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Author Nigel Curtis

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Reduced seroconversion in children compared to adults with mild COVID-19

Zheng Quan Toh, Jeremy Anderson, Nadia Mazarakis, Melanie Neeland, Rachel Higgins, Karin Rautenbacher, Kate Dohle, Jill Nguyen, Isabella Overmars, Celeste Donato, Sohinee Sarkar, Vanessa Clifford, Andrew Daley, Suellen Nicholson, Francesca Mordant, Kanta Subbarao, David Burgner, Nigel Curtis, Julie Bines, Sarah McNab, Andrew Steer, Kim Mulholland, Shidan Tosif, Nigel Crawford, Daniel Pellicci, Lien Anh Ha Do, Paul Licciardi,

<h4>Importance</h4> The immune response in children with SARS-CoV-2 infection is not well understood. <h4>Objective</h4> To compare seroconversion in children and adults with non-hospitalized (mild) SARS-CoV-2 infection and to understand the factors that influence this. <h4>Design</h4> Participants were part of a household cohort study of SARS-CoV-2 infection. Weekly nasopharyngeal/throat swabs and ... Read more >>

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Management of Bacille Calmette-Guérin Lymphadenitis and Abscess in Immunocompetent Children: A Systematic Review.

Paola Villanueva, Laure F Pittet, Nigel Curtis,

<h4>Background</h4>There is no consensus on managing common adverse reactions to Bacille Calmette-Guérin (BCG) vaccination. We systematically reviewed the management of BCG-associated regional lymphadenitis and injection site abscess in immunocompetent individuals.<h4>Methods</h4>Searches of Medline, Embase and PubMed were done until November 2020. Randomized controlled trials (RCTs) and cohort studies that compared management ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2021, 40(11):1037-1045]

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Infliximab for Paradoxical Reactions in Pediatric Central Nervous System Tuberculosis.

Yara-Natalie Abo, Nigel Curtis, Joshua Osowicki, Gabrielle Haeusler, Rachael Purcell, Seilesh Kadambari, Matthias De Wachter, Koen Vanden Driessche, Sven Dekeyzer, Lee Coleman, Nigel Crawford, Steve Graham, Ben Marais, Amanda Gwee,

Paradoxical reactions in central nervous system tuberculosis (CNS-TB) are associated with significant morbidity and mortality. We describe 4 HIV-uninfected children treated for CNS-TB with severe paradoxical reactions unresponsive to corticosteroids. All made recovery after treatment with infliximab, highlighting the safety and effectiveness of infliximab for this complication, and need for ... Read more >>

J Pediatric Infect Dis Soc (Journal of the Pediatric Infectious Diseases Society)
[2021, :]

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Neonatal Bacille Calmette-Guérin Vaccination and Infections in the First Year of Life: The MIS BAIR Randomized Controlled Trial.

Nicole L Messina, Laure F Pittet, Kaya Gardiner, Bridget Freyne, Kate L Francis, Christel Zufferey, Veronica Abruzzo, Clare Morrison, Katrina J Allen, Katie L Flanagan, Anne-Louise Ponsonby, Roy Robins-Browne, Frank Shann, Mike South, Peter Vuillermin, Susan Donath, Dan Casalaz, Nigel Curtis,

<h4>Background</h4>Bacille Calmette-Guérin (BCG) vaccination has beneficial off-target effects that may include protecting against non-mycobacterial infectious diseases. We aimed to determine whether neonatal BCG vaccination reduces lower respiratory tract infections (LRTI) in infants in the Melbourne Infant Study: BCG for Allergy and Infection Reduction (MIS BAIR) trial.<h4>Methods</h4>In this investigator-blinded trial, neonates ... Read more >>

J Infect Dis (The Journal of infectious diseases)
[2021, 224(7):1115-1127]

Cited: 1 time

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Factors affecting antibody responses to immunizations in infants born to women immunized against pertussis in pregnancy and unimmunized women: Individual-Participant Data Meta-analysis.

Bahaa Abu-Raya, Kirsten Maertens, Flor M Munoz, Petra Zimmermann, Nigel Curtis, Scott A Halperin, Nynke Rots, Daan Barug, Beth Holder, Thomas F Rice, Beate Kampmann, Elke Leuridan, Manish Sadarangani,

<h4>Background</h4>Exploring factors that affect immune responses to immunizations in infants born to women immunized with tetanus-diphtheria-acellular-pertussis (Tdap) in pregnancy compared with unimmunized women is important in designing immunization programs.<h4>Methods</h4>Individual-participant data meta-analysis of 8 studies reporting post-immunization immunoglobulin G (IgG) levels to vaccine antigens in infants born to either women immunized ... Read more >>

Vaccine (Vaccine)
[2021, 39(44):6545-6552]

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Prevention of infant eczema by neonatal bacille Calmette-Guérin vaccination: The MIS BAIR randomized controlled trial.

