Full Text Journal Articles by
Author Nick A Andrews

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The Stage of the Estrus Cycle Is Critical for Interpretation of Female Mouse Social Interaction Behavior.

Trishala Chari, Sophie Griswold, Nick A Andrews, Michela Fagiolini,

Female animals in biomedical research have traditionally been excluded from research studies due to the perceived added complexity caused by the estrus cycle. However, given the importance of sex differences in a variety of neurological disorders, testing female mice is critical to identifying sex-linked effects in diseases. To determine the ... Read more >>

Front Behav Neurosci (Frontiers in behavioral neuroscience)
[2020, 14:113]

Cited: 3 times

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Sepiapterin Reductase Inhibition Leading to Selective Reduction of Inflammatory Joint Pain in Mice and Increased Urinary Sepiapterin Levels in Humans and Mice.

Masahide Fujita, Débora da Luz Scheffer, Bruna Lenfers Turnes, Shane J F Cronin, Alban Latrémolière, Michael Costigan, Clifford J Woolf, Alexandra Latini, Nick A Andrews,

<h4>Objective</h4>To evaluate the antiinflammatory and analgesic effects of sepiapterin reductase (SPR) inhibition in a mouse model of inflammatory joint disease, and to determine whether urinary sepiapterin levels, as measured in mice and healthy human volunteers, could be useful as a noninvasive, translational biomarker of SPR inhibition/target engagement.<h4>Methods</h4>The collagen antibody-induced arthritis ... Read more >>

Arthritis Rheumatol (Arthritis & rheumatology (Hoboken, N.J.))
[2020, 72(1):57-66]

Cited: 3 times

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Novel charged sodium and calcium channel inhibitor active against neurogenic inflammation.

Seungkyu Lee, Sooyeon Jo, Sébastien Talbot, Han-Xiong Bear Zhang, Masakazu Kotoda, Nick A Andrews, Michelino Puopolo, Pin W Liu, Thomas Jacquemont, Maud Pascal, Laurel M Heckman, Aakanksha Jain, Jinbo Lee, Clifford J Woolf, Bruce P Bean,

Voltage-dependent sodium and calcium channels in pain-initiating nociceptor neurons are attractive targets for new analgesics. We made a permanently charged cationic derivative of an N-type calcium channel-inhibitor. Unlike cationic derivatives of local anesthetic sodium channel blockers like QX-314, this cationic compound inhibited N-type calcium channels more effectively with extracellular than ... Read more >>

Elife (eLife)
[2019, 8:]

Cited: 3 times

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Composite Pain Biomarker Signatures for Objective Assessment and Effective Treatment.

Irene Tracey, Clifford J Woolf, Nick A Andrews,

Pain is a subjective sensory experience that can, mostly, be reported but cannot be directly measured or quantified. Nevertheless, a suite of biomarkers related to mechanisms, neural activity, and susceptibility offer the possibility-especially when used in combination-to produce objective pain-related indicators with the specificity and sensitivity required for diagnosis and ... Read more >>

Neuron (Neuron)
[2019, 101(5):783-800]

Cited: 23 times

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Diltiazem Promotes Regenerative Axon Growth.

Eric A Huebner, Stéphane Budel, Zhaoxin Jiang, Takao Omura, Tammy Szu-Yu Ho, Lee Barrett, Janie S Merkel, Luis M Pereira, Nick A Andrews, Xingxing Wang, Bhagat Singh, Kush Kapur, Michael Costigan, Stephen M Strittmatter, Clifford J Woolf,

Axotomy results in permanent loss of function after brain and spinal cord injuries due to the minimal regenerative propensity of the adult central nervous system (CNS). To identify pharmacological enhancers of axon regeneration, 960 compounds were screened for cortical neuron axonal regrowth using an in vitro cortical scrape assay. Diltiazem, ... Read more >>

Mol Neurobiol (Molecular neurobiology)
[2019, 56(6):3948-3957]

Cited: 4 times

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Rigor and reproducibility in rodent behavioral research.

