Full Text Journal Articles by
Author Nicholas J Thomas


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Trends in 28-Day Mortality of Critical Care Patients With Coronavirus Disease 2019 in the United Kingdom: A National Cohort Study, March 2020 to January 2021.

John M Dennis, Andrew P McGovern, Nicholas J Thomas, Harrison Wilde, Sebastian J Vollmer, Bilal A Mateen,

<h4>Objectives</h4>To determine whether the previously described trend of improving mortality in people with coronavirus disease 2019 in critical care during the first wave was maintained, plateaued, or reversed during the second wave in United Kingdom, when B117 became the dominant strain.<h4>Design</h4>National retrospective cohort study.<h4>Setting</h4>All English hospital trusts (i.e., groups of ... Read more >>

Crit Care Med (Critical care medicine)
[2021, 49(11):1895-1900]

Cited: 1 time

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Brain Metastases in EGFR- and ALK-Positive NSCLC: Outcomes of Central Nervous System-Penetrant Tyrosine Kinase Inhibitors Alone Versus in Combination With Radiation.

Nicholas J Thomas, Nathaniel J Myall, Fangdi Sun, Tejas Patil, Rao Mushtaq, Chandler Yu, Sumi Sinha, Erqi L Pollom, Seema Nagpal, D Ross Camidge, Chad G Rusthoven, Steve E Braunstein, Heather A Wakelee, Caroline E McCoach,

<h4>Introduction</h4>Management of central nervous system (CNS) metastases in patients with driver-mutated NSCLC has traditionally incorporated both tyrosine kinase inhibitors (TKIs) and intracranial radiation. Whether next generation, CNS-penetrant TKIs can be used alone without upfront radiation, however, remains unknown. This multi-institutional retrospective analysis aimed to compare outcomes in patients with EGFR- ... Read more >>

J Thorac Oncol (Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer)
[2021, :]

Cited: 0 times

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DR15-DQ6 remains dominantly protective against type 1 diabetes throughout the first five decades of life.

Nicholas J Thomas, John M Dennis, Seth A Sharp, Akaal Kaur, Shivani Misra, Helen C Walkey, Desmond G Johnston, Nick S Oliver, William A Hagopian, Michael N Weedon, Kashyap A Patel, Richard A Oram,

<h4>Aims/hypothesis</h4>Among white European children developing type 1 diabetes, the otherwise common HLA haplotype DR15-DQ6 is rare, and highly protective. Adult-onset type 1 diabetes is now known to represent more overall cases than childhood onset, but it is not known whether DR15-DQ6 is protective in older-adult-onset type 1 diabetes. We sought ... Read more >>

Diabetologia (Diabetologia)
[2021, 64(10):2258-2265]

Cited: 0 times

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Stories from COVID-19 Reveal Hospitalized Patients with Limited English Proficiency Have Always Been Uniquely Prone to Social Isolation.

Natalie K Kucirek, Nicholas J Thomas, Joshua S Norman, Priyanka Athavale, Katrin Jaradeh, Esther Y Hsiang, Lev Malevanchik,

Through experiences with hospital visitor restrictions during the COVID-19 pandemic, a group of frontline trainees at the University of California San Francisco (UCSF) uncovered patient stories highlighting the unique challenges that patients with limited English proficiency (LEP) face in the hospital, particularly their vulnerability to social isolation. Here, we recount ... Read more >>

J Gen Intern Med (Journal of general internal medicine)
[2021, 36(3):786-789]

Cited: 0 times

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Long-term Follow-up of Glycemic and Neurological Outcomes in an International Series of Patients With Sulfonylurea-Treated ABCC8 Permanent Neonatal Diabetes.

Pamela Bowman, Frances Mathews, Fabrizio Barbetti, Maggie H Shepherd, Janine Sanchez, Barbara Piccini, Jacques Beltrand, Lisa R Letourneau-Freiberg, Michel Polak, Siri Atma W Greeley, Eamon Rawlins, Tarig Babiker, Nicholas J Thomas, Elisa De Franco, Sian Ellard, Sarah E Flanagan, Andrew T Hattersley, ,

<h4>Objective</h4><i>ABCC8</i> mutations cause neonatal diabetes mellitus that can be transient (TNDM) or, less commonly, permanent (PNDM); ∼90% of individuals can be treated with oral sulfonylureas instead of insulin. Previous studies suggested that people with <i>ABCC8-</i>PNDM require lower sulfonylurea doses and have milder neurological features than those with <i>KCNJ11-</i>PNDM. However, these ... Read more >>

Diabetes Care (Diabetes care)
[2021, 44(1):35-42]

Cited: 1 time

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Type 2 Diabetes and COVID-19-Related Mortality in the Critical Care Setting: A National Cohort Study in England, March-July 2020.

