Full Text Journal Articles by
Author Nicole E Scharping

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IRF1 Inhibits Antitumor Immunity through the Upregulation of PD-L1 in the Tumor Cell.

Lulu Shao, Weizhou Hou, Nicole E Scharping, Frank P Vendetti, Rashmi Srivastava, Chandra Nath Roy, Ashley V Menk, Yiyang Wang, Joe-Marc Chauvin, Pooja Karukonda, Stephen H Thorne, Veit Hornung, Hassane M Zarour, Christopher J Bakkenist, Greg M Delgoffe, Saumendra N Sarkar,

Multiple studies have associated the transcription factor IRF1 with tumor-suppressive activities. Here, we report an opposite tumor cell-intrinsic function of IRF1 in promoting tumor growth. IRF1-deficient tumor cells showed reduced tumor growth in MC38 and CT26 colon carcinoma and B16 melanoma mouse models. This reduction in tumor growth was dependent ... Read more >>

Cancer Immunol Res (Cancer immunology research)
[2019, 7(8):1258-1266]

Cited: 0 times

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Early TCR Signaling Induces Rapid Aerobic Glycolysis Enabling Distinct Acute T Cell Effector Functions.

Ashley V Menk, Nicole E Scharping, Rebecca S Moreci, Xue Zeng, Cliff Guy, Sonia Salvatore, Heekyong Bae, Jianxin Xie, Howard A Young, Stacy Gelhaus Wendell, Greg M Delgoffe,

To fulfill bioenergetic demands of activation, T cells perform aerobic glycolysis, a process common to highly proliferative cells in which glucose is fermented into lactate rather than oxidized in mitochondria. However, the signaling events that initiate aerobic glycolysis in T cells remain unclear. We show T cell activation rapidly induces glycolysis independent of transcription, ... Read more >>

Cell Rep (Cell Reports)
[2018, 22(6):1509-1521]

Cited: 26 times

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Efficacy of PD-1 Blockade Is Potentiated by Metformin-Induced Reduction of Tumor Hypoxia.

Nicole E Scharping, Ashley V Menk, Ryan D Whetstone, Xue Zeng, Greg M Delgoffe,

Blockade of the coinhibitory checkpoint molecule PD-1 has emerged as an effective treatment for many cancers, resulting in remarkable responses. However, despite successes in the clinic, most patients do not respond to PD-1 blockade. Metabolic dysregulation is a common phenotype in cancer, but both patients and tumors are metabolically heterogeneous. ... Read more >>

Cancer Immunol Res (Cancer immunology research)
[2017, 5(1):9-16]

Cited: 48 times

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Tumor Microenvironment Metabolism: A New Checkpoint for Anti-Tumor Immunity.

Nicole E Scharping, Greg M Delgoffe,

When a T cell infiltrates a tumor, it is subjected to a variety of immunosuppressive and regulatory signals in the microenvironment. However, it is becoming increasingly clear that due to the proliferative and energetically-deregulated nature of tumor cells, T cells also operate at a metabolic disadvantage. The nutrient dearth of ... Read more >>

Vaccines (Basel) (Vaccines)
[2016, 4(4):]

Cited: 13 times

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The Tumor Microenvironment Represses T Cell Mitochondrial Biogenesis to Drive Intratumoral T Cell Metabolic Insufficiency and Dysfunction.

Nicole E Scharping, Ashley V Menk, Rebecca S Moreci, Ryan D Whetstone, Rebekah E Dadey, Simon C Watkins, Robert L Ferris, Greg M Delgoffe,

Immunity (Immunity)
[2016, 45(3):701-703]

Cited: 30 times

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Cutting Edge: BAFF Overexpression Reduces Atherosclerosis via TACI-Dependent B Cell Activation.

Shaun W Jackson, Nicole E Scharping, Holly M Jacobs, Shari Wang, Alan Chait, David J Rawlings,

Patients with systemic lupus erythematosus exhibit accelerated atherosclerosis, a chronic inflammatory disease of the arterial wall. The impact of B cells in atherosclerosis is controversial, with both protective and pathogenic roles described. For example, natural IgM binding conserved oxidized lipid epitopes protect against atherosclerosis, whereas anti-oxidized low-density lipoprotein (oxLDL) IgG ... Read more >>

J. Immunol. (Journal of immunology (Baltimore, Md. : 1950))
[2016, 197(12):4529-4534]

Cited: 9 times

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The Tumor Microenvironment Represses T Cell Mitochondrial Biogenesis to Drive Intratumoral T Cell Metabolic Insufficiency and Dysfunction.

Nicole E Scharping, Ashley V Menk, Rebecca S Moreci, Ryan D Whetstone, Rebekah E Dadey, Simon C Watkins, Robert L Ferris, Greg M Delgoffe,

Although tumor-specific T cells recognize cancer cells, they are often rendered dysfunctional due to an immunosuppressive microenvironment. Here we showed that T cells demonstrated persistent loss of mitochondrial function and mass when infiltrating murine and human tumors, an effect specific to the tumor microenvironment and not merely caused by activation. Tumor-infiltrating T cells showed ... Read more >>

Immunity (Immunity)
[2016, 45(2):374-388]

Cited: 79 times

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Cutting Edge: BAFF Promotes Autoantibody Production via TACI-Dependent Activation of Transitional B Cells.

Holly M Jacobs, Christopher D Thouvenel, Sarah Leach, Tanvi Arkatkar, Genita Metzler, Nicole E Scharping, Nikita S Kolhatkar, David J Rawlings, Shaun W Jackson,

Mice overexpressing B cell activating factor of the TNF family (BAFF) develop systemic autoimmunity characterized by class-switched anti-nuclear Abs. Transmembrane activator and CAML interactor (TACI) signals are critical for BAFF-mediated autoimmunity, but the B cell developmental subsets undergoing TACI-dependent activation in settings of excess BAFF remain unclear. We report that, ... Read more >>

J. Immunol. (Journal of immunology (Baltimore, Md. : 1950))
[2016, 196(9):3525-3531]

Cited: 18 times

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Metabolic insufficiency underlies intratumoral cytotoxic T cell dysfunction.

Tushar Gupta, Nicole E Scharping, Rebecca S Moreci, Greg M Delgoffe,

J Immunother Cancer (Journal for immunotherapy of cancer)
[2015, 3(Suppl 2):P399-P399]

Cited: 0 times

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B-cell intrinsic TLR7 signals promote depletion of the marginal zone in a murine model of Wiskott-Aldrich syndrome.

Nikita S Kolhatkar, Nicole E Scharping, Jenna M Sullivan, Holly M Jacobs, Marc A Schwartz, Socheath Khim, Luigi D Notarangelo, Adrian J Thrasher, David J Rawlings, Shaun W Jackson,

Patients with Wiskott-Aldrich syndrome (WAS) exhibit prominent defects in splenic marginal zone (MZ), resulting in abnormal T-cell-independent antibody responses and increased bacterial infections. B-cell-intrinsic deletion of the affected gene WAS protein (WASp) markedly reduces splenic MZ B cells, without impacting the rate of MZ B-cell development, suggesting that abnormal B-cell ... Read more >>

Eur. J. Immunol. (European journal of immunology)
[2015, 45(10):2773-2779]

Cited: 8 times

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