Maria Gulinello, Heather A Mitchell, Qiang Chang, W Timothy O'Brien, Zhaolan Zhou, Ted Abel, Li Wang, Joshua G Corbin, Surabi Veeraragavan, Rodney C Samaco, Nick A Andrews, Michela Fagiolini, Toby B Cole, Thomas M Burbacher, Jacqueline N Crawley,

Behavioral neuroscience research incorporates the identical high level of meticulous methodologies and exacting attention to detail as all other scientific disciplines. To achieve maximal rigor and reproducibility of findings, well-trained investigators employ a variety of established best practices. Here we explicate some of the requirements for rigorous experimental design and ... Read more >>

Neurobiol Learn Mem (Neurobiology of learning and memory)
[2019, 165:106780]

Cited: 12 times

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Neuropathic pain drives anxiety behavior in mice, results consistent with anxiety levels in diabetic neuropathy patients.

Christine B Sieberg, Caitlin Taras, Aya Gomaa, Chelsea Nickerson, Cindy Wong, Catherine Ward, Georgios Baskozos, David L H Bennett, Juan D Ramirez, Andreas C Themistocleous, Andrew S C Rice, Pallai R Shillo, Solomon Tesfaye, Robert R Edwards, Nick A Andrews, Charles Berde, Michael Costigan,

<h4>Background</h4>Epidemiological studies in patients with neuropathic pain demonstrate a strong association with psychiatric conditions such as anxiety; however, the precipitating pathology between these symptoms remains unclear. To investigate this, we studied the effects of lifelong stress on levels of neuropathic pain-like behavior and conversely, the effects of chronic neuropathic injury ... Read more >>

Pain Rep (Pain reports)
[2018, 3(3):e651]

Cited: 11 times

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Mechanistic Differences in Neuropathic Pain Modalities Revealed by Correlating Behavior with Global Expression Profiling.

Enrique J Cobos, Chelsea A Nickerson, Fuying Gao, Vijayendran Chandran, Inmaculada Bravo-Caparrós, Rafael González-Cano, Priscilla Riva, Nick A Andrews, Alban Latremoliere, Corey R Seehus, Gloria Perazzoli, Francisco R Nieto, Nicole Joller, Michio W Painter, Chi Him Eddie Ma, Takao Omura, Elissa J Chesler, Daniel H Geschwind, Giovanni Coppola, Manu Rangachari, Clifford J Woolf, Michael Costigan,

Chronic neuropathic pain is a major morbidity of neural injury, yet its mechanisms are incompletely understood. Hypersensitivity to previously non-noxious stimuli (allodynia) is a common symptom. Here, we demonstrate that the onset of cold hypersensitivity precedes tactile allodynia in a model of partial nerve injury, and this temporal divergence was ... Read more >>

Cell Rep (Cell reports)
[2018, 22(5):1301-1312]

Cited: 40 times

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Ensuring transparency and minimization of methodologic bias in preclinical pain research: PPRECISE considerations.

Nick A Andrews, Alban Latrémolière, Allan I Basbaum, Jeffrey S Mogil, Frank Porreca, Andrew S C Rice, Clifford J Woolf, Gillian L Currie, Robert H Dworkin, James C Eisenach, Scott Evans, Jennifer S Gewandter, Tony D Gover, Hermann Handwerker, Wenlong Huang, Smriti Iyengar, Mark P Jensen, Jeffrey D Kennedy, Nancy Lee, Jon Levine, Katie Lidster, Ian Machin, Michael P McDermott, Stephen B McMahon, Theodore J Price, Sarah E Ross, Grégory Scherrer, Rebecca P Seal, Emily S Sena, Elizabeth Silva, Laura Stone, Camilla I Svensson, Dennis C Turk, Garth Whiteside,

There is growing concern about lack of scientific rigor and transparent reporting across many preclinical fields of biological research. Poor experimental design and lack of transparent reporting can result in conscious or unconscious experimental bias, producing results that are not replicable. The Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, ... Read more >>

Pain (Pain)
[2016, 157(4):901-909]

Cited: 33 times

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Identification and functional significance of N-glycosylation of the 5-ht5A receptor.

Alice C Dutton, Andrew N Massoura, Terri J Dover, Nick A Andrews, Nicholas M Barnes,

The presence and roles of N-glycosylation of the human (h) 5-ht(5A) receptor were investigated using a heterologous expression system. Following transient transfection of COS-7 cells with h5-ht(5A) receptor cDNA, SDS-PAGE/Western blot analysis of immunoreactivity demonstrated two protein species; a predominant species with a molecular weight of approximately 35-45 kDa and ... Read more >>

Neurochem Int (Neurochemistry international)
[2008, 52(3):419-425]

Cited: 10 times

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