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Neurosurgical Approaches to the Skull Base: A Guide for the Radiologist.

Jonathan Shapey, Nick W M Thomas, Steve E J Connor,

Skull base surgery relies on the assessment of detailed neuroimaging studies to assist with surgical planning. We review typical neuroimaging features associated with common neurosurgical skull base approaches, highlighting relevant imaging anatomy and pertinent postoperative imaging appearances. ... Read more >>

Neuroimaging Clin N Am (Neuroimaging clinics of North America)
[2021, 31(4):409-431]

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Surgical Management of Spinal Chordoma: A Systematic Review and Single-Center Experience.

Asfand Baig Mirza, James Bartram, Mohamed Okasha, Qusai Al Banna, Amisha Vastani, Eleni Maratos, Richard Gullan, Nick Thomas,

<h4>Objective</h4>Chordoma is a rare neoplasm of the neuraxis derived from remnants of the primitive notochord. The importance of wide margins and use of adjuvant therapy in spinal chordomas are still contentious points in the management of spinal chordomas. We conducted a systematic review of the surgical management of spinal chordomas ... Read more >>

World Neurosurg (World neurosurgery)
[2021, 156:e111-e129]

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Diagnosis of patients with heart failure with preserved ejection fraction in primary care: cohort study

Faye Forsyth, James Brimicombe, Joseph Cheriyan, Duncan Edwards, F.D. Richard Hobbs, Navazh Jalaludeen, Jonathan Mant, Mark Pilling, Rebekah Schiff, Clare J. Taylor, M. Justin Zaman, Christi Deaton, OPTIMISE HFpEF investigators and collaborators, Mollika Chakravorty, Sophie Maclachlan, Edward Kane, Jessica Odone, Natasha Thorley, Susana Borja‐Boluda, Ian Wellwood, Emma Sowden, Thomas Blakeman, Carolyn Chew‐Graham, Muhammed Hossain, John Sharpley, Brain Gordon, Joanna Taffe, Aaron Long, Affan Aziz, Hannah Swayze, Heather Rutter, Chris Schramm, Sine MacDonald, Helena Papworth, Julie Smith, Craig Needs, David Cronk, Chris Newark, Duncan Blake, Alistair Brown, Amman Basuita, Emma Gayton, Victoria Glover, Robin Fox, Jonathan Crawshaw, Helen Ashdown, Christine A'Court, Rachael Ayerst, Basilio Hernandez‐Diaz, Kyle Knox, Nick Wooding, Shamila Wanninayake, Christopher Keast, Adam Jones, Katherine Brown, Matthew Gaw, Nick Thomas, Sharon Dixon, Elisabetta Angeleri‐Rand,

Abstract <h4>Aims</h4> Heart failure with preserved ejection fraction (HFpEF) accounts for half of all heart failure (HF), but low awareness and diagnostic challenges hinder identification in primary care. Our aims were to evaluate the recruitment and diagnostic strategy in the Optimise HFpEF cohort and compare with recent recommendations for diagnosing ... Read more >>

ESC Heart Fail (ESC heart failure)
[2021, 8(6):4562-4571]

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What is the current clinical practice in pituitary adenoma surgery in Europe? European Pituitary Adenoma Surgery Survey (EU-PASS) results-technical part.

Martin Májovský, Andre Grotenhuis, Nicolas Foroglou, Francesco Zenga, Sebastien Froehlich, Florian Ringel, Nicolas Sampron, Nick Thomas, Martin Komarc, David Netuka,

Pituitary adenoma surgery has evolved rapidly in recent decades, changing clinical practice markedly and raising new challenges. There is no current consensus or guidelines for perioperative care that includes possible complication management. This study aims to determine current practice across European neurosurgical centres. We created a list of eligible departments ... Read more >>

Neurosurg Rev (Neurosurgical review)
[2021, :]

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Endocrinological Aspects of Pituitary Adenoma Surgery in Europe

David Netuka, André Grotenhuis, Nicolas Foroglou, Francesco Zenga, Sebastien Froehlich, Florian Ringel, Nicolas Sampron, Nick Thomas, Martin Komarc, Mikulas Kosak, Martin Majovsky,

<h4>Purpose: </h4> Hormone-secreting adenomas are treated in many neurosurgical centers within Europe. The goal of the survey is to shed light on different endocrinological aspects of hormone-secreting adenomas surgery. <h4>Methods: </h4>: A list of departments performing pituitary surgery was created. The survey consisted of 58 questions. This study focuses on ... Read more >>

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Use of prescribing safety quality improvement reports in UK general practices: a qualitative assessment.

