Full Text Journal Articles by
Author Nicholas J Thomas

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WEE1 kinase is a therapeutic vulnerability in CIC-DUX4 undifferentiated sarcoma.

Rovingaile Kriska M Ponce, Nicholas J Thomas, Nam Q Bui, Tadashi Kondo, Ross A Okimoto,

CIC-DUX4 rearrangements define an aggressive and chemotherapy-insensitive subset of undifferentiated sarcomas. The CIC-DUX4 fusion drives oncogenesis through direct transcriptional upregulation of cell cycle and DNA replication genes. Notably, CIC-DUX4-mediated CCNE1 upregulation compromises the G1/S transition to confer a dependence on the G2/M cell cycle checkpoint. Through an integrative transcriptional and ... Read more >>

JCI Insight (JCI insight)
[2022, 7(6):e152293]

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A striking dichotomy.

Nicholas J Thomas, Sharmin Shekarchian, Meredith A Bock, Brandon B Holmes, Rabih M Geha, Maulik P Shah,

J Hosp Med (Journal of hospital medicine)
[2022, 17(6):485-488]

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