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Author Nicholas T Broskey

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Effect of Aerobic Exercise-induced Weight Loss on the Components of Daily Energy Expenditure.

Nicholas T Broskey, Corby K Martin, Jeffrey H Burton, Timothy S Church, Eric Ravussin, Leanne M Redman,

<h4>Introduction</h4>Exercise usually results in less weight loss than expected. This suggests increased energy intake and/or deceased expenditure counteract the energy deficit induced by exercise. The aim of this study was to evaluate changes in components of daily energy expenditure (doubly labeled water and room calorimetry) after 24 wk of exercise ... Read more >>

Med Sci Sports Exerc (Medicine and science in sports and exercise)
[2021, 53(10):2164-2172]

Cited: 0 times

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Exercise during Pregnancy: Developmental Programming Effects and Future Directions in Humans.

Polina M Krassovskaia, Alec B Chaves, Joseph A Houmard, Nicholas T Broskey,

Epidemiological studies show that low birth weight is associated with mortality from cardiovascular disease in adulthood, indicating that chronic diseases could be influenced by hormonal or metabolic insults encountered <i>in utero</i>. This concept, now known as the Developmental Origins of Health and Disease hypothesis, postulates that the intrauterine environment may ... Read more >>

Int J Sports Med (International journal of sports medicine)
[2021, :]

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The influence of exercise during pregnancy on racial/ethnic health disparities and birth outcomes.

Madigan J Raper, Samantha McDonald, Carol Johnston, Christy Isler, Edward Newton, Devon Kuehn, David Collier, Nicholas T Broskey, Adrienne Muldrow, Linda E May,

<h4>Background</h4>Non-Hispanic black (NHB) pregnant women disproportionately experience adverse birth outcomes compared to Non-Hispanic white (NHW) pregnant women. The positive effects of prenatal exercise on maternal and neonatal health may mitigate these disparities. This study evaluated the influence of prenatal exercise on racial/ethnic disparities in gestational age (GA), birthweight (BW), and ... Read more >>

BMC Pregnancy Childbirth (BMC pregnancy and childbirth)
[2021, 21(1):258]

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The association between lactate and muscle aerobic substrate oxidation: Is lactate an early marker for metabolic disease in healthy subjects?

Nicholas T Broskey, Walter J Pories, Terry E Jones, Charles J Tanner, Donghai Zheng, Ronald N Cortright, Zhen W Yang, Nkaujyi Khang, Josh Yang, Joseph A Houmard, G Lynis Dohm,

Fasting plasma lactate concentrations are elevated in individuals with metabolic disease. The aim of this study was to determine if the variance in fasting lactate concentrations were associated with factors linked with cardiometabolic health even in a young, lean cohort. Young (age 22 ± 0.5; N = 30) lean (BMI (22.4 ± 0.4 kg/m<sup>2</sup> ) women were ... Read more >>

Physiol Rep (Physiological reports)
[2021, 9(3):e14729]

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The impact of advanced maternal age on pregnancy and offspring health: A mechanistic role for placental angiogenic growth mediators.

Ericka M Biagioni, Linda E May, Nicholas T Broskey,

The birth rates among women of advanced maternal age (AMA) have risen over the last two decades; yet, pregnancies with AMA are considered high-risk and are associated with a significant increase in pregnancy complications. Although the mechanisms leading to pregnancy complications in women with AMA are not fully understood, it ... Read more >>

Placenta (Placenta)
[2021, 106:15-21]

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Identification of changes in sleep across pregnancy and the impact on cardiometabolic health and energy intake in women with obesity.

Emily W Flanagan, Jasper Most, Nicholas T Broskey, Abby D Altazan, Robbie A Beyl, Sarah K Keadle, Kimberly L Drews, Prachi Singh, Leanne M Redman,

This prospective, observational study investigated changes in sleep and the effect on energy intake, gestational weight gain, and cardiometabolic health across pregnancy in 52 healthy pregnant women with obesity. Habitual sleep was assessed by wrist-worn actigraphy (time spent in bed; TIB, total sleep time; TST, and sleep efficiency) in early ... Read more >>

Sleep Med (Sleep medicine)
[2021, 77:120-127]

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Discrimination of wear and non-wear in infants using data from hip- and ankle-worn devices.

