Full Text Journal Articles by
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Structural insights into TSC complex assembly and GAP activity on Rheb

Huirong Yang, Zishuo Yu, Xizi Chen, Jiabei Li, Ningning Li, Jiaxuan Cheng, Ning Gao, Hai-Xin Yuan, Dan Ye, Kun-Liang Guan, Yanhui Xu,

Abstract Tuberous sclerosis complex (TSC) integrates upstream stimuli and regulates cell growth by controlling the activity of mTORC1. TSC functions as a GTPase-activating protein (GAP) towards small GTPase Rheb and inhibits Rheb-mediated activation of mTORC1. Mutations in TSC genes cause tuberous sclerosis. In this study, the near-atomic resolution structure of ... Read more >>

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Time-varying networks of ERPs in P300-speller paradigms based on spatially and semantically congruent audiovisual bimodality.

Zhaohua Lu, Qi Li, Ning Gao, Jingjing Yang,

OBJECTIVE:In the P300-speller paradigm using spatially and semantically congruent audiovisual (AV) stimuli, AV stimuli elicited significantly higher event-related potential (ERP) amplitudes than those for a single visual (V) stimulus. Nevertheless, it remains unclear whether ERPs in AV and V spelling paradigms are generated with identical brain network architecture. APPROACH:In this ... Read more >>

J Neural Eng (Journal of neural engineering)
[2020, :]

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Hyperhomocysteinemia-induced oxidative stress aggravates renal damage in hypertensive rats.

Ning Gao, Yuzhen Zhang, Li Li, Lei Lei, Ping Cao, Xuan Zhao, Lin Lin, Rui Xu,

BACKGROUND:Hyperhomocysteinemia (HHcy) plays a synergistic role with hypertension in vascular injury; however, the relationship between HHcy and hypertension in renal injury remains unclear. Here, we sought to evaluate the relationship between HHcy and hypertension in the context of renal injury and to elucidate the mechanism of action underlying this relationship. ... Read more >>

Am. J. Hypertens. (American journal of hypertension)
[2020, :]

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Role of Melt Plasticizing Temperature in Morphology and Properties of PE100 Pipes Prepared by a Rotational Shear System.

Zexiang Xie, Ning Gao, Zuchen Du, Hao Yang, Kaizhi Shen, Qiang Fu, Xueqin Gao,

To increase the maximum internal pressure that a polyethylene (PE) pipe can withstand, a novel rotational shear system (RSS) was constructed in this study to fabricate PE pipes with enhanced hoop strength by applying hoop shear on the pipes using a rotational mandrel. The microstructure and morphology with the influences ... Read more >>

ACS Omega (ACS omega)
[2020, 5(22):12660-12671]

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Low doses of folic acid can reduce hyperhomocysteinemia-induced glomerular injury in spontaneously hypertensive rats.

Ning Gao, Yuzhen Zhang, Lei Lei, Li Li, Ping Cao, Xuan Zhao, Lin Lin, Rui Xu,

Hypertension associated with hyperhomocysteinemia (HHcy) is associated with a high risk of vascular diseases. However, the mechanisms of HHcy-associated hypertensive renal damage and the efficacy of folic acid (FA) as a treatment have not been fully elucidated. The aim of the present study was to evaluate whether lowering the plasma ... Read more >>

Hypertens. Res. (Hypertension research : official journal of the Japanese Society of Hypertension)
[2020, :]

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Folic Acid Can Reduce Hyperhomocysteinemia-induced Vascular Damage by Immune/Inflammatory Response in Spontaneously Hypertensive Rats

Lihua Zhang, Zhongliang li, Changcheng Xing, Ning Gao, Ping Cao, Qingcheng Hui, Lin Yun, Rui Xu,

Abstract Background Hypertension associated with hyperhomocysteinemia (HHcy) is correlated with a high risk of vascular diseases. However, the mechanisms of HHcy-associated hypertensive vascular damage and the efficacy of folic acid (FA) as a treatment have not been fully elucidated. The aim of the present study was to evaluate the ... Read more >>

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Incorporating Genome Annotation Into Genomic Prediction for Carcass Traits in Chinese Simmental Beef Cattle.

