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Author Nirmish Singla

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Predictive model for systemic recurrence following cisplatin-based neoadjuvant chemotherapy and radical nephroureterectomy for high risk upper tract urothelial carcinoma.

Rashed A Ghandour, Yuval Freifeld, Joseph Cheaib, Nirmish Singla, Xiaosong Meng, Alexander Kenigsberg, Aditya Bagrodia, Solomon Woldu, Jean Hoffman-Censits, Dmitry Enikeev, Leonid Rapoport, Firas G Petros, Jay D Raman, Philip M Pierorazio, Surena F Matin, Vitaly Margulis,

<h4>Introduction</h4>Neoadjuvant chemotherapy (NAC) is increasingly used prior to radical nephroureterectomy (RNU) for upper tract urothelial carcinoma (UTUC). Systemic recurrence (SR) carries a dismal prognosis. We sought to determine risk factors associated with SR in this setting.<h4>Methods</h4>We evaluated a multi-center database of patients with UTUC who received cisplatin-based NAC before RNU. ... Read more >>

Urol Oncol (Urologic oncology)
[2021, :]

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Decision-making in active surveillance in kidney cancer: current trends and future urine and tissue markers.

Sunil H Patel, Nirmish Singla, Phillip M Pierorazio,

Surveillance for small renal masses is a growing choice of management amongst physicians and patients. These decisions, however, can be difficult as patient factors and tumor factors may blur the line between continued surveillance and intervention. Currently, there are no biomarkers that are readily available to aid in the decision ... Read more >>

World J Urol (World journal of urology)
[2021, 39(8):2869-2874]

Cited: 1 time

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Locally Advanced Kidney Cancer: A New Space for Immunotherapy?

Nirmish Singla, Vitaly Margulis,

Eur Urol Oncol (European urology oncology)
[2021, :]

Cited: 0 times

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Evolving biological associations of upfront cytoreductive nephrectomy in metastatic renal cell carcinoma.

Andrew W Silagy, Ritesh R Kotecha, Stanley Weng, Arturo Holmes, Nirmish Singla, Roy Mano, Kyrollis Attalla, Kate L Weiss, Renzo G DiNatale, Sujata Patil, Jonathan A Coleman, Robert J Motzer, Paul Russo, Martin H Voss, A Ari Hakimi,

<h4>Background</h4>Systemic responses to cytoreductive nephrectomy (CN) in the management of metastatic renal cell carcinoma (mRCC) are variable and difficult to anticipate. The authors aimed to determine the association of CN with modifiable International Metastatic Renal Cell Carcinoma Database Consortium (IMDC) risk factors and oncological outcomes.<h4>Methods</h4>Consecutive patients with mRCC referred for ... Read more >>

Cancer (Cancer)
[2021, :]

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Molecular subtypes of upper tract urothelial cancer: Setting the stage for precision therapy.

David J McConkey, Nirmish Singla, Phillip Pierorazio, Kara Lombardo, Andres Matoso, Jean Hoffman-Censits,

A comprehensive genomic characterization of a large, high-quality cohort of upper tract urothelial carcinomas (UTUCs) in this issue of Cancer Cell reveals that UTUCs can be divided into five DNA-based molecular subtypes. Feasibility data establish that molecular subtyping can be performed non-invasively by sequencing tumor DNA in urine. ... Read more >>

Cancer Cell (Cancer cell)
[2021, 39(6):745-747]

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Differences between Upper Tract Urothelial Carcinoma and Bladder Cancer.

Nirmish Singla, Vitaly Margulis,

AUA News (AUA news)
[2021, 26(7):15-16]

Cited: 0 times

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Volume-outcome relationships for kidney cancer may be driven by disparities and patient risk.

Julia J Wainger, Joseph G Cheaib, Hiten D Patel, Mitchell M Huang, Michael J Biles, Meredith R Metcalf, Joseph K Canner, Nirmish Singla, Bruce J Trock, Mohamad E Allaf, Phillip Pierorazio,

<h4>Purpose</h4>Provider and hospital factors influence healthcare quality, but data are lacking to assess their impact on renal cancer surgery. We aimed to assess factors related to surgeon and hospital volume and study their impact on 30-day outcomes after radical nephrectomy.<h4>Materials and methods</h4>Renal surgery data were abstracted from Maryland's Health Service ... Read more >>

Urol Oncol (Urologic oncology)
[2021, 39(7):439.e1-439.e8]

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Novel Strategies in Locally Advanced Kidney Cancer - Highlights from KEYNOTE-564.