John M Dennis, Bilal A Mateen, Raphael Sonabend, Raphael Sonabend, Nicholas J Thomas, Kashyap A Patel, Andrew T Hattersley, Spiros Denaxas, Spiros Denaxas, Andrew P McGovern, Sebastian J Vollmer,

<h4>Objective</h4>To describe the relationship between type 2 diabetes and all-cause mortality among adults with coronavirus disease 2019 (COVID-19) in the critical care setting.<h4>Research design and methods</h4>This was a nationwide retrospective cohort study in people admitted to hospital in England with COVID-19 requiring admission to a high dependency unit (HDU) or ... Read more >>

Diabetes Care (Diabetes care)
[2021, 44(1):50-57]

Cited: 25 times

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Therapy-Induced Evolution of Human Lung Cancer Revealed by Single-Cell RNA Sequencing.

Ashley Maynard, Caroline E McCoach, Julia K Rotow, Lincoln Harris, Franziska Haderk, D Lucas Kerr, Elizabeth A Yu, Erin L Schenk, Weilun Tan, Alexander Zee, Michelle Tan, Philippe Gui, Tasha Lea, Wei Wu, Anatoly Urisman, Kirk Jones, Rene Sit, Pallav K Kolli, Eric Seeley, Yaron Gesthalter, Daniel D Le, Kevin A Yamauchi, David M Naeger, Sourav Bandyopadhyay, Khyati Shah, Lauren Cech, Nicholas J Thomas, Anshal Gupta, Mayra Gonzalez, Hien Do, Lisa Tan, Bianca Bacaltos, Rafael Gomez-Sjoberg, Matthew Gubens, Thierry Jahan, Johannes R Kratz, David Jablons, Norma Neff, Robert C Doebele, Jonathan Weissman, Collin M Blakely, Spyros Darmanis, Trever G Bivona,

Lung cancer, the leading cause of cancer mortality, exhibits heterogeneity that enables adaptability, limits therapeutic success, and remains incompletely understood. Single-cell RNA sequencing (scRNA-seq) of metastatic lung cancer was performed using 49 clinical biopsies obtained from 30 patients before and during targeted therapy. Over 20,000 cancer and tumor microenvironment (TME) ... Read more >>

Cell (Cell)
[2020, 182(5):1232-1251.e22]

Cited: 36 times

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IgA Nephropathy Genetic Risk Score to Estimate the Prevalence of IgA Nephropathy in UK Biobank.

Kittiya Sukcharoen, Seth A Sharp, Nicholas J Thomas, Robert A Kimmitt, Jamie Harrison, Coralie Bingham, Monika Mozere, Michael N Weedon, Jessica Tyrrell, Jonathan Barratt, Daniel P Gale, Richard A Oram,

<h4>Background</h4>IgA nephropathy (IgAN) is the commonest glomerulonephritis worldwide. Its prevalence is difficult to estimate, as people with mild disease do not commonly receive a biopsy diagnosis. We aimed to generate an IgA nephropathy genetic risk score (IgAN-GRS) and estimate the proportion of people with hematuria who had IgAN in the ... Read more >>

Kidney Int Rep (Kidney international reports)
[2020, 5(10):1643-1650]

Cited: 3 times

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Type 1 diabetes defined by severe insulin deficiency occurs after 30 years of age and is commonly treated as type 2 diabetes.

Nicholas J Thomas, Anita L Lynam, Anita V Hill, Michael N Weedon, Beverley M Shields, Richard A Oram, Timothy J McDonald, Andrew T Hattersley, Angus G Jones,

<h4>Aims/hypothesis</h4>Late-onset type 1 diabetes can be difficult to identify. Measurement of endogenous insulin secretion using C-peptide provides a gold standard classification of diabetes type in longstanding diabetes that closely relates to treatment requirements. We aimed to determine the prevalence and characteristics of type 1 diabetes defined by severe endogenous insulin ... Read more >>

Diabetologia (Diabetologia)
[2019, 62(7):1167-1172]

Cited: 19 times

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Effectiveness and safety of long-term treatment with sulfonylureas in patients with neonatal diabetes due to KCNJ11 mutations: an international cohort study.

