Full Text Journal Articles by
Author Nicholas J Thomas


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Type 1 diabetes defined by severe insulin deficiency occurs after 30 years of age and is commonly treated as type 2 diabetes.

Nicholas J Thomas, Anita L Lynam, Anita V Hill, Michael N Weedon, Beverley M Shields, Richard A Oram, Timothy J McDonald, Andrew T Hattersley, Angus G Jones,

AIMS/HYPOTHESIS:Late-onset type 1 diabetes can be difficult to identify. Measurement of endogenous insulin secretion using C-peptide provides a gold standard classification of diabetes type in longstanding diabetes that closely relates to treatment requirements. We aimed to determine the prevalence and characteristics of type 1 diabetes defined by severe endogenous insulin ... Read more >>

Diabetologia (Diabetologia)
[2019, 62(7):1167-1172]

Cited: 1 time

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A Meta-analysis of the Association Between Needle Exchange Programs and HIV Seroconversion Among Injection Drug Users.

Mohammed U Mir, Faisal Akhtar, Mengxi Zhang, Nicholas J Thomas, Hui Shao,

We assessed the association between different levels of needle exchange program (NEP) use and human immunodeficiency virus (HIV) seroconversion in the injecting drug user (IDU) population using meta-analysis to aggregate risk estimates from any reported cohort studies or randomized controlled trials (RCTs) in the literature. We searched the literature for ... Read more >>

Cureus (Cureus)
[2018, 10(9):e3328]

Cited: 0 times

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Genetic risk scores in adult-onset type 1 diabetes - Authors' reply.

Nicholas J Thomas, Samuel E Jones, Michael N Weedon, Beverley M Shields, Andrew T Hattersley, Richard A Oram,

Lancet Diabetes Endocrinol (The lancet. Diabetes & endocrinology)
[2018, 6(3):169]

Cited: 0 times

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Effectiveness and safety of long-term treatment with sulfonylureas in patients with neonatal diabetes due to KCNJ11 mutations: an international cohort study.

Pamela Bowman, Åsta Sulen, Fabrizio Barbetti, Jacques Beltrand, Pernille Svalastoga, Ethel Codner, Ellen H Tessmann, Petur B Juliusson, Torild Skrivarhaug, Ewan R Pearson, Sarah E Flanagan, Tarig Babiker, Nicholas J Thomas, Maggie H Shepherd, Sian Ellard, Iwar Klimes, Magdalena Szopa, Michel Polak, Dario Iafusco, Andrew T Hattersley, Pål R Njølstad, ,

BACKGROUND:KCNJ11 mutations cause permanent neonatal diabetes through pancreatic ATP-sensitive potassium channel activation. 90% of patients successfully transfer from insulin to oral sulfonylureas with excellent initial glycaemic control; however, whether this control is maintained in the long term is unclear. Sulfonylurea failure is seen in about 44% of people with type ... Read more >>

Lancet Diabetes Endocrinol (The lancet. Diabetes & endocrinology)
[2018, 6(8):637-646]

Cited: 8 times

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Frequency and phenotype of type 1 diabetes in the first six decades of life: a cross-sectional, genetically stratified survival analysis from UK Biobank.

Nicholas J Thomas, Samuel E Jones, Michael N Weedon, Beverley M Shields, Richard A Oram, Andrew T Hattersley,

BACKGROUND:Type 1 diabetes is typically considered a disease of children and young adults. Genetic susceptibility to young-onset type 1 diabetes is well defined and does not predispose to type 2 diabetes. It is not known how frequently genetic susceptibility to type 1 diabetes leads to a diagnosis of diabetes after ... Read more >>

Lancet Diabetes Endocrinol (The lancet. Diabetes & endocrinology)
[2018, 6(2):122-129]

Cited: 35 times

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Women's Work, Gender Roles, and Intimate Partner Violence in Nigeria.

Anastasia J Gage, Nicholas J Thomas,

The purpose of this study was to determine the contribution of women's labor force participation to the risk of intimate partner violence (IPV) victimization in the past 12 months, using data for 20,635 currently married women aged 15-49 years from the 2013 nationally representative Nigeria Demographic and Health Survey. Multilevel logistic regression ... Read more >>

Arch Sex Behav (Archives of sexual behavior)
[2017, 46(7):1923-1938]

Cited: 4 times

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Does Adjunctive Botulinum Toxin A Reduce Pain Scores When Combined With Temporomandibular Joint Arthroscopy for the Treatment of Concomitant Temporomandibular Joint Arthralgia and Myofascial Pain?

Nicholas J Thomas, Sharon Aronovich,

Currently, there is no standard of care for the treatment of refractory myofascial pain and concomitant temporomandibular joint (TMJ) arthralgia. This comparative study was conducted to determine the effectiveness of botulinum toxin A (Btx), as an adjunct to TMJ arthroscopy, in this patient population.A retrospective cohort study was conducted of ... Read more >>

J. Oral Maxillofac. Surg. (Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons)
[2017, 75(12):2521-2528]

Cited: 1 time

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Tumor vessel normalization after aerobic exercise enhances chemotherapeutic efficacy.

