal of the National Comprehensive Cancer Network : JNCCN)
[2019, 17(1):29-37]

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Clinician-observed and patient-reported toxicities and their association with poor tolerance to therapy in older patients with head and neck or lung cancer treated with curative radiotherapy.

Dominic H Moon, Bhishamjit S Chera, Allison M Deal, Yue Wang, Hyman B Muss, Noam A VanderWalde,

OBJECTIVES:The agreement between clinician- and patient-reported toxicities and their association with poor tolerance to therapy were assessed in an older population receiving curative radiotherapy (RT). MATERIALS AND METHODS:Patients ≥ 65 years old with newly-diagnosed head and neck or lung cancer receiving curative RT ± chemotherapy were enrolled on a prospective, observational study. Agreement between clinician ... Read more >>

J Geriatr Oncol (Journal of geriatric oncology)
[2019, 10(1):42-47]

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The Older Adult With Locoregionally Advanced Head and Neck Squamous Cell Carcinoma: Knowledge Gaps and Future Direction in Assessment and Treatment.

Ronald Maggiore, Zachary S Zumsteg, Karlynn BrintzenhofeSzoc, Kelly M Trevino, Ajeet Gajra, Beatriz Korc-Grodzicki, Joel B Epstein, Stewart M Bond, Ira Parker, Julie A Kish, Barbara A Murphy, Noam A VanderWalde, ,

Older adults with head and neck squamous cell carcinoma (HNSCC) pose unique treatment and supportive care challenges to oncologists and other cancer care providers. The majority of patients with HNSCC present with locoregionally advanced disease, for which combined-modality treatment integrating chemotherapy and radiation therapy is often necessary to maximize tumor ... Read more >>

Int. J. Radiat. Oncol. Biol. Phys. (International journal of radiation oncology, biology, physics)
[2017, 98(4):868-883]

Cited: 2 times

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Comparative Neurologic Outcomes of Salvage and Definitive Gamma Knife Radiosurgery for Glomus Jugulare: A 20-Year Experience.

Daniel V Wakefield, Garrett T Venable, Noam A VanderWalde, L Madison Michael, Jeffery M Sorenson, Jon H Robertson, David Cunninghan, Matthew T Ballo,

Objective  This case series investigates management of glomus jugulare (GJ) tumors utilizing definitive and salvage Gamma Knife stereotactic radiosurgery (GKSRS). Methods  A retrospective chart review was performed to collect data. Statistical analysis included patient, tumor, and treatment information. Results  From 1996 to 2013, 17 patients with GJ received GKSRS. Median ... Read more >>

J Neurol Surg B Skull Base (Journal of neurological surgery. Part B, Skull base)
[2017, 78(3):251-255]

Cited: 1 time

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Geriatric Assessment as a Predictor of Tolerance, Quality of Life, and Outcomes in Older Patients With Head and Neck Cancers and Lung Cancers Receiving Radiation Therapy.

Noam A VanderWalde, Allison M Deal, Elizabeth Comitz, Lori Stravers, Hyman Muss, Bryce B Reeve, Ethan Basch, Joel Tepper, Bhishamjit Chera,

To evaluate the association between functional status based on a geriatric assessment (GA) and outcomes of tolerance to treatment in patients with lung or head and neck cancer receiving radiation therapy (RT) or chemoradiation (CRT).A prospective cohort study was conducted in patients aged ≥65 years with head and neck cancer or lung cancer ... Read more >>

Int. J. Radiat. Oncol. Biol. Phys. (International journal of radiation oncology, biology, physics)
[2017, 98(4):850-857]

Cited: 0 times

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Accessibility, availability, and quality of online information for US radiation oncology residencies.

Daniel V Wakefield, Bogdan A Manole, Amit Jethanandani, Michael E May, Samuel R Marcrom, Michael R Farmer, Matthew T Ballo, Noam A VanderWalde,

Radiation oncology (RO) residency applicants commonly use Internet resources for information on residency programs. The purpose of this study is to assess the accessibility, availability, and quality of online information for RO graduate medical education.Accessibility of online information was determined by surveying databases for RO residency programs within the Fellowship ... Read more >>

Pract Radiat Oncol (Practical radiation oncology)
[2016, 6(3):160-165]

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Treatment of muscle invasive bladder cancer in the elderly: navigating the trade-offs of risk and benefit.

