Full Text Journal Articles by
Author Nikhil Vasdev

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Major Urological Cancer Surgery for Patients is Safe and Surgical Training Should Be Encouraged During the COVID-19 Pandemic: A Multicentre Analysis of 30-day Outcomes.

Wei Shen Tan, Rajan Arianayagam, Pramit Khetrapal, Edward Rowe, Samantha Kearley, Ahmed Mahrous, Raj Pal, William Fowler, Rakesh Heer, Mohamed Elajnaf, Jayne Douglas-Moore, T R Leyshon Griffiths, James Voss, Daniel Wilby, Omar Al Kadhi, Jonathan Noel, Nikhil Vasdev, Alastair McKay, Imran Ahmad, Islam Abu-Nayla, Benjamin Lamb, George T Hill, Krishna Narahari, Howard Kynaston, Arzu Yousuf, Venkata R M Kusuma, Jo Cresswell, Pete Cooke, Aniruddha Chakravarti, Ravi Barod, Axel Bex, John D Kelly, ,

COVID-19 has resulted in the deferral of major surgery for genitourinary (GU) cancers with the exception of cancers with high risk of progression. We report outcomes for major GU cancer operations, namely radical prostatectomy (RP), radical cystectomy (RC), radical nephrectomy (RN), partial nephrectomy (PN), and nephroureterectomy performed at 13 major ... Read more >>

Eur Urol Open Sci (European urology open science)
[2021, :]

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Urinary biomarkers to mitigate diagnostic delay in bladder cancer during the COVID-19 era.

Kenrick Ng, Krishna Vinnakota, Anand Sharma, John Kelly, Prokar Dasgupta, Nikhil Vasdev,

Nat Rev Urol (Nature reviews. Urology)
[2020, :]

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Review of the evidence for robotic-assisted robotic cystectomy and intra-corporeal urinary diversion in bladder cancer.

Andrew Brodie, Kittinut Kijvikai, Karel Decaestecker, Nikhil Vasdev,

Radical cystectomy, pelvic lymph node dissection and urinary diversion is the gold-standard treatment for muscle-invasive bladder cancer. The surgery is both complex and highly morbid. Robotic cystectomy is now in its 16<sup>th</sup> year with established techniques and sufficient research maturity to enable comparison with its open counterpart. The present review ... Read more >>

Transl Androl Urol (Translational andrology and urology)
[2020, 9(6):2946-2955]

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Urinary biomarkers to mitigate diagnostic delay in bladder cancer during the COVID-19 era

Kenrick Ng, Krishna Vinnakota, Anand Sharma, John Kelly, Prokar Dasgupta, Nikhil Vasdev,

The COVID-19 pandemic has resulted in a substantial increase in waiting times for cystoscopies, prompting concerns of delayed diagnoses and substandard surveillance of bladder cancer. Expanding the role of urinary biomarkers in diagnostic and surveillance pathways could be a strategy to address this problem, and several novel biomarkers have shown ... Read more >>

Nat Rev Urol (Nature reviews. Urology)
[2020, :1-3]

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Technical caveats in salvage robot assisted radical prostatectomy.

Ashwin Tamhankar, Alexander Hampson, Nikhil Vasdev,

Transl Androl Urol (Translational andrology and urology)
[2020, 9(6):2862-2863]

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Survival Outcomes After High-dose Chemotherapy and Stem Cell Transplantation in the Salvage Setting for Relapsed or Refractory Germ Cell Cancers.

Anand Sharma, Deshveer S Babra, Priya V Joshi, Marcia Hall, Andrew Gogbashian, Nikhil Vasdev, Magdalene Joseph, Amir Yazdan, Edward Kanfer,

<h4>Background/aim</h4>High-dose chemotherapy (HDCT) and stem cell transplantation (SCT) have been established as the standard of care in patients with relapsed germ cell tumours (GCTs). We evaluated the safety, efficacy and tolerability of HDCT/ SCT in patients with relapsed GCTs.<h4>Patients and methods</h4>Twenty-eight patients with relapsed GCTs, treated with HDCT, were included ... Read more >>

In Vivo (In vivo (Athens, Greece))
[2020, 34(6):3675-3679]

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Guideline of guidelines: Muscle-invasive bladder cancer.

Nicolas Pavlos Omorphos, John Carlo Pansaon Piedad, Nikhil Vasdev,

Muscle-invasive bladder cancer accounts for 25% of bladder cancer cases and represents a spectrum of disease, which can result in significant morbidity and mortality for anyone affected. Current management has evolved through years of research and clinical practice. It is based on a risk-benefit approach, which is often tailored to ... Read more >>

Turk J Urol (Turkish journal of urology)
[2020, :]

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The Emerging Role of Artificial Intelligence in the Fight Against COVID-19.

