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Author Nicola Tarantino

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Prevalence, Outcomes, and Management of Ventricular Arrhythmias in COVID-19 Patients

Nicola Tarantino, Domenico G. Della Rocca, Fengwei Zou, Aung Lin, Andrea Natale, Luigi Di Biase,

Synopsis We review the current data on epidemiology, the clinical significance, the pathophysiologic mechanisms, and the treatment of VAs in the setting of COVID-19. VAs prevail in 0.15-8% of in hospitalized patients, but only sustained and rapid tachyarrhythmias are purportedly associated with a significant increase in mortality. Multiple factors can ... Read more >>

Card Electrophysiol Clin (Cardiac electrophysiology clinics)
[2021, :]

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Half-Dose Direct Oral Anticoagulation Versus Standard Antithrombotic Therapy After Left Atrial Appendage Occlusion.

Domenico G Della Rocca, Michele Magnocavallo, Luigi Di Biase, Sanghamitra Mohanty, Chintan Trivedi, Nicola Tarantino, Carola Gianni, Carlo Lavalle, Christoffel Johannes Van Niekerk, Jorge Romero, David F Briceño, Mohamed Bassiouny, Amin Al-Ahmad, J David Burkhardt, Veronica N Natale, G Joseph Gallinghouse, Armando Del Prete, Giovanni B Forleo, Javier Sanchez, Dhanunjaya Lakkireddy, Rodney P Horton, Douglas N Gibson, Andrea Natale,

<h4>Objectives</h4>This study evaluated the long-term efficacy of a standard antithrombotic strategy versus half-dose direct oral anticoagulation (DOAC) after Watchman implantation.<h4>Background</h4>No consensus currently exists on the selection of the most effective antithrombotic strategy to prevent device-related thrombosis (DRT) in patients undergoing endocardial left atrial appendage closure.<h4>Methods</h4>After successful left atrial appendage closure, ... Read more >>

JACC Cardiovasc Interv (JACC. Cardiovascular interventions)
[2021, 14(21):2353-2364]

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Prognostic role of neoplastic markers in Takotsubo syndrome.

Francesco Santoro, Tecla Zimotti, Adriana Mallardi, Alessandra Leopizzi, Enrica Vitale, Nicola Tarantino, Armando Ferraretti, Antonio Giovanni Solimando, Vito Racanelli, Massimo Iacoviello, Michele Cannone, Matteo Di Biase, Natale Daniele Brunetti,

Takotsubo syndrome (TTS) is an acute heart failure syndrome with significant rates of in and out-of-hospital mayor cardiac adverse events (MACE). To evaluate the possible role of neoplastic biomarkers [CA-15.3, CA-19.9 and Carcinoembryonic Antigen (CEA)] as prognostic marker at short- and long-term follow-up in subjects with TTS. Ninety consecutive subjects ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):16548]

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Targeting non-pulmonary vein triggers in persistent atrial fibrillation: results from a prospective, multicentre, observational registry.

Domenico G Della Rocca, Luigi Di Biase, Sanghamitra Mohanty, Chintan Trivedi, Carola Gianni, Jorge Romero, Nicola Tarantino, Michele Magnocavallo, Mohamed Bassiouny, Veronica N Natale, Angel Quintero Mayedo, Bryan Macdonald, Carlo Lavalle, Ghulam Murtaza, Krishna Akella, Giovanni B Forleo, Amin Al-Ahmad, John David Burkhardt, Gerald Joseph Gallinghouse, Javier E Sanchez, Rodney P Horton, Juan F Viles-Gonzalez, Dhanunjaya Lakkireddy, Andrea Natale,

<h4>Aims</h4>We evaluated the efficacy of an ablation strategy empirically targeting pulmonary veins (PVs) and posterior wall (PW) and the prevalence and clinical impact of extrapulmonary trigger inducibility and ablation in a large cohort of patients with persistent atrial fibrillation (PerAF).<h4>Methods and results</h4>A total of 1803 PerAF patients were prospectively enrolled. ... Read more >>

Europace (Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology)
[2021, :]

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Radiofrequency Energy Applications Targeting Significant Residual Leaks After Watchman Implantation: A Prospective, Multicenter Experience.