Nada F Khan, Helen P Booth, Puja Myles, David Mullett, Arlene Gallagher, Catheryn Evans, Nicholas Pb Thomas, Janet Valentine,

<h4>Background</h4>Quality improvement (QI) initiatives are increasingly used to improve the quality of care and reduce prescribing errors. The Royal College of General Practitioners (RCGP) and Clinical Practice Research Datalink (CPRD) QI initiative uses routinely collected electronic primary care data to provide bespoke practice-level reports on prescribing safety. The aim of ... Read more >>

BMC Health Serv Res (BMC health services research)
[2021, 21(1):394]

Cited: 1 time

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What is the current clinical practise in pituitary adenoma surgery in Europe? European Pituitary Adenoma Surgery Survey (EU-PASS) results - technical part

Martin Májovský, Andre Grotenhuis, Nicolas Foroglou, Francesco Zenga, Sebastien Froehlich, Florian Ringel, Nicolas Sampron, Nick Thomas, Martin Komarc, David Netuka,

Pituitary adenoma surgery has evolved rapidly in recent decades, changing clinical practice markedly and raising new challenges. There is no current consensus or guidelines for perioperative care that includes possible complication management. This study aims to determine current practice across European neurosurgical centers. We created a list of eligible departments ... Read more >>

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Artificial Intelligence Opportunities for Vestibular Schwannoma Management Using Image Segmentation and Clinical Decision Tools.

Jonathan Shapey, Aaron Kujawa, Reuben Dorent, Shakeel R Saeed, Neil Kitchen, Rupert Obholzer, Sebastien Ourselin, Tom Vercauteren, Nick W M Thomas,

World Neurosurg (World neurosurgery)
[2021, 149:269-270]

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The disproportionate excess mortality risk of COVID-19 in younger people with diabetes warrants vaccination prioritisation.

Andrew P McGovern, Nick J Thomas, Sebastian J Vollmer, Andrew T Hattersley, Bilal A Mateen, John M Dennis,

Diabetologia (Diabetologia)
[2021, 64(5):1184-1186]

Cited: 6 times

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Hospital bed capacity and usage across secondary healthcare providers in England during the first wave of the COVID-19 pandemic: a descriptive analysis.

Bilal Akhter Mateen, Harrison Wilde, John M Dennis, Andrew Duncan, Nick Thomas, Andrew McGovern, Spiros Denaxas, Matt Keeling, Sebastian Vollmer,

<h4>Objective</h4>In this study, we describe the pattern of bed occupancy across England during the peak of the first wave of the COVID-19 pandemic.<h4>Design</h4>Descriptive survey.<h4>Setting</h4>All non-specialist secondary care providers in England from 27 March27to 5 June 2020.<h4>Participants</h4>Acute (non-specialist) trusts with a type 1 (ie, 24 hours/day, consultant-led) accident and emergency department (n=125), ... Read more >>

BMJ Open (BMJ open)
[2021, 11(1):e042945]

Cited: 9 times

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CSF Rhinorrhoea After Endonasal Intervention to the Skull Base (CRANIAL) - Part 1: Multicenter Pilot Study.

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<h4>Background</h4>CRANIAL (CSF Rhinorrhoea After Endonasal Intervention to the Skull Base) is a prospective multicenter observational study seeking to determine 1) the scope of skull base repair methods used and 2) corresponding rates of postoperative cerebrospinal fluid (CSF) rhinorrhea in the endonasal transsphenoidal approach (TSA) and the expanded endonasal approach (EEA) ... Read more >>

World Neurosurg (World neurosurgery)
[2021, 149:e1077-e1089]

Cited: 1 time

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Prolactinoma in childhood and adolescence-Tumour size at presentation predicts management strategy: Single centre series and a systematic review and meta-analysis.