Nirmish Singla,

Kidney Cancer J (Kidney cancer journal : official journal of the Kidney Cancer Association)
[2021, 19(2 Suppl):74]

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Local and Regional Recurrences of Clinically Localized Renal Cell Carcinoma after Nephrectomy: A 15 Year Institutional Experience with Prognostic Features and Oncologic Outcomes.

Shagnik Ray, Joseph G Cheaib, Michael J Biles, Kevin G Pineault, Michael H Johnson, Yasser M A Ged, Mark C Markowski, Nirmish Singla, Mohamad E Allaf, Phillip M Pierorazio,

<h4>Objective</h4>To evaluate outcomes for patients with local recurrence (LR) of clinically localized renal cell carcinoma (RCC) without concurrent systemic metastasis from our institution, an event that occurs rarely (1%-3%) after surgery. LR may be a harbinger of poor outcomes, and the best management of these patients is unclear.<h4>Materials/methods</h4>We retrospectively reviewed ... Read more >>

Urology (Urology)
[2021, 154:201-207]

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Re: Robert J. Motzer, Paul Russo, Naomi Haas, et al. Adjuvant Pazopanib Versus Placebo After Nephrectomy in Patients with Localized or Locally Advanced Renal Cell Carcinoma: Final Overall Survival Analysis of the Phase 3 PROTECT Trial. Eur Urol 2021;79:334-8: PROTECTing Patients with Locally Advanced Kidney Cancer.

Nirmish Singla, Phillip Pierorazio, Mohamad Allaf, Yasser Ged,

Eur Urol (European urology)
[2021, 80(1):e33-e34]

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Contemporary Prognostic Model for Renal Cell Carcinoma: Is it Time for Biomarkers?

Sunil H Patel, Nirmish Singla, Phillip M Pierorazio,

Eur Urol (European urology)
[2021, 80(1):32-33]

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Re: Patrick D. McGillivray, Daiki Ueno, Aydin Pooli, et al. Distinguishing Benign Renal Tumors with an Oncocytic Gene Expression (ONEX) Classifier. Eur Urol 2021;79:107-11: Integrating 99mTc-sestamibi and ONEX to Optimize Risk Stratification for Renal Masses.

Alexa R Meyer, Steven P Rowe, Nirmish Singla,

Eur Urol (European urology)
[2021, 80(1):e20-e21]

Cited: 0 times

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Open partial nephrectomy with kidney split: Effective surgical approach to resect completely endophytic tumors.

Nirmish Singla, Chun Huang, Nicole E Benfante, Nathan C Wong, A Ari Hakimi, Paul Russo,

<h4>Objectives</h4>To review perioperative, renal functional, and oncological outcomes of the kidney split technique in performing partial nephrectomy (PN) to resect completely endophytic renal tumors.<h4>Methods</h4>All consecutive patients who underwent open PN with kidney split between 2015 and 2019 at our institution were included. In this approach the kidney is incised along ... Read more >>

Urol Oncol (Urologic oncology)
[2021, 39(6):371.e1-371.e5]

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Serum Small RNA Sequencing and miR-375 Assay Do Not Identify the Presence of Pure Teratoma at Postchemotherapy Retroperitoneal Lymph Node Dissection.

John T Lafin, Alexander P Kenigsberg, Xiaosong Meng, Dreaux Abe, Anna Savelyeva, Nirmish Singla, Solomon L Woldu, Yair Lotan, Ryan J Mauck, Cheryl M Lewis, Vitaly Margulis, Daniel Wong, Liwei Jia, Payal Kapur, Lin Xu, Ryan W Speir, Gregory T Chesnut, A Lindsay Frazier, Douglas W Strand, Nicholas Coleman, Matthew J Murray, James F Amatruda, Aditya Bagrodia,

Existing tumor markers for testicular germ cell tumor (TGCT) cannot detect the presence of pure teratoma. Serum miRNAs have strong performance detecting other subtypes of TGCT. Previous reports suggest high levels of miR-375 expression in teratoma tissue. The purpose of this study was to explore the role of serum miRNA, ... Read more >>

Eur Urol Open Sci (European urology open science)
[2021, 26:83-87]

Cited: 2 times

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Assessing quality of care in the diagnosis and treatment of early-stage testicular cancer: A critical review and summary.

