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Mechanistic process understanding of the self-assembling behaviour of asymmetric bolaamphiphilic short-peptides and their templating for silica and titania nanomaterials.

Shengjie Wang, Fangyuan Liu, Ning Ma, Yanpeng Li, Qian Jing, Xinming Zhou, Yongqing Xia,

Investigation of the self-assembly of peptides is critically important to clarify certain biophysical phenomena, fulfill some biological functions, and construct functional materials. However, it is still a challenge to precisely predict the self-assembled structures of peptides because of their complicated driving forces and various assembling pathways. In this work, to ... Read more >>

Nanoscale (Nanoscale)
[2021, 13(31):13318-13327]

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Mesenchymal stem cell conditioned medium attenuates oxidative stress injury in hepatocytes partly by regulating the miR-486-5p/PIM1 axis and the TGF-β/Smad pathway.

Ning Ma, Shuo Li, Chao Lin, Xianbin Cheng, Zihui Meng,

This study investigated the role of microRNA (miRNA) miR-486-5p in oxidative stress injury in hepatocytes under the treatment of mesenchymal stem cell conditioned medium (MSC-CM). The oxidative stress injury in hepatocytes (L02) was induced by H<sub>2</sub>O<sub>2</sub>. Human umbilical cord blood MSC-CM (UCB-MSC-CM) was prepared. The effects of UCB-MSC-CM on the ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):6434-6447]

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Optogenetic operated probiotics to regulate host metabolism by mimicking enteroendocrine

Xinyu Zhang, Ning Ma, Wei Ling, Gaoju Pang, Tao Sun, Jing Liu, Huizhuo Pan, Meihui Cui, Chunli Han, Chun Yang, Jin Chang, Xian Huang, Hanjie Wang,

The enteroendocrine system plays an important role in metabolism. The gut microbiome regulates enteroendocrine in an extensive way, arousing attention in biomedicine. However, conventional strategies of enteroendocrine regulation via gut microbiome are usually non-specific or imprecise. Here, an optogenetic operated probiotics system was developed combining synthetic biology and flexible electronics ... Read more >>

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Proprioceptive and Clinical Outcomes after Remnant Preserved Anterior Cruciate Ligament Reconstruction: Assessment with Minimal Confounding Factors.

Yufeng Liu, Chunbao Li, Ning Ma, Wei Qi, Feng Gao, Bo Hu, Baiqing Zhang, Zhongli Li, Yujie Liu, Min Wei,

To evaluate the proprioceptive and clinical function of the knee joint after anterior cruciate ligament reconstruction (ACLR) with various amounts of remnant preserved with as few confounding factors as possible. This retrospective study included 46 patients who underwent ACLR with remnant preservation between March 2013 and February 2019. These patients ... Read more >>

Orthop Surg (Orthopaedic surgery)
[2021, :]

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High-resolution magnetic resonance vessel wall imaging-guided endovascular recanalization for nonacute intracranial artery occlusion.

Zhikai Hou, Long Yan, Zhe Zhang, Jing Jing, Jinhao Lyu, Ferdinand K Hui, Weilun Fu, Ying Yu, Rongrong Cui, Min Wan, Jia Song, Yongjun Wang, Zhongrong Miao, Xin Lou, Ning Ma,

On the basis of the characteristics of occluded segments on high-resolution magnetic resonance vessel wall imaging (MR-VWI), the authors evaluated the role of high-resolution MR-VWI-guided endovascular recanalization for patients with symptomatic nonacute intracranial artery occlusion (ICAO). Consecutive patients with symptomatic nonacute ICAO that was refractory to aggressive medical treatment were ... Read more >>

J Neurosurg (Journal of neurosurgery)
[2021, :1-7]

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A Digital Case-Finding Algorithm for Diagnosed but Untreated Hepatitis C: A Tool for Increasing Linkage to Treatment and Cure.

