Full Text Journal Articles by
Author Nihal Ahmad

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Dietary Phytochemicals in Zinc Homeostasis: A Strategy for Prostate Cancer Management.

Chandra K Singh, Gagan Chhabra, Arth Patel, Hao Chang, Nihal Ahmad,

Studies have suggested an important role of the trace element zinc (Zn) in prostate biology and functions. Zn has been shown to exist in very high concentrations in the healthy prostate and is important for several prostatic functions. In prostate cancer (PCa), Zn levels are significantly decreased and inversely correlated ... Read more >>

Nutrients (Nutrients)
[2021, 13(6):]

Cited: 0 times

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A randomized, double-blind, dose-ranging, pilot trial of piperine with resveratrol on the effects on serum levels of resveratrol.

Howard H Bailey, Jeremy J Johnson, Taja Lozar, Cameron O Scarlett, Barbara W Wollmer, KyungMann Kim, Thomas Havinghurst, Nihal Ahmad,

Resveratrol (3,4,5-trihydroxystilbene) is a naturally occurring phytoalexin with purported health-promoting effects, but with limited oral bioavailability. Our prior murine modeling research observed enhanced resveratrol bioavailability with piperine co-administration. In this study, single-dose pharmacokinetics of resveratrol with or without piperine and the associated toxicities were studied on a cohort of healthy ... Read more >>

Eur J Cancer Prev (European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP))
[2021, 30(3):285-290]

Cited: 0 times

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Genetic Manipulation of Sirtuin 3 Causes Alterations of Key Metabolic Regulators in Melanoma.

Chandra K Singh, Jasmine George, Gagan Chhabra, Minakshi Nihal, Hao Chang, Nihal Ahmad,

The mitochondrial sirtuin SIRT3 plays key roles in cellular metabolism and energy production, which makes it an obvious target for the management of cancer, including melanoma. Previously, we have demonstrated that SIRT3 was constitutively upregulated in human melanoma and its inhibition resulted in anti-proliferative effects <i>in vitro</i> in human melanoma ... Read more >>

Front Oncol (Frontiers in oncology)
[2021, 11:676077]

Cited: 0 times

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Recent Advancements on Immunomodulatory Mechanisms of Resveratrol in Tumor Microenvironment.

Gagan Chhabra, Chandra K Singh, Deeba Amiri, Neha Akula, Nihal Ahmad,

Immunomodulation of the tumor microenvironment is emerging as an important area of research for the treatment of cancer patients. Several synthetic and natural agents are being investigated for their ability to enhance the immunogenic responses of immune cells present in the tumor microenvironment to impede tumor cell growth and dissemination. ... Read more >>

Molecules (Molecules (Basel, Switzerland))
[2021, 26(5):]

Cited: 1 time

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Role of Polo-Like Kinase 4 (PLK4) in Epithelial Cancers and Recent Progress in its Small Molecule Targeting for Cancer Management.

Debra R Garvey, Gagan Chhabra, Mary A Ndiaye, Nihal Ahmad,

The polo-like kinases (PLKs) are a family of serine/threonine kinases traditionally linked to cell-cycle regulation. A structurally unique member of this family, PLK4, has been shown to regulate centriole duplication during the cell cycle via interactions with a variety of centrosomal proteins. Recent findings suggest that PLK4 is overexpressed in ... Read more >>

Mol Cancer Ther (Molecular cancer therapeutics)
[2021, 20(4):632-640]

Cited: 1 time

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PLK1 and NOTCH Positively Correlate in Melanoma and Their Combined Inhibition Results in Synergistic Modulations of Key Melanoma Pathways.

Shengqin Su, Gagan Chhabra, Mary A Ndiaye, Chandra K Singh, Ting Ye, Wei Huang, Colin N Dewey, Vijayasaradhi Setaluri, Nihal Ahmad,

Melanoma is one of the most serious forms of skin cancer, and its increasing incidence coupled with nonlasting therapeutic options for metastatic disease highlights the need for additional novel approaches for its management. In this study, we determined the potential interactions between polo-like kinase 1 (PLK1, a serine/threonine kinase involved ... Read more >>

Mol Cancer Ther (Molecular cancer therapeutics)
[2021, 20(1):161-172]

Cited: 0 times

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Combined Inhibition of Specific Sirtuins as a Potential Strategy to Inhibit Melanoma Growth.