Pamela Bowman, Åsta Sulen, Fabrizio Barbetti, Jacques Beltrand, Pernille Svalastoga, Ethel Codner, Ellen H Tessmann, Petur B Juliusson, Torild Skrivarhaug, Ewan R Pearson, Sarah E Flanagan, Tarig Babiker, Nicholas J Thomas, Maggie H Shepherd, Sian Ellard, Iwar Klimes, Magdalena Szopa, Michel Polak, Dario Iafusco, Andrew T Hattersley, Pål R Njølstad, ,

BACKGROUND:KCNJ11 mutations cause permanent neonatal diabetes through pancreatic ATP-sensitive potassium channel activation. 90% of patients successfully transfer from insulin to oral sulfonylureas with excellent initial glycaemic control; however, whether this control is maintained in the long term is unclear. Sulfonylurea failure is seen in about 44% of people with type ... Read more >>

Lancet Diabetes Endocrinol (The lancet. Diabetes & endocrinology)
[2018, 6(8):637-646]

Cited: 37 times

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A Meta-analysis of the Association Between Needle Exchange Programs and HIV Seroconversion Among Injection Drug Users.

Mohammed U Mir, Faisal Akhtar, Mengxi Zhang, Nicholas J Thomas, Hui Shao,

We assessed the association between different levels of needle exchange program (NEP) use and human immunodeficiency virus (HIV) seroconversion in the injecting drug user (IDU) population using meta-analysis to aggregate risk estimates from any reported cohort studies or randomized controlled trials (RCTs) in the literature. We searched the literature for ... Read more >>

Cureus (Cureus)
[2018, 10(9):e3328]

Cited: 1 time

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Genetic risk scores in adult-onset type 1 diabetes - Authors' reply.

Nicholas J Thomas, Samuel E Jones, Michael N Weedon, Beverley M Shields, Andrew T Hattersley, Richard A Oram,

Lancet Diabetes Endocrinol (The lancet. Diabetes & endocrinology)
[2018, 6(3):169]

Cited: 0 times

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Frequency and phenotype of type 1 diabetes in the first six decades of life: a cross-sectional, genetically stratified survival analysis from UK Biobank.

Nicholas J Thomas, Samuel E Jones, Michael N Weedon, Beverley M Shields, Richard A Oram, Andrew T Hattersley,

BACKGROUND:Type 1 diabetes is typically considered a disease of children and young adults. Genetic susceptibility to young-onset type 1 diabetes is well defined and does not predispose to type 2 diabetes. It is not known how frequently genetic susceptibility to type 1 diabetes leads to a diagnosis of diabetes after ... Read more >>

Lancet Diabetes Endocrinol (The lancet. Diabetes & endocrinology)
[2018, 6(2):122-129]

Cited: 96 times

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Women's Work, Gender Roles, and Intimate Partner Violence in Nigeria.

Anastasia J Gage, Nicholas J Thomas,

The purpose of this study was to determine the contribution of women's labor force participation to the risk of intimate partner violence (IPV) victimization in the past 12 months, using data for 20,635 currently married women aged 15-49 years from the 2013 nationally representative Nigeria Demographic and Health Survey. Multilevel logistic regression ... Read more >>

Arch Sex Behav (Archives of sexual behavior)
[2017, 46(7):1923-1938]

Cited: 7 times

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Does Adjunctive Botulinum Toxin A Reduce Pain Scores When Combined With Temporomandibular Joint Arthroscopy for the Treatment of Concomitant Temporomandibular Joint Arthralgia and Myofascial Pain?

Nicholas J Thomas, Sharon Aronovich,

<h4>Purpose</h4>Currently, there is no standard of care for the treatment of refractory myofascial pain and concomitant temporomandibular joint (TMJ) arthralgia. This comparative study was conducted to determine the effectiveness of botulinum toxin A (Btx), as an adjunct to TMJ arthroscopy, in this patient population.<h4>Materials and methods</h4>A retrospective cohort study was ... Read more >>

J Oral Maxillofac Surg (Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons)
[2017, 75(12):2521-2528]

Cited: 2 times

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Tumor vessel normalization after aerobic exercise enhances chemotherapeutic efficacy.

Keri L Schadler, Nicholas J Thomas, Peter A Galie, Dong Ha Bhang, Kerry C Roby, Prince Addai, Jacob E Till, Kathleen Sturgeon, Alexander Zaslavsky, Christopher S Chen, Sandra Ryeom,

Targeted therapies aimed at tumor vasculature are utilized in combination with chemotherapy to improve drug delivery and efficacy after tumor vascular normalization. Tumor vessels are highly disorganized with disrupted blood flow impeding drug delivery to cancer cells. Although pharmacologic anti-angiogenic therapy can remodel and normalize tumor vessels, there is a ... Read more >>

Oncotarget (Oncotarget)
[2016, 7(40):65429-65440]

Cited: 41 times

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Mapping and Analyzing Stakeholders in China's Essential Drug System by Using a Circular Model: Who We Should Deal with Next?