Domenico G Della Rocca, Ghulam Murtaza, Luigi Di Biase, Krishna Akella, Subramaniam C Krishnan, Michele Magnocavallo, Sanghamitra Mohanty, Carola Gianni, Chintan Trivedi, Carlo Lavalle, Giovanni B Forleo, Veronica N Natale, Nicola Tarantino, Jorge Romero, Rakesh Gopinathannair, Philip J Patel, Mohamed Bassiouny, Armando Del Prete, Amin Al-Ahmad, J David Burkhardt, G Joseph Gallinghouse, Javier E Sanchez, Shephal K Doshi, Rodney P Horton, Dhanunjaya Lakkireddy, Andrea Natale,

<h4>Objectives</h4>The aim of this study was to evaluate the efficacy of radiofrequency (RF) energy applications targeting the atrial side of a significant residual leak in patients with acute and chronic evidence of incomplete percutaneous left atrial appendage (LAA) occlusion.<h4>Background</h4>RF applications have been proved to prevent recanalization of intracranial aneurysms after ... Read more >>

JACC Clin Electrophysiol (JACC. Clinical electrophysiology)
[2021, :]

Cited: 1 time

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Clinical presentation, diagnosis, and treatment of atrioesophageal fistula resulting from atrial fibrillation ablation.

Domenico G Della Rocca, Michele Magnocavallo, Veronica N Natale, Carola Gianni, Sanghamitra Mohanty, Chintan Trivedi, Carlo Lavalle, Giovanni B Forleo, Nicola Tarantino, Jorge Romero, Xiadong Zhang, Mohamed Bassiouny, Amin Al-Ahmad, David J Burkhardt, Joseph G Gallinghouse, Javier E Sanchez, Rodney P Horton, Luigi Di Biase, Andrea Natale,

<h4>Background</h4>Atrioesophageal fistula (AEF) is a worrisome complication of atrial fibrillation (AF) ablation. Its clinical manifestations and time course are unpredictable and may contribute to diagnostic and treatment delays. We conducted a systematic review of all available cases of AEF, aiming at characterizing clinical presentation, time course, diagnostic pitfalls, and outcomes.<h4>Methods</h4>The ... Read more >>

J Cardiovasc Electrophysiol (Journal of cardiovascular electrophysiology)
[2021, 32(9):2441-2450]

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Incidence of Device-Related Thrombosis in Watchman Patients Undergoing a Genotype-Guided Antithrombotic Strategy.

Domenico G Della Rocca, Rodney P Horton, Luigi Di Biase, Carola Gianni, Chintan Trivedi, Sanghamitra Mohanty, Alisara Anannab, Michele Magnocavallo, Qiong Chen, Nicola Tarantino, Mohamed Bassiouny, Carlo Lavalle, Veronica N Natale, Giovanni B Forleo, Armando Del Prete, Christoffel Johannes Van Niekerk, Amin Al-Ahmad, J David Burkhardt, G Joseph Gallinghouse, Javier E Sanchez, Dhanunjaya Lakkireddy, Douglas N Gibson, Andrea Natale,

<h4>Objectives</h4>This study sought to report the incidence of device-related thrombosis (DRT) and thromboembolic (TE) events when an alternative to clopidogrel is prescribed in loss-of-function (LOF) allele carriers of the cytochrome P450 2C19 (CYP2C19) gene.<h4>Background</h4>LOF polymorphisms of the CYP2C19 gene are associated with reduced hepatic bioactivation of clopidogrel.<h4>Methods</h4>One thousand two Watchman ... Read more >>

JACC Clin Electrophysiol (JACC. Clinical electrophysiology)
[2021, :]

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Catheter ablation of ventricular tachycardia in ischemic cardiomyopathy: Impact of concomitant amiodarone therapy on short- and long-term clinical outcomes.