Chandra K Singh, Jennifer E Panackal, Sarah Siddiqui, Nihal Ahmad, Minakshi Nihal,

Front Oncol (Frontiers in oncology)
[2020, 10:591972]

Cited: 3 times

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Quercetin-Resveratrol Combination for Prostate Cancer Management in TRAMP Mice.

Chandra K Singh, Gagan Chhabra, Mary A Ndiaye, Imtiaz A Siddiqui, Jennifer E Panackal, Charlotte A Mintie, Nihal Ahmad,

Prostate Cancer (PCa) is a leading cause of cancer-related morbidity and mortality in men. Therefore, novel mechanistically-driven approaches are needed for PCa management. Here, we determined the effects of grape antioxidants quercetin and/or resveratrol (60 and 600 mg/kg, respectively, in diet) against PCa in Transgenic Adenocarcinoma of Mouse Prostate (TRAMP)-model ... Read more >>

Cancers (Basel) (Cancers)
[2020, 12(8):]

Cited: 3 times

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CRISPR/Cas9-mediated Knockout of SIRT6 Imparts Remarkable Antiproliferative Response in Human Melanoma Cells in vitro and in vivo.

Liz M Garcia-Peterson, Mary A Ndiaye, Gagan Chhabra, Chandra K Singh, Glorimar Guzmán-Pérez, Kenneth A Iczkowski, Nihal Ahmad,

Melanoma is one of the most aggressive, potentially fatal forms of skin cancer and has been shown to be associated with solar ultraviolet radiation-dependent initiation and progression. Despite remarkable recent advances with targeted and immune therapeutics, lasting and recurrence-free survival remain significant concerns. Therefore, additional novel mechanism-based approaches are needed ... Read more >>

Photochem Photobiol (Photochemistry and photobiology)
[2020, 96(6):1314-1320]

Cited: 2 times

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Protective Effects of Dietary Grape on UVB-Mediated Cutaneous Damages and Skin Tumorigenesis in SKH-1 Mice.

Charlotte A Mintie, Anna K Musarra, Chandra K Singh, Mary A Ndiaye, Ruth Sullivan, Jens C Eickhoff, Nihal Ahmad,

Non-melanoma skin cancers (NMSCs) are the most diagnosed cancers in the US and occur more frequently in males. We previously demonstrated chemoprotective effects of dietary grape powder (GP) against UVB-mediated skin tumorigenesis in female SKH-1 mice. To expand on this, here, we determined the effects of GP in a short-term ... Read more >>

Cancers (Basel) (Cancers)
[2020, 12(7):]

Cited: 2 times

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Mitochondrial Sirtuins in Skin and Skin Cancers.

Shengqin Su, Mary Ndiaye, Chandra K Singh, Nihal Ahmad,

Mammalian sirtuins (SIRTs 1-7) are a family of NAD+-dependent deacetylases with distinct subcellular localization and biological functions that regulate various important cellular processes. Among these, SIRTs -3, -4 and -5 are located in the mitochondria and have been implicated in caloric restriction, oxidative stress, aging and various human diseases. Emerging ... Read more >>

Photochem Photobiol (Photochemistry and photobiology)
[2020, 96(5):973-980]

Cited: 2 times

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The sirtuin 6: An overture in skin cancer.

Liz M Garcia-Peterson, Glorimar Guzmán-Pérez, Cassandre R Krier, Nihal Ahmad,

In the recent past, the sirtuins have been under intense investigation for their roles in biology and disease, including cancer. The sirtuin SIRT6 is comparatively a lesser studied member of this family of seven proteins. Like certain other sirtuins, SIRT6 is emerging to have an oncogenic function as well as ... Read more >>

Exp Dermatol (Experimental dermatology)
[2020, 29(2):124-135]

Cited: 6 times

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Whole Fruit Phytochemicals Combating Skin Damage and Carcinogenesis.