Aruni Ghose, Sabyasachi Roy, Nikhil Vasdev, Jonathon Olsburgh, Prokar Dasgupta,

The coronavirus disease 2019 (COVID-19) pandemic has generated large volumes of clinical data that can be an invaluable resource towards answering a number of important questions for this and future pandemics. Artificial intelligence can have an important role in analysing such data to identify populations at higher risk of COVID-19-related ... Read more >>

Eur Urol (European urology)
[2020, 78(6):775-776]

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Outcomes of the 2019 novel coronavirus in patients with or without a history of cancer: a multi-centre North London experience.

Nalinie Joharatnam-Hogan, Daniel Hochhauser, Kai-Keen Shiu, Hannah Rush, Valerie Crolley, William Wilson, Anand Sharma, Aun Muhammad, Muhammad Anwar, Nikhil Vasdev, Robert Goldstein, Ganna Kantser, Aramita Saha, Fharat Raja, John Bridgewater, Khurum Khan,

<h4>Background</h4>This study aims to compare the outcomes of COVID-19-positive disease in patients with a history of cancer to those without.<h4>Methods</h4>We retrospectively collected clinical data and outcomes of COVID-19 positive cancer patients treated consecutively in five North London hospitals (cohort A). Outcomes recorded included time interval between most recent anti-cancer treatment ... Read more >>

Ther Adv Med Oncol (Therapeutic advances in medical oncology)
[2020, 12:1758835920956803]

Cited: 1 time

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Urinary biomarkers in bladder cancer: A review of the current landscape and future directions.

Kenrick Ng, Arnulf Stenzl, Anand Sharma, Nikhil Vasdev,

<h4>Aim</h4>This narrative review aims to describe established and emerging urinary biomarkers in the diagnosis and surveillance of non-muscle invasive bladder cancer. It provides a comprehensive account of classical, FDA-approved protein biomarkers and discusses their limitations. Further, we discuss the role that epigenetic, genetic, and exosomal markers can play to enhance ... Read more >>

Urol Oncol (Urologic oncology)
[2021, 39(1):41-51]

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Robot-assisted vs open radical cystectomy for bladder cancer in adults.

Bhavan Prasad Rai, Jasper Bondad, Nikhil Vasdev, Jim Adshead, Tim Lane, Kamran Ahmed, Mohammed S Khan, Prokar Dasgupta, Khurshid Guru, Piotr L Chlosta, Omar M Aboumarzouk,

<h4>Background</h4>It has been suggested that, in comparison with open radical cystectomy (ORC), robot-assisted radical cystectomy (RARC) results in less blood loss, shorter convalescence and fewer complications, with equivalent short-term oncological and functional outcomes; however, uncertainty remains as to the magnitude of these benefits.<h4>Objectives</h4>To assess the effects of RARC vs ORC ... Read more >>

BJU Int (BJU international)
[2020, 125(6):765-779]

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The clinical and financial implications of a decade of prostate biopsies in the NHS: analysis of Hospital Episode Statistics data 2008-2019.

Ashwin Sunil Tamhankar, Omar El-Taji, Nikhil Vasdev, Charlotte Foley, Rick Popert, Jim Adshead,

<h4>Objective</h4>To evaluate the clinical and financial implications of a decade of prostate biopsies performed in the UK National Health Service (NHS) through the transrectal (TR) vs the transperineal (TP) route.<h4>Methods</h4>We conducted an evaluation of the TR vs the TP biopsy approach in the context of 28 days post-procedure complications and readmissions. ... Read more >>

BJU Int (BJU international)
[2020, 126(1):133-141]

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Outcomes of the 2019 Novel Coronavirus in patients with or without a history of cancer - a multi-centre North London experience

Nalinie Joharatnam-Hogan, Daniel Hochhauser, Kai-Keen Shiu, Hannah Rush, Valerie Crolley, Emma Butcher, Anand Sharma, Aun Muhammad, Muhammad Anwar, Nikhil Vasdev, Ganna Kantser, Aramita Saha, Fharat Raja, John Bridgewater, Khurum Khan,

<h4>Background</h4> Four months after the first known case of the 2019 novel coronavirus disease (COVID-19), on the 11 th March 2020, the WHO declared the outbreak a pandemic and acknowledged the potential to overwhelm national healthcare systems. The high prevalence and associated healthcare, social and economic challenges of COVID-19 suggest ... Read more >>

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Is Non-Chlamydial Non-Gonococcal Urethritis Associated with Significant Clinical Complications in Men? A Systematic Review.