Laure F Pittet, Nicole L Messina, Kaya Gardiner, Bridget Freyne, Veronica Abruzzo, Kate L Francis, Clare Morrison, Christel Zufferey, Peter Vuillermin, Katrina J Allen, Anne-Louise Ponsonby, Roy Robins-Browne, Frank Shann, Katie L Flanagan, Rod Phillips, Susan Donath, Dan Casalaz, Nigel Curtis,

<h4>Background</h4>Bacille Calmette-Guérin (BCG) vaccine could play a role in counteracting the rising prevalence of atopic diseases, through its beneficial off-target effects. We aimed to determine whether neonatal BCG vaccination reduces the incidence of eczema in infants.<h4>Methods</h4>Randomized controlled trial with 1272 infants allocated to receive BCG-Denmark or no BCG at birth. ... Read more >>

Allergy (Allergy)
[2021, :]

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Author Correction: Trained immunity, tolerance, priming and differentiation: distinct immunological processes.

Maziar Divangahi, Peter Aaby, Shabaana Abdul Khader, Luis B Barreiro, Siroon Bekkering, Triantafyllos Chavakis, Reinout van Crevel, Nigel Curtis, Andrew R DiNardo, Jorge Dominguez-Andres, Raphael Duivenvoorden, Stephanie Fanucchi, Zahi Fayad, Elaine Fuchs, Melanie Hamon, Kate L Jeffrey, Nargis Khan, Leo A B Joosten, Eva Kaufmann, Eicke Latz, Giuseppe Matarese, Jos W M van der Meer, Musa Mhlanga, Simone J C F M Moorlag, Willem J M Mulder, Shruti Naik, Boris Novakovic, Luke O'Neill, Jordi Ochando, Keiko Ozato, Niels P Riksen, Robert Sauerwein, Edward R Sherwood, Andreas Schlitzer, Joachim L Schultze, Michael H Sieweke, Christine Stabell Benn, Henk Stunnenberg, Joseph Sun, Frank L van de Veerdonk, Sebastian Weis, David L Williams, Ramnik Xavier, Mihai G Netea,

Nat Immunol (Nature immunology)
[2021, 22(7):928]

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Saliva testing for severe acute respiratory syndrome coronavirus 2 in children.

Vanessa Clifford, Nigel Curtis,

Clin Microbiol Infect (Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases)
[2021, 27(9):1199-1201]

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Candidemia in Children: A 16-year Longitudinal Epidemiologic Study.

Eloise J Silvester, Melissa M Y Watanabe, Laure F Pittet, Alison Boast, Penelope A Bryant, Gabrielle M Haeusler, Andrew J Daley, Nigel Curtis, Amanda Gwee,

<h4>Background</h4>Candida species are the most common cause of systemic fungal infections in children. Risk factors for candidemia vary in different patient populations, posing challenges for clinical prediction of infection. We describe the epidemiology and clinical disease of candidemia in children admitted to a tertiary pediatric hospital.<h4>Methods</h4>Retrospective audit of children ≤18 ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2021, 40(6):537-543]

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Bacterial Meningitis in the Absence of Pleocytosis in Children: A Systematic Review.

Petra Zimmermann, Nigel Curtis,

One of the main features of bacterial meningitis is pleocytosis. However, when children with meningitis present within hours of onset of symptoms, there is the possibility that the meninges are not yet sufficiently inflamed to lead to a raised cerebrospinal fluid (CSF) white blood cell count. A systematic search was ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2021, 40(6):582-587]

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Postnatal Exposure to Herpes Simplex Virus: To Treat or Not to Treat?

Laure F Pittet, Nigel Curtis,

Neonatal herpes simplex virus (HSV) infection carries significant morbidity and mortality. In contrast to perinatal exposure, there are no clear guidelines for the management of postnatal HSV exposure. This review focuses on the risk of HSV infection following postnatal exposure and suggests an approach to management. While many infants are ... Read more >>

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2021, 40(5S):S16-S21]

Cited: 1 time

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Correlation of Vaccine Responses.

Petra Zimmermann, Nicole Ritz, Kirsten P Perrett, Nicole L Messina, Fiona R M van der Klis, Nigel Curtis,

<h4>Introduction</h4>The humoral response to vaccinations varies widely between individuals. There is no data available on the correlation between responses to different vaccines. In this study, we investigated the correlation of antibody responses between routine vaccine antigens in infants.<h4>Methods</h4>One and seven months after the 6-month vaccinations and one month after the ... Read more >>

Front Immunol (Frontiers in immunology)
[2021, 12:646677]

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The safety of BCG revaccination: A systematic review.

