Full Text Journal Articles by
Author Nicole C Panarelli

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Reproducibility of AJCC Criteria for Classifying Deeply Invasive Colon Cancers Is Suboptimal for Consistent Cancer Staging.

Nicole C Panarelli, Suntrea T G Hammer, Jingmei Lin, Purva Gopal, ILKe Nalbantoglu, Lili Zhao, Jerome Cheng, Adam J Gersten, Jonathan B McHugh, Vinita Parkash, Elena Lucas, Maria Westerhoff,

The eighth edition of the American Joint Committee on Cancer (AJCC) Staging Manual attempts to address ambiguity in the pT category assignment for colon cancer from prior editions. Despite modifications, the distinction between the pT3 and pT4a categories continues to be a source of diagnostic confusion. In this study, we ... Read more >>

Am J Surg Pathol (The American journal of surgical pathology)
[2020, 44(10):1381-1388]

Cited: 0 times

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Features of endoscopic procedure site reaction associated with a recently approved submucosal lifting agent.

Carlos A Castrodad-Rodríguez, Nicole C Panarelli, Adam J Gersten, Qiang Liu, Michael Feely, Tony El Jabbour,

Endoscopic resection techniques, such as endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD), are frequently aided by injection of submucosal lifting solutions that create a plane for dissection and protect deeper mural layers. ORISE™ gel is a recently approved synthetic lifting solution that produces a localized inflammatory reaction associated ... Read more >>

Mod. Pathol. (Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc)
[2020, 33(8):1581-1588]

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Smooth muscle tumors of the gastrointestinal tract: an analysis of prognostic features in 407 cases.

Lindsay Alpert, Ram Al-Sabti, Rondell P Graham, Rish K Pai, Raul S Gonzalez, Xuefeng Zhang, Vanessa Smith, Hanlin L Wang, Lindsey Westbrook, John R Goldblum, Ahmed Bakhshwin, Sindhu Shetty, David S Klimstra, Jinru Shia, Gokce Askan, Marie E Robert, Courtney Thomas, Wendy L Frankel, Mohammed Alsomali, Catherine Hagen, Mohamed E Mostafa, Michael M Feely, Naziheh Assarzadegan, Joseph Misdraji, Angela R Shih, Diana Agostini-Vulaj, Jeanne M Meis, Sherry Tang, Deyali Chatterjee, Liang-I Kang, John Hart, Sang Mee Lee, Theresa Smith, Rhonda K Yantiss, Erika M Hissong, Zu-Hua Gao, JingBo Wu, Murray B Resnick, Elizabeth Yiru Wu, Reet K Pai, Lei Zhao, Leona A Doyle, Shefali Chopra, Nicole C Panarelli, Shaomin Hu, Teri A Longacre, Shyam Sampath Raghavan, Gregory Y Lauwers, Masoumeh Ghayouri, Harry S Cooper, Rajeswari Nagarathinam, Andrew M Bellizzi, Sanjay Kakar, Mojgan Hosseini, Juan Rong, Joel K Greenson, Laura W Lamps, Zachary Dong, Mary P Bronner,

Smooth muscle tumors represent the second most common mural mesenchymal neoplasm in the gastrointestinal tract, but established criteria for prognostic assessment of these tumors are lacking. A large cohort of surgically resected intramural gastrointestinal smooth muscle tumors from 31 institutions was analyzed to identify potential prognostic features. Pathologic features were ... Read more >>

Mod. Pathol. (Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc)
[2020, 33(7):1410-1419]

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Systematic Selective Sampling of Cholecystectomy Specimens Is Adequate to Detect Incidental Gallbladder Adenocarcinoma.

Ashwin S Akki, Wei Zhang, Kathryn E Tanaka, Sun M Chung, Qiang Liu, Nicole C Panarelli,

Many gallbladder adenocarcinomas (ACs) are detected incidentally in routine cholecystectomy specimens, yet sampling practices vary when intestinal metaplasia (IM) or dysplasia are found via routine sampling. Our practice has been to submit 5 additional sections when IM is found, but cases with dysplasia are entirely submitted. We sought to determine ... Read more >>

Am. J. Surg. Pathol. (The American journal of surgical pathology)
[2019, 43(12):1668-1673]

Cited: 0 times

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Cystic Lesions of the Pancreas: Differential Diagnosis and Cytologic-Histologic Correlation.

Amrou Abdelkader, Bryan Hunt, Christopher P Hartley, Nicole C Panarelli, Tamara Giorgadze,

CONTEXT.—:Pancreatic cystic lesions (PCLs) are very common, and their detection is increasing with the advances in imaging techniques. Because of the major implications for management, distinguishing between neoplastic and nonneoplastic PCLs is critical. Neoplastic cysts with potential to progress into cancer include mucinous PCLs (intraductal papillary mucinous neoplasms and mucinous ... Read more >>

Arch. Pathol. Lab. Med. (Archives of pathology & laboratory medicine)
[2020, 144(1):47-61]

Cited: 1 time

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Educational Case: Ischemic Disorders of the Gut in Adult Patients.

