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Author Nicola S Lewis

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Emergence and spread of novel H5N8, H5N5 and H5N1 clade 2.3.4.4 highly pathogenic avian influenza in 2020.

Nicola S Lewis, Ashley C Banyard, Elliot Whittard, Talgat Karibayev, Thamer Al Kafagi, Ilya Chvala, Alex Byrne, Saduakassova Meruyert Akberovna, Jacqueline King, Timm Harder, Christian Grund, Steve Essen, Scott M Reid, Adam Brouwer, Nikolay G Zinyakov, Azimkhan Tegzhanov, Victor Irza, Anne Pohlmann, Martin Beer, Ron A M Fouchier, Sultanov Akhmetzhan Akievich, Ian H Brown,

Analyses of HPAI H5 viruses from poultry outbreaks across a wide Eurasian region since July 2020 including the Russian Federation, Republics of Iraq and Kazakhstan, and recent detections in migratory waterfowl in the Netherlands, revealed undetected maintenance of H5N8, likely in galliform poultry since 2017/18 and both H5N5 and H5N1. ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2021, 10(1):148-151]

Cited: 9 times

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Antigenic evolution of contemporary clade 2.3.4.4 HPAI H5 influenza A viruses and impact on vaccine use for mitigation and control.

Nicola S Lewis, Ashley C Banyard, Steve Essen, Elliot Whittard, Amelia Coggon, Rowena Hansen, Scott Reid, Ian H Brown,

Since 2003, highly pathogenic avian influenza (HPAI) viruses of the H5 subtype have been maintained in poultry, periodically spilling back into wild migratory birds and spread to other geographic regions, with re-introduction to domestic birds causing severe impacts for poultry health, production and food sustainability. Successive waves of infection have ... Read more >>

Vaccine (Vaccine)
[2021, 39(29):3794-3798]

Cited: 0 times

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Swine Influenza A Viruses and the Tangled Relationship with Humans.

Tavis K Anderson, Jennifer Chang, Zebulun W Arendsee, Divya Venkatesh, Carine K Souza, J Brian Kimble, Nicola S Lewis, C Todd Davis, Amy L Vincent,

Influenza A viruses (IAVs) are the causative agents of one of the most important viral respiratory diseases in pigs and humans. Human and swine IAV are prone to interspecies transmission, leading to regular incursions from human to pig and vice versa. This bidirectional transmission of IAV has heavily influenced the ... Read more >>

Cold Spring Harb Perspect Med (Cold Spring Harbor perspectives in medicine)
[2021, 11(3):]

Cited: 10 times

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Characterization of contemporary 2010.1 H3N2 swine influenza A viruses circulating in United States pigs.

Joshua D Powell, Eugenio J Abente, Jennifer Chang, Carine K Souza, Daniela S Rajao, Tavis K Anderson, Michael A Zeller, Phillip C Gauger, Nicola S Lewis, Amy L Vincent,

In 2012, swine influenza surveillance detected a novel reassorted influenza A virus (IAV) strain containing human-seasonal hemagglutinin (HA) and neuraminidase (NA). Subsequently, these viruses reassorted, maintaining only the human-origin H3, which resulted in a new lineage of viruses that became the most frequently detected H3 clade in US swine (2010.1 ... Read more >>

Virology (Virology)
[2021, 553:94-101]

Cited: 0 times

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Outbreak Severity of Highly Pathogenic Avian Influenza A(H5N8) Viruses Is Inversely Correlated to Polymerase Complex Activity and Interferon Induction.

René M Vigeveno, Marjolein J Poen, Edyth Parker, Melle Holwerda, Karen de Haan, Thijs van Montfort, Nicola S Lewis, Colin A Russell, Ron A M Fouchier, Menno D de Jong, Dirk Eggink,

Highly pathogenic avian influenza A(H5N8) viruses first emerged in China in 2010 and in 2014 spread throughout Asia and to Europe and the United States via migrating birds. Influenza A(H5N8) viruses were first detected in the Netherlands in 2014 and caused five outbreaks in poultry farms but were infrequently detected ... Read more >>

J Virol (Journal of virology)
[2020, 94(11):]

Cited: 2 times

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Regional Transmission and Reassortment of 2.3.4.4b Highly Pathogenic Avian Influenza (HPAI) Viruses in Bulgarian Poultry 2017/18.