Samantha Bannister, Eva Sudbury, Paola Villanueva, Kirsten Perrett, Nigel Curtis,

<h4>Introduction</h4>Revaccination with Bacillus Calmette-Guérin (BCG) vaccine is not generally recommended due to a lack of proven efficacy of repeat doses for protection against tuberculosis. However, there is a growing interest in the use of BCG vaccine for its 'off-target' effects which might involve revaccination. We did a systematic review of ... Read more >>

Vaccine (Vaccine)
[2021, 39(20):2736-2745]

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Innate cell profiles during the acute and convalescent phase of SARS-CoV-2 infection in children.

Melanie R Neeland, Samantha Bannister, Vanessa Clifford, Kate Dohle, Kim Mulholland, Philip Sutton, Nigel Curtis, Andrew C Steer, David P Burgner, Nigel W Crawford, Shidan Tosif, Richard Saffery,

Children have mild severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) confirmed disease (COVID-19) compared to adults and the immunological mechanisms underlying this difference remain unclear. Here, we report acute and convalescent innate immune responses in 48 children and 70 adults infected with, or exposed to, SARS-CoV-2. We find clinically mild ... Read more >>

Nat Commun (Nature communications)
[2021, 12(1):1084]

Cited: 14 times

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Refractory thoracic conidiobolomycosis treated with mepolizumab immunotherapy.

Daniel K Yeoh, Thomas Saunders, Coen Butters, David Burgner, Penelope A Bryant, Timothy M Cain, Jessica Ng, Amanda Gwee, Andrew J Daley, Theresa Cole, Nigel Curtis, Joanne Harrison, Joshua Osowicki,

J Allergy Clin Immunol Pract (The journal of allergy and clinical immunology. In practice)
[2021, 9(6):2527-2530.e6]

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Trained immunity, tolerance, priming and differentiation: distinct immunological processes.

Maziar Divangahi, Peter Aaby, Shabaana Abdul Khader, Luis B Barreiro, Siroon Bekkering, Triantafyllos Chavakis, Reinout van Crevel, Nigel Curtis, Andrew R DiNardo, Jorge Dominguez-Andres, Raphael Duivenvoorden, Stephanie Fanucchi, Zahi Fayad, Elaine Fuchs, Melanie Hamon, Kate L Jeffrey, Nargis Khan, Leo A B Joosten, Eva Kaufmann, Eicke Latz, Giuseppe Matarese, Jos W M van der Meer, Musa Mhlanga, Simone J C F M Moorlag, Willem J M Mulder, Shruti Naik, Boris Novakovic, Luke O'Neill, Jordi Ochando, Keiko Ozato, Niels P Riksen, Robert Sauerwein, Edward R Sherwood, Andreas Schlitzer, Joachim L Schultze, Michael H Sieweke, Christine Stabell Benn, Henk Stunnenberg, Joseph Sun, Frank L van de Veerdonk, Sebastian Weis, David L Williams, Ramnik Xavier, Mihai G Netea,

Nat Immunol (Nature immunology)
[2021, 22(1):2-6]

Cited: 14 times

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Mycobacterium ulcerans-specific immune response after immunisation with bacillus Calmette-Guérin (BCG) vaccine.

Laure F Pittet, Marc Tebruegge, Binita Dutta, Susan Donath, Nicole Messina, Dan Casalaz, Willem A Hanekom, Warwick J Britton, Roy Robins-Browne, Nigel Curtis, Nicole Ritz, ,

<h4>Background</h4>Bacillus Calmette-Guérin (BCG) vaccine provides partial protection against Buruli ulcer caused by Mycobacterium ulcerans in epidemiological studies. This study aimed to quantify M. ulcerans-specific immune responses induced by BCG immunisation.<h4>Methods</h4>Intracellular cytokine analysis of in-vitro experiments done 10 weeks after BCG immunisation in 130 Australian infants randomised to one of three BCG ... Read more >>

Vaccine (Vaccine)
[2021, 39(4):652-657]

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Why is COVID-19 less severe in children? A review of the proposed mechanisms underlying the age-related difference in severity of SARS-CoV-2 infections.

