Full Text Journal Articles by
Author Nicola Disma

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A decade later, there are still major issues to be addressed in paediatric anaesthesia.

Walid Habre, Nicola Disma,

<h4>Purpose of review</h4>Despite real advances in paediatric anaesthesia management, such as a growing awareness of the relevance of anaesthesia conduct as well as of the lack of evidence for neurotoxicity of anaesthetic agents, it must be said that there are still important questions in our specialty that remain unanswered. Standardization ... Read more >>

Curr Opin Anaesthesiol (Current opinion in anaesthesiology)
[2021, 34(3):271-275]

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Coronavirus disease 2019 and pediatric anesthesia.

Jonathan M Tan, Nicola Disma, Clyde T Matava,

<h4>Purpose of review</h4>The purpose of this review is to provide the latest evidence for delivering safe and effective anesthesia care for pediatric patients with coronavirus disease 2019 (COVID-19) and to highlight continuing gaps in the literature.<h4>Recent findings</h4>Safe and efficient care of pediatric patients with COVID-19 can be delivered with the ... Read more >>

Curr Opin Anaesthesiol (Current opinion in anaesthesiology)
[2021, 34(3):292-298]

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Morbidity and mortality after anaesthesia in early life: results of the European prospective multicentre observational study, neonate and children audit of anaesthesia practice in Europe (NECTARINE).

Nicola Disma, Francis Veyckemans, Katalin Virag, Tom G Hansen, Karin Becke, Pierre Harlet, Laszlo Vutskits, Suellen M Walker, Jurgen C de Graaff, Marzena Zielinska, Dusica Simic, Thomas Engelhardt, Walid Habre, , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , ,

<h4>Background</h4>Neonates and infants requiring anaesthesia are at risk of physiological instability and complications, but triggers for peri-anaesthetic interventions and associations with subsequent outcome are unknown.<h4>Methods</h4>This prospective, observational study recruited patients up to 60 weeks' postmenstrual age undergoing anaesthesia for surgical or diagnostic procedures from 165 centres in 31 European countries ... Read more >>

Br J Anaesth (British journal of anaesthesia)
[2021, :]

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Difficult tracheal intubation in neonates and infants. NEonate and Children audiT of Anaesthesia pRactice IN Europe (NECTARINE): a prospective European multicentre observational study.

Nicola Disma, Katalin Virag, Thomas Riva, Jost Kaufmann, Thomas Engelhardt, Walid Habre, , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , ,

<h4>Background</h4>Neonates and infants are susceptible to hypoxaemia in the perioperative period. The aim of this study was to analyse interventions related to anaesthesia tracheal intubations in this European cohort and identify their clinical consequences.<h4>Methods</h4>We performed a secondary analysis of tracheal intubations of the European multicentre observational trial (NEonate and Children ... Read more >>

Br J Anaesth (British journal of anaesthesia)
[2021, :]

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European Society of Anaesthesiology and Intensive Care Guidelines on peri-operative use of ultrasound for regional anaesthesia (PERSEUS regional anesthesia): Peripheral nerves blocks and neuraxial anaesthesia.

Emmanuel Boselli, Philip Hopkins, Massimo Lamperti, Jean-Pierre Estèbe, Régis Fuzier, Daniele G Biasucci, Nicola Disma, Mauro Pittiruti, Vilma Traškaitė, Andrius Macas, Christian Breschan, Davide Vailati, Matteo Subert,

Nowadays, ultrasound-guidance is commonly used in regional anaesthesia (USGRA) and to locate the spinal anatomy in neuraxial analgesia. The aim of this second guideline on the PERi-operative uSE of UltraSound (PERSEUS-RA) is to provide evidence as to which areas of regional anaesthesia the use of ultrasound guidance should be considered ... Read more >>

Eur J Anaesthesiol (European journal of anaesthesiology)
[2021, 38(3):219-250]

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The use of lung ultrasound compared to chest X-ray to diagnose pneumothorax following the Nuss procedure for pectus excavatum repair in children.

Rachele Bonfiglio, Nicola Disma, Nicola Stagnaro, Rossano Girometti, Alice Gentile, Michele Torre, Tiziana Bove, Luigi Vetrugno,

<h4>Background</h4>Pectus Excavatum is the most common deformation of the skeletal chest wall, and the Nuss procedure is used to correct this deformation. Residual pneumothorax is a frequent postoperative complication after thoracoscopy. Primary aim of this prospective observational study was to compare the level of agreement among readers using lung ultrasound ... Read more >>

Paediatr Anaesth (Paediatric anaesthesia)
[2020, 30(11):1224-1232]

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High-dose versus low-dose tranexamic acid for paediatric craniosynostosis surgery: a double-blind randomised controlled non-inferiority trial.

