Full Text Journal Articles by
Author Nicolas F Schlecht

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Impact of Nonadherence to NCCN Adjuvant Radiotherapy Initiation Guidelines in Head and Neck Squamous Cell Carcinoma in an Underserved Urban Population.

Anusha Ponduri, David Z Liao, Nicolas F Schlecht, Gregory Rosenblatt, Michael B Prystowsky, Rafi Kabarriti, Madhur Garg, Thomas J Ow, Bradley A Schiff, Richard V Smith, Vikas Mehta,

<h4>Background</h4>Nonadherence to NCCN Guidelines during time from surgery to postoperative radiotherapy (S-PORT) can alter survival outcomes in head and neck squamous cell carcinomna (HNSCC). There is a need to validate this impact in an underserved urban population and to understand risk factors and reasons for delay. We sought to investigate ... Read more >>

J Natl Compr Canc Netw (Journal of the National Comprehensive Cancer Network : JNCCN)
[2021, :1-7]

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Racial/Ethnic Disparities in Survival Among Women Diagnosed with Invasive Cancer of the Anal Canal: an Analysis of Surveillance, Epidemiology, and End Results (SEER) Data.

Ashley E Stenzel, Nicolas F Schlecht, Kirsten B Moysich,

<h4>Objective</h4>To identify differences in survival among women diagnosed with cancer of the anal canal from varying racial and ethnic backgrounds.<h4>Methods</h4>Data from the Surveillance, Epidemiology and End Results (SEER) registry between the years of 1975 and 2016 were analyzed, which included 19,048 women with cancer of the anal canal. Multivariable Cox ... Read more >>

J Gastrointest Cancer (Journal of gastrointestinal cancer)
[2021, 52(3):854-862]

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Incidence and Types of Human Papillomavirus Infections in Adolescent Girls and Young Women Immunized With the Human Papillomavirus Vaccine.

Nicolas F Schlecht, Angela Diaz, Anne Nucci-Sack, Kathleen Shyhalla, Viswanathan Shankar, Mary Guillot, Dominic Hollman, Howard D Strickler, Robert D Burk,

<h4>Importance</h4>Rates of human papillomavirus (HPV) infection have decreased since the introduction of HPV vaccines in populations with high vaccine uptake. Data are limited for adolescent and young adult populations in US metropolitan centers.<h4>Objective</h4>To determine HPV infection rates in adolescent girls and young women aged 13 to 21 years in New ... Read more >>

JAMA Netw Open (JAMA network open)
[2021, 4(8):e2121893]

Cited: 1 time

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Neighborhood Profiles and Body Mass Index Trajectory in Female Adolescents and Young Adults.

Li Niu, Lindsay T Hoyt, Sarah Pickering, Anne Nucci-Sack, Anthony Salandy, Viswanathan Shankar, Elisa M Rodriguez, Robert D Burk, Nicolas F Schlecht, Angela Diaz,

<h4>Purpose</h4>The purpose of this study is to identify distinct neighborhood profiles patterned by key structural, physical, and social characteristics and test whether living in different profiles are associated with body mass index trajectories during adolescence in racial/ethnic minority female youth.<h4>Methods</h4>Participants were 1,328 sexually active female adolescents and young adults aged ... Read more >>

J Adolesc Health (The Journal of adolescent health : official publication of the Society for Adolescent Medicine)
[2021, :]

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Genes Relevant to Tissue Response to Cancer Therapy Display Diurnal Variation in mRNA Expression in Human Oral Mucosa.

Fangyi Gu, Eduardo Cortes Gomez, Jianhong Chen, Matthew F Buas, Nicolas F Schlecht, Karen Hulme, Shweta Vishwas Kulkarni, Prashant K Singh, Richard O'Connor, Christine B Ambrosone, Anurag K Singh, Jianmin Wang,

<h4>Background</h4>To address a critical gap for application of cancer chronotherapy of when would be the best time(s) for treating an individual cancer patient, we conducted a pilot study to characterize diurnal variations of gene expression in oral mucosal tissue, which is vulnerable to damage from cancer therapies.<h4>Methods</h4>We conducted RNA-seq assay ... Read more >>

J Circadian Rhythms (Journal of circadian rhythms)
[2021, 19:8]

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Changes in cannabis, tobacco, and alcohol use among sexually active female adolescents and young adults over a twelve-year period ending in 2019.