Petra Zimmermann, Nigel Curtis,

In contrast to other respiratory viruses, children have less severe symptoms when infected with the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In this review, we discuss proposed hypotheses for the age-related difference in severity of coronavirus disease 2019 (COVID-19).Factors proposed to explain the difference in severity of COVID-19 ... Read more >>

Arch Dis Child (Archives of disease in childhood)
[2020, :]

Cited: 56 times

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Immune responses to SARS-CoV-2 in three children of parents with symptomatic COVID-19.

Shidan Tosif, Melanie R Neeland, Philip Sutton, Paul V Licciardi, Sohinee Sarkar, Kevin J Selva, Lien Anh Ha Do, Celeste Donato, Zheng Quan Toh, Rachel Higgins, Carolien Van de Sandt, Melissa M Lemke, Christina Y Lee, Suzanne K Shoffner, Katie L Flanagan, Kelly B Arnold, Francesca L Mordant, Kim Mulholland, Julie Bines, Kate Dohle, Daniel G Pellicci, Nigel Curtis, Sarah McNab, Andrew Steer, Richard Saffery, Kanta Subbarao, Amy W Chung, Katherine Kedzierska, David P Burgner, Nigel W Crawford,

Compared to adults, children with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have predominantly mild or asymptomatic infections, but the underlying immunological differences remain unclear. Here, we describe clinical features, virology, longitudinal cellular, and cytokine immune profile, SARS-CoV-2-specific serology and salivary antibody responses in a family of two parents with ... Read more >>

Nat Commun (Nature communications)
[2020, 11(1):5703]

Cited: 25 times

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Mycobacterium tuberculosis-specific cytokine biomarkers to differentiate active TB and LTBI: A systematic review.

Eva L Sudbury, Vanessa Clifford, Nicole L Messina, Rinn Song, Nigel Curtis,

<h4>Objectives</h4>New tests are needed to overcome the limitations of existing immunodiagnostic tests for tuberculosis (TB) infection, including their inability to differentiate between active TB and latent TB infection (LTBI). This review aimed to identify the most promising cytokine biomarkers for use as stage-specific markers of TB infection.<h4>Methods</h4>A systematic review was ... Read more >>

J Infect (The Journal of infection)
[2020, 81(6):873-881]

Cited: 4 times

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Does bacillus Calmette-Guérin vaccine prevent herpes simplex virus recurrences? A systematic review.

Laure F Pittet, Nigel Curtis,

Recurrent infections with herpes simplex virus (HSV) in the orofacial (cold sores), ocular or genital region are common and sometimes disabling, calling for an effective preventive intervention. The bacillus Calmette-Guérin (BCG) vaccine has beneficial off-target effects that might impact recurrence of HSV infections. In this systematic review, Medline, EMBASE, and ... Read more >>

Rev Med Virol (Reviews in medical virology)
[2021, 31(1):1-9]

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What time interval is needed between the administration of live attenuated vaccines?

Petra Zimmermann, Andrew J Pollard, Nigel Curtis,

Arch Dis Child (Archives of disease in childhood)
[2020, 105(12):1232-1235]

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BCG vaccination: An update on current Australian practices.

Jemma Wittner Taylor, Nigel Curtis, Justin Denholm,

<h4>Background</h4>The Bacille Calmette-Guérin (BCG) vaccine is primarily used to prevent tuberculosis (TB) infection and disease in settings with high TB incidence.<h4>Objective</h4>The aim of this review article is to describe the current uses of BCG vaccination in Australia, including the indications and contraindications, efficacy and other off-target effects, and the role of ... Read more >>

Aust J Gen Pract (Australian journal of general practice)
[2020, 49(10):651-655]

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Bacille Calmette Guérin (BCG) and new TB vaccines: Specific, cross-mycobacterial and off-target effects.

Nora Fritschi, Nigel Curtis, Nicole Ritz,

The Bacille Calmette Guérin (BCG) vaccine was developed over a century ago and has become one of the most used vaccines without undergoing a modern vaccine development life cycle. Despite this, the vaccine has protected many millions from severe and disseminated forms of tuberculosis (TB). In addition, BCG has cross-mycobacterial ... Read more >>

Paediatr Respir Rev (Paediatric respiratory reviews)
[2020, 36:57-64]

Cited: 1 time

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The impact of human single nucleotide polymorphisms on Bacillus Calmette-Guérin responses.

Nicole L Messina, Mihai G Netea, Nigel Curtis,

The influence of genetic variability on human immune responses has major implications for the understanding of disease mechanisms and host-pathogen interactions. Bacillus Calmette-Guérin (BCG) vaccine, which is given globally to protect against tuberculosis, has high variability in its protective efficacy against mycobacteria and its beneficial off-target (heterologous) effects. Single nucleotide ... Read more >>

Vaccine (Vaccine)
[2020, 38(40):6224-6235]

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