Susan M Goobie, Steven J Staffa, John G Meara, Mark R Proctor, Miriam Tumolo, Giuliana Cangemi, Nicola Disma,

BACKGROUND:Tranexamic acid (TXA) reduces blood loss and transfusion in paediatric craniosynostosis surgery. The hypothesis is that low-dose TXA, determined by pharmacokinetic modelling, is non-inferior to high-dose TXA in decreasing blood loss and transfusion in children. METHODS:Children undergoing craniosynostosis surgery were enrolled in a two-centre, prospective, double-blind, randomised, non-inferiority controlled trial ... Read more >>

Br J Anaesth (British journal of anaesthesia)
[2020, 125(3):336-345]

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European Society of Anaesthesiology guidelines on peri-operative use of ultrasound-guided for vascular access (PERSEUS vascular access).

Massimo Lamperti, Daniele Guerino Biasucci, Nicola Disma, Mauro Pittiruti, Christian Breschan, Davide Vailati, Matteo Subert, Vilma Traškaitė, Andrius Macas, Jean-Pierre Estebe, Regis Fuzier, Emmanuel Boselli, Philip Hopkins,

: Ultrasound for diagnostic and procedural purposes is becoming a standard in daily clinical practice including anaesthesiology and peri-operative medicine. The project of European Society of Anaesthesiology (ESA) Task Force for the development of clinical guidelines on the PERioperative uSE of Ultra-Sound (PERSEUS) project has focused on the use of ... Read more >>

Eur J Anaesthesiol (European journal of anaesthesiology)
[2020, 37(5):344-376]

Cited: 3 times

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Reply to: will one hour less make any difference?

Nicola Disma, Mark Thomas, Arash Afshari, Francis Veyckemans, Stefan De Hert,

Eur J Anaesthesiol (European journal of anaesthesiology)
[2020, 37(1):53]

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A New Device for Thoracoscopic Cryoanalgesia in Pectus Excavatum Repair: Preliminary Single Center Experience.

Michele Torre, Leila Mameli, Rachele Bonfiglio, Vittorio Guerriero, Lucia Derosas, Loredana Palomba, Nicola Disma,

<b>Introduction:</b> Cryoanalgesia has been recently described as alternative technique for immediate and persistent pain treatment after pectus excavatum repair. Cryoanalgesia has the potentiality to reduce analgesic consumption and length of hospitalization. However, cryoanalgesia has not been standardized yet: the previous reports describe different techniques and systems and include only small ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2020, 8:614097]

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Pediatric anesthesia practice in Italy: a multicenter national prospective observational study derived from the APRICOT Trial.

Andrea Wolfler, Annalisa De Silvestri, Anna Camporesi, Giorgio Ivani, Alessandro Vittori, Nicola Zadra, Lorena Pasini, Marinella Astuto, Bruno Locatelli, Andrea Cortegiani, Nicola Disma, ,

<h4>Background</h4>Pediatric anesthesia nowadays requires specific knowledge and expertise. The Anesthesia PRactice In Children Observational Trial (APRICOT) was a European multicenter study designed for the identification of perioperative severe critical events and management. We aimed at analyzing the Italian database in an attempt to determine the practice of anesthesia and the ... Read more >>

Minerva Anestesiol (Minerva anestesiologica)
[2020, 86(3):295-303]

Cited: 1 time

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A prospective observational cohort study on the incidence of postoperative sore throat in the pediatric population.

Alice Miskovic, Mae Johnson, Louise Frost, Elena Fernandez, Angela Pistorio, Nicola Disma,

BACKGROUND:Postoperative sore throat is common after general anesthesia. The incidence in pediatric anesthesia is variable, and the etiology unclear. Establishing risk factors would enable prevention and could improve quality of care. AIMS:We performed a prospective single-center cohort study aiming to establish the incidence of postoperative sore throat in children undergoing ... Read more >>

Paediatr Anaesth (Paediatric anaesthesia)
[2019, 29(12):1179-1185]

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Response to comments on 'The European Society of Anaesthesiology Task Force review on the place of nitrous oxide in current clinical practice' (Br J Anaesth 2019; 122:587-604).