Mitchell M Huang, Joseph G Cheaib, Zhuo T Su, Michael J Biles, Ritu Sharma, Allen Zhang, Nirmish Singla, Eric B Bass, Phillip M Pierorazio,

<h4>Objective</h4>To review the current literature on quality of care in the diagnosis and management of early-stage testicular cancer.<h4>Methods</h4>PubMed, Embase, and the Cochrane Central Register of Controlled Trials were searched for studies on quality of care in testicular cancer diagnosis and management from January 1980 to August 2018. Major overlapping themes ... Read more >>

Urol Oncol (Urologic oncology)
[2021, 39(7):400-408]

Cited: 0 times

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Rational Therapeutic Sequencing in Metastatic Renal Cell Carcinoma: Insights Gained from IMmotion150.

Nirmish Singla,

Eur Urol (European urology)
[2021, 79(5):674-675]

Cited: 0 times

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Neoadjuvant SABR for Renal Cell Carcinoma Inferior Vena Cava Tumor Thrombus-Safety Lead-in Results of a Phase 2 Trial.

Vitaly Margulis, Yuval Freifeld, Laurentiu M Pop, Subrata Manna, Payal Kapur, Ivan Pedrosa, Alana Christie, Osama Mohamad, Samantha Mannala, Nirmish Singla, Michael Wait, Aditya Bagrodia, Solomon L Woldu, Jeffrey Gahan, James Brugarolas, Robert Timmerman, Raquibul Hannan,

<h4>Purpose</h4>To evaluate the feasibility, safety, oncologic outcomes, and immune effect of neoadjuvant stereotactic radiation (Neo-SAbR) followed by radical nephrectomy and thrombectomy (RN-IVCT).<h4>Methods and materials</h4>These are results from the safety lead-in portion of a single-arm phase 1 and 2 trial. Patients with kidney cancer (renal cell carcinoma [RCC]) and inferior vena ... Read more >>

Int J Radiat Oncol Biol Phys (International journal of radiation oncology, biology, physics)
[2021, 110(4):1135-1142]

Cited: 0 times

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Clinical utility of the AJCC 8th edition pT1 subclassification and impact on practice patterns in stage I seminoma.

Rohit R Badia, Solomon Woldu, Hiten D Patel, Nirmish Singla, Arnav Srivastava, Joseph G Cheaib, Phillip M Pierorazio, Aditya Bagrodia,

<h4>Background</h4>The American Joint Committee on Cancer 8<sup>th</sup> edition staging guidelines for testicular cancer established a 3 cm cutoff to subclassify stage T1 seminomas (<3 cm = pT1a and ≥3 cm = pT1b). The efficacy of this cutoff in predicting metastatic disease and impact on treatment patterns have not been studied.<h4>Methods</h4>We retrospectively reviewed patients with ... Read more >>

Urol Oncol (Urologic oncology)
[2021, 39(2):136.e19-136.e25]

Cited: 1 time

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Academic Mentorship: Choosing the Right Research Mentor(s).

Nirmish Singla,

Kidney Cancer J (Kidney cancer journal : official journal of the Kidney Cancer Association)
[2020, 18(4):114]

Cited: 0 times

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The Significance of Preoperative Serum Sodium and Hemoglobin in Outcomes of Upper Tract Urothelial Carcinoma: Multi-Center Analysis Between China and the United States.