Luigi Di Biase, Jorge Romero, Xianfeng Du, Sanghamitra Mohanty, Chintan Trivedi, Domenico G Della Rocca, Kavisha Patel, Javier Sanchez, Ruike Yang, Isabella Alviz, Prasant Mohanty, Carola Gianni, Nicola Tarantino, Xiao-Dong Zhang, Rodney Horton, Amin Al-Ahmad, Dhanunjaya Lakkireddy, David J Burkhardt, Minglong Chen, Andrea Natale,

<h4>Background</h4>Substrate catheter ablation of scar-related ventricular tachycardia (VT) is a widely accepted therapeutic option for patients with ischemic cardiomyopathy (ICM).<h4>Objective</h4>The purpose of this study was to investigate whether concomitant amiodarone therapy affects procedural outcomes.<h4>Methods</h4>A total of 134 consecutive patients (89% male; age 66 ± 10 years) with ICM undergoing catheter ablation ... Read more >>

Heart Rhythm (Heart rhythm)
[2021, 18(6):885-893]

Cited: 1 time

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Catheter Ablation of Life-Threatening Ventricular Arrhythmias in Athletes.

Nicola Tarantino, Domenico G Della Rocca, Nicole S De Leon De La Cruz, Eric D Manheimer, Michele Magnocavallo, Carlo Lavalle, Carola Gianni, Sanghamitra Mohanty, Chintan Trivedi, Amin Al-Ahmad, Rodney P Horton, Mohamed Bassiouny, J David Burkhardt, G Joseph Gallinghouse, Giovanni B Forleo, Luigi Di Biase, Andrea Natale,

A recent surveillance analysis indicates that cardiac arrest/death occurs in ≈1:50,000 professional or semi-professional athletes, and the most common cause is attributable to life-threatening ventricular arrhythmias (VAs). It is critically important to diagnose any inherited/acquired cardiac disease, including coronary artery disease, since it frequently represents the arrhythmogenic substrate in a ... Read more >>

Medicina (Kaunas) (Medicina (Kaunas, Lithuania))
[2021, 57(3):]

Cited: 2 times

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First-line ablation of ventricular tachycardia in ischemic cardiomyopathy: stratification of outcomes by left ventricular function.

David F Briceño, Jorge Romero, Kavisha Patel, Wasla Liaqat, Xiao-Dong Zhang, Isabella Alviz, Ruike Yang, Daniel Rodriguez, Dhanunjaya Lakkireddy, Domenico Della Rocca, Nicola Tarantino, Rakesh Gopinathannair, Andrea Natale, Luigi Di Biase,

<h4>Purpose</h4>First-line catheter ablation of ventricular tachycardia/ventricular fibrillation (VT/VF) in patients with ischemic cardiomyopathy (ICM) has been associated with improved outcomes; however, most benefit seems to be in patients with moderately depressed left ventricular ejection fraction (LVEF). Herein, outcomes were stratified based on LVEF.<h4>Methods</h4>A meta-analysis of randomized controlled trials (RCTs) evaluating ... Read more >>

J Interv Card Electrophysiol (Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing)
[2021, 62(2):391-400]

Cited: 1 time

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Evidence of systemic endothelial injury and microthrombosis in hospitalized COVID-19 patients at different stages of the disease.

Domenico G Della Rocca, Michele Magnocavallo, Carlo Lavalle, Jorge Romero, Giovanni B Forleo, Nicola Tarantino, Cristina Chimenti, Isabella Alviz, Maria T Gamero, Mario J Garcia, Luigi Di Biase, Andrea Natale,

J Thromb Thrombolysis (Journal of thrombosis and thrombolysis)
[2021, 51(3):571-576]

Cited: 4 times

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Use of a Novel Septal Occluder Device for Left Atrial Appendage Closure in Patients With Postsurgical and Postlariat Leaks or Anatomies Unsuitable for Conventional Percutaneous Occlusion.

