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Author Nicola C Partridge

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Regulation of transforming growth factor-β1-stimulation of Runx2 acetylation for matrix metalloproteinase 13 expression in osteoblastic cells.

Kanagaraj Gomathi, Muthukumar Rohini, Nicola C Partridge, Nagarajan Selvamurugan,

Transforming growth factor beta 1 (TGF-β1) functions as a coupling factor between bone development and resorption. Matrix metalloproteinase 13 (MMP13) is important in bone remodeling, and skeletal dysplasia is caused by a deficiency in MMP13 expre-ssion. Runx2, a transcription factor is essential for bone development, and MMP13 is one of ... Read more >>

Biol Chem (Biological chemistry)
[2021, :]

Cited: 0 times

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Osteoblastic monocyte chemoattractant protein-1 (MCP-1) mediation of parathyroid hormone's anabolic actions in bone implicates TGF-β signaling.

Jawed A Siddiqui, Carole Le Henaff, Joshua Johnson, Zhiming He, Daniel B Rifkin, Nicola C Partridge,

Parathyroid hormone (PTH) is necessary for the regulation of calcium homeostasis and PTH (1-34) was the first approved osteoanabolic therapy for osteoporosis. It is well established that intermittent PTH increases bone formation and that bone remodeling and several cytokines and chemokines play an essential role in this process. Earlier, we ... Read more >>

Bone (Bone)
[2021, 143:115762]

Cited: 1 time

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Abaloparatide at the Same Dose Has the Same Effects on Bone as PTH (1-34) in Mice.

Carole Le Henaff, Florante Ricarte, Brandon Finnie, Zhiming He, Joshua Johnson, Johanna Warshaw, Victoria Kolupaeva, Nicola C Partridge,

Abaloparatide, a novel analog of parathyroid hormone-related protein (PTHrP 1-34), became in 2017 the second osteoanabolic therapy for the treatment of osteoporosis. This study aims to compare the effects of PTH (1-34), PTHrP (1-36), and abaloparatide on bone remodeling in male mice. Intermittent daily subcutaneous injections of 80 μg/kg/d were administered ... Read more >>

J Bone Miner Res (Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research)
[2020, 35(4):714-724]

Cited: 8 times

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miR-873-3p targets HDAC4 to stimulate matrix metalloproteinase-13 expression upon parathyroid hormone exposure in rat osteoblasts.

Desai Malavika, Srinivasan Shreya, Vembar Raj Priya, Muthukumar Rohini, Zhiming He, Nicola C Partridge, Nagarajan Selvamurugan,

Matrix metalloproteinase-13 (MMP-13) plays a predominant role in endochondral bone formation and bone remodeling. Parathyroid hormone (PTH) stimulates the expression of MMP-13 via Runx2, a bone transcription factor in rat osteoblastic cells (UMR106-01), and histone deacetylase 4 (HDAC4) acts as a corepressor of Runx2. Moreover, microRNAs (miRNAs) play an important ... Read more >>

J Cell Physiol (Journal of cellular physiology)
[2020, 235(11):7996-8009]

Cited: 1 time

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Parathyroid hormone(1-34) and its analogs differentially modulate osteoblastic Rankl expression via PKA/SIK2/SIK3 and PP1/PP2A-CRTC3 signaling.

Florante R Ricarte, Carole Le Henaff, Victoria G Kolupaeva, Thomas J Gardella, Nicola C Partridge,

Osteoporosis can result from the loss of sex hormones and/or aging. Abaloparatide (ABL), an analog of parathyroid hormone-related protein (PTHrP(1-36)), is the second osteoanabolic therapy approved by the United States Food and Drug Administration after teriparatide (PTH(1-34)). All three peptides bind PTH/PTHrP receptor type 1 (PTHR1), but the effects of ... Read more >>

J Biol Chem (The Journal of biological chemistry)
[2018, 293(52):20200-20213]

Cited: 13 times

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The Deletion of Hdac4 in Mouse Osteoblasts Influences Both Catabolic and Anabolic Effects in Bone.

Teruyo Nakatani, Tiffany Chen, Joshua Johnson, Jennifer J Westendorf, Nicola C Partridge,

Histone deacetylase 4 (Hdac4) is known to control chondrocyte hypertrophy and bone formation. We have previously shown that parathyroid hormone (PTH) regulates many aspects of Hdac4 function in osteoblastic cells in vitro; however, in vivo confirmation was previously precluded by preweaning lethality of the Hdac4-deficient mice. To analyze the function ... Read more >>

J Bone Miner Res (Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research)
[2018, 33(7):1362-1375]

Cited: 8 times

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MEF2C Interacts With c-FOS in PTH-Stimulated Mmp13 Gene Expression in Osteoblastic Cells.

