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Author Ning Zhang

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A vanadium-based oxide-nitride heterostructure as a multifunctional sulfur host for advanced Li-S batteries.

Menglong Zhao, Yang Lu, Ya Yang, Mengjie Zhang, Zhenjie Yue, Ning Zhang, Tao Peng, Xianming Liu, Yongsong Luo,

The commercial application of lithium-sulfur (Li-S) batteries is obstructed by the inherent dissolution/shuttling of lithium polysulfides (LiPSs) in a sluggish redox reaction. Here, a heterophase V<sub>2</sub>O<sub>3</sub>-VN yolk-shell nanosphere encapsulated by a nitrogen-doped carbon layer has been designed to address the problems of the short cycle life and rapid capacity decay ... Read more >>

Nanoscale (Nanoscale)
[2021, 13(30):13085-13094]

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A spectroscopic study of solvent effects on the formation of Cu(ii)-chloride complexes in aqueous solution.

Ning Zhang, Jianfeng Tang, Yuntian Ma, Minghui Liang, Dewen Zeng, Glenn Hefter,

A combination of electronic (UV-vis) and X-ray absorption (EXAFS, XANES) spectroscopies has been used to investigate the formation of copper(ii)/chloride complexes in concentrated aqueous solutions. It is established that lowering the water activity by the addition of Mg(ClO<sub>4</sub>)<sub>2</sub> at a constant Cl<sup>-</sup>/Cu(ii) ratio results in the replacement of water molecules ... Read more >>

Phys Chem Chem Phys (Physical chemistry chemical physics : PCCP)
[2021, 23(11):6807-6814]

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One-pot intramolecular cyclization of 5-hydroxymethylcytosine for sequencing DNA hydroxymethylation at single-base resolution.

Yangde Ma, Ning Zhang, Shaokun Chen, Jingwei Sun, Yan Liu, Xiangjun Li, Hailin Wang,

Here we establish a one-pot reaction to directly convert the DNA base 5-hydroxymethylcytosine (5hmC) to an intramolecular cyclization nucleobase, which loses both protons of the exocyclic N4-amino group and thus is recognized as thymine (T) by DNA polymerase. Based on this 5hmC-specific reaction, a prospective bisulfite-free strategy for 5hmC sequencing ... Read more >>

Analyst (The Analyst)
[2021, 146(3):820-824]

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Design, synthesis and biological evaluation of dihydro-2-quinolone platinum(iv) hybrids as antitumor agents displaying mitochondria injury and DNA damage mechanism.

Zhifang Liu, Zuojie Li, Tao Du, Yan Chen, Qingpeng Wang, Guoshuai Li, Min Liu, Ning Zhang, Dacheng Li, Jun Han,

The design of novel platinum(iv) complexes with mitochondria injury competence, besides the DNA damage mechanism, is a promising way to develop new platinum drugs. Herein, dihydro-2-quinolone (DHQLO) as a mitocan was incorporated into the platinum(iv) system for the first time to prepare a new series of DHQLO platinum(iv) compounds. Complex ... Read more >>

Dalton Trans (Dalton transactions (Cambridge, England : 2003))
[2021, 50(1):362-375]

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Water flow inside various geometric nano-confinement channels.

Xujun Xu, Yanyan Zhao, Jicheng Wang, Ning Zhang, Chunlei Wang, Jicheng Zhang, Ning Wei,

In nano-confined systems, the properties of a fluid are different from those of macroscopic systems, and the properties of a nanotube can significantly affect water transport. However, our knowledge of the effects of nanotube shape is far from adequate. In the present work, we study the properties of a fluid ... Read more >>

Phys Chem Chem Phys (Physical chemistry chemical physics : PCCP)
[2020, 22(42):24633-24639]

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Cancer stem cells: advances in biology and clinical translation-a Keystone Symposia report.

Jennifer Cable, Duanqing Pei, Lola M Reid, Xin Wei Wang, Sonam Bhatia, Panagiotis Karras, Jan Joseph Melenhorst, Markus Grompe, Justin D Lathia, Erwei Song, Calvin J Kuo, Ning Zhang, Richard M White, Stephanie Ky Ma, Lichun Ma, Y Rebecca Chin, Michael M Shen, Irene Oi Lin Ng, Klaus H Kaestner, Lei Zhou, Shaheen Sikandar, Clemens A Schmitt, Wei Guo, Carmen Chak-Lui Wong, Junfang Ji, Dean G Tang, Anna Dubrovska, Chunzhang Yang, Wolf R Wiedemeyer, Irving L Weissman,

The test for the cancer stem cell (CSC) hypothesis is to find a target expressed on all, and only CSCs in a patient tumor, then eliminate all cells with that target that eliminates the cancer. That test has not yet been achieved, but CSC diagnostics and targets found on CSCs ... Read more >>

Ann N Y Acad Sci (Annals of the New York Academy of Sciences)
[2021, :]

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Ritlecitinib and brepocitinib demonstrate significant improvement in scalp alopecia areata biomarkers.