Domenico G Della Rocca, Rodney P Horton, Nicola Tarantino, Christoffel Johannes Van Niekerk, Chintan Trivedi, Qiong Chen, Sanghamitra Mohanty, Alisara Anannab, Ghulam Murtaza, Krishna Akella, Carola Gianni, Mohamed Bassiouny, Ashkan Ahmadian-Tehrani, Amin Al-Ahmad, J David Burkhardt, Veronica N Natale, Matthew Price, G Joseph Gallinghouse, Douglas N Gibson, Dhanunjaya Lakkireddy, Luigi Di Biase, Andrea Natale,

<h4>Background</h4>Interventional therapies aiming at excluding the left atrial appendage (LAA) from systemic circulation have been established as a valid alternative to oral anticoagulation in patients at high thromboembolic risk. However, their efficacy on stroke prophylaxis may be compromised owing to incomplete LAA closure. Additionally, the need for an alternative thromboembolic ... Read more >>

Circ Cardiovasc Interv (Circulation. Cardiovascular interventions)
[2020, 13(10):e009227]

Cited: 2 times

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Epicardial Ablation Complications.

Nicola Tarantino, Domenico G Della Rocca, Michela Faggioni, Xiao-Dong Zhang, Sanghamitra Mohanty, Alisara Anannab, Ugur Canpolat, Huseyin Ayhan, Mohamed Bassiouny, Anu Sahore, Kudret Aytemir, Annahita Sarcon, Giovanni B Forleo, Carlo Lavalle, Rodney P Horton, Chintan Trivedi, Amin Al-Ahmad, Jorge Romero, David J Burkhardt, Joseph G Gallinghouse, Luigi Di Biase, Andrea Natale,

The percutaneous epicardial approach has become an adjunctive tool for electrophysiologists to treat disparate cardiac arrhythmias, including accessory pathways, atrial tachycardia, and particularly ventricular tachycardia. This novel technique prompted a strong impulse to perform epicardial access as an alternative strategy for pacing and defibrillation, left atrial appendage exclusion, heart failure ... Read more >>

Card Electrophysiol Clin (Cardiac electrophysiology clinics)
[2020, 12(3):409-418]

Cited: 1 time

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Chromogranin-A serum levels in patients with takotsubo syndrome and ST elevation acute myocardial infarction.

Nicola Tarantino, Francesco Santoro, Luigi Di Biase, Vito Di Terlizzi, Enrica Vitale, Roberta Barone, Domenico Giovanni Della Rocca, Nicole Stephany De Leon De La Cruz, Matteo Di Biase, Natale Daniele Brunetti,

<h4>Background</h4>Sympathergic hyperactivity is considered one of the main trigger precipitating takotsubo syndrome (TTS). Chromogranin-A (CgA), a prognostic biomarker of sympatho-adrenal activation, is markedly high in acute coronary syndrome (ACS) and heart failure (HF), but its role in TTS is unknown.<h4>Methods</h4>CgA serum levels from patients with TTS and symptoms onset <24 ... Read more >>

Int J Cardiol (International journal of cardiology)
[2020, 320:12-17]

Cited: 4 times

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Non-pulmonary vein triggers in nonparoxysmal atrial fibrillation: Implications of pathophysiology for catheter ablation.

Domenico G Della Rocca, Nicola Tarantino, Chintan Trivedi, Sanghamitra Mohanty, Alisara Anannab, Anu S Salwan, Carola Gianni, Mohamed Bassiouny, Amin Al-Ahmad, Jorge Romero, David F Briceño, J David Burkhardt, G Joseph Gallinghouse, Rodney P Horton, Luigi Di Biase, Andrea Natale,

Rhythm control of persistent atrial fibrillation (AF) patients represents a challenge for the modern interventional cardiac electrophysiologist; as a matter of fact, there is still divergence regarding the best ablative approach to adopt in this population. Different investigational endpoints, variability of techniques and tools, significant technological evolution, and the lack ... Read more >>

J Cardiovasc Electrophysiol (Journal of cardiovascular electrophysiology)
[2020, 31(8):2154-2167]

Cited: 7 times

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On the role of echocardiography and beta-receptors downregulation in multipattern Takotsubo.

Nicola Tarantino, Francesco Santoro, Luigi Di Biase, Domenico Giovanni Della Rocca, Natale Daniele Brunetti,

Echocardiography (Echocardiography (Mount Kisco, N.Y.))
[2020, 37(7):1134-1135]

Cited: 1 time

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Is transesophageal echocardiography necessary in patients undergoing ablation of atrial fibrillation on an uninterrupted direct oral anticoagulant regimen? Results from a prospective multicenter registry.