Samuel R LaMunion, Scott E Crouter, Nicholas T Broskey, Abby D Altazan, Leanne M Redman,

<h4>Introduction</h4>A key component to analyzing wearable sensor data is identifying periods of non-wear. Traditionally, strings of consecutive zero counts (e.g. >60-minutes) are identified indicating periods of non-movement. The non-movement window length is then evaluated as wear or non-wear. Given that non-movement is not equivalent to non-wear, additional criteria should be ... Read more >>

PLoS One (PloS one)
[2020, 15(11):e0240604]

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The effects of aerobic exercise on markers of maternal metabolism during pregnancy.

Samantha M McDonald, Cody Strom, Mary-Margaret Remchak, Alec Chaves, Nicholas T Broskey, Christy Isler, Kelley Haven, Edward Newton, James DeVente, Pedro Acosta-Manzano, Virginia A Aparicio, Linda E May,

<h4>Background</h4>Optimal maternal metabolism during pregnancy is essential for healthy fetal growth and development. Chronic exercise is shown to positively affect metabolism, predominantly demonstrated in nonpregnant populations.<h4>Objective</h4>To determine the effects of aerobic exercise on maternal metabolic biomarkers during pregnancy, with expected lower levels of glucose, insulin, and lipids among exercise-trained pregnant ... Read more >>

Birth Defects Res (Birth defects research)
[2021, 113(3):227-237]

Cited: 0 times

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Plasma Lactate as a Marker for Metabolic Health.

Nicholas T Broskey, Kai Zou, G Lynis Dohm, Joseph A Houmard,

Blood lactate concentrations traditionally have been used as an index of exercise intensity or clinical hyperlactatemia. However, more recent data suggest that fasting plasma lactate can also be indicative of the risk for subsequent metabolic disease. The hypothesis presented is that fasting blood lactate accumulation reflects impaired mitochondrial substrate use, ... Read more >>

Exerc Sport Sci Rev (Exercise and sport sciences reviews)
[2020, 48(3):119-124]

Cited: 3 times

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The Panacea of Human Aging: Calorie Restriction Versus Exercise.

Nicholas T Broskey, Kara L Marlatt, Jasper Most, Melissa L Erickson, Brian A Irving, Leanne M Redman,

Primary aging is the progressive decline in health and fitness and depends on metabolic rate and oxidative stress. Untoward changes in body composition and metabolic function characterize secondary aging. We hypothesize that both exercise and calorie restriction (CR) improve secondary aging, but only CR improves primary. However, CR followed with ... Read more >>

Exerc Sport Sci Rev (Exercise and sport sciences reviews)
[2019, 47(3):169-175]

Cited: 2 times

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Hybrid fiber alterations in exercising seniors suggest contribution to fast-to-slow muscle fiber shift.

Maxime Moreillon, Sonia Conde Alonso, Nicholas T Broskey, Chiara Greggio, Cyril Besson, Valentin Rousson, Francesca Amati,

<h4>Background</h4>Human skeletal muscle is composed of a functional and metabolic continuum of slow (Type I) and fast fibers (IIa and IIx). Hybrid fibers co-expressing different myosin heavy chains are also present and seem to be more prominent in aging muscle. Their role is debated; hybrid fibers were reported either in ... Read more >>

J Cachexia Sarcopenia Muscle (Journal of cachexia, sarcopenia and muscle)
[2019, 10(3):687-695]

Cited: 5 times

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Is Energy Balance in Pregnancy Involved in the Etiology of Gestational Diabetes in Women with Obesity?

Jasper Most, Nicholas T Broskey, Abby D Altazan, Robbie A Beyl, Marshall St Amant, Daniel S Hsia, Eric Ravussin, Leanne M Redman,

Cell Metab (Cell metabolism)
[2019, 29(2):231-233]

Cited: 3 times

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Metabolic inflexibility in women with PCOS is similar to women with type 2 diabetes.