Ling Xu, Ning Gao, Zezhao Wang, Lei Xu, Ying Liu, Yan Chen, Lingyang Xu, Xue Gao, Lupei Zhang, Huijiang Gao, Bo Zhu, Junya Li,

Various methods have been proposed for genomic prediction (GP) in livestock. These methods have mainly focused on statistical considerations and did not include genome annotation information. In this study, to improve the predictive performance of carcass traits in Chinese Simmental beef cattle, we incorporated the genome annotation information into GP. ... Read more >>

Front Genet (Frontiers in genetics)
[2020, 11:481]

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Structural insights into secretory immunoglobulin A and its interaction with a pneumococcal adhesin.

Yuxin Wang, Guopeng Wang, Yaxin Li, Qinyu Zhu, Hao Shen, Ning Gao, Junyu Xiao,

Secretory Immunoglobulin A (SIgA) is the most abundant antibody at the mucosal surface. It possesses two additional subunits besides IgA: the joining chain (J-chain) and secretory component (SC). SC is the ectodomain of the polymeric immunoglobulin receptor (pIgR), which functions to transport IgA to the mucosa. How the J-chain and ... Read more >>

Cell Res. (Cell Research)
[2020, :]

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IL-33/ST2/IL-9/IL-9R signaling disrupts ocular surface barrier in allergic inflammation.

Jiaoyue Hu, Ning Gao, Yun Zhang, Xin Chen, Jinmiao Li, Fang Bian, Wei Chi, Zuguo Liu, Cintia S de Paiva, Stephen C Pflugfelder, De-Quan Li,

This study was to explore a novel IL-33/ST2/IL-9/IL-9R signaling pathway that disrupts ocular surface barrier and amplifies allergic inflammation. Two murine models of experimental allergic conjunctivitis (EAC) and IL-9 topical challenge in wild type Balb/c and ST2-/- mice, and two culture models of primarily human corneal epithelial cells (HCECs) and ... Read more >>

Mucosal Immunol (Mucosal immunology)
[2020, :]

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LncRNA H19 Aggravates Cerebral Ischemia/Reperfusion Injury by Functioning as a ceRNA for miR-19a-3p to Target PTEN.

Ning Gao, Hong Tang, Ling Gao, Guo-Long Tu, Han Luo, Ying Xia,

Long non-coding RNAs (lncRNAs) play critical roles in regulating the progression of cerebral ischemia. LncRNA H19 was significantly up-regulated under ischemia-reperfusion (I/R) damage and implicatedin I/R injury progression, but the mechanisms remain unclear. Mice were subjected to middle cerebral artery occlusion (MCAO)/R (1 h/24 h) to build an I/R injury model and ... Read more >>

Neuroscience (Neuroscience)
[2020, 437:117-129]

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Spectroscopic Investigation and Nanoscale Characterization of Epinephrine Autooxidation under Alkaline Conditions.

Lulin Hu, Ning Gao, Jingkai Shan, Xueying Wang, Huan Wang, Xinglong Yang, Hongmin Ma, Qin Wei,

Melanins are intriguing biomaterials with unique physical and chemical properties. Due to the insoluble nature of the synthetic melanins prepared from different precursors, such as 3,4-dihydroxy-phenylalanine (DOPA) and dopamine (DA), it is still challenging to reveal the structure-property relationships. In this work, the autoxidation of epinephrine (EP) under basic conditions ... Read more >>

Langmuir (Langmuir : the ACS journal of surfaces and colloids)
[2020, 36(18):5040-5047]

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Cryo-EM structures of human pannexin 1 channel.

Qiuheng Jin, Bo Zhang, Xiang Zheng, Ningning Li, Lingyi Xu, Yuan Xie, Fangjun Song, Eijaz Ahmed Bhat, Yuan Chen, Ning Gao, Jiangtao Guo, Xiaokang Zhang, Sheng Ye,

Cell Res. (Cell research)
[2020, 30(5):449-451]

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A compact Cas9 ortholog from Staphylococcus Auricularis (SauriCas9) expands the DNA targeting scope.

Ziying Hu, Shuai Wang, Chengdong Zhang, Ning Gao, Miaomiao Li, Deqian Wang, Daqi Wang, Dong Liu, Huihui Liu, Sang-Ging Ong, Hongyan Wang, Yongming Wang,

Compact CRISPR/Cas9 systems that can be packaged into an adeno-associated virus (AAV) hold great promise for gene therapy. Unfortunately, currently available small Cas9 nucleases either display low activity or require a long protospacer adjacent motif (PAM) sequence, limiting their extensive applications. Here, we screened a panel of Cas9 nucleases and ... Read more >>

PLoS Biol. (PLoS biology)
[2020, 18(3):e3000686]

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CYP3A4 and CYP11A1 variants are risk factors for ischemic stroke: a case control study.