Teruyo Nakatani, Nicola C Partridge,

Parathyroid hormone (PTH) regulates the transcription of many genes in the osteoblast. One of these genes is Mmp13, which is involved in bone remodeling and early stages of endochondral bone formation. Previously, we reported that PTH induces Mmp13 transcription by regulating the dissociation of histone deacetylase 4 (HDAC4) from runt-related ... Read more >>

Endocrinology (Endocrinology)
[2017, 158(11):3778-3791]

Cited: 6 times

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Pulsed electromagnetic fields inhibit human osteoclast formation and gene expression via osteoblasts.

Zhiming He, Nagarajan Selvamurugan, Johanna Warshaw, Nicola C Partridge,

Pulsed electromagnetic fields (PEMFs) can be effective in promoting the healing of delayed union or nonunion fractures. We previously reported that PEMF (Spinal-Stim® by Orthofix, Inc., Lewisville, TX) stimulated proliferation, differentiation and mineralization of rat calvarial osteoblastic cells in culture. In the present work we investigated the effects of PEMF ... Read more >>

Bone (Bone)
[2018, 106:194-203]

Cited: 18 times

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Catabolic Effects of Human PTH (1-34) on Bone: Requirement of Monocyte Chemoattractant Protein-1 in Murine Model of Hyperparathyroidism.

Jawed A Siddiqui, Joshua Johnson, Carole Le Henaff, Claudine L Bitel, Joseph A Tamasi, Nicola C Partridge,

The bone catabolic actions of parathyroid hormone (PTH) are seen in patients with hyperparathyroidism, or with infusion of PTH in rodents. We have previously shown that the chemokine, monocyte chemoattractant protein-1 (MCP-1), is a mediator of PTH's anabolic effects on bone. To determine its role in PTH's catabolic effects, we ... Read more >>

Sci Rep (Scientific reports)
[2017, 7(1):15300]

Cited: 6 times

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Characterization of Runx2 phosphorylation sites required for TGF-β1-mediated stimulation of matrix metalloproteinase-13 expression in osteoblastic cells.

Balasubramanian Arumugam, Mariappanadar Vairamani, Nicola C Partridge, Nagarajan Selvamurugan,

Transforming growth factor-beta1 (TGF-β1), a highly abundant growth factor in skeletal tissues, stimulates matrix metalloproteinase-13 (MMP-13) expression in osteoblastic cells. MMP-13 plays a critical role in bone remodeling. Runx2, a bone transcription factor, is required for TGF-β1-mediated stimulation of MMP-13 expression in osteoblastic cells. In this study, the molecular mechanism ... Read more >>

J Cell Physiol (Journal of cellular physiology)
[2018, 233(2):1082-1094]

Cited: 4 times

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CCL2/Monocyte Chemoattractant Protein 1 and Parathyroid Hormone Action on Bone.

Jawed Akhtar Siddiqui, Nicola C Partridge,

Chemokines are small molecules that play a crucial role as chemoattractants for several cell types, and their components are associated with host immune responses and repair mechanisms. Chemokines selectively recruit monocytes, neutrophils, and lymphocytes and induce chemotaxis through the activation of G protein-coupled receptors. Two well-described chemokine families (CXC and ... Read more >>

Front Endocrinol (Lausanne) (Frontiers in endocrinology)
[2017, 8:49]

Cited: 19 times

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MMP-13 is one of the critical mediators of the effect of HDAC4 deletion on the skeleton.

Teruyo Nakatani, Tiffany Chen, Nicola C Partridge,

Histone deacetylase 4 (Hdac4) regulates chondrocyte hypertrophy. Hdac4(-/-) mice are runted in size and do not survive to weaning. This phenotype is primarily due to the acceleration of onset of chondrocyte hypertrophy and, as a consequence, inappropriate endochondral mineralization. Previously, we reported that Hdac4 is a repressor of matrix metalloproteinase-13 ... Read more >>

Bone (Bone)
[2016, 90:142-151]

Cited: 8 times

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Physiological Bone Remodeling: Systemic Regulation and Growth Factor Involvement.

