Full Text Journal Articles by
Author Nicola Rizzardi

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Coenzyme Q10 Phytosome Formulation Improves CoQ10 Bioavailability and Mitochondrial Functionality in Cultured Cells.

Nicola Rizzardi, Irene Liparulo, Giorgia Antonelli, Francesca Orsini, Antonella Riva, Christian Bergamini, Romana Fato,

Coenzyme Q10 (CoQ10) is a lipid-soluble molecule with a dual role: it transfers electrons in the mitochondrial transport chain by promoting the transmembrane potential exploited by the ATPase to synthesize ATP and, in its reduced form, is a membrane antioxidant. Since the high CoQ10 hydrophobicity hinders its bioavailability, several formulations ... Read more >>

Antioxidants (Basel) (Antioxidants (Basel, Switzerland))
[2021, 10(6):]

Cited: 1 time

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Biallelic variants in LIG3 cause a novel mitochondrial neurogastrointestinal encephalomyopathy.

Elena Bonora, Sanjiban Chakrabarty, Georgios Kellaris, Makiko Tsutsumi, Francesca Bianco, Christian Bergamini, Farid Ullah, Federica Isidori, Irene Liparulo, Chiara Diquigiovanni, Luca Masin, Nicola Rizzardi, Mariapia Giuditta Cratere, Elisa Boschetti, Valentina Papa, Alessandra Maresca, Giovanna Cenacchi, Rita Casadio, Pierluigi Martelli, Ivana Matera, Isabella Ceccherini, Romana Fato, Giuseppe Raiola, Serena Arrigo, Sara Signa, Angela Rita Sementa, Mariasavina Severino, Pasquale Striano, Chiara Fiorillo, Tsuyoshi Goto, Shumpei Uchino, Yoshinobu Oyazato, Hisayoshi Nakamura, Sushil K Mishra, Yu-Sheng Yeh, Takema Kato, Kandai Nozu, Jantima Tanboon, Ichiro Morioka, Ichizo Nishino, Tatsushi Toda, Yu-Ichi Goto, Akira Ohtake, Kenjiro Kosaki, Yoshiki Yamaguchi, Ikuya Nonaka, Kazumoto Iijima, Masakazu Mimaki, Hiroki Kurahashi, Anja Raams, Alyson MacInnes, Mariel Alders, Marc Engelen, Gabor Linthorst, Tom de Koning, Wilfred den Dunnen, Gerard Dijkstra, Karin van Spaendonck, Dik C van Gent, Eleonora M Aronica, Paolo Picco, Valerio Carelli, Marco Seri, Nicholas Katsanis, Floor A M Duijkers, Mariko Taniguchi-Ikeda, Roberto De Giorgio,

Abnormal gut motility is a feature of several mitochondrial encephalomyopathies, and mutations in genes such as TYMP and POLG, have been linked to these rare diseases. The human genome encodes three DNA ligases, of which only one, ligase III (LIG3), has a mitochondrial splice variant and is crucial for mitochondrial ... Read more >>

Brain (Brain : a journal of neurology)
[2021, 144(5):1451-1466]

Cited: 4 times

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Root Extracts of Two Cultivars of Paeonia Species: Lipid Composition and Biological Effects on Different Cell Lines: Preliminary Results.

Natalia Calonghi, Giovanna Farruggia, Carla Boga, Gabriele Micheletti, Elena Fini, Lucia Romani, Dario Telese, Erika Faraci, Christian Bergamini, Stefano Cerini, Nicola Rizzardi,

The roots of two cultivars of <i>Paeonia</i>, namely <i>Paeonia officinalis</i> "Rubra Plena" and <i>Paeonia</i> "Pink Hawaiian Coral", have been extracted with chloroform. The composition of the lipid fraction, analyzed by GC-MS technique, revealed the absence of paeonol and the presence of phenol, benzoic acid, fatty acid-and some sterol-derivatives. The chloroformic ... Read more >>

Molecules (Molecules (Basel, Switzerland))
[2021, 26(3):]

Cited: 0 times

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Coenzyme Q Depletion Reshapes MCF-7 Cells Metabolism.