Ning Gao, Hong Tang, Ling Gao, Guolong Tu, Han Luo, Ying Xia,

BACKGROUND:This study aimed to investigate the roles of CYP3A4 and CYP11A1 variants in ischemic stroke (IS) susceptibility among the Han Chinese population. METHODS:Four hundred seventy-seven patients with IS and 493 healthy controls were enrolled. Seven single-nucleotide polymorphisms (SNPs) of CYP3A4 and CYP11A1 were genotyped by Agena MassARRAY. Odds ratio (OR) ... Read more >>

BMC Neurol (BMC neurology)
[2020, 20(1):77]

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Structural insights into immunoglobulin M.

Yaxin Li, Guopeng Wang, Ningning Li, Yuxin Wang, Qinyu Zhu, Huarui Chu, Wenjun Wu, Ying Tan, Feng Yu, Xiao-Dong Su, Ning Gao, Junyu Xiao,

Immunoglobulin M (IgM) plays a pivotal role in both humoral and mucosal immunity. Its assembly and transport depend on the joining chain (J-chain) and the polymeric immunoglobulin receptor (pIgR), but the underlying molecular mechanisms of these processes are unclear. We report a cryo-electron microscopy structure of the Fc region of ... Read more >>

Science (Science (New York, N.Y.))
[2020, 367(6481):1014-1017]

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Co-stimulation-removed audiovisual semantic integration and modulation of attention: An event-related potential study.

Yang Xi, Qi Li, Ning Gao, Guangjian Li, Weihong Lin, Jinglong Wu,

The integration of multisensory objects containing semantic information involves processing of both low-level co-stimulation and high-order semantic integration. To investigate audiovisual semantic integration, we utilized bimodal stimuli (AV, simultaneous presentation of an auditory sound and a visual picture; An, simultaneous presentation of an auditory sound and a visual noise; Vn, ... Read more >>

Int J Psychophysiol (International journal of psychophysiology : official journal of the International Organization of Psychophysiology)
[2020, 151:7-17]

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ROCK1 activation-mediated mitochondrial translocation of Drp1 and cofilin are required for arnidiol-induced mitochondrial fission and apoptosis.

Jinjiao Hu, Hongwei Zhang, Jie Li, Xiuxing Jiang, Yanhao Zhang, Qin Wu, Liwen Shen, Jingshan Shi, Ning Gao,

BACKGROUND:Arnidiol is a pentacyclic triterpene diol that has multiple pharmacological activities. However, the apoptotic activities of arnidiol in human cancer cells have not yet been explored, nor has the mechanism by which arnidiol induces apoptosis been examined in depth. METHODS:MDA-MB-231 cells and xenografted mice were treated with arnidiol. Mitochondrial fission ... Read more >>

J. Exp. Clin. Cancer Res. (Journal of experimental & clinical cancer research : CR)
[2020, 39(1):37]

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Dihydroartemisinin inhibits the tumorigenesis and metastasis of breast cancer via downregulating CIZ1 expression associated with TGF-β1 signaling.

Yue Li, Xiaoyan Zhou, Jiali Liu, Ning Gao, Ruihua Yang, Qi Wang, Jing Ji, Ling Ma, Qian He,

AIMS:Dihydroartemisinin (DHA) is currently considered as the promising cancer therapeutic drug. In this study, we aimed to investigate the anti-proliferative and anti-metastasis effects of DHA. MAIN METHODS:Utilizing breast cancer cells MCF-7, MDA-MB-231 and BT549, cell proliferation, migration and invasion were detected. RT-qPCR was performed to detect CIZ1, TGF-β1 and Snail ... Read more >>

Life Sci. (Life sciences)
[2020, 248:117454]

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Structural insights into secretory immunoglobulin A and its interaction with a pneumococcal adhesin

Yuxin Wang, Guopeng Wang, Yaxin Li, Hao Shen, Huarui Chu, Ning Gao, Junyu Xiao,

Abstract Secretory Immunoglobulin A (SIgA) is the most abundant antibody at the mucosal surface. SIgA possesses two additional subunits besides IgA: the joining chain (J-chain) and secretory component (SC). SC is the ectodomain of the polymeric immunoglobulin receptor (pIgR), which functions to transport IgA to the mucosa. The underlying mechanism ... Read more >>

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Happy emotion cognition of bimodal audiovisual stimuli optimizes the performance of the P300 speller.