Emma Guttman-Yassky, Ana B Pavel, Aisleen Diaz, Ning Zhang, Ester Del Duca, Yeriel Estrada, Brett King, Anindita Banerjee, Christopher Banfield, Lori Ann Cox, Martin E Dowty, Karen Page, Michael S Vincent, Weidong Zhang, Linda Zhu, Elena Peeva,

Janus kinase (JAK) inhibitors have shown encouraging results in the treatment of alopecia areata (AA), an autoimmune form of hair loss, in small, uncontrolled studies and case reports. To conduct a biopsy sub-study during the randomized, double-blind, placebo-controlled first 24 weeks of a phase 2a clinical trial that evaluated the ... Read more >>

J Allergy Clin Immunol (The Journal of allergy and clinical immunology)
[2021, :]

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Ketoprofen and Loxoprofen Platinum(IV) Complexes Displaying Antimetastatic Activities by Inducing DNA Damage, Inflammation Suppression, and Enhanced Immune Response.

Zuojie Li, Qingpeng Wang, Linming Li, Yan Chen, Jichun Cui, Min Liu, Ning Zhang, Zhifang Liu, Jun Han, Zhengping Wang,

Metastasis is a major contributor of death in cancer patients, and there is an urgent need for effective treatments of metastatic malignancies. Herein, ketoprofen (KP) and loxoprofen (LP) platinum(IV) complexes with antiproliferative and antimetastatic properties were designed and prepared by integrating chemotherapy and immunotherapy targeting cyclooxygenase-2 (COX-2), matrix metalloproteinase-9 (MMP-9), ... Read more >>

J Med Chem (Journal of medicinal chemistry)
[2021, :]

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Upregulated expression of long non-coding RNA MEG3 serves as a prognostic biomarker in severe pneumonia children and its regulatory mechanism.

Jie Guo, Ning Zhang, Guozhi Liu, Aimei Zhang, Xin Liu, Jie Zheng,

Severe pneumonia is a high-mortality disorder in children. The expression and underlying effects of lncRNA maternally expressed 3 (MEG3) were detected. The relationships between MEG3 and other parameters were reported by Pearson correlation. The prognostic importance of MEG3 was assessed by Kaplan-Meier (K-M) curve and COX analysis and its diagnostic ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):7120-7131]

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[email protected] nanocages as multifunctional sulfur hosts for superior lithium-sulfur batteries.

Ning Zhang, Shuangshuang Zheng, Menglong Zhao, Yang Lu, Jinbing Cheng, Ya Yang, Tao Peng, Yongsong Luo,

The lithium polysulfide (LiPS) shuttle effect and low redox kinetics are the key problems that hinder performance improvement and prevent achieving the commercial requirements for lithium-sulfur batteries (LSBs), and the reasonable construction of sulfur hosts is one effective strategy to relieve the polysulfide shuttle effect and improve redox kinetics. Herein, ... Read more >>

Dalton Trans (Dalton transactions (Cambridge, England : 2003))
[2021, 50(46):17120-17128]

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The decrotonylase FoSir5 facilitates mitochondrial metabolic state switching in conidial germination of Fusarium oxysporum

Ning Zhang, Limin Song, Yang Xu, Xueyuan Pei, Ben Luisi, Wenxing Liang,

Fusarium oxysporum is one of the most important pathogenic fungi with a broad range of plant and animal hosts. The first key step of its infection cycle is conidial germination, but there is limited information available on the molecular events supporting this process. We show here that germination is accompanied ... Read more >>

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The relationship between health literacy and health-related quality of life among school-aged children in regional China.

Huifen Qiao, Xiaorong Wang, Zhenzhen Qin, Na Wang, Ning Zhang, Fei Xu,

<h4>Objectives</h4>To examine the association between health literacy (HL) and health-related quality of life (HRQoL) among primary and high school students in Nanjing, China.<h4>Methods</h4>A cross-sectional study was conducted among randomly selected primary (graders 4-6), junior (graders 7-9) and senior (graders 10-12) high school students in 2018 in Nanjing Municipality of China. ... Read more >>

Health Qual Life Outcomes (Health and quality of life outcomes)
[2021, 19(1):262]

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Disparities in Anticoagulation Use by Race and Ethnicity in Long-Term Care Residents With Atrial Fibrillation.