Cassandra E L Fairhead, Alexander Hampson, Louis Dwyer-Hemmings, Nikhil Vasdev,

Background:It is estimated that between 50 and 89% of non-gonococcal urethritis is not caused by Chlamydia trachomatis. Associations between non-chlamydial non-gonococcal urethritis (NCNGU) with balanoposthitis, epididymo-orchitis and reactive arthritis have been suggested, but evidence to support these often-theoretical relationships is sparse and further investigation is called for. Concerns over increasing ... Read more >>

Curr Urol (Current urology)
[2020, 14(1):1-13]

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A Comparison of Urology Training Across Five Major English-Speaking Countries.

Rishi Naik, Indrajeet Mandal, Alexander Hampson, Rowan Casey, Nikhil Vasdev,

Background:Urology is a rapidly evolving specialty, although wide variations exist between training programs in different countries. We aimed to compare the status of urology training in 5 English-speaking countries. Materials and Methods:Features compared include the training pathway structure, training requirements, competition levels and the process of moving country for international ... Read more >>

Curr Urol (Current urology)
[2020, 14(1):14-21]

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Impact of sex on response to neoadjuvant chemotherapy in patients with bladder cancer.

David D'Andrea, Peter C Black, Homayoun Zargar, Kamran Zargar-Shoshtari, Sonja Zehetmayer, Adrian S Fairey, Laura S Mertens, Colin P Dinney, Maria C Mir, Laura-Maria Krabbe, Michael S Cookson, Niels-Erik Jacobsen, Jeffrey S Montgomery, Nikhil Vasdev, Evan Y Yu, Evanguelos Xylinas, Nicholas J Campain, Wassim Kassouf, Marc A Dall'Era, Jo-An Seah, Cesar E Ercole, Simon Horenblas, Srikala S Sridhar, John S McGrath, Jonathan Aning, Jonathan L Wright, Andrew C Thorpe, Todd M Morgan, Jeffrey M Holzbeierlein, Trinity J Bivalacqua, Scott North, Daniel A Barocas, Yair Lotan, Petros Grivas, Andrew J Stephenson, Jay B Shah, Bas W van Rhijn, Siamak Daneshmand, Philippe E Spiess, Shahrokh F Shariat,

OBJECTIVE:To assess the effect of patient's sex on response to neoadjuvant chemotherapy (NAC) in patients with clinically nonmetastatic muscle-invasive bladder cancer (MIBC). METHODS:Complete pathologic response, defined as ypT0N0 at radical cystectomy, and downstaging were evaluated using sex-adjusted univariable and multivariable logistic regression modeling. We used interaction terms to account for ... Read more >>

Urol Oncol (Urologic oncology)
[2020, 38(7):639.e1-639.e9]

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Robot-assisted laparoscopic prostatectomy: How can we get better?

Nicolas Omorphos, Nikhil Vasdev,

Asian J Urol (Asian journal of urology)
[2020, 7(2):177-178]

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Does neuroendocrine like tumor pathology impact neoadjuvant chemotherapy response precystectomy.

Anand Sharma, Nikhil Vasdev,

Urol Oncol (Urologic oncology)
[2020, 38(5):555]

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Incidental Lymphoplasmacytic Lymphoma Diagnosed Following Robotic-Assisted Laparoscopic Prostatectomy for Prostate Cancer.

Omar El-Taji, Altan Omer, Abdullah Al-Mitwalli A, Samita Agarwal, Anand Sharma, Nikhil Vasdev,

We report a case of prostatic lymphoma of the Walden-ström's macroglobulinemia subtype in a 64-year-old gentleman who underwent a robotic-assisted laparoscopic prostatectomy following lower urinary tract symptoms and high grade adenocarcinoma on transperineal prostate biopsy's. Histopathological and immunohistochemistry analysis at the time of surgery was consistent with a CD5-negative small ... Read more >>

Curr Urol (Current urology)
[2019, 13(3):166-168]

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The prognostic value of the neutrophil-to-lymphocyte ratio in patients with muscle-invasive bladder cancer treated with neoadjuvant chemotherapy and radical cystectomy.