Ved Bhushan Arya, Simon J B Aylwin, Tony Hulse, Michal Ajzensztejn, Jennifer Kalitsi, Nicolas Kalogirou, Istvan Bodi, Nick Thomas, Tim Hampton, Ritika R Kapoor, Charles R Buchanan,

<h4>Objective</h4>To report the clinical presentation, management and outcomes of young patients with prolactinomas (<20 years) and conduct a systematic review and meta-analysis.<h4>Patients and design</h4>Clinical, biochemical and radiological data (1996-2018) were collected from our centre. A systematic review and meta-analysis of published literature (1994-2019) on prolactinoma (age <20 years) were conducted. Both random ... Read more >>

Clin Endocrinol (Oxf) (Clinical endocrinology)
[2021, 94(3):413-423]

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D-MannosE to prevent Recurrent urinary tract InfecTions (MERIT): protocol for a randomised controlled trial.

Marloes Franssen, Johanna Cook, Jared Robinson, Nicola Williams, Margaret Glogowska, Yaling Yang, Julie Allen, Christopher C Butler, Nick Thomas, Alastair Hay, Michael Moore, Gail Hayward,

<h4>Introduction</h4>Recurrent urinary tract infections (RUTIs) have a significant negative impact on quality of life and healthcare costs. To date, daily prophylactic antibiotics are the only treatment which have been shown to help prevent RUTIs. D-mannose is a type of sugar which is believed to inhibit bacterial adherence to uroepithelial cells, ... Read more >>

BMJ Open (BMJ open)
[2021, 11(1):e037128]

Cited: 1 time

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CSF Rhinorrhea After Endonasal Intervention to the Skull Base (CRANIAL) - Part 2: Impact of COVID-19.

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<h4>Background</h4>During the coronavirus disease 2019 (COVID-19) pandemic, concerns have been raised regarding the increased risk of perioperative mortality for patients with COVID-19, and the transmission risk to healthcare workers, especially during endonasal neurosurgical operations. The Pituitary Society has produced recommendations to guide management during this era. We sought to assess ... Read more >>

World Neurosurg (World neurosurgery)
[2021, 149:e1090-e1097]

Cited: 1 time

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Neurosurgery and coronavirus: impact and challenges-lessons learnt from the first wave of a global pandemic.

Keyoumars Ashkan, Josephine Jung, Alexandra Maria Velicu, Ahmed Raslan, Mohammed Faruque, Pandurang Kulkarni, Cristina Bleil, Harutomo Hasegawa, Ahilan Kailaya-Vasan, Eleni Maratos, Gordan Grahovac, Francesco Vergani, Bassel Zebian, Sinan Barazi, Irfan Malik, David Bell, Daniel Walsh, Ranjeev Bhangoo, Christos Tolias, Sanjeev Bassi, Richard Selway, Nick Thomas, Christopher Chandler, Richard Gullan,

<h4>Introduction and objectives</h4>The novel severe acute respiratory syndrome coronavirus 2 (COVID-19) pandemic has had drastic effects on global healthcare with the UK amongst the countries most severely impacted. The aim of this study was to examine how COVID-19 challenged the neurosurgical delivery of care in a busy tertiary unit serving ... Read more >>

Acta Neurochir (Wien) (Acta neurochirurgica)
[2021, 163(2):317-329]

Cited: 4 times

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Neurosurgery and Coronavirus: Impact and Challenges. Lessons Learnt from the First Wave of a Global Pandemic

Keyoumars Ashkan, Josephine Jung, Alexandra Maria Velicu, Ahmed Raslan, Mohammed Faruque, Pandurang Kulkarni, Cristina Bleil, Harumoto Hasegawa, Ahilan Kailaya-Vasan, Eleni Maratos, Gordan Grahovac, Francesco Vergani, Bassel Zebian, Sinan Barazi, Irfan Malik, David Bell, Daniel Walsh, Ranjeev Bhangoo, Christos Tolias, Sanjeev Bassi, Richard Selway, Nick Thomas, Christopher Chandler, Richard Gullan,

Background: The novel severe acute respiratory syndrome coronavirus 2 (COVID-19) pandemic has had a drastic effect on global healthcare with the UK amongst the countries most severely impacted. The aim of this study was to examine how COVID-19 challenged the neurosurgical delivery of care in a busy tertiary unit serving ... Read more >>

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CSF rhinorrhoea after endonasal intervention to the anterior skull base (CRANIAL): proposal for a prospective multicentre observational cohort study.

