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Differential desensitization, receptor phosphorylation, beta-arrestin recruitment, and ERK1/2 activation by the two endogenous ligands for the CC chemokine receptor 7.

Trudy A Kohout, Shelby L Nicholas, Stephen J Perry, Greg Reinhart, Sachiko Junger, R Scott Struthers,

Many members of the chemokine receptor family of G protein-coupled receptors utilize multiple endogenous ligands. However, differences between the signaling properties of multiple chemokines through a single receptor have yet to be well characterized. In this study we investigated the early signaling events of CCR7 initiated by its two endogenous ... Read more >>

J Biol Chem (The Journal of biological chemistry)
[2004, 279(22):23214-23222]

Cited: 189 times

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