Kathleen Shyhalla, Danielle M Smith, Angela Diaz, Anne Nucci-Sack, Mary Guillot, Dominic Hollman, Maciej L Goniewicz, Richard J O'Connor, Viswanathan Shankar, Robert D Burk, Nicolas F Schlecht,

<h4>Background</h4>The United States has experienced an increasing divergence in cannabis, tobacco, and alcohol use among adolescents and young adults (AYA). We assessed the changes in cannabis, tobacco and alcohol use in an inner-city population of predominantly minority AYA females attending a large adolescent-specific health center in New York City.<h4>Methods</h4>This was ... Read more >>

Addict Behav (Addictive behaviors)
[2021, 121:106994]

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Palbociclib Renders Human Papilloma Virus-Negative Head and Neck Squamous Cell Carcinoma Vulnerable to the Senolytic Agent Navitoclax.

Nicholas J Gadsden, Cory D Fulcher, Daniel Li, Nitisha Shrivastava, Carlos Thomas, Jeffrey E Segall, Michael B Prystowsky, Nicolas F Schlecht, Evripidis Gavathiotis, Thomas J Ow,

We demonstrate that inhibition of cyclin-dependent kinases 4/6 (CDK4/6) leads to senescence in human papillomavirus (HPV)-negative (-) head and neck squamous cell carcinoma (HNSCC), but not in HPV-positive (+) HNSCC. The BCL-2 family inhibitor, navitoclax, has been shown to eliminate senescent cells effectively. We evaluated the efficacy of combining palbociclib ... Read more >>

Mol Cancer Res (Molecular cancer research : MCR)
[2021, 19(5):862-873]

Cited: 2 times

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Profiles of Childhood Maltreatment: Associations with Sexual Risk Behavior during Adolescence in a Sample of Racial/Ethnic Minority Girls.

Li Niu, Joshua Brown, Lindsay Till Hoyt, Anthony Salandy, Anne Nucci-Sack, Viswanathan Shankar, Robert D Burk, Nicolas F Schlecht, Angela Diaz,

This study examines associations between childhood maltreatment and developmental trajectories of sexual risk behaviors (SRBs) in a sample of 882 sexually active adolescent girls, predominantly Hispanic or Black, assessed every 6 months between 13 and 23 years. Latent profile analyses revealed four distinct maltreatment profiles: Low Maltreatment (76%), Moderate Emotional Neglect Only ... Read more >>

Child Dev (Child development)
[2021, 92(4):1421-1438]

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Peer navigation-delivered loving kindness meditation: A pilot project.

Alyson Moadel-Robblee, Fernando Camacho, Gabrielle E Milner, Alexander Kertzner, Nicolas F Schlecht,

Peer navigators (PNs), including trained cancer survivor volunteers, can be an important resource to the cancer care team in reducing barriers to screening, treatment, and psychosocial care among underserved communities through their roles in outreach, education, advocacy, and peer support. As cancer centers face growing patient demand and evidence for ... Read more >>

Complement Ther Med (Complementary therapies in medicine)
[2021, 57:102661]

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HIV Modifies the Effect of Tobacco Smoking on Oral Human Papillomavirus Infection.

Babatunde Y Alli, Robert D Burk, Mahnaz Fatahzadeh, Julie Kazimiroff, Robert M Grossberg, Richard V Smith, Thomas J Ow, Mauricio Wiltz, Jacqueline Polanco, Marie-Claude Rousseau, Belinda Nicolau, Nicolas F Schlecht,

<h4>Background</h4>People living with HIV (PLWH) are more likely to smoke and harbor oral human papillomavirus (HPV) infections, putting them at higher risk for head and neck cancer. We investigated effects of HIV and smoking on oral HPV risk.<h4>Methods</h4>Consecutive PLWH (n = 169) and at-risk HIV-negative individuals (n = 126) were recruited from 2 US ... Read more >>

J Infect Dis (The Journal of infectious diseases)
[2020, 222(4):646-654]

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In Response to Regarding: Apoptosis Signaling Molecules as Treatment Targets in Head and Neck Squamous Carcinoma.