Zhaohua Lu, Qi Li, Ning Gao, Jingjing Yang, Ou Bai,

OBJECTIVE:Prior studies of emotional cognition have found that emotion-based bimodal face and voice stimuli can elicit larger event-related potential (ERP) amplitudes and enhance neural responses compared with visual-only emotional face stimuli. Recent studies on brain-computer interface have shown that emotional face stimuli have significantly improved the performance of the traditional ... Read more >>

Brain Behav (Brain and behavior)
[2019, 9(12):e01479]

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miR-200a-3p plays tumor suppressor roles in gastric cancer cells by targeting KLF12.

Changhe Jia, Yanrui Zhang, Yi Xie, Ying Ren, Haihui Zhang, Yinglei Zhou, Ning Gao, Songze Ding, Shuangyin Han,

Background: The role of miR-200a-3p in gastric cancer (GC) remain unclear. Materials and methods: miR-200a-3p expression in 65 paired GC and adjacent tissues (AT) were evaluated by quantitative real-time PCR (qRT-PCR) and Western blot. Cell proliferation, cell cycle, and cell migration were assessed by cell growth counting assay, cell cycle ... Read more >>

Artif Cells Nanomed Biotechnol (Artificial cells, nanomedicine, and biotechnology)
[2019, 47(1):3697-3703]

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MircroRNA-10b Promotes Human Embryonic Stem Cell-Derived Cardiomyocyte Proliferation via Novel Target Gene LATS1.

Yifang Xie, Qiaozi Wang, Ning Gao, Fujian Wu, Feng Lan, Feng Zhang, Li Jin, Zheyong Huang, Junbo Ge, Hongyan Wang, Yongming Wang,

Adult mammalian cardiomyocytes (CMs) retain a limited proliferative ability, which is insufficient for the repair of CM loss in ischemic cardiac injury. Regulation of the Hippo signaling pathway to promote endogenous CM proliferation has emerged as a promising strategy for heart regeneration. Previous studies have shown that the microRNA cluster ... Read more >>

Mol Ther Nucleic Acids (Molecular therapy. Nucleic acids)
[2020, 19:437-445]

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The Association between Health Beliefs and Fall-Related Behaviors and Its Implication for Fall Intervention among Chinese Elderly.

Fenfen Li, Deding Zhou, Yue Chen, Yan Yu, Ning Gao, Juanjuan Peng, Shumei Wang,

To apply the Health Belief Model (HBM) to fall prevention of the elderly and estimate fall health beliefs and their relationships with fall-related behaviors, a citywide cross-sectional study was conducted among people aged 60 years or over in 13 out of 16 districts in Shanghai, China, in September 2018. A ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2019, 16(23):]

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EED-Targeted PROTACs Degrade EED, EZH2, and SUZ12 in the PRC2 Complex.

Jessie Hao-Ru Hsu, Timothy Rasmusson, James Robinson, Fiona Pachl, Jon Read, Sameer Kawatkar, Daniel H O' Donovan, Sharan Bagal, Erin Code, Philip Rawlins, Argyrides Argyrou, Ronald Tomlinson, Ning Gao, Xiahui Zhu, Elisabetta Chiarparin, Kelly Jacques, Minhui Shen, Haley Woods, Emma Bednarski, David M Wilson, Lisa Drew, M Paola Castaldi, Stephen Fawell, Andrew Bloecher,

Deregulation of the PRC2 complex, comprised of the core subunits EZH2, SUZ12, and EED, drives aberrant hypermethylation of H3K27 and tumorigenicity of many cancers. Although inhibitors of EZH2 have shown promising clinical activity, preclinical data suggest that resistance can be acquired through secondary mutations in EZH2 that abrogate drug target ... Read more >>

Cell Chem Biol (Cell chemical biology)
[2020, 27(1):41-46.e17]

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Weighted single-step GWAS identified candidate genes associated with semen traits in a Duroc boar population.

Ning Gao, Yilong Chen, Xiaohong Liu, Yunxiang Zhao, Lin Zhu, Ali Liu, Wei Jiang, Xing Peng, Conglin Zhang, Zhenshuang Tang, Xinyun Li, Yaosheng Chen,

BACKGROUND:In the pig production industry, artificial insemination (AI) plays an important role in enlarging the beneficial impact of elite boars. Understanding the genetic architecture and detecting genetic markers associated with semen traits can help in improving genetic selection for such traits and accelerate genetic progress. In this study, we utilized ... Read more >>

BMC Genomics (BMC genomics)
[2019, 20(1):797]

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