Wenping Wang, Irene Liparulo, Nicola Rizzardi, Paola Bolignano, Natalia Calonghi, Christian Bergamini, Romana Fato,

Mitochondrial dysfunction plays a significant role in the metabolic flexibility of cancer cells. This study aimed to investigate the metabolic alterations due to Coenzyme Q depletion in MCF-7 cells.<h4>Method</h4>The Coenzyme Q depletion was induced by competitively inhibiting with 4-nitrobenzoate the coq2 enzyme, which catalyzes one of the final reactions in ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 22(1):]

Cited: 2 times

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Castanea sativa Mill. bark extract cardiovascular effects in a rat model of high-fat diet.

Matteo Micucci, Roberta Budriesi, Rita Aldini, Romana Fato, Christian Bergamini, Fabio Vivarelli, Donatella Canistro, Cristiano Bolchi, Alberto Chiarini, Nicola Rizzardi, Marco Pallavicini, Maria Frosini, Andrea Angeletti,

Ellagitannins may have a beneficial impact in cardiovascular diseases. The aim of the study was to evaluate the effect of high-fat diet (HFD) and the efficacy of Castanea sativa Mill. bark extract (ENC) on cardiac and vascular parameters. Rats were fed with regular diet, (RD, n = 15), HFD (n = 15), ... Read more >>

Phytother Res (Phytotherapy research : PTR)
[2021, 35(4):2145-2156]

Cited: 0 times

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Coenzyme Q biosynthesis inhibition induces HIF-1α stabilization and metabolic switch toward glycolysis.

Irene Liparulo, Christian Bergamini, Marco Bortolus, Natalia Calonghi, Giuseppe Gasparre, Giuseppe Gasparre, Ivana Kurelac, Luca Masin, Nicola Rizzardi, Michela Rugolo, Wenping Wang, Serena J Aleo, Alisar Kiwan, Cristian Torri, Claudia Zanna, Romana Fato,

Coenzyme Q<sub>10</sub> (CoQ, ubiquinone) is a redox-active lipid endogenously synthesized by the cells. The final stage of CoQ biosynthesis is performed at the mitochondrial level by the 'complex Q', where coq2 is responsible for the prenylation of the benzoquinone ring of the molecule. We report that the competitive coq2 inhibitor ... Read more >>

FEBS J (The FEBS journal)
[2021, 288(6):1956-1974]

Cited: 5 times

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Turning Donepezil into a Multi-Target-Directed Ligand through a Merging Strategy.

Rosaria Perone, Claudia Albertini, Elisa Uliassi, Flaminia Di Pietri, Pedro de Sena Murteira Pinheiro, Sabrina Petralla, Nicola Rizzardi, Romana Fato, Lenka Pulkrabkova, Ondrej Soukup, Anna Tramarin, Manuela Bartolini, Maria Laura Bolognesi,

Thanks to the widespread use and safety profile of donepezil (1) in the treatment of Alzheimer's disease (AD), one of the most widely adopted multi-target-directed ligand (MTDL) design strategies is to modify its molecular structure by linking a second fragment carrying an additional AD-relevant biological property. Herein, supported by a ... Read more >>

ChemMedChem (ChemMedChem)
[2021, 16(1):187-198]

Cited: 2 times

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Early-Stage Supraglottic "In Situ" Squamous Cell Carcinoma of the Larynx Incidentally Detected by 18F-Fluorocholine PET/CT.

Stefano Attilio Mangili, Nicola Rizzardi, Sonia Illuminati, Claudio Bnà, Giordano Savelli,

F-fluorocholine (F-FCH) PET/CT is widely used to study patients affected by prostate cancer. Despite its specificity, however, F-FCH may be taken up by other neoplasms such as multiple myeloma, lymphomas, lung, bladder, and colon cancer; brain tumors; and renal and hepatocellular carcinoma. This is due to its ability to evaluate ... Read more >>

Clin Nucl Med (Clinical nuclear medicine)
[2019, 44(7):e435-e438]

Cited: 0 times

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A novel mutation in SPART gene causes a severe neurodevelopmental delay due to mitochondrial dysfunction with complex I impairments and altered pyruvate metabolism.