Thomas J Ow, Carlos Thomas, Cory D Fulcher, Jianhong Chen, Andrea López, Denis E Reyna, Michael B Prystowsky, Richard V Smith, Bradley A Schiff, Gregory Rosenblatt, Thomas J Belbin, Thomas M Harris, Geoffrey C Childs, Nicole Kawachi, Nicolas F Schlecht, Evripidis Gavathiotis,

Laryngoscope (The Laryngoscope)
[2020, 130(8):E458-E459]

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The interaction between pubertal timing and childhood maltreatment on the risk of human papillomavirus infection among adolescent girls and young women.

Li Niu, Lindsay Till Hoyt, Anthony Salandy, Anne Nucci-Sack, Viswanathan Shankar, Howard Strickler, Robert D Burk, Nicolas F Schlecht, Angela Diaz,

<h4>Purpose</h4>The goal of this study was to evaluate the effect of pubertal timing, and its interaction with prior childhood maltreatment, on the risk of cervical human papillomavirus (HPV) among sexually active adolescent minority female adolescents and young adults.<h4>Methods</h4>This cross-sectional study includes 842 adolescent girls and young women (aged 12 to ... Read more >>

Prev Med (Preventive medicine)
[2020, 138:106126]

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Daily Time of Radiation Treatment Is Associated with Subsequent Oral Mucositis Severity during Radiotherapy in Head and Neck Cancer Patients.

Fangyi Gu, Mark K Farrugia, William D Duncan, Yingdong Feng, Alan D Hutson, Nicolas F Schlecht, Elizabeth A Repasky, Marina P Antoch, Austin Miller, Alexis Platek, Mary E Platek, Austin J Iovoli, Anurag K Singh,

<h4>Background</h4>Limited treatment options are available for oral mucositis, a common, debilitating complication of cancer therapy. We examined the association between daily delivery time of radiotherapy and the severity of oral mucositis in patients with head and neck cancer.<h4>Methods</h4>We used electronic medical records of 190 patients with head and neck squamous ... Read more >>

Cancer Epidemiol Biomarkers Prev (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology)
[2020, 29(5):949-955]

Cited: 1 time

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Apoptosis signaling molecules as treatment targets in head and neck squamous cell carcinoma.

Thomas J Ow, Carlos Thomas, Cory D Fulcher, Jianhong Chen, Andrea López, Denis E Reyna, Michael B Prystowsky, Richard V Smith, Bradley A Schiff, Gregory Rosenblatt, Thomas J Belbin, Thomas M Harris, Geoffrey C Childs, Nicole Kawachi, Nicolas F Schlecht, Evripidis Gavathiotis,

<h4>Objectives</h4>To evaluate BCL-2 family signaling molecules in head and neck squamous cell carcinoma (HNSCC) and examine the ability of therapeutic agents with variable mechanisms of action to induce apoptosis in HNSCC cells.<h4>Methods</h4>messenger ribonculeic acid (mRNA) expression of BAK, BAX, B-cell lymphoma (Bcl-2), BCL2 Like 1 (BCL2L1), and MCL1 were measured ... Read more >>

Laryngoscope (The Laryngoscope)
[2020, 130(11):2643-2649]

Cited: 7 times

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Effect of child abuse and neglect on risk behaviors in inner-city minority female adolescents and young adults.

Angela Diaz, Viswanathan Shankar, Anne Nucci-Sack, Lourdes Oriana Linares, Anthony Salandy, Howard D Strickler, Robert D Burk, Nicolas F Schlecht,

<h4>Background</h4>Over six million children each year are referred to child protective services for child abuse (sexual, physical and emotional) and neglect (physical and emotional).<h4>Objective</h4>While the relationship between child sexual abuse and sexually transmitted infections has been documented, there has been little research regarding the effects of other forms of maltreatment.<h4>Participants ... Read more >>

Child Abuse Negl (Child abuse & neglect)
[2020, 101:104347]

Cited: 3 times

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Association of Delayed Time to Treatment Initiation With Overall Survival and Recurrence Among Patients With Head and Neck Squamous Cell Carcinoma in an Underserved Urban Population.