Alok Kapoor, Hammad Sadiq, Jay Patel, Ning Zhang, Kathleen Mazor, Sybil Crawford, Zhiyong Chen, Jerry Gurwitz, David McManus, Amresh Hanchate,

J Am Heart Assoc (Journal of the American Heart Association)
[2021, :e023428]

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Prognosis and role of clinical and imaging features in patients with malignant pericardial effusion: a single-center study in China.

Shucai Wang, Jiazheng Zhao, Chanchan Wang, Ning Zhang,

<h4>Background</h4>The diagnosis of malignant pericardial effusion (MPE) is often associated with a poor prognosis, but due to the complexity and unspecific nature of MPE patients' clinical manifestations, imaging often performs an essential role in diagnosis and prognosis.<h4>Methods</h4>Patients diagnosed with MPE between 2013 and 2018 at one tumor hospital were included ... Read more >>

BMC Cardiovasc Disord (BMC cardiovascular disorders)
[2021, 21(1):565]

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Machine learning-based pathomics signature could act as a novel prognostic marker for patients with clear cell renal cell carcinoma.

Siteng Chen, Liren Jiang, Feng Gao, Encheng Zhang, Tao Wang, Ning Zhang, Xiang Wang, Junhua Zheng,

<h4>Background</h4>Traditional histopathology performed by pathologists through naked eyes is insufficient for accurate survival prediction of clear cell renal cell carcinoma (ccRCC).<h4>Methods</h4>A total of 483 whole slide images (WSIs) data from three patient cohorts were retrospectively analyzed. We performed machine learning algorithm to identify optimal digital pathological features and constructed machine ... Read more >>

Br J Cancer (British journal of cancer)
[2021, :]

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Advanced approaches for improving bioavailability and controlled release of anthocyanins.

Yixiao Shen, Ning Zhang, Jinlong Tian, Guang Xin, Ling Liu, Xiyun Sun, Bin Li,

Anthocyanins are a group of phytochemicals responsible for the purple or red color of plants. Additionally, they are recognized to have health promoting functions including anti-cardiovascular, anti-thrombotic, anti-diabetic, antimicrobial, neuroprotective, and visual protective effect as well as anti-cancer activities. Thus, consumption of anthocyanin supplement or anthocyanin-rich foods has been recommended ... Read more >>

J Control Release (Journal of controlled release : official journal of the Controlled Release Society)
[2021, 341:285-299]

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Ethical Issues of Smart Home-based Elderly Care: A Scoping Review.

Junhong Zhu, Kanyuan Shi, Chengyue Yang, Yanping Niu, Yingchun Zeng, Ning Zhang, Tao Liu, Charlene H Chu,

<h4>Aim</h4>To explore current research on the ethics of smart home technologies including artificial intelligence and information technologies for elderly care by conducting a scoping review.<h4>Background</h4>The development of smart home technologies for care of the older adults provides potential solutions to reduce the caregiver burden within families where they are urgently ... Read more >>

J Nurs Manag (Journal of nursing management)
[2021, :]

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The Trajectory and Influence Factors of Breast Cancer Patients’ Main Chemotherapy-Related Symptoms: A Longitudinal Study

Yishu Qi, Ning Zhang, Ye Ma, Ewen Xu, Qingmei Huang, Lu Lin, zhaokang bao, Jie Qi, Jianhua Chen, Xiaokang Chen, Li Tian,

<h4>Introduction: </h4> Identifying the pattern of change in symptoms is critical to effective symptom management. This study aimed to determine the trajectory of Main Chemotherapy-related Symptoms (MCRS) in breast cancer patients, explore the influencing factors of potential categories of MCRS trajectory. <h4>Methods: </h4>: Patient-reported Outcomes Measurement System- breast-chemotherapy was used ... Read more >>

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[Retracted] miR‑663 promotes NPC cell proliferation by directly targeting CDKN2A.