Chiara Diquigiovanni, Christian Bergamini, Rebeca Diaz, Irene Liparulo, Francesca Bianco, Luca Masin, Vito Antonio Baldassarro, Nicola Rizzardi, Antonia Tranchina, Francesco Buscherini, Anita Wischmeijer, Tommaso Pippucci, Emanuela Scarano, Duccio Maria Cordelli, Romana Fato, Marco Seri, Silvia Paracchini, Elena Bonora,

Loss-of-function mutations in the <i>SPART</i> gene cause Troyer syndrome, a recessive form of spastic paraplegia resulting in muscle weakness, short stature, and cognitive defects. <i>SPART</i> encodes for Spartin, a protein linked to endosomal trafficking and mitochondrial membrane potential maintenance. Here, we identified with whole exome sequencing (WES) a novel frameshift ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2019, 33(10):11284-11302]

Cited: 2 times

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Role of heme oxygenase in modulating endothelial function in mesenteric small resistance arteries of spontaneously hypertensive rats.

Enzo Porteri, Luigi F Rodella, Rita Rezzani, Damiano Rizzoni, Silvia Paiardi, Carolina de Ciuceis, Gianluca E M Boari, Eleonora Foglio, Gaia Favero, Nicola Rizzardi, Caterina Platto, Enrico Agabiti Rosei,

It has been proposed that endothelial dysfunction is due to the excessive degradation of nitric oxide (NO) by oxidative stress. The enzyme heme-oxygenase (HO) seems to exert a protective effect on oxidative stress in the vasculature, both in animal models and in humans. The objective of this study is to ... Read more >>

Clin Exp Hypertens (Clinical and experimental hypertension (New York, N.Y. : 1993))
[2009, 31(7):560-571]

Cited: 5 times

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Hypertrophic remodeling of subcutaneous small resistance arteries in patients with Cushing's syndrome.

Damiano Rizzoni, Enzo Porteri, Carolina De Ciuceis, Luigi F Rodella, Silvia Paiardi, Nicola Rizzardi, Caterina Platto, Gianluca E M Boari, Annamaria Pilu, Guido A M Tiberio, Stefano M Giulini, Gaia Favero, Rita Rezzani, Claudia Agabiti Rosei, Giuseppe Bulgari, Daniele Avanzi, Enrico Agabiti Rosei,

<h4>Objective</h4>Structural alterations of small resistance arteries in essential hypertensive patients (EH) are mostly characterized by inward eutrophic remodeling. However, we observed hypertrophic remodeling in patients with renovascular hypertension, in those with acromegaly, as well as in patients with non-insulin-dependent diabetes mellitus, suggesting a relevant effect of humoral growth factors on ... Read more >>

J Clin Endocrinol Metab (The Journal of clinical endocrinology and metabolism)
[2009, 94(12):5010-5018]

Cited: 17 times

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Altered structure of small cerebral arteries in patients with essential hypertension.

Damiano Rizzoni, Carolina De Ciuceis, Enzo Porteri, Silvia Paiardi, Gianluca E M Boari, Pietro Mortini, Claudio Cornali, Marco Cenzato, Luigi F Rodella, Elisa Borsani, Nicola Rizzardi, Caterina Platto, Rita Rezzani, Enrico Agabiti Rosei,

<h4>Objective</h4>Structural alterations in the microcirculation may be considered an important mechanism of organ damage. An increased media-to-lumen ratio of subcutaneous small resistance arteries has been demonstrated to predict the development of cardiocerebrovascular events in hypertensive patients. Alterations in the structure of small cerebral arteries have been demonstrated in animal models ... Read more >>

J Hypertens (Journal of hypertension)
[2009, 27(4):838-845]

Cited: 48 times

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Immunohistochemical evaluation of microvascular rarefaction in hypertensive humans and in spontaneously hypertensive rats.

Silvia Paiardi, Luigi F Rodella, Carolina De Ciuceis, Enzo Porteri, Gianluca E M Boari, Rita Rezzani, Nicola Rizzardi, Caterina Platto, Guido A M Tiberio, Stefano M Giulini, Damiano Rizzoni, Enrico Agabiti-Rosei,

<h4>Objective</h4>No data are presently available about changes in capillary density in the skeletal muscle and in the brain of spontaneously hypertensive rats (SHR) in relation to the development of hypertension.<h4>Design and methods</h4>We have investigated 4 week-old and 12 week-old SHR and age-matched normotensive Wistar-Kyoto controls (WKY). Microvessel density (MVD) in ... Read more >>

Clin Hemorheol Microcirc (Clinical hemorheology and microcirculation)
[2009, 42(4):259-268]

Cited: 31 times

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Determinants of the structure of resistance-sized arteries in hypertensive patients.