Kavisha Patel, Andrea Natale, Ruike Yang, Chintan Trivedi, Jorge Romero, David Briceno, Sanghamitra Mohanty, Isabella Alviz, Veronica Natale, Javier Sanchez, Domenico G Della Rocca, Nicola Tarantino, Xiao-Dong Zhang, Prasant Mohanty, Rodney Horton, David Burkhardt, Rakesh Gopinathannair, G Joseph Gallinghouse, Dhanunjaya Lakkireddy, Luigi Di Biase,

<h4>Background</h4>Thromboembolic stroke is a rare but devastating consequence of atrial fibrillation (AF) ablation. Transesophageal echocardiography (TEE) is recommended to rule out left atrial appendage thrombus; however, its use is variable.<h4>Objective</h4>The purpose of this study was to assess whether TEE is mandatory in patients undergoing AF ablation on uninterrupted direct oral ... Read more >>

Heart Rhythm (Heart rhythm)
[2020, 17(12):2093-2099]

Cited: 4 times

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Endo-epicardial ablation vs endocardial ablation for the management of ventricular tachycardia in arrhythmogenic right ventricular cardiomyopathy: A systematic review and meta-analysis.

Jorge Romero, Kavisha Patel, David Briceno, Isabella Alviz, Mohamed Gabr, Juan Carlos Diaz, Chintan Trivedi, Sanghamitra Mohanty, Domenico Della Rocca, Amin Al-Ahmad, Ruike Yang, Saul Rios, Luis Cerna, Xianfeng Du, Nicola Tarantino, Xiao-Dong Zhang, Dhanunjaya Lakkireddy, Andrea Natale, Luigi Di Biase,

<h4>Background</h4>The pathologic process of ARVC (arrhythmogenic right ventricular cardiomyopathy) typically originates in the epicardium or subepicardial layers with progression toward endocardium. However, in the most recent ARVC international task force consensus statement, epicardial ventricular tachycardia (VT) ablation is recommended as a Class I indication only in patients with at least ... Read more >>

J Cardiovasc Electrophysiol (Journal of cardiovascular electrophysiology)
[2020, 31(8):2022-2031]

Cited: 1 time

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Beyond Pulmonary Vein Isolation in Nonparoxysmal Atrial Fibrillation: Posterior Wall, Vein of Marshall, Coronary Sinus, Superior Vena Cava, and Left Atrial Appendage.

David F Briceño, Kavisha Patel, Jorge Romero, Isabella Alviz, Nicola Tarantino, Domenico G Della Rocca, Veronica Natale, Xiao-Dong Zhang, Luigi Di Biase,

The optimal ablation strategy for non-paroxysmal atrial fibrillation remains controversial. Non-PV triggers have been shown to have a major arrhythmogenic role in these patients. Common sources of non-PV triggers are: posterior wall, left atrial appendage, superior vena cava, coronary sinus, vein of Marshall, interatrial septum, crista terminalis/Eustachian ridge, and mitral ... Read more >>

Card Electrophysiol Clin (Cardiac electrophysiology clinics)
[2020, 12(2):219-231]

Cited: 0 times

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Fluoroless Atrial Fibrillation Catheter Ablation: Technique and Clinical Outcomes.

Jorge Romero, Kavisha Patel, David Briceno, Isabella Alviz, Nicola Tarantino, Domenico G Della Rocca, Veronica Natale, Xiao-Dong Zhang, Luigi Di Biase,

Fluoroscopy continues to be considered an indispensable part of atrial fibrillation (AF) ablation worldwide. Deleterious effects of radiation exposure to patients, physicians, and catheter laboratory personnel are gaining increased consideration. Safety and efficacy of a fluoroless approach for AF ablation is comparable with outcomes achieved with fluoroscopy use. This article ... Read more >>

Card Electrophysiol Clin (Cardiac electrophysiology clinics)
[2020, 12(2):233-245]

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Clinical Implications and Management Strategies for Left Atrial Appendage Leaks.