Divya Venkatesh, Adam Brouwer, Gabriela Goujgoulova, Richard Ellis, James Seekings, Ian H Brown, Nicola S Lewis,

Between 2017 and 2018, several farms across Bulgaria reported outbreaks of H5 highly-pathogenic avian influenza (HPAI) viruses. In this study we used genomic and traditional epidemiological analyses to trace the origin and subsequent spread of these outbreaks within Bulgaria. Both methods indicate two separate incursions, one restricted to the northeastern ... Read more >>

Viruses (Viruses)
[2020, 12(6):]

Cited: 4 times

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Detection of H3N8 influenza A virus with multiple mammalian-adaptive mutations in a rescued Grey seal (Halichoerus grypus) pup.

Divya Venkatesh, Carlo Bianco, Alejandro Núñez, Rachael Collins, Darryl Thorpe, Scott M Reid, Sharon M Brookes, Steve Essen, Natalie McGinn, James Seekings, Jayne Cooper, Ian H Brown, Nicola S Lewis,

Avian influenza A viruses (IAVs) in different species of seals display a spectrum of pathogenicity, from sub-clinical infection to mass mortality events. Here we present an investigation of avian IAV infection in a 3- to 4-month-old Grey seal (<i>Halichoerus grypus</i>) pup, rescued from St Michael's Mount, Cornwall in 2017. The ... Read more >>

Virus Evol (Virus evolution)
[2020, 6(1):veaa016]

Cited: 3 times

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A30 Avian influenza viruses in wild birds: Virus evolution in a multi-host ecosystem

Divya Venkatesh, Marjolein J Poen, Theo M Bestebroer, Rachel D Scheuer, Oanh Vuong, Mzia Chkhaidze, Anna Machablishvili, Jimsher Mamuchadze, Levan Ninua, Nadia B Fedorova, Rebecca A Halpin, Xudong Lin, Amy Ransier, Timothy B Stockwell, David E Wentworth, Divya Kriti, Jayeeta Dutta, Harm van Bakel, Anita Puranik, Marek J Slomka, Steve Essen, Ian H Brown, Ron A M Fouchier, Nicola S Lewis,

Abstract Wild ducks and gulls are the major reservoirs for avian influenza A viruses (AIVs). The mechanisms that drive AIV evolution are complex at sites where various duck and gull species from multiple flyways breed, winter, or stage. The Republic of Georgia is located at the intersection of three migratory ... Read more >>

Virus Evol (Virus evolution)
[2019, 5(Suppl 1):]

Cited: 0 times

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Updated unified phylogenetic classification system and revised nomenclature for Newcastle disease virus.

Kiril M Dimitrov, Celia Abolnik, Claudio L Afonso, Emmanuel Albina, Justin Bahl, Mikael Berg, Francois-Xavier Briand, Ian H Brown, Kang-Seuk Choi, Ilya Chvala, Diego G Diel, Peter A Durr, Helena L Ferreira, Alice Fusaro, Patricia Gil, Gabriela V Goujgoulova, Christian Grund, Joseph T Hicks, Tony M Joannis, Mia Kim Torchetti, Sergey Kolosov, Bénédicte Lambrecht, Nicola S Lewis, Haijin Liu, Hualei Liu, Sam McCullough, Patti J Miller, Isabella Monne, Claude P Muller, Muhammad Munir, Dilmara Reischak, Mahmoud Sabra, Siba K Samal, Renata Servan de Almeida, Ismaila Shittu, Chantal J Snoeck, David L Suarez, Steven Van Borm, Zhiliang Wang, Frank Y K Wong,

Several Avian paramyxoviruses 1 (synonymous with Newcastle disease virus or NDV, used hereafter) classification systems have been proposed for strain identification and differentiation. These systems pioneered classification efforts; however, they were based on different approaches and lacked objective criteria for the differentiation of isolates. These differences have created discrepancies among ... Read more >>

Infect Genet Evol (Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases)
[2019, 74:103917]

Cited: 55 times

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Co-circulation of genetically distinct highly pathogenic avian influenza A clade 2.3.4.4 (H5N6) viruses in wild waterfowl and poultry in Europe and East Asia, 2017-18.

Marjolein J Poen, Divya Venkatesh, Theo M Bestebroer, Oanh Vuong, Rachel D Scheuer, Bas B Oude Munnink, Dennis de Meulder, Mathilde Richard, Thijs Kuiken, Marion P G Koopmans, Leon Kelder, Yong-Joo Kim, Youn-Jeong Lee, Mieke Steensels, Benedicte Lambrecht, Adam Dan, Anne Pohlmann, Martin Beer, Vladimir Savic, Ian H Brown, Ron A M Fouchier, Nicola S Lewis,

Highly pathogenic avian influenza (HPAI) H5 clade 2.3.4.4 viruses were first introduced into Europe in late 2014 and re-introduced in late 2016, following detections in Asia and Russia. In contrast to the 2014-15 H5N8 wave, there was substantial local virus amplification in wild birds in Europe in 2016-17 and associated ... Read more >>

Virus Evol (Virus evolution)
[2019, 5(1):vez004]

Cited: 17 times

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Plasticity of Amino Acid Residue 145 Near the Receptor Binding Site of H3 Swine Influenza A Viruses and Its Impact on Receptor Binding and Antibody Recognition.