Gianluca E M Boari, Nicola Rizzardi, Carolina de Ciuceis, Caterina Platto, Silvia Paiardi, Enzo Porteri, Anna Paini, Massimo Salvetti, Maria Lorenza Muiesan, Damiano Rizzoni, Enrico Agabiti Rosei,

<h4>Objective</h4>It has been previously demonstrated that structural alterations of subcutaneous small resistance arteries of hypertensive patients, as indicated by an increased media to lumen (M/L) ratio, is the most potent predictor of cardiovascular events. The aim of the present study was to identify possible determinants of small resistance artery structure ... Read more >>

Blood Press (Blood pressure)
[2008, 17(4):204-211]

Cited: 9 times

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A strange chest pain after dental surgery.

Enzo Porteri, Nicola Rizzardi, Damiano Rizzoni, Andrea Salvi, Carolina De Ciuceis, Davide Farina, Gianluca E M Boari, Caterina Platto, Silvia Paiardi, Almajdalawi Raed, Enrico Agabiti Rosei,

Intern Emerg Med (Internal and emergency medicine)
[2008, 3(2):123-126]

Cited: 0 times

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Effects of insulin on endothelial and contractile function of subcutaneous small resistance arteries of hypertensive and diabetic patients.

Carolina De Ciuceis, Damiano Rizzoni, Enzo Porteri, Gianluca E M Boari, Francesca Zani, Marco Miclini, Guido A M Tiberio, Stefano M Giulini, Silvia Paiardi, Nicola Rizzardi, Caterina Platto, Enrico Agabiti-Rosei,

The effect of insulin on the vasoconstriction induced by norepinephrine is at present controversial. We have previously demonstrated that high-concentration insulin may induce an increased reactivity to norepinephrine in mesenteric small resistance arteries of spontaneously hypertensive rats. The aim of the present study was to evaluate the effects of low- ... Read more >>

J Vasc Res (Journal of vascular research)
[2008, 45(6):512-520]

Cited: 6 times

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Structural alterations of subcutaneous small-resistance arteries may predict major cardiovascular events in patients with hypertension.

Carolina De Ciuceis, Enzo Porteri, Damiano Rizzoni, Nicola Rizzardi, Silvia Paiardi, Gianluca E M Boari, Marco Miclini, Francesca Zani, Maria Lorenza Muiesan, Francesco Donato, Massimo Salvetti, Maurizio Castellano, Guido A M Tiberio, Stefano M Giulini, Enrico Agabiti Rosei,

<h4>Background</h4>Structural alterations in the microcirculation may be considered an important mechanism of organ damage. An increased tunica media to internal lumen ratio of subcutaneous small-resistance arteries (M:L) may predict the development of cardiovascular events in a high-risk population. However, it is not known whether structural alterations of small arteries may ... Read more >>

Am J Hypertens (American journal of hypertension)
[2007, 20(8):846-852]

Cited: 74 times

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Morning rise of blood pressure and subcutaneous small resistance artery structure.

Damiano Rizzoni, Enzo Porteri, Caterina Platto, Nicola Rizzardi, Carolina De Ciuceis, Gianluca E M Boari, Maria Lorenza Muiesan, Massimo Salvetti, Francesca Zani, Marco Miclini, Silvia Paiardi, Maurizio Castellano, Enrico Agabiti Rosei,

<h4>Objectives</h4>It has been previously demonstrated that the morning rise (MoR) of blood pressure (BP) may predict major cardiovascular events in hypertensive patients. Structural alterations of small resistance arteries, as evaluated by the tunica media to internal lumen ratio (M/L) of subcutaneous small resistance arteries, may also predict cardiovascular events. Because ... Read more >>

J Hypertens (Journal of hypertension)
[2007, 25(8):1698-1703]

Cited: 34 times

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