Anu Sahore, Domenico G Della Rocca, Alisara Anannab, Sanghamitra Mohanty, Krishna Akella, Ghulam Murtaza, Chintan Trivedi, Carola Gianni, Qiong Chen, Mohamed Bassiouny, Ashkan Ahmadian-Tehrani, Bryan Macdonald, Amin Al-Ahmad, Nicola Tarantino, Donatello Cirone, Rodney P Horton, Jorge Romero, Dhanunjaya Lakkireddy, Luigi Di Biase, Andrea Natale,

Left atrial appendage (LAA) is the dominant source of systemic thromboembolic (TE) events in patients with nonvalvular atrial fibrillation (AF). In patients with significant bleeding risk, various LAA exclusion strategies have been developed as an alternative to pharmacologic TE prophylaxis. Nevertheless, in a relatively small percentage of patients, incomplete LAA ... Read more >>

Card Electrophysiol Clin (Cardiac electrophysiology clinics)
[2020, 12(1):89-96]

Cited: 0 times

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Toward a Uniform Ablation Protocol for Paroxysmal, Persistent, and Permanent Atrial Fibrillation.

Domenico Giovanni Della Rocca, Carlo Lavalle, Carola Gianni, Marco Valerio Mariani, Sanghamitra Mohanty, Chintan Trivedi, Ugur Canpolat, Bryan MacDonald, Huseyin Ayhan, Agostino Piro, Mohamed Bassiouny, Amin Al-Ahmad, John David Burkhardt, Joseph G Gallinghouse, Rodney P Horton, Javier Sanchez, Nicola Tarantino, Luigi Di Biase, Andrea Natale,

Atrial fibrillation catheter ablation has emerged as the most effective strategy to restore and maintain sinus rhythm. The cornerstone of atrial fibrillation ablation is elimination of triggers from the pulmonary veins by pulmonary vein isolation. Nevertheless, some patients may experience atrial tachyarrhythmia recurrences even with permanent pulmonary vein antral isolation. ... Read more >>

Card Electrophysiol Clin (Cardiac electrophysiology clinics)
[2019, 11(4):731-738]

Cited: 0 times

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Time to pause ventricular tachycardia: the PAUSE-SCD trial.

David F Briceño, Jorge Romero, Isabella Alviz, Nicola Tarantino, Luigi Di Biase,

J Interv Card Electrophysiol (Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing)
[2020, 57(2):219-220]

Cited: 0 times

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Burn and plug: is it too much for the left atrial appendage?

Nicola Tarantino, Jorge Romero, Xiao-Dong Zhang, David Briceño, Luigi Di Biase,

J Interv Card Electrophysiol (Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing)
[2020, 57(1):39-42]

Cited: 0 times

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Assessment of the German and Italian Stress Cardiomyopathy Score for Risk Stratification for In-hospital Complications in Patients With Takotsubo Syndrome.

Francesco Santoro, Iván J Núñez Gil, Thomas Stiermaier, Ibrahim El-Battrawy, Federico Guerra, Giuseppina Novo, Francesca Guastafierro, Nicola Tarantino, Salvatore Novo, Enrica Mariano, Francesco Romeo, Fabiana Romeo, Alessandro Capucci, Edda Bahlmann, Maddalena Zingaro, Michele Cannone, Pasquale Caldarola, Maria Francesca Marchetti, Roberta Montisci, Luigi Meloni, Holger Thiele, Matteo Di Biase, Manuel Almendro-Delia, Alessandro Sionis, Ibrahim Akin, Ingo Eitel, Natale Daniele Brunetti,

<h4>Importance</h4>Takotsubo syndrome (TTS) is an acute, reversible heart failure syndrome featured by significant rates of in-hospital complications. There is a lack of data for risk stratification during hospitalization.<h4>Objective</h4>To derive a simple clinical score for risk prediction of in-hospital complications among patients with TTS.<h4>Design, setting, and participants</h4>In this prognostic study, 1007 ... Read more >>

JAMA Cardiol (JAMA cardiology)
[2019, 4(9):892-899]

Cited: 14 times

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