Brooke Wyatt, Ponni V Perumalswami, Anna Mageras, Mark Miller, Alyson Harty, Ning Ma, Chip A Bowman, Francina Collado, Jihae Jeon, Lismeiry Paulino, Amreen Dinani, Douglas Dieterich, Li Li, Maxence Vandromme, Andrea D Branch,

<h4>Background and aims</h4>Although chronic HCV infection increases mortality, thousands of patients remain diagnosed-but-untreated (DBU). We aimed to (1) develop a DBU phenotyping algorithm, (2) use it to facilitate case finding and linkage to care, and (3) identify barriers to successful treatment.<h4>Approach and results</h4>We developed a phenotyping algorithm using Java and ... Read more >>

Hepatology (Hepatology (Baltimore, Md.))
[2021, 74(6):2974-2987]

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Microfluidic system-based time-course tracking of physical proximity between cells and its effect on gene expression for elucidating live single cancer-immune cell interactions

Bianca Flores, Smriti Chawla, Ning Ma, Chad Sanada, Praveen Kumar Kujur, Ludmilla Chinen, Kyle Hukari, Mark Lynch, Naveen Ramalingam, Debarka Sengupta, Stefanie Jeffrey,

<h4>Summary</h4> Cell-cell communication and physical interactions play a vital role in cancer initiation, homeostasis, progression, and immune response. Here, we report a system that combines live capture of different cell types, co-incubation, time-lapse imaging, and gene expression profiling of doublets using a microfluidic integrated fluidic circuit (IFC) that enables measurement ... Read more >>

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Changes of cerebral cortical structure and cognitive dysfunction in "healthy hemisphere" after stroke: a study about cortical complexity and sulcus patterns in bilateral ischemic adult moyamoya disease.

Ziqi Liu, Shihao He, Yanchang Wei, Ran Duan, Cai Zhang, Tian Li, Ning Ma, Xin Lou, Rong Wang, Xiaoyuan Liu,

<h4>Background</h4>Moyamoya disease (MMD) is an uncommon cerebrovascular disease which leads to progressive stenosis and occlusion of the bilateral internal carotid artery and main intracerebral arteries. Concerns are always on how the hemisphere with infarction affects cognitive function, while little attention is paid to the role that the non-infarcted hemisphere plays. ... Read more >>

BMC Neurosci (BMC neuroscience)
[2021, 22(1):66]

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Endovascular Treatment in Acute Ischemic Stroke with Large Vessel Occlusion According to Different Stroke Subtypes: Data from ANGEL-ACT Registry.

Xiaochuan Huo, Dapeng Sun, Raynald, Baixue Jia, Xu Tong, Anxin Wang, Ning Ma, Feng Gao, Dapeng Mo, Gaoting Ma, Sheyar Amin, Zeguang Ren, Zhongrong Miao, ,

<h4>Introduction</h4>Endovascular treatment's (EVT) safety and efficacy have been proven in treating acute ischemic stroke (AIS) due to large vessel occlusion (LVO). However, limited data exist in different stroke subtypes. We aimed to investigate the differences in efficacy and safety of EVT for acute LVO according to different stroke subtypes.<h4>Methods</h4>A total of ... Read more >>

Neurol Ther (Neurology and therapy)
[2021, :]

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Application of Straight-needle, Three-tailed, Knot-free, Peritoneal Sutures in Laparoscopic Transabdominal Preperitoneal Hernia Repair.

Ning Ma, Zhen Zong, Fu-Xing Tang, En-Min Huang, Tao Ma, Wei-Sheng Yang, Jia-Lin Chen, Shuang Chen, Tai-Cheng Zhou,

Laparoscopic transabdominal preperitoneal hernia repair (TAPP) is one of the most widely used methods in inguinal hernia surgery. After the mesh is placed, the peritoneum must be resutured to avoid contact with the tissues and organs in the abdominal cavity. If the peritoneal suture time is too long, the operation ... Read more >>

J Vis Exp (Journal of visualized experiments : JoVE)
[2021, (177):]

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Associations of plasma 8-iso-prostaglandin Flevels with fasting blood glucose (FBG) and intra-abdominal fat (IAF) area in various Glycometabolism populations.