Jawed A Siddiqui, Nicola C Partridge,

Bone remodeling is essential for adult bone homeostasis. It comprises two phases: bone formation and resorption. The balance between the two phases is crucial for sustaining bone mass and systemic mineral homeostasis. This review highlights recent work on physiological bone remodeling and discusses our knowledge of how systemic and growth ... Read more >>

Physiology (Bethesda) (Physiology (Bethesda, Md.))
[2016, 31(3):233-245]

Cited: 67 times

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DMP-1-mediated Ghr gene recombination compromises skeletal development and impairs skeletal response to intermittent PTH.

Zhongbo Liu, Oran D Kennedy, Luis Cardoso, Jelena Basta-Pljakic, Nicola C Partridge, Mitchell B Schaffler, Clifford J Rosen, Shoshana Yakar,

Bone minerals are acquired during growth and are key determinants of adult skeletal health. During puberty, the serum levels of growth hormone (GH) and its downstream effector IGF-1 increase and play critical roles in bone acquisition. The goal of the current study was to determine how bone cells integrate signals ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2016, 30(2):635-652]

Cited: 14 times

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Sirtuin 1 is a negative regulator of parathyroid hormone stimulation of matrix metalloproteinase 13 expression in osteoblastic cells: role of sirtuin 1 in the action of PTH on osteoblasts.

Yurong Fei, Emi Shimizu, Michael W McBurney, Nicola C Partridge,

Parathyroid hormone (PTH) is the only current anabolic treatment for osteoporosis in the United States. PTH stimulates expression of matrix metalloproteinase 13 (MMP13) in bone. Sirtuin 1 (SIRT1), an NAD-dependent deacetylase, participates in a variety of human diseases. Here we identify a role for SIRT1 in the action of PTH ... Read more >>

J Biol Chem (The Journal of biological chemistry)
[2015, 290(13):8373-8382]

Cited: 14 times

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A positive role of microRNA-15b on regulation of osteoblast differentiation.

S Vimalraj, Nicola C Partridge, N Selvamurugan,

Osteoblast differentiation is tightly regulated by several factors including microRNAs (miRNAs). In this paper, we report that pre-mir-15b is highly expressed in differentiated osteoblasts. The functional role of miR-15b in osteoblast differentiation was determined using miR-15b mimic/inhibitor and the expression of osteoblast differentiation marker genes such as alkaline phosphatase (ALP), ... Read more >>

J Cell Physiol (Journal of cellular physiology)
[2014, 229(9):1236-1244]

Cited: 74 times

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Parathyroid hormone regulates histone deacetylase (HDAC) 4 through protein kinase A-mediated phosphorylation and dephosphorylation in osteoblastic cells.

Emi Shimizu, Teruyo Nakatani, Zhiming He, Nicola C Partridge,

Histone deacetylases (HDACs) are crucial regulators of gene expression in transcriptional co-repressor complexes. Previously, we reported that HDAC4 was a basal repressor of matrix metalloproteinase-13 (MMP-13) transcription and parathyroid hormone (PTH) regulates HDAC4 to control MMP-13 promoter activity through dissociation from Runx2. Here, we show that PTH induces the protein ... Read more >>

J Biol Chem (The Journal of biological chemistry)
[2014, 289(31):21340-21350]

Cited: 21 times

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Monocyte chemoattractant protein-1 is a mediator of the anabolic action of parathyroid hormone on bone.

Joseph A Tamasi, Anatoliy Vasilov, Emi Shimizu, Noah Benton, Joshua Johnson, Claudine L Bitel, Nigel Morrison, Nicola C Partridge,

Parathyroid hormone (PTH) has a significant role as an anabolic hormone in bone when administered by intermittent injection. Previous microarray studies in our laboratory have shown that the most highly regulated gene, monocyte chemoattractant protein-1 (MCP-1), is rapidly and transiently induced when hPTH(1-34) is injected intermittently in rats. Through further ... Read more >>

J Bone Miner Res (Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research)
[2013, 28(9):1975-1986]

Cited: 20 times

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Dancing with sex hormones, could iron contribute to the gender difference in osteoporosis?

Xi Huang, Youjia Xu, Nicola C Partridge,

Bone (Bone)
[2013, 55(2):458-460]

Cited: 15 times

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Triclosan blocks MMP-13 expression in hormone-stimulated osteoblasts.