Anna J Black, Homayoun Zargar, Kamran Zargar-Shoshtari, Adrian S Fairey, Laura S Mertens, Colin P Dinney, Maria C Mir, Laura-Maria Krabbe, Michael S Cookson, Niels-Erik Jacobsen, Joshua Griffin, Jeffrey S Montgomery, Nikhil Vasdev, Evan Y Yu, Evanguelos Xylinas, Nicholas J Campain, Wassim Kassouf, Marc A Dall'Era, Jo-An Seah, Cesar E Ercole, Simon Horenblas, John S McGrath, Jonathan Aning, Shahrokh F Shariat, Jonathan L Wright, Andrew C Thorpe, Todd M Morgan, Jeff M Holzbeierlein, Trinity J Bivalacqua, Scott North, Daniel A Barocas, Yair Lotan, Petros Grivas, Andrew J Stephenson, Jay B Shah, Bas W van Rhijn, Philippe E Spiess, Siamak Daneshmand, Srikala S Sridhar, Peter C Black,

<h4>Introduction</h4>The neutrophil-to-lymphocyte ratio (NLR) is an attractive marker because it is derived from routine bloodwork. NLR has shown promise as a prognostic factor in muscle invasive bladder cancer (MIBC) but its value in patients receiving neoadjuvant chemotherapy (NAC) before radical cystectomy (RC) is not yet established. Since NLR is related ... Read more >>

Urol Oncol (Urologic oncology)
[2020, 38(1):3.e17-3.e27]

Cited: 1 time

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The role of extended venous thromboembolism prophylaxis for major urological cancer operations.

Rishi Naik, Indrajeet Mandal, Alexander Hampson, Tim Lane, Jim Adshead, Bhavan Prasad Rai, Nikhil Vasdev,

<h4>Objectives</h4>Venous thromboembolism (VTE), consisting of both pulmonary embolism (PE) and deep vein thromboses (DVT), remains a well-recognised complication of major urological cancer surgery. Several international guidelines recommend extended thromboprophylaxis (ETP) with LMWH, whereby the period of delivery is extended to the post-discharge period, where the majority of VTE occurs. In ... Read more >>

BJU Int (BJU international)
[2019, 124(6):935-944]

Cited: 0 times

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Somatic Transformation in Metastatic Testicular Germ Cell Tumours - A Different Disease Entity.

Anand Sharma, Constantine Alifrangis, Marina Milic, Marcia Hall, Nikhil Vasdev, Peter Wilson, Andrew Gogbashian, David Hrouda, Daniel Berney, Jonathan Shamash,

<h4>Background/aim</h4>The occurrence of somatic transformation in germ cell tumour (GCT) is rare, with increased incidence in teratomatous tumours. The aim of this study was to understand the clinical outcomes of patients with metastatic GCT with somatic transformation.<h4>Materials and methods</h4>A retrospective study was conducted in two tertiary cancer centres in London. ... Read more >>

Anticancer Res (Anticancer research)
[2019, 39(9):4911-4916]

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Radical cystectomy complications and perioperative mortality.

Alex Hampson, Amy Vincent, Prokar Dasgupta, Nikhil Vasdev,

BJU Int (BJU international)
[2019, 124(1):3-4]

Cited: 0 times

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Robotic versus open radical cystectomy for bladder cancer in adults.

Bhavan Prasad Rai, Jasper Bondad, Nikhil Vasdev, Jim Adshead, Tim Lane, Kamran Ahmed, Mohammed S Khan, Prokar Dasgupta, Khurshid Guru, Piotr L Chlosta, Omar M Aboumarzouk,

<h4>Background</h4>It has been suggested that in comparison with open radical cystectomy, robotic-assisted radical cystectomy results in less blood loss, shorter convalescence, and fewer complications with equivalent short-term oncological and functional outcomes; however, uncertainty remains as to the magnitude of these benefits.<h4>Objectives</h4>To assess the effects of robotic-assisted radical cystectomy versus open ... Read more >>

Cochrane Database Syst Rev (The Cochrane database of systematic reviews)
[2019, 4:CD011903]

Cited: 5 times

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Detection rates of recurrent prostate cancer: 68Gallium (Ga)-labelled prostate-specific membrane antigen versus choline PET/CT scans. A systematic review.

Masood Moghul, Bhaskar Somani, Tim Lane, Nikhil Vasdev, Brian Chaplin, Clive Peedell, Gokul Vignesh KandaSwamy, Bhavan Prasad Rai,

<h4>Background</h4>The aim of this work was to assess the use of prostate-specific membrane antigen (PSMA)-labelled radiotracers in detecting the recurrence of prostate cancer. PSMA is thought to have higher detection rates when utilized in positron emission tomography (PET)/computed tomography (CT) scans, particularly at lower prostate-specific antigen (PSA) levels, compared with ... Read more >>

Ther Adv Urol (Therapeutic advances in urology)
[2019, 11:1756287218815793]

Cited: 6 times

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