Nicholas T Broskey, Charmaine S Tam, Elizabeth F Sutton, Abby D Altazan, Jeffrey H Burton, Eric Ravussin, Leanne M Redman,

<h4>Background</h4>An ability to switch between primarily oxidizing fat in the fasted state to carbohydrate in the fed state, termed metabolic flexibility, is associated with insulin sensitivity. Metabolic flexibility has been explored previously in women with polycystic ovary syndrome (PCOS), yet the independent or synergistic contributions of androgen excess and/or insulin ... Read more >>

Nutr Metab (Lond) (Nutrition & metabolism)
[2018, 15:75]

Cited: 2 times

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Distinct patterns of skeletal muscle mitochondria fusion, fission and mitophagy upon duration of exercise training.

Yoan Arribat, Nicholas T Broskey, Chiara Greggio, Marie Boutant, Sonia Conde Alonso, Sameer S Kulkarni, Sylviane Lagarrigue, Elvis A Carnero, Cyril Besson, Carles Cantó, Francesca Amati,

<h4>Aim</h4>Healthy ageing interventions encompass regular exercise to prevent mitochondrial dysfunction, key player in sarcopenia pathogenesis. Mitochondrial biogenesis has been well documented, but mitochondrial remodelling in response to exercise training is poorly understood. Here we investigated fusion, fission and mitophagy before and after an exercise intervention in older adults.<h4>Methods</h4>Skeletal muscle biopsies ... Read more >>

Acta Physiol (Oxf) (Acta physiologica (Oxford, England))
[2019, 225(2):e13179]

Cited: 13 times

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Skeletal muscle ceramides and daily fat oxidation in obesity and diabetes.

Nicholas T Broskey, Diana N Obanda, Jeffrey H Burton, William T Cefalu, Eric Ravussin,

BACKGROUND/OBJECTIVES:Ectopic accumulation of lipids in skeletal muscle and the formation of deleterious lipid intermediates is thought to contribute to the development of insulin resistance and type 2 diabetes mellitus (T2DM). Similarly, impaired fat oxidation (metabolic inflexibility) are predictors of weight gain and the development of T2DM; however, no study has ... Read more >>

Metabolism (Metabolism: clinical and experimental)
[2018, 82:118-123]

Cited: 8 times

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Early Pregnancy Weight Gain Exerts the Strongest Effect on Birth Weight, Posing a Critical Time to Prevent Childhood Obesity.

Nicholas T Broskey, Peng Wang, Nan Li, Junhong Leng, Weiqin Li, Leishen Wang, L Anne Gilmore, Gang Hu, Leanne M Redman,

<h4>Objective</h4>Gestational weight gain (GWG) is associated with infant birth weight and childhood obesity; however, the patterns of GWG on infant birth weight are poorly understood.<h4>Methods</h4>This analysis in 16,218 mother-child dyads from Tianjin, China, determined the risk of infant size at birth according to GWG occurring throughout the first and second ... Read more >>

Obesity (Silver Spring) (Obesity (Silver Spring, Md.))
[2017, 25(9):1569-1576]

Cited: 14 times

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Assessing Energy Requirements in Women With Polycystic Ovary Syndrome: A Comparison Against Doubly Labeled Water.

Nicholas T Broskey, Monica C Klempel, L Anne Gilmore, Elizabeth F Sutton, Abby D Altazan, Jeffrey H Burton, Eric Ravussin, Leanne M Redman,

<h4>Context</h4>Weight loss is prescribed to offset the deleterious consequences of polycystic ovary syndrome (PCOS), but a successful intervention requires an accurate assessment of energy requirements.<h4>Objective</h4>Describe energy requirements in women with PCOS and evaluate common prediction equations compared with doubly labeled water (DLW).<h4>Design</h4>Cross-sectional study.<h4>Setting</h4>Academic research center.<h4>Participants</h4>Twenty-eight weight-stable women with PCOS completed ... Read more >>

J Clin Endocrinol Metab (The Journal of clinical endocrinology and metabolism)
[2017, 102(6):1951-1959]

Cited: 2 times

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Enhanced Respiratory Chain Supercomplex Formation in Response to Exercise in Human Skeletal Muscle.