Danyal Z Khan, Soham Bandyopadhyay, Vikesh Patel, Benjamin E Schroeder, Ivan Cabrilo, David Choi, Simon A Cudlip, Neil Donnelly, Neil L Dorward, Daniel M Fountain, Joan Grieve, Jane Halliday, Angelos G Kolias, Richard J Mannion, Alice O'Donnell, Nick Phillips, Rory J Piper, Bhavna Ramachandran, Thomas Santarius, Parag Sayal, Rishi Sharma, Georgios Solomou, James R Tysome, Hani J Marcus, , Andrew F Alalade, Shahzada Ahmed, Sinan Al-Barazi, Rafid Al-Mahfoudh, Anuj Bahl, David Bennett, Raj Bhalla, Pragnesh Bhatt, Graham Dow, Anastasios Giamouriadis, Catherine Gilkes, Kanna Gnanalingham, Brendan Hanna, Caroline Hayhurst, Jonathan Hempenstall, Kismet Hossain-Ibrahim, Mark Hughes, Mohsen Javadpour, Alistair Jenkins, Mahmoud Kamel, Mohammad Habibullah Khan, Peter Lacy, Eleni Maratos, Andrew Martin, Nijaguna Mathad, Nigel Mendoza, Showkat Mirza, Sam Muquit, Ramesh Nair, Claire Nicholson, Alex Paluzzi, Dimitris Paraskevopoulos, Omar Pathmanaban, Jonathan Pollock, Bhaskar Ram, Iain Robertson, Peter Ross, Simon Shaw, Alireza Shoakazemi, Saurabh Sinha, Simon Stapleton, Patrick Statham, Benjamin Stew, Nick Thomas, Georgios Tsermoulas, Philip Weir, Adam Williams,

<h4>Background</h4>The endonasal transsphenoidal approach (TSA) has emerged as the preferred approach in order to treat pituitary adenoma and related sellar pathologies. The recently adopted expanded endonasal approach (EEA) has improved access to the ventral skull base whilst retaining the principles of minimally invasive surgery. Despite the advantages these approaches offer, ... Read more >>

Br J Neurosurg (British journal of neurosurgery)
[2021, 35(4):408-417]

Cited: 5 times

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Lack of Correlation Between Immunohistochemical Expression of SPARC and Invasion in Different Grades of Meningiomas.

Harcharan K Rooprai, Andrew J Martin, Andrew King, Usha D Appadu, Richard W Gullan, Nick W M Thomas, Geoffrey J Pilkington,

BACKGROUND:Grade I meningiomas are generally benign and non-invasive whereas Grade II (atypical) and Grade III (malignant) meningiomas tend to be invasive with a high risk of recurrence. SPARC, secreted protein, acidic and rich in cysteine, is a multifunctional glycoprotein which has been proposed to be a potential diagnostic marker of ... Read more >>

Anticancer Res (Anticancer research)
[2020, 40(6):3081-3089]

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Combined extradural-interdural-intradural approach to a trigeminal nerve cystic haemangiopericytoma with intra-operative cranial nerve monitoring

Joseph Frantzias, José Lavrador, Noémia Pereira, Richard Gullan, Keyoumars Ashkan, Francesco Vergani, Ranjeev Bhangoo, Nick Thomas,

Abstract Objectives Haemangiopericytoma of the trigemimal nerve is extremely rare, with only two previous cases described to our knowledge. We present the surgical approach to this tumour, and describe a previously poorly reported method of monitoring the function of the branches of the trigeminal nerve: mapping of the sensory roots ... Read more >>

Neuro Oncol (Neuro-oncology)
[2019, 21(Suppl 4):iv18-iv18]

Cited: 0 times

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Endoscopic skull base neurosurgical practice in the United Kingdom.