Ning Ma, Yujian Zhang, Binbin Liu, Xiaojiao Jia, Rui Wang, Qiang Lu,

<h4>Background</h4>This study aimed to investigate the differences in oxidative stress (OS) levels represented by 8-iso-prostaglandin F<sub>2α</sub> (8-iso-PGF<sub>2α</sub>) and analyze its correlation with the intra-abdominal fat (IAF) area and the glycolipid index.<h4>Methods</h4>We recruited a total of 160 eligible subjects. According to the blood glucose levels and the T2DM duration, subjects were ... Read more >>

BMC Endocr Disord (BMC endocrine disorders)
[2021, 21(1):215]

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Leonurine alleviates ferroptosis in cisplatin-induced acute kidney injury by activating the Nrf2 signaling pathway

Jianqiang HU, Wenjing Gu, Ning Ma, Xiaoye Fan, Xinxin Ci,

<h4>Background: </h4> and purpose: Increasing evidence suggests that ferroptosis plays a key role in the pathophysiology of acute kidney injury induced by cisplatin. The Nrf2 signaling pathway regulates oxidative stress and lipid peroxidation and positively regulates cisplatin-induced AKI (CI-AKI). However, Nrf2 and its activator leonurine on ferroptosis after CI-AKI remain ... Read more >>

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Ochratoxin A Induces Steatosis via PPARγ-CD36 Axis.

Qian-Wen Zheng, Xu-Fen Ding, Hui-Jun Cao, Qian-Zhi Ni, Bing Zhu, Ning Ma, Feng-Kun Zhang, Yi-Kang Wang, Sheng Xu, Tian-Wei Chen, Ji Xia, Xiao-Song Qiu, Dian-Zhen Yu, Dong Xie, Jing-Jing Li,

Ochratoxin A(OTA) is considered to be one of the most important contaminants of food and feed worldwide. The liver is one of key target organs for OTA to exert its toxic effects. Due to current lifestyle and diet, nonalcoholic fatty liver disease (NAFLD) has been the most common liver disease. ... Read more >>

Toxins (Basel) (Toxins)
[2021, 13(11):]

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The gut microbiota confers the glucose-and lipid-lowering effect of Laurolitsine in db/db mice

Rui-qi Wang, Fang Zhang, Ya-nan Yang, Yin-feng Tan, Yong Zhang, Lin Dong, Ning Ma, Wei-ying Lu, Chong-ming Wu, Xiao-po Zhang,

<h4>Background: </h4> Modulations on gut microbiota by traditional Chinese medicines (TCMs) and their active components are emerging as potential therapeutic agents on diabetes. Litsea glutinosa is a TCM used in clinic to treat diabetes with alkaloids as the active constituents, and the Laurolitsine is the richest one. Purpose Based ... Read more >>

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Altered Cardiac Energetics and Mitochondrial Dysfunction in Hypertrophic Cardiomyopathy.

Sara Ranjbarvaziri, Kristina B Kooiker, Mathew Ellenberger, Giovanni Fajardo, Mingming Zhao, Alison Schroer Vander Roest, Rahel A Woldeyes, Tiffany T Koyano, Robyn Fong, Ning Ma, Lei Tian, Gavin M Traber, Frandics Chan, John Perrino, Sushma Reddy, Wah Chiu, Joseph C Wu, Joseph Y Woo, Kathleen M Ruppel, James A Spudich, Michael P Snyder, Kévin Contrepois, Daniel Bernstein,

<h4>Background</h4>Hypertrophic cardiomyopathy (HCM) is a complex disease partly explained by the effects of individual gene variants on sarcomeric protein biomechanics. At the cellular level, HCM mutations most commonly enhance force production, leading to higher energy demands. Despite significant advances in elucidating sarcomeric structure-function relationships, there is still much to be ... Read more >>

Circulation (Circulation)
[2021, 144(21):1714-1731]

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Multiple predictors of in-stent restenosis after stent implantation in symptomatic intracranial atherosclerotic stenosis.