Keri L Schadler, Nicholas J Thomas, Peter A Galie, Dong Ha Bhang, Kerry C Roby, Prince Addai, Jacob E Till, Kathleen Sturgeon, Alexander Zaslavsky, Christopher S Chen, Sandra Ryeom,

Targeted therapies aimed at tumor vasculature are utilized in combination with chemotherapy to improve drug delivery and efficacy after tumor vascular normalization. Tumor vessels are highly disorganized with disrupted blood flow impeding drug delivery to cancer cells. Although pharmacologic anti-angiogenic therapy can remodel and normalize tumor vessels, there is a ... Read more >>

Oncotarget (Oncotarget)
[2016, 7(40):65429-65440]

Cited: 16 times

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Mapping and Analyzing Stakeholders in China's Essential Drug System by Using a Circular Model: Who We Should Deal with Next?

Hui Shao, Shixue Li, Lingzhong Xu, Shuang Yang, Nicholas J Thomas, Mohammed Umer Mir, Zhen Guo, Bo Ning, Lizheng Shi,

To predict the prospects of the essential drug system by using the Stakeholder Impact Index (SII) and evaluate the current performance of each main stakeholder and suggested dangerous stakeholders and dormant stakeholders.A Delphi method was used, involving 36 experts with experience in implementation and evaluation of the essential drug policy, ... Read more >>

Value Health Reg Issues (Value in health regional issues)
[2015, 6:111-117]

Cited: 0 times

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Vascular endothelial growth factor a inhibition in gastric cancer.

Do Joong Park, Nicholas J Thomas, Changhwan Yoon, Sam S Yoon,

Angiogenesis is a vital process in the progression and metastasis of solids tumors including gastric adenocarcinoma. Tumors induce angiogenesis by secreting proangiogenic molecules such as vascular endothelial growth factor A (VEGF-A), and VEGF-A inhibition has become a common therapeutic strategy for many cancers. Several drugs targeting the VEGF-A pathway have ... Read more >>

Gastric Cancer (Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association)
[2015, 18(1):33-42]

Cited: 28 times

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Concomitant low-dose doxorubicin treatment and exercise.

Kathleen Sturgeon, Keri Schadler, Geetha Muthukumaran, Dennis Ding, Akinyemi Bajulaiye, Nicholas J Thomas, Victor Ferrari, Sandra Ryeom, Joseph R Libonati,

Cardiotoxicity is a side effect for cancer patients treated with doxorubicin (DOX). We tested the hypothesis that low-intensity aerobic exercise concomitant with DOX treatment would offset DOX-induced cardiotoxicity while also improving the therapeutic efficacy of DOX on tumor progression. B16F10 melanoma cells (3 × 10(5)) were injected subcutaneously into the ... Read more >>

Am. J. Physiol. Regul. Integr. Comp. Physiol. (American journal of physiology. Regulatory, integrative and comparative physiology)
[2014, 307(6):R685-92]

Cited: 14 times

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CD44 expression denotes a subpopulation of gastric cancer cells in which Hedgehog signaling promotes chemotherapy resistance.

Changhwan Yoon, Do Joong Park, Benjamin Schmidt, Nicholas J Thomas, Hae-June Lee, Teresa S Kim, Yelena Y Janjigian, Deirdre J Cohen, Sam S Yoon,

Gastric cancers may harbor a subset of cells with cancer stem cell (CSC) properties, including chemotherapy resistance, and CD44 is a gastric CSC marker. The Hedgehog (HH) pathway is a key developmental pathway that can be subverted by CSCs during tumorigenesis. Here, we examine the role of HH signaling in ... Read more >>

Clin. Cancer Res. (Clinical cancer research : an official journal of the American Association for Cancer Research)
[2014, 20(15):3974-3988]

Cited: 68 times

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The impact of gender on urine C-peptide creatinine ratio interpretation.

Nicholas J Thomas, Beverley M Shields, Rachel E J Besser, Angus G Jones, Andrew Rawlingson, Emily Goodchild, Christopher Leighton, Pamela Bowman, Maggie Shepherd, Bridget A Knight, Timothy J McDonald, Andrew T Hattersley,

Urinary C-peptide creatinine ratio (UCPCR) is a non-invasive and convenient way of assessing endogenous insulin production. Adjusting for urine creatinine levels allows for differences in urine concentration. Creatinine excretion is known to be higher in men due to gender differences in muscle mass. We investigated the impact of gender on ... Read more >>

Ann. Clin. Biochem. (Annals of clinical biochemistry)
[2012, 49(Pt 4):363-368]

Cited: 8 times

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IGF-I abuse in sport.

Nishan Guha, Alexander Dashwood, Nicholas J Thomas, Alexander J Skingle, Peter H Sönksen, Richard I G Holt,

It is widely believed that growth hormone (GH) is abused by athletes for its anabolic and lipolytic effects. Many of the physiological effects of GH are mediated by the production of insulin-like growth factor-I (IGF-I). Both GH and IGF-I appear on the World Anti-Doping Agency list of prohibited substances. Little ... Read more >>

Curr Drug Abuse Rev (Current drug abuse reviews)
[2009, 2(3):263-272]

Cited: 9 times

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