Charlotte A Mintie, Chandra K Singh, Nihal Ahmad,

Skin is arguably the largest organ of the body and is continuously subjected to intrinsic, extrinsic, and environmental stresses. Therefore, skin developed elaborate mechanisms to maintain homeostasis, including antioxidant, antiinflammatory, and DNA damage repair capabilities. However, repeated and excessive stresses can overwhelm these systems, causing serious cutaneous damages, including skin ... Read more >>

Transl Oncol (Translational oncology)
[2020, 13(2):146-156]

Cited: 4 times

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4'-Bromo-resveratrol, a dual Sirtuin-1 and Sirtuin-3 inhibitor, inhibits melanoma cell growth through mitochondrial metabolic reprogramming.

Jasmine George, Minakshi Nihal, Chandra K Singh, Nihal Ahmad,

Sirtuin-1 and -3 (SIRT1 and SIRT3) are important nicotinamide adenine dinucleotide (NAD<sup>+</sup> )-dependent deacetylases known to regulate a variety of cellular functions. Studies have shown that SIRT1 and SIRT3 were overexpressed in human melanoma cells and tissues and their inhibition resulted in a significant antiproliferative response in human melanoma cells ... Read more >>

Mol Carcinog (Molecular carcinogenesis)
[2019, 58(10):1876-1885]

Cited: 8 times

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Inhibition of enhancer of zeste homolog 2 (EZH2) overcomes enzalutamide resistance in castration-resistant prostate cancer.

Yunfeng Bai, Zhuangzhuang Zhang, Lijun Cheng, Ruixin Wang, Xiaoliang Chen, Yifan Kong, Feng Feng, Nihal Ahmad, Lang Li, Xiaoqi Liu,

Enzalutamide, approved by the United States Food and Drug Administration in 2018 for the management of metastatic castration-resistant prostate cancer (CRPC), is an androgen receptor (AR) inhibitor. It blocks androgen binding to the AR, AR nuclear translocation, and AR-mediated DNA binding. Unfortunately, a considerable proportion of tumors eventually develop resistance ... Read more >>

J Biol Chem (The Journal of biological chemistry)
[2019, 294(25):9911-9923]

Cited: 13 times

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Chemoprotective Effects of Dietary Grape Powder on UVB Radiation-Mediated Skin Carcinogenesis in SKH-1 Hairless Mice.

Chandra K Singh, Charlotte A Mintie, Mary A Ndiaye, Gagan Chhabra, Panshak P Dakup, Ting Ye, Menggang Yu, Nihal Ahmad,

Skin cancer is the most frequently diagnosed cancer in the United States, and solar UVR is an established causative factor for approximately 90% of these cases. Despite efforts aimed at UV protection, including use of sunscreen and clothing, annual cases of skin cancer continue to rise. Here, we report that ... Read more >>

J Invest Dermatol (The Journal of investigative dermatology)
[2019, 139(3):552-561]

Cited: 4 times

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Effects and Mechanism of Nicotinamide Against UVA- and/or UVB-mediated DNA Damages in Normal Melanocytes.

Gagan Chhabra, Debra R Garvey, Chandra K Singh, Charlotte A Mintie, Nihal Ahmad,

Melanoma incidences are increasing rapidly, and ultraviolet (UV) radiation from the sun is believed to be its major contributing factor. UV exposure causes DNA damage in skin which may initiate cutaneous skin cancers including melanoma. Melanoma arises from melanocytes, the melanin-producing skin cells, following genetic dysregulations resulting into hyperproliferative phenotype ... Read more >>

Photochem Photobiol (Photochemistry and photobiology)
[2019, 95(1):331-337]

Cited: 4 times

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Prostate cancer chemoprevention by natural agents: Clinical evidence and potential implications.

Gagan Chhabra, Chandra K Singh, Mary Ann Ndiaye, Samantha Fedorowicz, Arielle Molot, Nihal Ahmad,

Prostate cancer (PCa) is the most common non-skin cancer and the second leading cause of cancer-related deaths in American men. Due to its long latency period, PCa is considered as an ideal cancer type for chemopreventive interventions. Chemopreventive agents include various natural or synthetic agents that prevent or delay cancer ... Read more >>

Cancer Lett (Cancer letters)
[2018, 422:9-18]

Cited: 9 times

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Centriole Overduplication is the Predominant Mechanism Leading to Centrosome Amplification in Melanoma.