David Z Liao, Nicolas F Schlecht, Gregory Rosenblatt, Corin M Kinkhabwala, James A Leonard, Ryan S Ference, Michael B Prystowsky, Thomas J Ow, Bradley A Schiff, Richard V Smith, Vikas Mehta,

<h4>Importance</h4>Delay in time to treatment initiation (TTI) can alter survival and oncologic outcomes. There is a need to characterize these consequences and identify risk factors and reasons for treatment delay, particularly in underserved urban populations.<h4>Objectives</h4>To investigate the association of delayed treatment initiation with outcomes of overall survival and recurrence among ... Read more >>

JAMA Otolaryngol Head Neck Surg (JAMA otolaryngology-- head & neck surgery)
[2019, 145(11):1001-1009]

Cited: 7 times

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Latency of tobacco smoking for head and neck cancer among HPV-positive and HPV-negative individuals.

Sreenath Madathil, Marie-Claude Rousseau, Lawrence Joseph, François Coutlée, Nicolas F Schlecht, Eduardo Franco, Belinda Nicolau,

Human papillomavirus (HPV) infection and tobacco smoking are well-known risk factors for head and neck cancers (HNC). Although an effect modification between oral HPV infection and tobacco smoking may exist, evidence is lacking on how they interact temporally. We investigated the latency and life course effects of tobacco smoking on ... Read more >>

Int J Cancer (International journal of cancer)
[2020, 147(1):56-64]

Cited: 2 times

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Risk of Oral Human Papillomavirus Infection Among Sexually Active Female Adolescents Receiving the Quadrivalent Vaccine.

Nicolas F Schlecht, Martin Masika, Angela Diaz, Anne Nucci-Sack, Anthony Salandy, Sarah Pickering, Howard D Strickler, Viswanathan Shankar, Robert D Burk,

Importance:Human papillomavirus (HPV) is the most common sexually transmitted infection in the United States, and oral HPV infection is associated with increased risk of oropharyngeal cancer. Objective:To describe the risk factors for oral HPV in sexually active female adolescents receiving the quadrivalent vaccine. Design, Setting, and Participants:Longitudinal cohort study involving ... Read more >>

JAMA Netw Open (JAMA network open)
[2019, 2(10):e1914031]

Cited: 4 times

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Genetic variants in CYP and GST genes, smoking and risk for head and neck cancers: a gene-environment interaction hospital-based case-control study among Canadian Caucasians.

Akhil Soman ThekkePurakkal, Belinda Nicolau, Robert D Burk, Eduardo L Franco, Nicolas F Schlecht,

The evidence for genetic polymorphisms in genes encoding Cytochrome P450 (CYP) and Glutathione S-transferase (GST) enzymes as risk factors for squamous cell carcinomas of the head and neck (SCCHN) in Caucasians is conflicting. Furthermore, the interactive effects with smoking have not been documented. We estimated the effects of five single ... Read more >>

Carcinogenesis (Carcinogenesis)
[2019, :]

Cited: 0 times

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Association between pretreatment obesity, sarcopenia, and survival in patients with head and neck cancer.

Michael Fattouh, Gina Y Chang, Thomas J Ow, Keivan Shifteh, Gregory Rosenblatt, Viraj M Patel, Richard V Smith, Michael B Prystowsky, Nicolas F Schlecht,

<h4>Background</h4>Body mass index (BMI), sarcopenia, and obesity-related comorbidities have been associated with head and neck squamous cell carcinoma (HNSCC) progression.<h4>Methods</h4>We conducted a retrospective analysis of 441 normal-weight, overweight, and obese HNSCC patients treated at Montefiore Medical Center (New York). Patients were grouped by BMI prior to treatment and assessed for ... Read more >>

Head Neck (Head & neck)
[2019, 41(3):707-714]

Cited: 9 times

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Optimal targeting of BCL-family proteins in head and neck squamous cell carcinoma requires inhibition of both BCL-xL and MCL-1.