Noam A VanderWalde, Michelle T Chi, Arti Hurria, Matthew D Galsky, Matthew E Nielsen,

Despite the fact that bladder cancer patients have the highest median age of any type of cancer, older patients with muscle invasion are often under-treated.In this review, we report the most up to date literature on the patterns of care and treatment of older patients with muscle invasive bladder cancer. ... Read more >>

World J Urol (World journal of urology)
[2016, 34(1):3-11]

Cited: 6 times

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Positron emission tomography and stage migration in head and neck cancer.

Noam A VanderWalde, Ramzi G Salloum, Tsai-Ling Liu, Mark C Hornbrook, Maureen C O'Keeffe Rosetti, Debra P Ritzwoller, Paul A Fishman, Jennifer Elston Lafata, Amir H Khandani, Bhishamjit S Chera,

Since 2001, there has been a rapid adoption of positron emission tomography (PET) for diagnosis and American Joint Committee on Cancer (AJCC) staging of head and neck cancer (HNC) without data describing improved clinical outcomes.To determine the association between increased use of PET and stage and/or survival for patients with ... Read more >>

JAMA Otolaryngol Head Neck Surg (JAMA otolaryngology-- head & neck surgery)
[2014, 140(7):654-661]

Cited: 8 times

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Hypofractionation for breast cancer: lessons learned from our neighbors to the north and across the pond.

Michael J Eblan, Noam A Vanderwalde, Elaine M Zeman, Ellen Jones,

Adjuvant whole breast irradiation was established within the standard of care for breast-conserving therapy in the early 1980s, following the results of major randomized trials comparing mastectomy vs breast-conserving surgery and radiation. Since that time, techniques and treatment strategies have evolved, but one major thread that carries forward is the ... Read more >>

Oncology (Williston Park, N.Y.) (Oncology (Williston Park, N.Y.))
[2014, 28(6):536-546]

Cited: 3 times

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Effectiveness of chemoradiation for head and neck cancer in an older patient population.

Noam A VanderWalde, Anne Marie Meyer, Allison M Deal, J Bradley Layton, Huan Liu, William R Carpenter, Mark C Weissler, David N Hayes, Mary E Fleming, Bhishamjit S Chera,

PURPOSE: The purpose of this study was to compare chemoradiation therapy (CRT) with radiation therapy (RT) only in an older patient population with head and neck squamous cell carcinoma (HNSCC). METHODS AND MATERIALS: Using the Surveillance, Epidemiology, and End Results (SEER)-Medicare linked database (1992-2007), we identified a retrospective cohort of ... Read more >>

Int. J. Radiat. Oncol. Biol. Phys. (International journal of radiation oncology, biology, physics)
[2014, 89(1):30-37]

Cited: 14 times

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Treatment of older patients with head and neck cancer: a review.

Noam A VanderWalde, Mary Fleming, Jared Weiss, Bhishamjit S Chera,

The incidence of head and neck cancer (HNC) in the elderly is increasing. The treatment of HNC often includes multimodality therapy that can be quite morbid. Older patients (herein, defined as ≥65 years) with HNC often have significant comorbidity and impaired functional status that may hinder their ability to receive ... Read more >>

Oncologist (The oncologist)
[2013, 18(5):568-578]

Cited: 29 times

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Patterns of care in older patients with squamous cell carcinoma of the head and neck: a surveillance, epidemiology, and end results-medicare analysis.

Noam A VanderWalde, Anne-Marie Meyer, Huan Liu, Seth D Tyree, Leah L Zullig, William R Carpenter, Carol D Shores, Mark C Weissler, David N Hayes, Mary Fleming, Bhishamjit S Chera,

BACKGROUND:There is growing evidence in the literature that older patients may not benefit from more intensive therapy for head and neck squamous cell carcinoma (HNSCC). A growing number of patients with HNSCC are age 65 years or older; however, much of the evidence base informing treatment decisions is based on ... Read more >>

J Geriatr Oncol (Journal of geriatric oncology)
[2013, 4(3):262-270]

Cited: 13 times

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