Priyanka Patil, Nicole C Panarelli,

The following fictional case is intended as a learning tool within the Pathology Competencies for Medical Education (PCME), a set of national standards for teaching pathology. These are divided into three basic competencies: Disease Mechanisms and Processes, Organ System Pathology, and Diagnostic Medicine and Therapeutic Pathology. For additional information, and ... Read more >>

(Academic pathology)
[2019, 6:2374289519888709]

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Inflammatory and infectious manifestations of immunodeficiency in the gastrointestinal tract.

Nicole C Panarelli, Rhonda K Yantiss,

Immune compromise may result from genetic abnormalities, HIV/AIDS, or consequences of therapy for neoplastic and autoimmune diseases. Many immunocompromised patients develop severe gastrointestinal symptoms, particularly diarrhea, accompanied by non-specific or mild endoscopic abnormalities; mucosal biopsy with pathologic interpretation has a major role in the diagnosis and management of these patients. ... Read more >>

Mod. Pathol. (Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc)
[2018, 31(6):844-861]

Cited: 2 times

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Educational Case: Immune-Related Disorders of the Bowel: Celiac Disease.

Shaomin Hu, Nicole C Panarelli,

The following fictional case is intended as a learning tool within the Pathology Competencies for Medical Education (PCME), a set of national standards for teaching pathology. These are divided into three basic competencies: Disease Mechanisms and Processes, Organ System Pathology, and Diagnostic Medicine and Therapeutic Pathology. For additional information, and ... Read more >>

(Academic pathology)
[2018, 5:2374289518799253]

Cited: 0 times

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Idiopathic Myointimal Hyperplasia of Mesenteric Veins: An Uncommon Cause of Ischemic Colitis With Distinct Mucosal Features.

Rhonda K Yantiss, Isabelle Cui, Nicole C Panarelli, Jose Jessurun,

Idiopathic myointimal hyperplasia of mesenteric veins causes chronic ischemic mucosal injury with segmental strictures that mimic inflammatory bowel disease and nonocclusive ischemic colitis. It is characterized by myointimal proliferative changes that narrow the lumina of veins combined with ischemic injury and ulcers. Most cases reported to date have been diagnosed ... Read more >>

Am. J. Surg. Pathol. (The American journal of surgical pathology)
[2017, 41(12):1657-1665]

Cited: 3 times

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Other Forms of Esophagitis: It Is Not Gastroesophageal Reflux Disease, So Now What Do I Do?

Nicole C Panarelli,

Esophagitis results from diverse causes, including gastroesophageal reflux, immune-mediated or allergic reactions, therapeutic complications, and infections. The appropriate clinical management differs in each of these situations and is often guided by pathologic interpretation of endoscopic mucosal biopsy specimens. This review summarizes the diagnostic features of unusual forms of esophagitis, including ... Read more >>

Surg Pathol Clin (Surgical pathology clinics)
[2017, 10(4):765-779]

Cited: 2 times

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Cytology Preparations of Formalin Fixative Aid Detection of Giardia in Duodenal Biopsy Samples.

Nicole C Panarelli, Nariman Gobara, Rana S Hoda, Michael Chaump, Jose Jessurun, Rhonda K Yantiss,

Giardiasis is the most common intestinal parasitic infection in the United States. The organism elicits no, or minimal, inflammatory changes in duodenal biopsy samples, so it can be easily overlooked. We performed this study to determine whether Giardia could be isolated from the formalin fixative of biopsy samples, and to ... Read more >>

Am. J. Surg. Pathol. (The American journal of surgical pathology)
[2017, 41(4):570-574]

Cited: 2 times

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Immunohistochemistry Improves the Detection of Adenovirus in Gastrointestinal Biopsy Specimens From Hematopoietic Stem Cell Transplant Recipients.

Anna-Sophie Weidner, Nicole C Panarelli, Hanna Rennert, Jose Jessurun, Rhonda K Yantiss,

Gastrointestinal infections by cytomegalovirus (CMV) and adenovirus may complicate hematopoietic stem cell transplantation (HSCT). Although CMV and adenovirus produce recognizable cytopathic changes, these changes may be subtle or focal. The value of viral immunohistochemistry in detecting infection in HSCT recipients when cytopathic changes are not identified has not been demonstrated.H&E-stained ... Read more >>

Am. J. Clin. Pathol. (American journal of clinical pathology)
[2016, 146(5):627-631]

Cited: 3 times

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The importance of biopsy sampling practices in the pathologic evaluation of gastrointestinal disorders.