Hui Shao, Shixue Li, Lingzhong Xu, Shuang Yang, Nicholas J Thomas, Mohammed Umer Mir, Zhen Guo, Bo Ning, Lizheng Shi,

<h4>Objectives</h4>To predict the prospects of the essential drug system by using the Stakeholder Impact Index (SII) and evaluate the current performance of each main stakeholder and suggested dangerous stakeholders and dormant stakeholders.<h4>Methods</h4>A Delphi method was used, involving 36 experts with experience in implementation and evaluation of the essential drug policy, ... Read more >>

Value Health Reg Issues (Value in health regional issues)
[2015, 6:111-117]

Cited: 0 times

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Vascular endothelial growth factor a inhibition in gastric cancer.

Do Joong Park, Nicholas J Thomas, Changhwan Yoon, Sam S Yoon,

Angiogenesis is a vital process in the progression and metastasis of solids tumors including gastric adenocarcinoma. Tumors induce angiogenesis by secreting proangiogenic molecules such as vascular endothelial growth factor A (VEGF-A), and VEGF-A inhibition has become a common therapeutic strategy for many cancers. Several drugs targeting the VEGF-A pathway have ... Read more >>

Gastric Cancer (Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association)
[2015, 18(1):33-42]

Cited: 33 times

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Concomitant low-dose doxorubicin treatment and exercise.

Kathleen Sturgeon, Keri Schadler, Geetha Muthukumaran, Dennis Ding, Akinyemi Bajulaiye, Nicholas J Thomas, Victor Ferrari, Sandra Ryeom, Joseph R Libonati,

Cardiotoxicity is a side effect for cancer patients treated with doxorubicin (DOX). We tested the hypothesis that low-intensity aerobic exercise concomitant with DOX treatment would offset DOX-induced cardiotoxicity while also improving the therapeutic efficacy of DOX on tumor progression. B16F10 melanoma cells (3 × 10(5)) were injected subcutaneously into the ... Read more >>

Am J Physiol Regul Integr Comp Physiol (American journal of physiology. Regulatory, integrative and comparative physiology)
[2014, 307(6):R685-92]

Cited: 21 times

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CD44 expression denotes a subpopulation of gastric cancer cells in which Hedgehog signaling promotes chemotherapy resistance.

Changhwan Yoon, Do Joong Park, Benjamin Schmidt, Nicholas J Thomas, Hae-June Lee, Teresa S Kim, Yelena Y Janjigian, Deirdre J Cohen, Sam S Yoon,

<h4>Purpose</h4>Gastric cancers may harbor a subset of cells with cancer stem cell (CSC) properties, including chemotherapy resistance, and CD44 is a gastric CSC marker. The Hedgehog (HH) pathway is a key developmental pathway that can be subverted by CSCs during tumorigenesis. Here, we examine the role of HH signaling in ... Read more >>

Clin Cancer Res (Clinical cancer research : an official journal of the American Association for Cancer Research)
[2014, 20(15):3974-3988]

Cited: 92 times

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The impact of gender on urine C-peptide creatinine ratio interpretation.

Nicholas J Thomas, Beverley M Shields, Rachel E J Besser, Angus G Jones, Andrew Rawlingson, Emily Goodchild, Christopher Leighton, Pamela Bowman, Maggie Shepherd, Bridget A Knight, Timothy J McDonald, Andrew T Hattersley,

<h4>Background</h4>Urinary C-peptide creatinine ratio (UCPCR) is a non-invasive and convenient way of assessing endogenous insulin production. Adjusting for urine creatinine levels allows for differences in urine concentration. Creatinine excretion is known to be higher in men due to gender differences in muscle mass. We investigated the impact of gender on ... Read more >>

Ann Clin Biochem (Annals of clinical biochemistry)
[2012, 49(Pt 4):363-368]

Cited: 9 times

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IGF-I abuse in sport.

Nishan Guha, Alexander Dashwood, Nicholas J Thomas, Alexander J Skingle, Peter H Sönksen, Richard I G Holt,

It is widely believed that growth hormone (GH) is abused by athletes for its anabolic and lipolytic effects. Many of the physiological effects of GH are mediated by the production of insulin-like growth factor-I (IGF-I). Both GH and IGF-I appear on the World Anti-Doping Agency list of prohibited substances. Little ... Read more >>

Curr Drug Abuse Rev (Current drug abuse reviews)
[2009, 2(3):263-272]

Cited: 11 times

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