Full Text Journal Articles by
Author Nicolas Clere


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Endothelial-to-Mesenchymal Transition in Cancer.

Nicolas Clere, Sarah Renault, Isabelle Corre,

Cancer is one of the most important causes of morbidity and mortality worldwide. Tumor cells grow in a complex microenvironment constituted of immune, stromal, and vascular cells that supports growth, angiogenesis, and metastasis. Endothelial cells (ECs) are major components of the vascular microenvironment. These cells have been described for their ... Read more >>

Front Cell Dev Biol (Frontiers in cell and developmental biology)
[2020, 8:747]

Cited: 0 times

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Endothelial-to-Mesenchymal Transition (EndoMT): Roles in Tumorigenesis, Metastatic Extravasation and Therapy Resistance.

Valentin Platel, Sébastien Faure, Isabelle Corre, Nicolas Clere,

Cancer cells evolve in a very complex tumor microenvironment, composed of several cell types, among which the endothelial cells are the major actors of the tumor angiogenesis. Today, these cells are also characterized for their plasticity, as endothelial cells have demonstrated their potential to modify their phenotype to differentiate into ... Read more >>

J Oncol (Journal of oncology)
[2019, 2019:8361945]

Cited: 5 times

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In vivo comparison of the proangiogenic properties of chlordecone and three of its dechlorinated derivatives formed by in situ chemical reduction.

Eid Alabed Alibrahim, Samuel Legeay, Pierre-André Billat, Emmanuelle Bichon, Ingrid Guiffard, Jean-Philippe Antignac, Pierre Legras, Jérôme Roux, Sébastien Bristeau, Nicolas Clere, Sébastien Faure, Christophe Mouvet,

In situ chemical reduction (ISCR) has been identified as a possible way for the remediation of soils contaminated by chlordecone (CLD). Evidences provided by the literature indicate an association between the development of prostate cancer and CLD exposure (Multigner et al. 2010). In a previous in vitro study, we demonstrated ... Read more >>

Environ Sci Pollut Res Int (Environmental science and pollution research international)
[2019, :]

Cited: 0 times

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Melanoma tumour vasculature heterogeneity: from mice models to human.

Vincent Pautu, Adélie Mellinger, Pauline Resnier, Elise Lepeltier, Ludovic Martin, Lise Boussemart, Franck Letournel, Catherine Passirani, Nicolas Clere,

Tumour angiogenesis is defined by an anarchic vasculature and irregularities in alignment of endothelial cells. These structural abnormalities could explain the variability in distribution of nanomedicines in various tumour models. Then, the main goal of this study was to compare and to characterize the tumour vascular structure in different mouse ... Read more >>

J. Cancer Res. Clin. Oncol. (Journal of cancer research and clinical oncology)
[2019, 145(3):589-597]

Cited: 1 time

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Enhanced and preferential internalization of lipid nanocapsules into human glioblastoma cells: effect of a surface-functionalizing NFL peptide.

Reatul Karim, Elise Lepeltier, Lucille Esnault, Pascal Pigeon, Laurent Lemaire, Claire Lépinoux-Chambaud, Nicolas Clere, Gérard Jaouen, Joel Eyer, Géraldine Piel, Catherine Passirani,

Increasing intracellular drug concentration using nanocarriers can be a potential strategy to improve efficacy against glioblastoma (GBM). Here, the fluorescent-labelled NFL-TBS·40-63 peptide (fluoNFL) concentration on a lipid nanocapsule (LNC) was studied to enhance nanovector internalization into human GBM cells. LNC surface-functionalization with various fluoNFL concentrations was performed by adsorption. LNC ... Read more >>

Nanoscale (Nanoscale)
[2018, 10(28):13485-13501]

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Extract Enriched in Flavan-3-ols and Mainly Procyanidin Dimers Improves Metabolic Alterations in a Mouse Model of Obesity-Related Disorders Partially via Estrogen Receptor Alpha.

Daniela Leonetti, Raffaella Soleti, Nicolas Clere, Luisa Vergori, Caroline Jacques, Lucie Duluc, Catherine Dourguia, Maria C Martínez, Ramaroson Andriantsitohaina,

Red wine polyphenol extracts improve cardiovascular and metabolic disorders linked to obesity. Their vascular protection is mediated by the activation of the alpha isoform of the estrogen receptor (ERα). In the present study, we explored the effects of a grape seed extract (GSE) enriched in the flavan-3-ols procyanidin dimers on ... Read more >>

Front Pharmacol (Frontiers in pharmacology)
[2018, 9:406]

Cited: 2 times

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Unusual modes of action of the repellent DEET in insects highlight some human side effects.