Andrew F Alalade, Sara Venturini, Neil Dorward, Nick Thomas,

<b>Background:</b> Endoscopic skull base surgery (ESBS) is a new subspecialty area that has become more popular over the past 20 years. It is fast evolving and the indications are getting increasingly diverse. The skill-sets also continue to significantly improve, hence, we, the authors aim to assess the current status of ... Read more >>

Br J Neurosurg (British journal of neurosurgery)
[2019, 33(5):508-513]

Cited: 1 time

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Our experience with a novel CSF leak repair material in 14 patients following anterior skull base surgery.

Katherine De Rome, Elinor Warner, Kostas Barkas, Nick Thomas, Sinan Barazi, Pavol Surda,

Clin Otolaryngol (Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery)
[2019, 44(3):416-419]

Cited: 0 times

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CRAN-08. NATIONAL UK GUIDELINES FOR THE INVESTIGATION, TREATMENT AND LONG-TERM FOLLOW-UP OF PAEDIATRIC CRANIOPHARYNGIOMA

Hoong-Wei Gan, Kristian Aquilina, Paul Morillon, Assunta Albanese, Konstantinos Barkas, Chris Chandler, Yen-Ching Chang, Christina Daousi, Evangelos Drimtzias, Sarah Farndon, Tom Jacques, Marta Korbonits, Adam Kuczynski, Jennifer Limond, Louise Robinson, Ian Simmons, Nick Thomas, Sophie Thomas, Nicola Thorpe, Faraneh Vargha-Khadem, Daniel Warren, Bassel Zebian, Conor Mallucci, Ashley Gamble, Sophie Wilne, Barney Harrison, Helen Spoudeas,

Abstract <h4>BACKGROUND</h4> Craniopharyngiomas are the commonest suprasellar tumour in childhood. Despite high overall survival, children with craniopharyngiomas are at risk of multiple relapses and long-term tumour- and treatment-related morbidity. We sought to provide, for the first time, a national evidence-based standard for best practice for the assessment, treatment, and follow-up ... Read more >>

Neuro Oncol (Neuro-oncology)
[2018, 20(Suppl 2):i38-i38]

Cited: 0 times

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Congenital Epidermoid Cyst Presenting as Isolated Painful Trigeminal Neuropathy: Indications for Neuroimaging in the Diagnostic Process.

Kimberley Kok, Chris Sproat, Mun-Seng Chong, Chris Chandler, Nick Thomas, Hoong-Wei Gan,

This article reports a case of a cerebellopontine angle epidermoid cyst presenting as isolated painful trigeminal neuropathy. The indolent nature of these uncommon benign tumors leads to frequent delays in their presentation and diagnosis, with patients often initially undergoing dental procedures. This is illustrated in the present case reported here, ... Read more >>

J Oral Facial Pain Headache (Journal of oral & facial pain and headache)
[2017, 31(4):e10-e14]

Cited: 0 times

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Giant thoracic discs: treatment, outcome, and follow-up of 33 patients in a single centre.

Saurabh Kapoor, Meriem Amarouche, Farah Al-Obeidi, Jean Marie U-King-Im, Nick Thomas, David Bell,

<h4>Purpose</h4>To help guide treatment strategies and create insight into functional outcomes in patients with Giant herniated thoracic discs (GHTD), which are defined as occupying more than 40% of spinal canal.<h4>Methods</h4>Authors did a retrospective analysis of prospective cohort of 33 cases of GHTD, using clinical letters, notes, and telephonic questionnaires to ... Read more >>

Eur Spine J (European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society)
[2018, 27(7):1555-1566]

Cited: 1 time

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Spectroscopic Evidence for a H Bond Network at Y356 Located at the Subunit Interface of Active E. coli Ribonucleotide Reductase.

Thomas U Nick, Kanchana R Ravichandran, JoAnne Stubbe, Müge Kasanmascheff, Marina Bennati,

The reaction catalyzed by E. coli ribonucleotide reductase (RNR) composed of α and β subunits that form an active α2β2 complex is a paradigm for proton-coupled electron transfer (PCET) processes in biological transformations. β2 contains the diferric tyrosyl radical (Y<sub>122</sub>·) cofactor that initiates radical transfer (RT) over 35 Å via ... Read more >>

Biochemistry (Biochemistry)
[2017, 56(28):3647-3656]

Cited: 11 times

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