Ying Yu, Long Yan, Yake Lou, Rongrong Cui, Kaijiang Kang, Lingxian Jiang, Dapeng Mo, Feng Gao, Yongjun Wang, Xin Lou, Zhongrong Miao, Ning Ma,

<h4>Objective</h4>This study aimed to identify predictors of intracranial in-stent restenosis (ISR) after stent placement in symptomatic intracranial atherosclerotic stenosis (ICAS).<h4>Methods</h4>The authors retrospectively collected data from consecutive patients who suffered from symptomatic ICAS and underwent successful stent placement in Beijing Tiantan hospital. Eligible patients were classified into "ISR," "indeterminate ISR," or ... Read more >>

J Neurosurg (Journal of neurosurgery)
[2021, :1-10]

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Significance and Surgical Options for Nontranssexual Phalloplasty: A Retrospective Single-Center Analysis of 166 Patients.

Qi Wu, Liqiang Liu, Zhe Yang, Ning Ma, Weixin Wang, Yang-Qun Li,

<h4>Objective</h4>This study aimed to evaluate the long-term outcomes of phalloplasty and explore the clinical significance and selection of methods for penile reconstruction.<h4>Methods</h4>The same surgical team performed primary phalloplasty in 166 nontranssexual patients using different surgical approaches between September 2000 and September 2020. All patients had at least 6 months of ... Read more >>

Ann Plast Surg (Annals of plastic surgery)
[2021, :]

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Mangiferin Ameliorates HFD-Induced NAFLD through Regulation of the AMPK and NLRP3 Inflammasome Signal Pathways.

Zhang Yong, Wang Ruiqi, Yao Hongji, Ma Ning, Jiang Chenzuo, Zhou Yu, Xia Zhixuan, Liu Qiang, Liu Qibing, Lu Weiying, Zhang Xiaopo,

Nonalcoholic fatty liver disease (NAFLD) is closely related to glycolipid metabolism and liver inflammation. And there is no effective drug approved for its clinical therapy. In this study, we focused on mangiferin (Man) and explored its effects and mechanisms on NAFLD treatment based on the regulation of glycolipid metabolism and ... Read more >>

J Immunol Res (Journal of immunology research)
[2021, 2021:4084566]

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Targeting Ferroptosis: Pathological Mechanism and Treatment of Ischemia-Reperfusion Injury.

Xinye Li, Ning Ma, Juping Xu, Yanchi Zhang, Pan Yang, Xin Su, Yanfeng Xing, Na An, Fan Yang, Guoxia Zhang, Lijing Zhang, Yanwei Xing,

Ischemia-reperfusion (I/R) is a pathological process that occurs in many organs and diseases. Reperfusion, recovery of blood flow, and reoxygenation often lead to reperfusion injury. Drug therapy and early reperfusion therapy can reduce tissue injury and cell necrosis caused by ischemia, leading to irreversible I/R injury. Ferroptosis was clearly defined ... Read more >>

Oxid Med Cell Longev (Oxidative medicine and cellular longevity)
[2021, 2021:1587922]

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KLF6 Promotes Pyroptosis of Renal Tubular Epithelial Cells in Septic Acute Kidney Injury.

Min Gao, Hongbin Li, Qilong Liu, Ning Ma, Panpan Zi, Huijuan Shi, Yuming Du,

<h4>Abstract</h4>Septic acute kidney injury (SAKI) represents a clinical challenge with high morbidity and mortality. The current study aimed to analyze the effects and molecular mechanism of Krüppel-like factor 6 (KLF6) on SAKI. Firstly, SAKI mouse models were established by cecum ligation and puncture, while in vivo cell models were established ... Read more >>

Shock (Shock (Augusta, Ga.))
[2021, :]

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In-hospital survival after pancreatoduodenectomy is greater in high-volume hospitals versus lower-volume hospitals: a meta-analysis.

Joshua G Kovoor, Ning Ma, David R Tivey, Meegan Vandepeer, Jonathan Henry W Jacobsen, Anje Scarfe, Thomas D Vreugdenburg, Brandon Stretton, Suzanne Edwards, Wendy J Babidge, Adrian A Anthony, Robert T A Padbury, Guy J Maddern,

<h4>Background</h4>Variation in cut-off values for what is considered a high volume (HV) hospital has made assessments of volume-outcome relationships for pancreaticoduodenectomy (PD) challenging. Accordingly, we performed a systematic review and meta-analysis comparing in-hospital mortality after PD in hospitals above and below HV thresholds of various cut-off values.<h4>Method</h4>PubMed/MEDLINE, Embase and Cochrane ... Read more >>

ANZ J Surg (ANZ journal of surgery)
[2021, :]

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Real-time monitoring of immunoglobulin G levels in milk using an ordered porous layer interferometric optical sensor.