Shaoqiang Liang, Ning Zhang, Yanming Deng, Lusi Chen, Yang Zhang, Zhenhe Zheng, Weijun Luo, Zhiqian Lv, Shaoen Li, Tao Xu,

Following the publication of this paper, it was drawn to the Editors' attention by a concerned reader that certain of the cell cycle assay data shown in Figs. 2D and 5C were strikingly similar to data appearing in different form in other articles by different authors. Owing to the fact that ... Read more >>

Mol Med Rep (Molecular medicine reports)
[2022, 25(1):]

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Interplay between copy number alterations and immune profiles in the early breast cancer Scandinavian Breast Group 2004-1 randomized phase II trial: results from a feasibility study.

Ioannis Zerdes, Michele Simonetti, Alexios Matikas, Luuk Harbers, Balazs Acs, Ceren Boyaci, Ning Zhang, Dimitrios Salgkamis, Susanne Agartz, Pablo Moreno-Ruiz, Yalai Bai, David L Rimm, Johan Hartman, Artur Mezheyeuski, Jonas Bergh, Nicola Crosetto, Theodoros Foukakis,

Emerging data indicate that genomic alterations can shape immune cell composition in early breast cancer. However, there is a need for complementary imaging and sequencing methods for the quantitative assessment of combined somatic copy number alteration (SCNA) and immune profiling in pathological samples. Here, we tested the feasibility of three ... Read more >>

NPJ Breast Cancer (NPJ breast cancer)
[2021, 7(1):144]

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Deep Learning-Based Diagnosis Method of Emergency Colorectal Pathology.

Chen Wang, Ning Zhang,

One of the most common malignant tumors of the digestive tract is emergency colorectal cancer. In recent years, both morbidity and mortality rates, particularly in our country, are getting higher and higher. At present, diagnosis of colorectal cancer, specifically in the emergency department of a hospital, is based on the ... Read more >>

J Healthc Eng (Journal of healthcare engineering)
[2021, 2021:3927828]

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Single-cell transcriptome analysis of Bisphenol A exposure reveals the key roles of the testicular microenvironment in male reproduction.

Ning Zhang, Yinuo Wang, Ziyu Chen, Jianhong Ren, Abdur Rehman, Dawood Warraich Ahmad, Deyu Long, Junyao Hou, Yaqi Zhou, Luyu Yang, Yu Ni, Yayu Li, Changjian Du, Yingcui Yu, Mingzhi Liao,

Testicular development during juvenile is crucial for subsequent male reproductive function. However, it remains poorly understood about the contribution of the testis microenvironment to human germ cell maturation. Therefore, we systematically analyzed scRNA-seq transcriptome and found the dramatic changes in cell-type composition in human testis during puberty. Then we constructed ... Read more >>

Biomed Pharmacother (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie)
[2021, 145:112449]

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High clonal diversity and spatial genetic admixture in early prostate cancer and surrounding normal tissue

Nicola Crosetto, Ning Zhang, Luuk Harbers, Michele Simonetti, Gabriel Longo, Enrico Berrino, Niklas Schultz, Firas Tarish, Peng Su, Bo Han, Wanzhong Wang, Sofia Onorato, Qifeng Yang, Thomas Helleday, Vassilis Roukos, Caterina Marchiò, Magda Bienko,

Copy number alterations (CNAs) are pervasive in advanced human cancers, but their prevalence in early-stage, localized tumors and their surrounding normal tissues is poorly characterized. To investigate this phenomenon, here we developed a method for spatially resolved single-cell CNA profiling and applied it to characterize the CNA landscape in 10,007 ... Read more >>

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Human Periodontal Ligament Stem Cell and Umbilical Vein Endothelial Cell Co-Culture to Prevascularize Scaffolds for Angiogenic and Osteogenic Tissue Engineering.

Zeqing Zhao, Yaxi Sun, Qingchen Qiao, Li Zhang, Xianju Xie, Michael D Weir, Abraham Schneider, Hockin H K Xu, Ning Zhang, Ke Zhang, Yuxing Bai,

(1) Background: Vascularization remains a critical challenge in bone tissue engineering. The objective of this study was to prevascularize calcium phosphate cement (CPC) scaffold by co-culturing human periodontal ligament stem cells (hPDLSCs) and human umbilical vein endothelial cells (hUVECs) for the first time; (2) Methods: hPDLSCs and/or hUVECs were seeded ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(22):]

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Research Progress of Gliomas in Machine Learning.

Yameng Wu, Yu Guo, Jun Ma, Yu Sa, Qifeng Li, Ning Zhang,

In the field of gliomas research, the broad availability of genetic and image information originated by computer technologies and the booming of biomedical publications has led to the advent of the big-data era. Machine learning methods were applied as possible approaches to speed up the data mining processes. In this ... Read more >>

Cells (Cells)
[2021, 10(11):]

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