Ryan A Denu, Maria Shabbir, Minakshi Nihal, Chandra K Singh, B Jack Longley, Mark E Burkard, Nihal Ahmad,

Centrosome amplification (CA) is common in cancer and can arise by centriole overduplication or by cell doubling events, including the failure of cell division and cell-cell fusion. To assess the relative contributions of these two mechanisms, the number of centrosomes with mature/mother centrioles was examined by immunofluorescence in a tissue ... Read more >>

Mol Cancer Res (Molecular cancer research : MCR)
[2018, 16(3):517-527]

Cited: 19 times

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SIRT6 histone deacetylase functions as a potential oncogene in human melanoma.

Liz Mariely Garcia-Peterson, Mary Ann Ndiaye, Chandra K Singh, Gagan Chhabra, Wei Huang, Nihal Ahmad,

Melanoma is an aggressive skin cancer that can rapidly metastasize to become fatal, if not diagnosed early. Despite recent therapeutic advances, management of melanoma remains difficult. Therefore, novel molecular targets and strategies are required to manage this neoplasm. This study was undertaken to determine the role of the sirtuin SIRT6 ... Read more >>

Genes Cancer (Genes & cancer)
[2017, 8(9-10):701-712]

Cited: 19 times

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The Role of Sirtuins in Antioxidant and Redox Signaling.

Chandra K Singh, Gagan Chhabra, Mary Ann Ndiaye, Liz Mariely Garcia-Peterson, Nicholas J Mack, Nihal Ahmad,

<h4>Significance</h4>Antioxidant and redox signaling (ARS) events are regulated by critical molecules that modulate antioxidants, reactive oxygen species (ROS) or reactive nitrogen species (RNS), and/or oxidative stress within the cell. Imbalances in these molecules can disturb cellular functions to become pathogenic. Sirtuins serve as important regulators of ARS in cells. Recent ... Read more >>

Antioxid Redox Signal (Antioxidants & redox signaling)
[2018, 28(8):643-661]

Cited: 96 times

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Sirtuins in Skin and Skin Cancers.

Liz Mariely Garcia-Peterson, Melissa Jean Wilking-Busch, Mary Ann Ndiaye, Christine Gaby Azer Philippe, Vijayasaradhi Setaluri, Nihal Ahmad,

The sirtuins are a family of proteins that comprise class III of the histone deacetylases. These NAD+-dependent proteins have been found to be intricately involved in a variety of important and skin-relevant cellular functions and processes, including aging, UV damage response, oxidative stress, and wound repair. In addition, recent research ... Read more >>

Skin Pharmacol Physiol (Skin pharmacology and physiology)
[2017, 30(4):216-224]

Cited: 11 times

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Introduction.

Nihal Ahmad,

Photochem Photobiol (Photochemistry and photobiology)
[2017, 93(4):911]

Cited: 0 times

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Plk1 Phosphorylation of Mre11 Antagonizes the DNA Damage Response.

Zhiguo Li, Jie Li, Yifan Kong, Shan Yan, Nihal Ahmad, Xiaoqi Liu,

The mitotic kinase Plk1 contributes to the DNA damage response (DDR) by targeting multiple factors downstream of the core responder kinase ATM/ATR. In this study, we show that Polo-like kinase 1 (Plk1) also phosphorylates key factors upstream of ATM/ATR and regulates their DDR-related functions. Plk1 phosphorylated Mre11, a component of ... Read more >>

Cancer Res (Cancer research)
[2017, 77(12):3169-3180]

Cited: 16 times

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DNA Damage Response-Independent Role for MDC1 in Maintaining Genomic Stability.

Zhiguo Li, Chen Shao, Yifan Kong, Colin Carlock, Nihal Ahmad, Xiaoqi Liu,

MDC1 is a central player in checkpoint activation and subsequent DNA repair following DNA damage. Although MDC1 has been studied extensively, many of its known functions, to date, pertain to the DNA damage response (DDR) pathway. Herein we report a novel function of phosphorylated MDC1 that is independent of ATM ... Read more >>

Mol Cell Biol (Molecular and cellular biology)
[2017, 37(9):]

Cited: 3 times

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