Dong Fang, Nirmish Singla, Zhengqing Bao, Syed M Jafri, Xiaohong Su, Zhenpeng Cao, Gengyan Xiong, Lei Zhang, Solomon Woldu, Ryan Hutchinson, Arthur Sagalowsky, Yair Lotan, Xuesong Li, Jay D Raman, Vitaly Margulis, Liqun Zhou,

<h4>Purpose</h4>To analyze the effect of preoperative serum sodium and hemoglobin on oncologic outcomes in upper tract urothelial carcinoma (UTUC) based on a multi-center cohort from China and the United States (U.S.).<h4>Methods</h4>We retrospectively reviewed the records of 775 patients with UTUC treated surgically at tertiary care medical facilities in China or ... Read more >>

Cancer Manag Res (Cancer management and research)
[2020, 12:9825-9836]

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Re: Welk, et al., an opioid prescription for men undergoing minor urologic surgery is associated with an increased risk of new persistent opioid use.

Dmitry Enikeev, Mark Taratkin, Nikolai Lavrinenko, Alexander Panferov, Nirmish Singla,

Transl Androl Urol (Translational andrology and urology)
[2020, 9(5):2299-2301]

Cited: 0 times

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Re: Alison Birtle, Mark Johnson, John Chester, et al. Adjuvant Chemotherapy in Upper Tract Urothelial Carcinoma (the POUT Trial): A Phase 3, Open-label, Randomised Controlled Trial. Lancet 2020;395:1268-77: A New Standard for a Rare Disease? Optimizing the Timing of Chemotherapy for Upper Tract Urothelial Carcinoma.

Nirmish Singla, Vitaly Margulis, ,

Eur Urol (European urology)
[2021, 79(1):e28]

Cited: 1 time

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Feasibility and Safety of Robotic Excision of Ipsilateral Retroperitoneal Recurrence After Nephrectomy for Renal Cell Carcinoma.

Rashed Ghandour, Andre Filipe Miranda, Nirmish Singla, Xiaosong Meng, Dmitry Enikeev, Solomon Woldu, Aditya Bagrodia, Jeffrey Cadeddu, Jeffrey Gahan, Vitaly Margulis,

<h4>Objective</h4>To determine feasibility and safety of robotic excision of local ipsilateral recurrences after nephrectomy for renal cell carcinoma (RCC). Surgical resection is an option for treatment of low burden locally recurrent RCC, potentially delaying the use of systemic therapy. This has historically been performed by open technique, which can impart ... Read more >>

Urology (Urology)
[2020, 145:159-165]

Cited: 0 times

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Gender Differences in the Clinical Management of clinical T1a Renal Cell Carcinoma.

Meredith R Metcalf, Joseph G Cheaib, Julia Wainger, Vanessa N Peña, Hiten D Patel, Nirmish Singla, Phillip M Pierorazio,

<h4>Objective</h4>To evaluate gender differences in the management of clinical T1a (cT1a) renal cell carcinoma (RCC) before and after release of the AUA guidelines for management in 2009, which prioritized nephron-sparing approaches.<h4>Methods</h4>Patients aged ≥66 years diagnosed with cT1a RCC from 2004 to 2013 in Surveillance, Epidemiology, and End Results-Medicare were analyzed. ... Read more >>

Urology (Urology)
[2021, 151:129-137]

Cited: 0 times

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Real-World Application of Pre-Orchiectomy miR-371a-3p Test in Testicular Germ Cell Tumor Management.

Rohit R Badia, Dreaux Abe, Daniel Wong, Nirmish Singla, Anna Savelyeva, Nathan Chertack, Solomon L Woldu, Yair Lotan, Ryan Mauck, Dan Ouyang, Xiaosong Meng, Cheryl M Lewis, Kuntal Majmudar, Liwei Jia, Payal Kapur, Lin Xu, A Lindsay Frazier, Vitaly Margulis, Douglas W Strand, Nicholas Coleman, Matthew J Murray, James F Amatruda, John T Lafin, Aditya Bagrodia,

<h4>Purpose</h4>Current serum tumor markers for testicular germ cell tumor are limited by low sensitivity. Growing evidence supports the use of circulating miR-371a-3p as a superior marker for malignant (viable) germ cell tumor management. We evaluated the real-world application of serum miR-371a-3p levels in detecting viable germ cell tumor among patients ... Read more >>

J Urol (The Journal of urology)
[2021, 205(1):137-144]

Cited: 4 times

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