Full Text Journal Articles by
Author Nicola Tempest

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Laparoscopic Outcomes after Normal Clinical and Ultrasound Findings in Young Women with Chronic Pelvic Pain: A Cross-Sectional Study.

Nicola Tempest, Ekaterina Efstathiou, Zena Petros, Dharani K Hapangama,

Chronic pelvic pain (CPP) is one of the most common chronic pain problems experienced by women, with prevalence rates comparable to asthma and back pain. However, it is poorly understood and causative pathology is only seldom found. We aimed to establish prevalence of abnormal findings at diagnostic laparoscopy in young ... Read more >>

J Clin Med (Journal of clinical medicine)
[2020, 9(8):]

Cited: 0 times

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Endometriosis and the Fallopian Tubes: Theories of Origin and Clinical Implications.

Christopher J Hill, Marwa Fakhreldin, Alison Maclean, Lucy Dobson, Lewis Nancarrow, Alice Bradfield, Fiona Choi, Diandra Daley, Nicola Tempest, Dharani K Hapangama,

Endometriosis is a common, oestrogen driven chronic condition, where endometrium-like epithelial and stromal cells exist in ectopic sites. At present, no curative treatments are available and the existing evidence for disease progression is conflicting. The pathogenesis is still unknown and evidently complex, as mechanisms of initiation may depend on the ... Read more >>

J Clin Med (Journal of clinical medicine)
[2020, 9(6):]

Cited: 0 times

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Histological 3D reconstruction and in vivo lineage tracing of the human endometrium.

Nicola Tempest, Marnix Jansen, Ann-Marie Baker, Christopher J Hill, Mike Hale, Derek Magee, Darren Treanor, Nicholas A Wright, Dharani K Hapangama,

Regular menstrual shedding and repair of the endometrial functionalis is unique to humans and higher-order primates. The current consensus postulates endometrial glands to have a single-tubular architecture, where multi-potential stem cells reside in the blind-ending glandular-bases. Utilising fixed samples from patients, we have studied the three-dimensional (3D) micro-architecture of the ... Read more >>

J Pathol (The Journal of pathology)
[2020, 251(4):440-451]

Cited: 1 time

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Human Uterine Biopsy: Research Value and Common Pitfalls.

Alison Maclean, Areege Kamal, Meera Adishesh, Rafah Alnafakh, Nicola Tempest, Dharani K Hapangama,

The human uterus consists of the inner endometrium, the myometrium, and the outer serosa. Knowledge of the function of the uterus in health and disease is relevant to reproduction, fertility, embryology, gynaecology, endocrinology, and oncology. Research performed on uterine biopsies is essential to further the current understanding of human uterine ... Read more >>

Int J Reprod Med (International journal of reproductive medicine)
[2020, 2020:9275360]

Cited: 1 time

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Babies in occiput posterior position are significantly more likely to require an emergency cesarean birth compared with babies in occiput transverse position in the second stage of labor: A prospective observational study.

Nicola Tempest, Steven Lane, Dharani Hapangama, ,

INTRODUCTION:Malposition complicates 2-13% of births at delivery, leading to increased obstetric interventions (cesarean section and instrumental delivery) and higher rates of adverse fetal and maternal outcomes. Limited data are available regarding the likely rates of obstetric intervention and subsequent neonatal and maternal outcomes of births with babies in persistent occiput ... Read more >>

Acta Obstet Gynecol Scand (Acta obstetricia et gynecologica Scandinavica)
[2020, 99(4):537-545]

Cited: 1 time

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Evaluating the value of intrapartum fetal scalp blood sampling to predict adverse neonatal outcomes: A UK multicentre observational study.