Jefferson J S Santos, Eugenio J Abente, Adebimpe O Obadan, Andrew J Thompson, Lucas Ferreri, Ginger Geiger, Ana S Gonzalez-Reiche, Nicola S Lewis, David F Burke, Daniela S Rajão, James C Paulson, Amy L Vincent, Daniel R Perez,

The hemagglutinin (HA), a glycoprotein on the surface of influenza A virus (IAV), initiates the virus life cycle by binding to terminal sialic acid (SA) residues on host cells. The HA gradually accumulates amino acid substitutions that allow IAV to escape immunity through a mechanism known as antigenic drift. We ... Read more >>

J Virol (Journal of virology)
[2019, 93(2):]

Cited: 6 times

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Prevalence of Avian Influenza A(H5) and A(H9) Viruses in Live Bird Markets, Bangladesh.

Younjung Kim, Paritosh K Biswas, Mohammad Giasuddin, Mahmudul Hasan, Rashed Mahmud, Yu-Mei Chang, Steve Essen, Mohammed A Samad, Nicola S Lewis, Ian H Brown, Natalie Moyen, Md Ahasanul Hoque, Nitish C Debnath, Dirk U Pfeiffer, Guillaume Fournié,

We conducted a cross-sectional study in live bird markets (LBMs) in Dhaka and Chittagong, Bangladesh, to estimate the prevalence of avian influenza A(H5) and A(H9) viruses in different types of poultry and environmental areas by using Bayesian hierarchical logistic regression models. We detected these viruses in nearly all LBMs. Prevalence ... Read more >>

Emerg Infect Dis (Emerging infectious diseases)
[2018, 24(12):2309-2316]

Cited: 13 times

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Comparison of 2016-17 and Previous Epizootics of Highly Pathogenic Avian Influenza H5 Guangdong Lineage in Europe.

Pablo Alarcon, Adam Brouwer, Divya Venkatesh, Daisy Duncan, Chrysostomos I Dovas, George Georgiades, Isabella Monne, Alice Fusaro, Adam Dan, Krzysztof Śmietanka, Vassilios Ragias, Andrew C Breed, Taxiarchis Chassalevris, Gabriela Goujgoulova, Charlotte Kristiane Hjulsager, Eoin Ryan, Azucena Sánchez, Eric Niqueux, Niina Tammiranta, Siamak Zohari, David A Stroud, Vladimir Savić, Nicola S Lewis, Ian H Brown,

We analyzed the highly pathogenic avian influenza (HPAI) H5 epizootic of 2016-17 in Europe by epidemiologic and genetic characteristics and compared it with 2 previous epizootics caused by the same H5 Guangdong lineage. The 2016-17 epizootic was the largest in Europe by number of countries and farms affected and greatest ... Read more >>

Emerg Infect Dis (Emerging infectious diseases)
[2018, 24(12):2270-2283]

Cited: 17 times

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Antigenic evolution of H3N2 influenza A viruses in swine in the United States from 2012 to 2016.

Marcus J Bolton, Eugenio J Abente, Divya Venkatesh, Jered A Stratton, Michael Zeller, Tavis K Anderson, Nicola S Lewis, Amy L Vincent,

<h4>Background</h4>Six amino acid positions (145, 155, 156, 158, 159, and 189, referred to as the antigenic motif; H3 numbering) in the globular head region of hemagglutinin (HA1 domain) play an important role in defining the antigenic phenotype of swine Clade IV (C-IV) H3N2 IAV, containing an H3 from a late ... Read more >>

Influenza Other Respir Viruses (Influenza and other respiratory viruses)
[2019, 13(1):83-90]

Cited: 7 times

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The type of adjuvant in whole inactivated influenza a virus vaccines impacts vaccine-associated enhanced respiratory disease.

Carine K Souza, Daniela S Rajão, Matthew R Sandbulte, Sara Lopes, Nicola S Lewis, Crystal L Loving, Phillip C Gauger, Amy L Vincent,

Influenza A virus (IAV) causes a disease burden in the swine industry in the US and is a challenge to prevent due to substantial genetic and antigenic diversity of IAV that circulate in pig populations. Whole inactivated virus (WIV) vaccines formulated with oil-in-water (OW) adjuvant are commonly used in swine. ... Read more >>

Vaccine (Vaccine)
[2018, 36(41):6103-6110]

Cited: 5 times

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Avian Influenza Viruses in Wild Birds: Virus Evolution in a Multihost Ecosystem.