Samuel Legeay, Nicolas Clere, Véronique Apaire-Marchais, Sébastien Faure, Bruno Lapied,

N,N-diethyl-m-toluamide (DEET) induces favorable repellency against insects by acting on the sensory nervous system. According to emerging literature reports, DEET side effects in humans involve new molecular targets including the cholinergic system, acetylcholinesterase (AChE), muscarinic M1 and M3 receptor and the participation of the second messenger nitric oxide (NO). Most ... Read more >>

Eur. J. Pharmacol. (European journal of pharmacology)
[2018, 825:92-98]

Cited: 2 times

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Estrogen receptor α/HDAC/NFAT axis for delphinidin effects on proliferation and differentiation of T lymphocytes from patients with cardiovascular risks.

Ousama Dayoub, Soazig Le Lay, Raffaella Soleti, Nicolas Clere, Gregory Hilairet, Séverine Dubois, Frédéric Gagnadoux, Jérôme Boursier, Maria Carmen Martínez, Ramaroson Andriantsitohaina,

Delphinidin, an anthocyanin present in red wine, has been reported to preserve the integrity of endothelium via an estrogen receptor alpha (ERα)-dependent mechanism. However, the effect of delphinidin on the immune response in obesity-related inflammation remains unknown. Given the important role of T lymphocytes in obesity-related inflammation, we investigated the ... Read more >>

Sci Rep (Scientific reports)
[2017, 7(1):9378]

Cited: 1 time

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Pro-Angiogenic Effects of Low Dose Ethoxidine in a Murine Model of Ischemic Hindlimb: Correlation between Ethoxidine Levels and Increased Activation of the Nitric Oxide Pathway.

Nicolas Clere, Kim Hung Thien To, Samuel Legeay, Samuel Bertrand, Jean Jacques Helesbeux, Olivier Duval, Sébastien Faure,

Ethoxidine, a benzo[c]phenanthridine derivative, has been identified as a potent inhibitor of topoisomerase I in cancer cell lines. Our group has reported paradoxical properties of ethoxidine in cellular processes leading to angiogenesis on endothelial cells. Because low concentration ethoxidine is able to favor angiogenesis, the present study aimed to investigate ... Read more >>

Molecules (Molecules (Basel, Switzerland))
[2017, 22(4):]

Cited: 0 times

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Two dechlorinated chlordecone derivatives formed by in situ chemical reduction are devoid of genotoxicity and mutagenicity and have lower proangiogenic properties compared to the parent compound.

Samuel Legeay, Pierre-André Billat, Nicolas Clere, Fabrice Nesslany, Sébastien Bristeau, Sébastien Faure, Christophe Mouvet,

Chlordecone (CLD) is a chlorinated hydrocarbon insecticide, now classified as a persistent organic pollutant. Several studies have previously reported that chronic exposure to CLD leads to hepatotoxicity, neurotoxicity, raises early child development and pregnancy complications, and increases the risk of liver and prostate cancer. In situ chemical reduction (ISCR) has ... Read more >>

Environ Sci Pollut Res Int (Environmental science and pollution research international)
[2018, 25(15):14313-14323]

Cited: 1 time

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Nanomedicine as a potent strategy in melanoma tumor microenvironment.

Vincent Pautu, Daniela Leonetti, Elise Lepeltier, Nicolas Clere, Catherine Passirani,

Melanoma originated from melanocytes is the most aggressive type of skin cancer. Despite considerable progresses in clinical treatment with the discovery of BRAF or MEK inhibitors and monoclonal antibodies, the durability of response to treatment is often limited to the development of acquired resistance and systemic toxicity. The limited success ... Read more >>

Pharmacol. Res. (Pharmacological research)
[2017, 126:31-53]

Cited: 6 times

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The insect repellent N,N-diethyl-m-toluamide (DEET) induces angiogenesis via allosteric modulation of the M3 muscarinic receptor in endothelial cells.