Lu Wang, Lele Zhou, Ning Ma, Qianqian Su, Yizhen Wan, Yifan Zhang, Feng Wu, Weiping Qian,

Immunoglobulin G (IgG) is a significant ingredient of immunological activity in milk and colostrum, the activity and content of which is easily disturbed by potentially conditional variant during sterilization. Therefore, developing robust methods for the detection of IgG levels in milk is especially important. Herein, protein A from the Staphylococcus ... Read more >>

Talanta (Talanta)
[2022, 237:122958]

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Circulating microRNA-194 levels in Chinese patients with diabetic kidney disease: a case-control study.

Ning Ma, Ning Xu, Dong Yin, Ping Zheng, Weiwei Liu, Guofeng Wang, Yuan Hui, Jiping Zhang, Guanjun Han, Chuanhui Yang, Yiting Chen, Xingbo Cheng, Ming Cheng,

<h4>Objective</h4>MicroRNAs (miRNAs) regulate gene expression and are involved in diabetic kidney disease (DKD) pathogenesis. We investigated circulating miRNA-194 levels as a biomarker of DKD prevalence and incidence, and the relationship between miRNA-194 and CCAAT/enhancer binding protein (C/EBP) homologous protein (CHOP).<h4>Methods</h4>We recruited 136 type-2 diabetes mellitus (T2DM) patients at the First ... Read more >>

Ther Adv Endocrinol Metab (Therapeutic advances in endocrinology and metabolism)
[2021, 12:20420188211049615]

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Non-contrast head CT alone for thrombectomy in acute ischemic stroke: analysis of the ANGEL-ACT registry.

Zeguang Ren, Gaoting Ma, Maxim Mokin, Ashutosh P Jadhav, Baixue Jia, Xu Tong, Clayton Bauer, Raynald Liu, Anxin Wang, Xuelei Zhang, Dapeng Mo, Ning Ma, Feng Gao, Ligang Song, Xuan Sun, Xiaochuan Huo, Yiming Deng, Lian Liu, Gang Luo, Xiang Luo, Ya Peng, Liqiang Gui, Cunfeng Song, Jin Wu, Leyuan Wang, Chunlei Li, Tudor G Jovin, Yilong Wang, Yongjun Wang, Zhongrong Miao, ,

<h4>Backgroud</h4>The goal of this study was to determine if the choice of imaging paradigm performed in the emergency department influences the procedural or clinical outcomes after mechanical thrombectomy (MT).<h4>Methods</h4>This is a retrospective comparative outcome study which was conducted from the ANGEL-ACT registry. Comparisons were made between baseline characteristics and clinical ... Read more >>

J Neurointerv Surg (Journal of neurointerventional surgery)
[2021, :]

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Chitosan/Polyvinyl Alcohol/ Lauramidopropyl Betaine/2D-HOF Mixed Film with Abundant Hydrogen Bonds Acts as High Mechanical Strength Artificial Skin.

Qin Ye, Shu-Han Chen, Ya Zhang, Bo Ruan, Yi-Jie Zhang, Xin-Ke Zhang, Tao Jiang, Xiaoge Wang, Ning Ma, Fang-Chang Tsai,

The mechanical properties of artificial skins are complicated to maintain under ensuring air permeability and antimicrobial. Thus, a series of hydrophilic antimicrobial polymer networks are prepared by crosslinking chitosan and polyvinyl alcohol with the lauramidopropyl betaine and hydrogen bond organic framework (CS/PVA/LPB/2D-HOF). The mechanical performance of the control groups and ... Read more >>

Macromol Biosci (Macromolecular bioscience)
[2021, :e2100317]

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