Divya Venkatesh, Marjolein J Poen, Theo M Bestebroer, Rachel D Scheuer, Oanh Vuong, Mzia Chkhaidze, Anna Machablishvili, Jimsher Mamuchadze, Levan Ninua, Nadia B Fedorova, Rebecca A Halpin, Xudong Lin, Amy Ransier, Timothy B Stockwell, David E Wentworth, Divya Kriti, Jayeeta Dutta, Harm van Bakel, Anita Puranik, Marek J Slomka, Steve Essen, Ian H Brown, Ron A M Fouchier, Nicola S Lewis,

Wild ducks and gulls are the major reservoirs for avian influenza A viruses (AIVs). The mechanisms that drive AIV evolution are complex at sites where various duck and gull species from multiple flyways breed, winter, or stage. The Republic of Georgia is located at the intersection of three migratory flyways: ... Read more >>

J Virol (Journal of virology)
[2018, 92(15):]

Cited: 28 times

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Antigenic and genetic evolution of contemporary swine H1 influenza viruses in the United States.

Daniela S Rajao, Tavis K Anderson, Pravina Kitikoon, Jered Stratton, Nicola S Lewis, Amy L Vincent,

Several lineages of influenza A viruses (IAV) currently circulate in North American pigs. Genetic diversity is further increased by transmission of IAV between swine and humans and subsequent evolution. Here, we characterized the genetic and antigenic evolution of contemporary swine H1N1 and H1N2 viruses representing clusters H1-α (1A.1), H1-β (1A.2), ... Read more >>

Virology (Virology)
[2018, 518:45-54]

Cited: 19 times

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A Phylogeny-Based Global Nomenclature System and Automated Annotation Tool for H1 Hemagglutinin Genes from Swine Influenza A Viruses.

Tavis K Anderson, Catherine A Macken, Nicola S Lewis, Richard H Scheuermann, Kristien Van Reeth, Ian H Brown, Sabrina L Swenson, Gaëlle Simon, Takehiko Saito, Yohannes Berhane, Janice Ciacci-Zanella, Ariel Pereda, C Todd Davis, Ruben O Donis, Richard J Webby, Amy L Vincent,

The H1 subtype of influenza A viruses (IAVs) has been circulating in swine since the 1918 human influenza pandemic. Over time, and aided by further introductions from nonswine hosts, swine H1 viruses have diversified into three genetic lineages. Due to limited global data, these H1 lineages were named based on ... Read more >>

mSphere (mSphere)
[2016, 1(6):]

Cited: 44 times

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Influenza A virus vaccines for swine.

Amy L Vincent, Daniel R Perez, Daniela Rajao, Tavis K Anderson, Eugenio J Abente, Rasna R Walia, Nicola S Lewis,

Economic losses due to influenza A virus (IAV) infections are substantial and a global problem, ranking among the top three major health challenges in the swine industry. Currently, H1 and H3 subtypes circulate in pigs globally associated with different combinations of N1 and N2 subtypes; however, the origin, gene constellation, ... Read more >>

Vet Microbiol (Veterinary microbiology)
[2017, 206:35-44]

Cited: 31 times

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The Molecular Determinants of Antibody Recognition and Antigenic Drift in the H3 Hemagglutinin of Swine Influenza A Virus.

Eugenio J Abente, Jefferson Santos, Nicola S Lewis, Phillip C Gauger, Jered Stratton, Eugene Skepner, Tavis K Anderson, Daniela S Rajao, Daniel R Perez, Amy L Vincent,

<h4>Unlabelled</h4>Influenza A virus (IAV) of the H3 subtype is an important respiratory pathogen that affects both humans and swine. Vaccination to induce neutralizing antibodies against the surface glycoprotein hemagglutinin (HA) is the primary method used to control disease. However, due to antigenic drift, vaccine strains must be periodically updated. Six ... Read more >>

J Virol (Journal of virology)
[2016, 90(18):8266-8280]

Cited: 18 times

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The global antigenic diversity of swine influenza A viruses.