Virginia Monsul Barnes, Tao Xu, Emi Shimizu, Teruyo Nakatani, Steven Jefcoat, Anatoliy Vasilov, Ling Qin, Nicola C Partridge,

<h4>Background</h4>Matrix metalloproteinase-13 (MMP-13) is an important enzyme for the modulation of bone turnover and gingival recession. Elevated levels of MMP-13 are associated with alveolar bone resorption, periodontal ligament breakdown, and gingival attachment loss, which are the clinical symptoms of periodontal disease. Evidence continues to suggest that periodontal disease contributes to ... Read more >>

J Periodontol (Journal of periodontology)
[2013, 84(11):1683-1689]

Cited: 3 times

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Bio-composite scaffolds containing chitosan/nano-hydroxyapatite/nano-copper-zinc for bone tissue engineering.

Anjali Tripathi, Sekaran Saravanan, Soumitri Pattnaik, Ambigapathi Moorthi, Nicola C Partridge, Nagarajan Selvamurugan,

The current study involves fabrication and characterization of bio-composite scaffolds containing chitosan (CS), nano-hydroxyapatite (nHAp) and Cu-Zn alloy nanoparticles (nCu-Zn) by freeze drying technique. The fabricated composite scaffolds (CS/nHAp and CS/nHAp/nCu-Zn) were characterized by SEM, EDX, XRD and FT-IR studies. The addition of nCu-Zn in the CS/nHAp scaffolds significantly increased ... Read more >>

Int J Biol Macromol (International journal of biological macromolecules)
[2012, 50(1):294-299]

Cited: 41 times

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Epidermal growth factor receptor plays an anabolic role in bone metabolism in vivo.

Xianrong Zhang, Joseph Tamasi, Xin Lu, Ji Zhu, Haiyan Chen, Xiaoyan Tian, Tang-Cheng Lee, David W Threadgill, Barbara E Kream, Yibin Kang, Nicola C Partridge, Ling Qin,

While the epidermal growth factor receptor (EGFR)-mediated signaling pathway has been shown to have vital roles in many developmental and pathologic processes, its functions in the development and homeostasis of the skeletal system has been poorly defined. To address its in vivo role, we constructed transgenic and pharmacologic mouse models ... Read more >>

J Bone Miner Res (Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research)
[2011, 26(5):1022-1034]

Cited: 46 times

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Parathyroid hormone activation of matrix metalloproteinase-13 transcription requires the histone acetyltransferase activity of p300 and PCAF and p300-dependent acetylation of PCAF.

Minnkyong Lee, Nicola C Partridge,

Parathyroid hormone (PTH) regulates the transcription of many genes involved in bone remodeling in osteoblasts. One of these genes is matrix metalloproteinase-13 (MMP-13), which is involved in bone remodeling and early stages of endochondral bone formation. We have previously shown that Mmp-13 gene expression is highly induced by PTH treatment ... Read more >>

J Biol Chem (The Journal of biological chemistry)
[2010, 285(49):38014-38022]

Cited: 18 times

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EGFR signaling suppresses osteoblast differentiation and inhibits expression of master osteoblastic transcription factors Runx2 and Osterix.

Ji Zhu, Emi Shimizu, Xianrong Zhang, Nicola C Partridge, Ling Qin,

The epidermal growth factor receptor (EGFR) and its ligands regulate key processes of cell biology, such as proliferation, survival, differentiation, migration, and tumorigenesis. We previously showed that, EGFR signaling pathway is an important bone regulator and it primarily plays an anabolic role in bone metabolism. In this study, we demonstrated ... Read more >>

J Cell Biochem (Journal of cellular biochemistry)
[2011, 112(7):1749-1760]

Cited: 59 times

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HDAC4 represses matrix metalloproteinase-13 transcription in osteoblastic cells, and parathyroid hormone controls this repression.

Emi Shimizu, Nagarajan Selvamurugan, Jennifer J Westendorf, Eric N Olson, Nicola C Partridge,

Parathyroid hormone (PTH) is a hormone regulating bone remodeling through its actions on both bone formation and bone resorption. Previously we reported that PTH induces matrix metalloproteinase-13 (MMP-13) transcription in osteoblastic cells. Here, we show that histone deacetylase 4 (HDAC4) interacts with Runx2, binds the MMP-13 promoter, and suppresses MMP-13 ... Read more >>

J Biol Chem (The Journal of biological chemistry)
[2010, 285(13):9616-9626]

Cited: 47 times

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