Bassel H Al Wattar, Aarti Lakhiani, Adalina Sacco, Aditi Siddharth, Alexandra Bain, Alexandra Calvia, Atiyah Kamran, Bing Tiong, Bethan Warwick, Caroline MacMahon, Diana Marcus, Emma Long, Gillian Coyle, Gillian Elizabeth Lever, Gina Michel, Gomathy Gopal, Hana Baig, Hannah Louise Price, Hawra Badri, Helen Stevenson, Helene Hoyte, Humaira Malik, Jade Edwards, Jennifer Hartley, Jennifer Hemers, Jennifer Tamblyn, John Alexander William Dalton, Jonathan Frost, Kamana Subba, Kathryn Baxter, Kavitha Sivakumar, Kelly Murphy, Konstantinos Papadakis, Laura Rachel Bladon, Lorraine Kasaven, Louisa Manning, Mathew Prior, Mausumi Ghosh, Melanie Couch, Melis Altunel, Melissa Pearce, Michael Cocker, Michael Stephanou, Michelle Jie, Minesh Mistry, Mohammed Osama Wahby, Nabila Shahid Saidi, Nicola Louise Ramshaw, Nicola Tempest, Nina Parker, Phoebe L Tan, Racheal Louise Johnson, Rachel Harris, Rachel Tildesley, Ramya Ram, Ritu Painuly, Romana Cuffolo, Roberta Bugeja, Rose Ngadze, Rosie Grainger, Sabitra Gurung, Sammy Mak, Sara Farrell, Sarah Cowey, Sarah Neary, Sarah Quinn, Simrit Kaur Nijjar, Sophie Kenyon, Stephanie Lamb, Susan Tracey, Tara Lee, Therese Kinsella, Trecia Davidson, Trent Corr, Uzo Sampson, Victoria McQueen, William Parry Smith, Zora Castling, ,

OBJECTIVE:To evaluate the value of fetal scalp blood sampling (FBS) as an adjunct test to cardiotocography, to predict adverse neonatal outcomes. STUDY DESIGN:A multicentre service evaluation observational study in forty-four maternity units in the UK. We collected data retrospectively on pregnant women with singleton pregnancy who received FBS in labour ... Read more >>

Eur J Obstet Gynecol Reprod Biol (European journal of obstetrics, gynecology, and reproductive biology)
[2019, 240:62-67]

Cited: 0 times

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Neonatal and maternal outcomes of successful manual rotation to correct malposition of the fetal head; A retrospective and prospective observational study.

Nicola Tempest, Naomi McGuinness, Steven Lane, Dharani K Hapangama,

To evaluate the neonatal and maternal outcomes associated with successful operative vaginal births assisted by manual rotation.Prospective and retrospective observational study.Delivery suite in a tertiary referral teaching hospital in England.A cohort of 2,426 consecutive operative births, in the second stage of labour, complicated with malposition of the fetal head during ... Read more >>

PLoS One (PloS one)
[2017, 12(5):e0176861]

Cited: 2 times

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Hormones and endometrial carcinogenesis.

Areege Kamal, Nicola Tempest, Christina Parkes, Rafah Alnafakh, Sofia Makrydima, Meera Adishesh, Dharani K Hapangama,

Endometrial cancer (EC) is the commonest gynaecological cancer in the Western World with an alarmingly increasing incidence related to longevity and obesity. Ovarian hormones regulate normal human endometrial cell proliferation, regeneration and function therefore are implicated in endometrial carcinogenesis directly or via influencing other hormones and metabolic pathways. Although the ... Read more >>

Horm Mol Biol Clin Investig (Hormone molecular biology and clinical investigation)
[2016, 25(2):129-148]

Cited: 10 times

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Does advanced operative obstetrics still have a place in contemporary practice?

Nicola Tempest, Kate Navaratnam, Dharani Kosala Hapangama,

This article reviews recent significant contributions to the literature concerning advanced operative obstetric procedures used for rotational vaginal deliveries and their alternative, primary caesarean section.Rising caesarean section rates are a global concern. Caesarean section in the second stage of labour is associated with high rates of maternal and fetal morbidity. ... Read more >>

Curr Opin Obstet Gynecol (Current opinion in obstetrics & gynecology)
[2015, 27(2):115-120]

Cited: 1 time

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Theories on the pathogenesis of endometriosis.

Samer Sourial, Nicola Tempest, Dharani K Hapangama,

Endometriosis is a common, chronic inflammatory disease defined by the presence of extrauterine endometrial tissue. The aetiology of endometriosis is complex and multifactorial, where several not fully confirmed theories describe its pathogenesis. This review examines existing theories on the initiation and propagation of different types of endometriotic lesions, as well ... Read more >>

Int J Reprod Med (International journal of reproductive medicine)
[2014, 2014:179515]

Cited: 53 times

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