Thomas J Ow, Cory D Fulcher, Carlos Thomas, Pilib Ó Broin, Andrea López, Denis E Reyna, Richard V Smith, Catherine Sarta, Michael B Prystowsky, Nicolas F Schlecht, Bradley A Schiff, Gregory Rosenblatt, Thomas J Belbin, Thomas M Harris, Geoffrey C Childs, Nicole Kawachi, Chandan Guha, Evripidis Gavathiotis,

Mechanisms of treatment resistance in head and neck squamous cell carcinoma (HNSCC) are not well characterized. In this study, HNSCC tumors from a cohort of prospectively enrolled subjects on an ongoing tissue banking study were divided into those that persisted or recurred locoregionally (n=23) and those that responded without recurrence ... Read more >>

Oncotarget (Oncotarget)
[2019, 10(4):494-510]

Cited: 11 times

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Increased risk of oropharyngeal cancers mediated by oral human papillomavirus infection: Results from a Canadian study.

Claudie Laprise, Claudie Laprise, Sreenath Arekunnath Madathil, Nicolas F Schlecht, Geneviève Castonguay, Denis Soulières, Phuc Felix Nguyen-Tan, Paul Allison, François Coutlée, Michael Hier, Marie-Claude Rousseau, Eduardo L Franco, Belinda Nicolau,

<h4>Background</h4>This study aimed to estimate the extent to which oral sex behavior is associated with an increased risk of oropharyngeal cancers (OPCs), and how much of the association is mediated by oral human papillomavirus (HPV) infection.<h4>Methods</h4>We used data from a hospital-based case-control study conducted in Montreal, Canada. Information on oral ... Read more >>

Head Neck (Head & neck)
[2019, 41(3):678-685]

Cited: 4 times

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Differential impact of socioeconomic position across life on oral cancer risk in Kerala, India: An investigation of life-course models under a time-varying framework.

Akhil Soman ThekkePurakkal, Ashley I Naimi, Sreenath A Madathil, Shahul H Kumamangalam Puthiyannal, Gopalakrishnan Netuveli, Amanda Sacker, Nicolas F Schlecht, Belinda Nicolau,

<h4>Objectives</h4>The incidence of oral cancer has been rapidly increasing in India, calling for evidence contributing to a deeper understanding of its determinants. Although disadvantageous life-course socioeconomic position (SEP) is independently associated with the risk of these cancers, the explanatory mechanisms remain unclear. Possible pathways may be better understood by testing ... Read more >>

Community Dent Oral Epidemiol (Community dentistry and oral epidemiology)
[2018, 46(6):592-600]

Cited: 1 time

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Association of an intact E2 gene with higher HPV viral load, higher viral oncogene expression, and improved clinical outcome in HPV16 positive head and neck squamous cell carcinoma.

Nicole V Anayannis, Nicolas F Schlecht, Miriam Ben-Dayan, Richard V Smith, Thomas J Belbin, Thomas J Ow, Duk M Blakaj, Robert D Burk, Sarah M Leonard, Ciaran B Woodman, Joanna L Parish, Michael B Prystowsky,

To assess the relationship of E2 gene disruption with viral gene expression and clinical outcome in human papillomavirus (HPV) positive head and neck squamous cell carcinoma, we evaluated 31 oropharyngeal and 17 non-oropharyngeal HPV16 positive carcinomas using two PCR-based methods to test for disruption of E2, followed by Sanger sequencing. ... Read more >>

PLoS One (PloS one)
[2018, 13(2):e0191581]

Cited: 11 times

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Preoperative 18F-FDG-PET/CT vs Contrast-Enhanced CT to Identify Regional Nodal Metastasis among Patients with Head and Neck Squamous Cell Carcinoma.

Joshua K Cho, Thomas J Ow, Andrew Y Lee, Richard V Smith, Nicolas F Schlecht, Bradley A Schiff, Andrew B Tassler, Juan Lin, Renee M Moadel, Ana Valdivia, Tony Abraham, Edwin Gulko, Matthew Neimark, Berrin Ustun, Jacqueline A Bello, Keivan Shifteh,

Objective Our objective was to compare the accuracy of preoperative positron emission tomography (PET)/computed tomography (CT) and contrast-enhanced CT (CECT) in detecting cervical nodal metastases in patients treated with neck dissection and to scrutinize the ability of each modality to determine nodal stage. Study Design Case series with chart review. ... Read more >>

Otolaryngol Head Neck Surg (Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery)
[2017, 157(3):439-447]

Cited: 4 times

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