Wolfgang Buhre, Nicola Disma, Jan Hendrickx, Stefan De Hert, Markus W Hollmann, Ragnar Huhn, Jan Jakobsson, Peter Nagele, Philip Peyton, Laszlo Vutskits,

Br J Anaesth (British journal of anaesthesia)
[2019, 123(4):e482-e483]

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Anesthesia Neurotoxicity in the Developing Brain: Basic Studies Relevant for Neonatal or Perinatal Medicine.

Nicola Groes Clausen, Tom G Hansen, Nicola Disma,

Diagnostic and invasive procedures in premature infants may require general anesthesia. General anesthetics interfere with the development of the immature animal brain. Accelerated apoptosis, disturbed synaptogenesis, and cytoarchitecture are among the mechanisms suspected to underlie this phenomenon. The implications for humans are unknown. This article presents current suspected mechanisms of ... Read more >>

Clin Perinatol (Clinics in perinatology)
[2019, 46(4):647-656]

Cited: 1 time

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Anaesthetic neuroprotection in children: does it exist or is it all just bad?

Vanessa Marchesini, Nicola Disma,

<h4>Purpose of review</h4>In the last 20 years, data from studies of laboratory animals, including nonhuman primates, have provided ample evidence that general anaesthetic drugs cause pathological changes in developing central nervous system (neurotoxicity). Recently, a new area of research has been developed in order to recognize any possible actions that ... Read more >>

Curr Opin Anaesthesiol (Current opinion in anaesthesiology)
[2019, 32(3):363-369]

Cited: 1 time

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Clear fluids fasting for elective paediatric anaesthesia: The European Society of Anaesthesiology consensus statement.

Nicola Disma, Mark Thomas, Arash Afshari, Francis Veyckemans, Stefan De Hert,

Eur J Anaesthesiol (European journal of anaesthesiology)
[2019, 36(3):173-174]

Cited: 1 time

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European Society of Anaesthesiology Task Force on Nitrous Oxide: a narrative review of its role in clinical practice.

Wolfgang Buhre, Nicola Disma, Jan Hendrickx, Stefan DeHert, Markus W Hollmann, Ragnar Huhn, Jan Jakobsson, Peter Nagele, Philip Peyton, Laszlo Vutskits,

Nitrous oxide (N2O) is one of the oldest drugs still in use in medicine. Despite its superior pharmacokinetic properties, controversy remains over its continued use in clinical practice, reflecting in part significant improvements in the pharmacology of other anaesthetic agents and developing awareness of its shortcomings. This narrative review describes ... Read more >>

Br J Anaesth (British journal of anaesthesia)
[2019, 122(5):587-604]

Cited: 2 times

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Neurodevelopmental outcome at 5 years of age after general anaesthesia or awake-regional anaesthesia in infancy (GAS): an international, multicentre, randomised, controlled equivalence trial.

Mary Ellen McCann, Jurgen C de Graaff, Liam Dorris, Nicola Disma, Davinia Withington, Graham Bell, Anneke Grobler, Robyn Stargatt, Rodney W Hunt, Suzette J Sheppard, Jacki Marmor, Gaia Giribaldi, David C Bellinger, Penelope L Hartmann, Pollyanna Hardy, Geoff Frawley, Francesca Izzo, Britta S von Ungern Sternberg, Anne Lynn, Niall Wilton, Martin Mueller, David M Polaner, Anthony R Absalom, Peter Szmuk, Neil Morton, Charles Berde, Sulpicio Soriano, Andrew J Davidson, ,

<h4>Background</h4>In laboratory animals, exposure to most general anaesthetics leads to neurotoxicity manifested by neuronal cell death and abnormal behaviour and cognition. Some large human cohort studies have shown an association between general anaesthesia at a young age and subsequent neurodevelopmental deficits, but these studies are prone to bias. Others have ... Read more >>

Lancet (Lancet (London, England))
[2019, 393(10172):664-677]

Cited: 49 times

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An open label pilot study of a dexmedetomidine-remifentanil-caudal anesthetic for infant lower abdominal/lower extremity surgery: The T REX pilot study.

Peter Szmuk, Dean Andropoulos, Francis McGowan, Ansgar Brambrink, Christopher Lee, Katherine J Lee, Mary Ellen McCann, Yang Liu, Rita Saynhalath, Choon Looi Bong, Brian J Anderson, Charles Berde, Jurgen C De Graaff, Nicola Disma, Dean Kurth, Andreas Loepke, Beverley Orser, Daniel I Sessler, Justin J Skowno, Britta S von Ungern-Sternberg, Laszlo Vutskits, Andrew Davidson,

<h4>Background</h4>Concern over potential neurotoxicity of anesthetics has led to growing interest in prospective clinical trials using potentially less toxic anesthetic regimens, especially for prolonged anesthesia in infants. Preclinical studies suggest that dexmedetomidine may have a reduced neurotoxic profile compared to other conventional anesthetic regimens; however, coadministration with either anesthetic drugs ... Read more >>

Paediatr Anaesth (Paediatric anaesthesia)
[2019, 29(1):59-67]

Cited: 2 times

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Enrollment challenges in multicenter, international studies: The example of the GAS trial.