Nicola S Lewis, Colin A Russell, Pinky Langat, Tavis K Anderson, Kathryn Berger, Filip Bielejec, David F Burke, Gytis Dudas, Judith M Fonville, Ron Am Fouchier, Paul Kellam, Bjorn F Koel, Philippe Lemey, Tung Nguyen, Bundit Nuansrichy, Js Malik Peiris, Takehiko Saito, Gaelle Simon, Eugene Skepner, Nobuhiro Takemae, , Richard J Webby, Kristien Van Reeth, Sharon M Brookes, Lars Larsen, Simon J Watson, Ian H Brown, Amy L Vincent,

Swine influenza presents a substantial disease burden for pig populations worldwide and poses a potential pandemic threat to humans. There is considerable diversity in both H1 and H3 influenza viruses circulating in swine due to the frequent introductions of viruses from humans and birds coupled with geographic segregation of global ... Read more >>

Elife (eLife)
[2016, 5:e12217]

Cited: 61 times

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Novel Reassortant Human-Like H3N2 and H3N1 Influenza A Viruses Detected in Pigs Are Virulent and Antigenically Distinct from Swine Viruses Endemic to the United States.

Daniela S Rajão, Phillip C Gauger, Tavis K Anderson, Nicola S Lewis, Eugenio J Abente, Mary Lea Killian, Daniel R Perez, Troy C Sutton, Jianqiang Zhang, Amy L Vincent,

<h4>Unlabelled</h4>Human-like swine H3 influenza A viruses (IAV) were detected by the USDA surveillance system. We characterized two novel swine human-like H3N2 and H3N1 viruses with hemagglutinin (HA) genes similar to those in human seasonal H3 strains and internal genes closely related to those of 2009 H1N1 pandemic viruses. The H3N2 ... Read more >>

J Virol (Journal of virology)
[2015, 89(22):11213-11222]

Cited: 38 times

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Comparative virulence of wild-type H1N1pdm09 influenza A isolates in swine.

Jamie N Henningson, Daniela S Rajao, Pravina Kitikoon, Alessio Lorusso, Marie R Culhane, Nicola S Lewis, Tavis K Anderson, Amy L Vincent,

In 2009, a novel swine-origin H1N1 (H1N1pdm09) influenza A virus (IAV) reached pandemic status and was soon after detected in pigs worldwide. The objective of this study was to evaluate whether differences in the HA protein can affect pathogenicity and antigenicity of H1N1pdm09 in swine. We compared lung pathology, viral ... Read more >>

Vet Microbiol (Veterinary microbiology)
[2015, 176(1-2):40-49]

Cited: 4 times

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Molecular Epidemiology and Evolution of Influenza Viruses Circulating within European Swine between 2009 and 2013.

Simon J Watson, Pinky Langat, Scott M Reid, Tommy Tsan-Yuk Lam, Matthew Cotten, Michael Kelly, Kristien Van Reeth, Yu Qiu, Gaëlle Simon, Emilie Bonin, Emanuela Foni, Chiara Chiapponi, Lars Larsen, Charlotte Hjulsager, Iwona Markowska-Daniel, Kinga Urbaniak, Ralf Dürrwald, Michael Schlegel, Anita Huovilainen, Irit Davidson, Ádám Dán, Willie Loeffen, Stephanie Edwards, Michel Bublot, Thais Vila, Jaime Maldonado, Laura Valls, , Ian H Brown, Oliver G Pybus, Paul Kellam,

<h4>Unlabelled</h4>The emergence in humans of the A(H1N1)pdm09 influenza virus, a complex reassortant virus of swine origin, highlighted the importance of worldwide influenza virus surveillance in swine. To date, large-scale surveillance studies have been reported for southern China and North America, but such data have not yet been described for Europe. ... Read more >>

J Virol (Journal of virology)
[2015, 89(19):9920-9931]

Cited: 82 times

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Global circulation patterns of seasonal influenza viruses vary with antigenic drift.

Trevor Bedford, Steven Riley, Ian G Barr, Shobha Broor, Mandeep Chadha, Nancy J Cox, Rodney S Daniels, C Palani Gunasekaran, Aeron C Hurt, Anne Kelso, Alexander Klimov, Nicola S Lewis, Xiyan Li, John W McCauley, Takato Odagiri, Varsha Potdar, Andrew Rambaut, Yuelong Shu, Eugene Skepner, Derek J Smith, Marc A Suchard, Masato Tashiro, Dayan Wang, Xiyan Xu, Philippe Lemey, Colin A Russell,

Understanding the spatiotemporal patterns of emergence and circulation of new human seasonal influenza virus variants is a key scientific and public health challenge. The global circulation patterns of influenza A/H3N2 viruses are well characterized, but the patterns of A/H1N1 and B viruses have remained largely unexplored. Here we show that ... Read more >>

Nature (Nature)
[2015, 523(7559):217-220]

Cited: 185 times

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