Samuel Legeay, Nicolas Clere, Grégory Hilairet, Quoc-Tuan Do, Philippe Bernard, Jean-François Quignard, Véronique Apaire-Marchais, Bruno Lapied, Sébastien Faure,

The insect repellent N,N-diethyl-m-toluamide (DEET) has been reported to inhibit AChE (acetylcholinesterase) and to possess potential carcinogenic properties with excessive vascularization. In the present paper, we demonstrate that DEET specifically stimulates endothelial cells that promote angiogenesis which increases tumor growth. DEET activates cellular processes that lead to angiogenesis including proliferation, ... Read more >>

Sci Rep (Scientific reports)
[2016, 6:28546]

Cited: 3 times

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Estrogen Receptor α Participates to the Beneficial Effect of Red Wine Polyphenols in a Mouse Model of Obesity-Related Disorders.

Daniela Leonetti, Raffaella Soleti, Nicolas Clere, Luisa Vergori, Caroline Jacques, Lucie Duluc, Catherine Dourguia, Maria C Martínez, Ramaroson Andriantsitohaina,

Red wine polyphenol extracts (polyphenols) ameliorate cardiovascular and metabolic disorders associated with obesity. Previously, we demonstrated that the alpha isoform of estrogen receptor (ERα) triggers the vascular protection of polyphenols. Here, we investigated the contribution of ERα on the effects of polyphenols on cardiovascular and metabolic alterations associated with obesity. ... Read more >>

Front Pharmacol (Frontiers in Pharmacology)
[2016, 7:529]

Cited: 5 times

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Opposite effects of angiotensins receptors type 2 and type 4 on streptozotocin induced diabetes vascular alterations in mice.

Mohamad Nasser, Nicolas Clere, Laurent Botelle, James Javellaud, Nicole Oudart, Sébastien Faure, Jean-Michel Achard,

BACKGROUND: We examined the effect of chronic administration of angiotensin IV (AngIV) on the vascular alterations induced by type 1 diabetes in mice. METHODS: Diabetes was induced in adult Swiss mice with a single injection of streptozotocin (STZ). Mice were treated subcutaneously with AngIV (1.4 mg/kg/day) either immediately following diabetes induction ... Read more >>

Cardiovasc Diabetol (Cardiovascular diabetology)
[2014, 13:40]

Cited: 9 times

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Mycobacterial toxin induces analgesia in buruli ulcer by targeting the angiotensin pathways.

Estelle Marion, Ok-Ryul Song, Thierry Christophe, Jérémie Babonneau, Denis Fenistein, Joël Eyer, Frank Letournel, Daniel Henrion, Nicolas Clere, Vincent Paille, Nathalie C Guérineau, Jean-Paul Saint André, Philipp Gersbach, Karl-Heinz Altmann, Timothy Paul Stinear, Yannick Comoglio, Guillaume Sandoz, Laurence Preisser, Yves Delneste, Edouard Yeramian, Laurent Marsollier, Priscille Brodin,

Mycobacterium ulcerans, the etiological agent of Buruli ulcer, causes extensive skin lesions, which despite their severity are not accompanied by pain. It was previously thought that this remarkable analgesia is ensured by direct nerve cell destruction. We demonstrate here that M. ulcerans-induced hypoesthesia is instead achieved through a specific neurological pathway ... Read more >>

Cell (Cell)
[2014, 157(7):1565-1576]

Cited: 72 times

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Plasma cells release membrane microparticles in a mouse model of multiple myeloma.

Tarek Benameur, Daniel Chappard, Elodie Fioleau, Ramaroson Andriantsitohaina, M Carmen Martinez, Nicolas Clere, Hélène Marchand-Libouban,

Microparticles (MPs) released from the plasma membrane play a role in tumor progression. Involvement of MPs in myeloma (MM) has been poorly investigated. Because of the strong interaction of MM cells with bone microenvironment, we hypothesized an implication of MPs in MM using a murine model. Forty-four mice were injected ... Read more >>

Micron (Micron (Oxford, England : 1993))
[2013, 54-55:75-81]

Cited: 8 times

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Pleiotropic beneficial effects of epigallocatechin gallate, quercetin and delphinidin on cardiovascular diseases associated with endothelial dysfunction.

Ousama Dayoub, Ramaroson Andriantsitohaina, Nicolas Clere,

Cardiovascular diseases are an important public health problem because they represent a major cause of death worldwide. The pathophysiology of these chronic diseases is defined, among others, by an excess of reactive oxygen species production, a defect of endothelium-dependent vasodilation, a high blood pressure or a modification of platelet function. ... Read more >>

Cardiovasc Hematol Agents Med Chem (Cardiovascular & hematological agents in medicinal chemistry)
[2013, 11(4):249-264]

Cited: 11 times

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Estrogen receptor alpha as a key target of organochlorines to promote angiogenesis.