Nicole C Panarelli, Rhonda K Yantiss,

PURPOSE OF REVIEW:To summarize the literature regarding appropriate endoscopic sampling and surveillance protocols for common inflammatory diseases of the digestive tract. Gastroenterologists increasingly use endoscopy with mucosal biopsy to detect inflammatory diseases, assess response to therapy, and monitor for progression to dysplasia. RECENT FINDINGS:Many diseases show a patchy distribution in ... Read more >>

Curr. Opin. Gastroenterol. (Current opinion in gastroenterology)
[2016, 32(5):374-381]

Cited: 0 times

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Do Ancillary Studies Aid Detection and Classification of Barrett Esophagus?

Nicole C Panarelli, Rhonda K Yantiss,

Barrett esophagus is a preneoplastic condition defined by the presence of intestinal metaplasia (ie, goblet cells) in an endoscopically apparent columnar-lined esophagus. Dysplasia is the most important risk factor for cancer development among patients with Barrett esophagus; approximately 6% of patients with high-grade dysplasia progress to adenocarcinoma within 1 year. ... Read more >>

Am. J. Surg. Pathol. (The American journal of surgical pathology)
[2016, 40(8):e83-93]

Cited: 1 time

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Diagnostic Challenges Caused by Endoscopic Biopsy of Colonic Polyps: A Systematic Evaluation of Epithelial Misplacement With Review of Problematic Polyps From the Bowel Cancer Screening Program, United Kingdom.

Nicole C Panarelli, Thusitha Somarathna, Wade S Samowitz, Susan Kornacki, Scott A Sanders, Marco R Novelli, Neil A Shepherd, Rhonda K Yantiss,

Endoscopic mucosal biopsy may misplace mucosal elements into the submucosa of colonic adenomas, mimicking invasive adenocarcinoma. Biopsy-related misplacement can be more challenging to recognize than typical misplaced epithelium (pseudoinvasion) in pedunculated polyps. We compared the features of 16 polyps with biopsy-related misplaced epithelium with those of 10 adenomas with pseudoinvasion ... Read more >>

Am. J. Surg. Pathol. (The American journal of surgical pathology)
[2016, 40(8):1075-1083]

Cited: 8 times

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Bcl-xL promotes metastasis independent of its anti-apoptotic activity.

Soyoung Choi, Zhengming Chen, Laura H Tang, Yuanzhang Fang, Sandra J Shin, Nicole C Panarelli, Yao-Tseng Chen, Yi Li, Xuejun Jiang, Yi-Chieh Nancy Du,

Bcl-xL suppresses mitochondria-mediated apoptosis and is frequently overexpressed in cancer to promote cancer cell survival. Bcl-xL also promotes metastasis. However, it is unclear whether this metastatic function is dependent on its anti-apoptotic activity in the mitochondria. Here we demonstrate that Bcl-xL promotes metastasis independent of its anti-apoptotic activity. We show ... Read more >>

Nat Commun (Nature communications)
[2016, 7:10384]

Cited: 24 times

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Idelalisib-associated Colitis: Histologic Findings in 14 Patients.

Anna-Sophie Weidner, Nicole C Panarelli, Julia T Geyer, Erica B Bhavsar, Richard R Furman, John P Leonard, Jose Jessurun, Rhonda K Yantiss,

Idelalisib is an inhibitor of the PI3Kδ isoform approved for treatment of patients with relapsed chronic lymphocytic leukemia and indolent non-Hodgkin lymphoma. Many patients develop gastrointestinal symptoms during idelalisib therapy; however, the pathologic effects of this drug have not been characterized. We identified 50 patients who received at least 3 ... Read more >>

Am. J. Surg. Pathol. (The American journal of surgical pathology)
[2015, 39(12):1661-1667]

Cited: 44 times

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A cautionary note on the immunohistochemical detection of BRAF v600e mutations in serrated lesions of the colon.

Nicole C Panarelli, Anna-Sophie Weidner, Rhonda K Yantiss, Yao-Tseng Chen,

Mod. Pathol. (Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc)
[2015, 28(5):740-741]

Cited: 1 time

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Sporadic microsatellite instability-high colon cancers rarely display immunohistochemical evidence of Wnt signaling activation.

Nicole C Panarelli, Cecily P Vaughn, Wade S Samowitz, Rhonda K Yantiss,

Most sporadic colonic adenocarcinomas are microsatellite stable (MSS) and arise from conventional adenomas by dysregulation of the APC/β-catenin/Wnt signaling pathway. Sporadic adenocarcinomas with a high degree of microsatellite instability (MSI) likely arise from sessile serrated polyps through the serrated neoplastic pathway. These polyps contain BRAF mutations and are prone to ... Read more >>

Am. J. Surg. Pathol. (The American journal of surgical pathology)
[2015, 39(3):313-317]

Cited: 11 times

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Utility of ancillary stains for Helicobacter pylori in near-normal gastric biopsies.