Chiara Greggio, Pooja Jha, Sameer S Kulkarni, Sylviane Lagarrigue, Nicholas T Broskey, Marie Boutant, Xu Wang, Sonia Conde Alonso, Emmanuel Ofori, Johan Auwerx, Carles Cantó, Francesca Amati,

Mitochondrial dysfunction is a hallmark of multiple metabolic complications. Physical activity is known to increase mitochondrial content in skeletal muscle, counteracting age-related decline in muscle function and protecting against metabolic and cardiovascular complications. Here, we investigated the effect of 4 months of exercise training on skeletal muscle mitochondria electron transport chain ... Read more >>

Cell Metab (Cell metabolism)
[2017, 25(2):301-311]

Cited: 62 times

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Muscle Characteristics and Substrate Energetics in Lifelong Endurance Athletes.

John J Dubé, Nicholas T Broskey, Alex A Despines, Maja Stefanovic-Racic, Frederico G S Toledo, Bret H Goodpaster, Francesca Amati,

<h4>Purpose</h4>The goal of this study was to explore the effect of lifelong aerobic exercise (i.e., chronic training) on skeletal muscle substrate stores (intramyocellular triglyceride [IMTG] and glycogen), skeletal muscle phenotypes, and oxidative capacity (ox), in older endurance-trained master athletes (OA) compared with noncompetitive recreational younger (YA) athletes matched by frequency ... Read more >>

Med Sci Sports Exerc (Medicine and science in sports and exercise)
[2016, 48(3):472-480]

Cited: 10 times

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Exercise efficiency relates with mitochondrial content and function in older adults.

Nicholas T Broskey, Andreas Boss, Elie-Jacques Fares, Chiara Greggio, Gerald Gremion, Leo Schlüter, Didier Hans, Roland Kreis, Chris Boesch, Francesca Amati,

Chronic aerobic exercise has been shown to increase exercise efficiency, thus allowing less energy expenditure for a similar amount of work. The extent to which skeletal muscle mitochondria play a role in this is not fully understood, particularly in an elderly population. The purpose of this study was to determine ... Read more >>

Physiol Rep (Physiological reports)
[2015, 3(6):]

Cited: 13 times

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Regulation of Body Weight in Humans

Nicholas T Broskey, Darcy Johannsen, Leanne Redman,

Overweight and obesity among adults has dramatically increased in the last 50 years in the United States, although more recently the trend being that of a slight plateau. However, the rise of obesity in children has continued to increase, which is a major health concern for future generations. Body weight ... Read more >>

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Skeletal muscle mitochondria in the elderly: effects of physical fitness and exercise training.

Nicholas T Broskey, Chiara Greggio, Andreas Boss, Marie Boutant, Andrew Dwyer, Leopold Schlueter, Didier Hans, Gerald Gremion, Roland Kreis, Chris Boesch, Carles Canto, Francesca Amati,

<h4>Context</h4>Sarcopenia is thought to be associated with mitochondrial (Mito) loss. It is unclear whether the decrease in Mito content is consequent to aging per se or to decreased physical activity.<h4>Objectives</h4>The objective of the study was to examine the influence of fitness on Mito content and function and to assess whether ... Read more >>

J Clin Endocrinol Metab (The Journal of clinical endocrinology and metabolism)
[2014, 99(5):1852-1861]

Cited: 55 times

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Evidence of systematic and proportional error in a widely used glucose oxidase analyser: impact for clinical research?

Francesca Amati, Nicholas T Broskey, Elvis A Carnero,

Clin Endocrinol (Oxf) (Clinical endocrinology)
[2014, 80(5):768-770]

Cited: 1 time

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Skeletal muscle mitochondrial and lipid droplet content assessed with standardized grid sizes for stereology.

Nicholas T Broskey, Jean Daraspe, Bruno M Humbel, Francesca Amati,

<h4>Unlabelled</h4>Skeletal muscle mitochondrial (Mito) and lipid droplet (Lipid) content are often measured in human translational studies. Stereological point counting allows computing Mito and Lipid volume density (Vd) from micrographs taken with transmission electron microscopes. Former studies are not specific as to the size of individual squares that make up the ... Read more >>

J Appl Physiol (1985) (Journal of applied physiology (Bethesda, Md. : 1985))
[2013, 115(5):765-770]

Cited: 16 times

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