Nicolas Clere, Emilie Lauret, Yves Malthiery, Ramaroson Andriantsitohaina, Sébastien Faure,

Epidemiological studies report that exposure to pesticides like chlordecone and lindane increases risk of cancer. They may act as endocrine disruptors via the activation of estrogen receptor α (ERα). Carcinogenesis involved angiogenesis and no available data regarding these organochlorines have been reported. The present study aimed at investigating the effects ... Read more >>

Angiogenesis (Angiogenesis)
[2012, 15(4):745-760]

Cited: 6 times

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Paradoxical effects of ethoxidine, a topoisomerase I inhibitor, in the cellular processes leading to angiogenesis on endothelial cells.

Nicolas Clere, Sébastien Faure, Jean-Jacques Helesbeux, Olivier Duval, Ramaroson Andriantsitohaina,

Angiogenesis, a critical step in tumorigenesis, is defined by different processes leading to neovascularization. Topoisomerase I (Top I) is the target for some of the most successful anticancer drugs that decrease tumor cell proliferation. Ethoxidine, a benzo[c]phenanthridines derivative, camptothecin analogue, has been identified as a potent inhibitor of Top I ... Read more >>

Carcinogenesis (Carcinogenesis)
[2011, 32(3):286-295]

Cited: 4 times

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Anticancer properties of flavonoids: roles in various stages of carcinogenesis.

Nicolas Clere, Sébastien Faure, Maria Carmen Martinez, Ramaroson Andriantsitohaina,

High dietary intake of fruits and vegetables is consistently associated with a reduced risk of common human cancers. The specific mechanisms of action of most phytochemicals in cancer prevention are not yet clear but appear to be varied. One class of compounds currently under investigation is flavonoids, a large group ... Read more >>

Cardiovasc Hematol Agents Med Chem (Cardiovascular & hematological agents in medicinal chemistry)
[2011, 9(2):62-77]

Cited: 56 times

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Deficiency or blockade of angiotensin II type 2 receptor delays tumorigenesis by inhibiting malignant cell proliferation and angiogenesis.

Nicolas Clere, Isabelle Corre, Sébastien Faure, Anne-Laure Guihot, Emilie Vessières, Marie Chalopin, Alain Morel, Olivier Coqueret, Lutz Hein, Yves Delneste, François Paris, Daniel Henrion,

Despite significant expression level in cancer cells, the role of the angiotensin II Type 2 receptor (AT2R) in cancer progression remains poorly understood. We aimed to investigate the involvement of AT2R in tumorigenesis, hypothesizing a role in tumor cell proliferation and/or tumor angiogenesis. Two animal tumor models were used: fibrosarcoma ... Read more >>

Int. J. Cancer (International journal of cancer)
[2010, 127(10):2279-2291]

Cited: 44 times

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Heme oxygenase-1 induction restores high-blood-flow-dependent remodeling and endothelial function in mesenteric arteries of old rats.

Mohamed Lamine Freidja, Emilie Vessieres, Nicolas Clere, Valerie Desquiret, Anne-Laure Guihot, Bertrand Toutain, Laurent Loufrani, Alain Jardel, Vincent Procaccio, Sebastien Faure, Daniel Henrion,

Aging is associated with reduced structural and functional adaptation to chronic changes in blood flow (shear stress) in small arteries. As heme oxygenase-1 (HO-1) is induced by hemodynamic forces in vascular smooth muscle and endothelial cells, we hypothesized that it might improve flow-dependent remodeling in aging.First-order mesenteric arteries from 3 ... Read more >>

J. Hypertens. (Journal of hypertension)
[2011, 29(1):102-112]

Cited: 17 times

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The human papillomavirus type 18 E6 oncoprotein induces Vascular Endothelial Growth Factor 121 (VEGF121) transcription from the promoter through a p53-independent mechanism.

Nicolas Clere, Laurent Bermont, Sylvie Fauconnet, Isabelle Lascombe, Maëlle Saunier, Lucie Vettoretti, Marie-Laure Plissonnier, Christiane Mougin,

Altered angiogenic response is associated with high-grade cervical dysplasia and with invasive squamous carcinoma of the cervix. Vascular Endothelial Growth Factor (VEGF) is one of the most potent inducers of angiogenesis and is up-regulated in carcinoma of the cervix. Infection by high-risk human papillomavirus and persistent expression of viral oncogene ... Read more >>

Exp. Cell Res. (Experimental cell research)
[2007, 313(15):3239-3250]

Cited: 17 times

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