Nicole C Panarelli, Dara S Ross, Oren E Bernheim, Zachary B Landzberg, Audrey N Schuetz, Stephen G Jenkins, Brian R Landzberg, Jose Jessurun, Rhonda K Yantiss,

Documentation of Helicobacter pylori infection and eradication is important, prompting some clinicians and pathologists to request ancillary stains on all gastric samples that do not demonstrate H. pylori on initial histologic review. Studies evaluating the utility of ancillary stains in patients with minimal inflammation are lacking. We used Giemsa, Warthin-Starry, ... Read more >>

Hum. Pathol. (Human pathology)
[2015, 46(3):397-403]

Cited: 8 times

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Silencing of UCHL1 by CpG promoter hyper-methylation is associated with metastatic gastroenteropancreatic well-differentiated neuroendocrine (carcinoid) tumors.

David A Kleiman, Toni Beninato, Samuel Sultan, Michael J P Crowley, Brendan Finnerty, Ritu Kumar, Nicole C Panarelli, Yi-Fang Liu, Michael D Lieberman, Marco Seandel, Todd Evans, Olivier Elemento, Rasa Zarnegar, Thomas J Fahey,

BACKGROUND:Well-differentiated gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are rare tumors with varying metastatic potential. The underlying molecular basis for metastasis by GEP-NETs remains undefined. METHODS:Quantitative PCR and immunohistochemistry (IHC) staining for ubiquitin carboxyl-terminal esterase L1 (UCHL1) gene and protein expression was performed on a group of localized and metastatic well-differentiated GEP-NET samples ... Read more >>

Ann Surg Oncol (Annals of surgical oncology)
[2014, 21 Suppl 4:S672-9]

Cited: 8 times

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Drug-induced injury in the gastrointestinal tract.

Nicole C Panarelli,

Abnormalities of the gastrointestinal tract due to drug-induced injuries are common and often have important clinical consequences. Medications may cause damage by direct corrosive effects on mucosae or by alter processes, mucosal immunity, and local environmental conditions. The aim of this review is to guide practicing pathologists in the identification ... Read more >>

Semin Diagn Pathol (Seminars in diagnostic pathology)
[2014, 31(2):165-175]

Cited: 14 times

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Cancer-testis antigen expression in digestive tract carcinomas: frequent expression in esophageal squamous cell carcinoma and its precursor lesions.

Yao-Tseng Chen, Nicole C Panarelli, Kathryn C Piotti, Rhonda K Yantiss,

Cancer-testis (CT) antigens are attractive tumor antigens for cancer immunotherapy. They comprise a group of proteins normally expressed in germ cells and aberrantly activated in a variety of human cancers. The protein expression of eight cancer-testis antigens [MAGEA, NY-ESO-1, GAGE, MAGEC1 (CT7), MAGEC2 (CT10), CT45, SAGE1, and NXF2] was evaluated ... Read more >>

Cancer Immunol Res (Cancer immunology research)
[2014, 2(5):480-486]

Cited: 17 times

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Histologic features and cytologic techniques that aid pathologic stage assessment of colonic adenocarcinoma.

Nicole C Panarelli, Andrew M Schreiner, Suzanne M Brandt, Neil A Shepherd, Rhonda K Yantiss,

Cancer involvement of the colonic serosa is designated pT4a by the American Joint Committee on Cancer Staging Manual, 7th edition. The manual defines criteria for pT4a as either tumor penetration of the serosa or comingling of cancer cells and mesothelial cells in histologic sections. Unfortunately, the pT4a grouping is inconsistently ... Read more >>

Am. J. Surg. Pathol. (The American journal of surgical pathology)
[2013, 37(8):1252-1258]

Cited: 6 times

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Tissue-specific cadherin CDH17 is a useful marker of gastrointestinal adenocarcinomas with higher sensitivity than CDX2.

Nicole C Panarelli, Rhonda K Yantiss, Matthew M Yeh, Yifang Liu, Yao-Tseng Chen,

Cadherin 17 (CDH17) is a cell adhesion molecule expressed in intestinal epithelium and transcriptionally regulated by CDX2. We compared the usefulness of CDH17 as an immunohistochemical intestinal marker to that of CDX2 in gastrointestinal and extragastrointestinal carcinomas and nonneoplastic tissues. Nonneoplastic intestinal and pancreatic duct epithelia were CDH17-positive. Most esophageal ... Read more >>

Am. J. Clin. Pathol. (American journal of clinical pathology)
[2012, 138(2):211-222]

Cited: 24 times

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