Katherine R Gentry, Sarah J Arnup, Nicola Disma, Liam Dorris, Jurgen C de Graaff, Agnes Hunyady, Neil S Morton, Davinia E Withington, Mary Ellen McCann, Andrew J Davidson, Anne M Lynn, ,

<h4>Introduction</h4>Randomized trials are important for generating high-quality evidence, but are perceived as difficult to perform in the pediatric population. Thus far there has been poor characterization of the barriers to conducting trials involving children, and the variation in these barriers between countries remains undescribed. The General Anesthesia compared to Spinal ... Read more >>

Paediatr Anaesth (Paediatric anaesthesia)
[2019, 29(1):51-58]

Cited: 2 times

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Anesthesia and the developing brain: A way forward for laboratory and clinical research.

Nicola Disma, James D O'Leary, Andreas W Loepke, Ansgar M Brambrink, Karin Becke, Nicola G Clausen, Jurgen C De Graaff, Fang Liu, Tom G Hansen, Mary E McCann, Cynthia F Salorio, Sulpicio Soriano, Lena S Sun, Peter Szmuk, David O Warner, Laszlo Vutskits, Andrew J Davidson,

All commonly used general anesthetics have been shown to cause neurotoxicity in animal models, including nonhuman primates. Opinion, however, remains divided over how cumulative evidence from preclinical and human studies in this field should be interpreted and its translation to current practices in pediatric anesthesia and surgery. A group of ... Read more >>

Paediatr Anaesth (Paediatric anaesthesia)
[2018, 28(9):758-763]

Cited: 13 times

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Is spinal anaesthesia in young infants really safer and better than general anaesthesia?

Nicola Disma, Natasha Clunies-Ross, George A Chalkiadis,

Concerns regarding the potential neurotoxic effects of general anaesthesia have seen resurgence in awake spinal anaesthesia in neonates and infants. This review includes recently published data from a large prospective randomized controlled trial with view to determining if spinal anaesthesia is safer and better than general anaesthesia in this population.Compared ... Read more >>

Curr Opin Anaesthesiol (Current opinion in anaesthesiology)
[2018, 31(3):302-307]

Cited: 0 times

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Surgical practice and outcome in 711 neonates and infants undergoing hernia repair in a large multicenter RCT: Secondary results from the GAS Study.

Nicola Disma, Davinia Withington, Mary Ellen McCann, Rodney Wayne Hunt, Sarah Jane Arnup, Francesca Izzo, Jurgen C de Graaff, Girolamo Mattioli, Neil Morton, Geoff Frawley, Andrew Davidson, Anne Lynn, Peter Szmuk, Joss John Thomas, Philip Ragg, Alessio Pini Prato, ,

<h4>Background</h4>The GAS study is an international RCT to evaluate neurodevelopmental outcome comparing general plus regional anesthesia versus regional anesthesia alone in 722 neonates and infants who had inguinal hernia repair up to 60 weeks of postmenstrual age. This paper comprises a secondary descriptive analysis of hernias, aspects of surgery and ... Read more >>

J Pediatr Surg (Journal of pediatric surgery)
[2018, 53(9):1643-1650]

Cited: 1 time

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SIAARTI-SARNePI Clinical-Organizational Standards for pediatric anesthesia.

Nicola Disma, Edoardo Calderini, ,

Minerva Anestesiol (Minerva anestesiologica)
[2018, 84(2):143-146]

Cited: 0 times

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Atypical use of PICC in infants and small children: a unicentric experience.

Filippo Bernasconi, Clelia Zanaboni, Andrea Dato, Andrea Dolcino, Michela Bevilacqua, Luigi Montagnini, Nicola Disma,

<h4>Introduction</h4>The peripherally inserted central catheters (PICCs) are vascular access devices (VAD) that are increasingly being used in the pediatric population. If a small vein caliber prevents positioning the catheter in the arm, the following step is to position the same catheter in the supraclavicular area, which can be defined as ... Read more >>

J Vasc Access (The journal of vascular access)
[2017, 18(6):535-539]

Cited: 0 times

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