Full Text Journal Articles by
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Prostate-specific membrane antigen expression in melanoma metastases.

Hayden Snow, Stephen Hazell, Nicholas Francis, Kabir Mohammed, Stephanie O'Neill, Emma Davies, David Mansfield, Christina Messiou, Nabil Hujairi, David Nicol, Kevin Harrington, Myles Smith,

BACKGROUND:Prostate-specific membrane antigen (PSMA) is a prostatic epithelial protein that is used as a radiotracer (68Ga-PSMA-11) for prostate cancer staging. PSMA-PET/CT (positron emission tomography/computed tomography) performed for prostate cancer has been observed to detect melanoma metastases. The aim of this study was to investigate the performance of PSMA immunohistochemistry on ... Read more >>

J. Cutan. Pathol. (Journal of cutaneous pathology)
[2020, :]

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Chemical Synthesis of Shiga Toxin Subunit B Using a Next-Generation Traceless “Helping Hand” Solubilizing Tag

James Fulcher, Mark Petersen, riley giesler, Zachary Cruz, debra eckert, Nicholas Francis, eric kawamoto, Michael Jacobsen, Michael Kay,

This manuscript describes the development and characterization of a second-generation "helping hand" solubilizing tag. This semipermanent tag aids solubility of peptides during purification and handling steps and is compatible with common native chemical ligation conditions. The utility of this tag is demonstrated by the synthesis of the Shiga toxin B ... Read more >>

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Characterization of resistance to a potent D-peptide HIV entry inhibitor

Amanda Smith, Matthew Weinstock, Amanda Siglin, Frank Whitby, Nicholas Francis, Christopher Hill, Debra Eckert, Michael Root, Michael Kay,

Abstract Background PIE12-trimer is a highly potent D-peptide HIV-1 entry inhibitor that broadly targets group M isolates. It specifically binds the three identical conserved hydrophobic pockets at the base of the gp41 N-trimer with sub-femtomolar affinity. This extremely high affinity for the transiently exposed gp41 trimer provides a reserve of ... Read more >>

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Priority Needs for Conducting Pandemic-relevant Clinical Research With Children in Europe: A Consensus Study With Pediatric Clinician-researchers.

Micaela Gal, Nina Gobat, Nicholas A Francis, Kerenza Hood, Christopher C Butler, Julia Bielicki, Pieter L Fraaij, Mike Sharland, Jessica Jarvis, Annemarie M C van Rossum, Terho Heikkinen, Federico Martinon-Torres, Jethro Herberg, Angela Watkins, Steve A R Webb, Ronnie Moore, Prasanth Sukumar, Alistair Nichol,

BACKGROUND:Infectious disease (ID) pandemics pose a considerable global threat and can disproportionately affect vulnerable populations including children. Pediatric clinical research in pandemics is essential to improve children's healthcare and minimize risks of harm by interventions that lack an adequate evidence base for this population. The unique features of ID pandemics ... Read more >>

Pediatr. Infect. Dis. J. (The Pediatric infectious disease journal)
[2019, 38(5):e82-e86]

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Cancelled operations: a 7-day cohort study of planned adult inpatient surgery in 245 UK National Health Service hospitals.

D J N Wong, S K Harris, S R Moonesinghe, , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , ,

BACKGROUND:Cancellation of planned surgery impacts substantially on patients and health systems. This study describes the incidence and reasons for cancellation of inpatient surgery in the UK NHS. METHODS:We conducted a prospective observational cohort study over 7 consecutive days in March 2017 in 245 NHS hospitals. Occurrences and reasons for previous ... Read more >>

Br J Anaesth (British journal of anaesthesia)
[2018, 121(4):730-738]

Cited: 5 times

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A mysterious postoperative rash.

Maria Chicco, George Filobbos, Nicholas Francis, Paul Ziprin,

This case report describes the development of a rash in a patient admitted with large bowel obstruction secondary to carcinoma of the sigmoid colon. The patient underwent a Hartmann's procedure and right hemicolectomy for a metastatic deposit at the terminal ileum. On postoperative day 3, the patient developed a bullous ... Read more >>

BMJ Case Rep (BMJ case reports)
[2018, 2018:]

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Matching diagnostics development to clinical need: Target product profile development for a point of care test for community-acquired lower respiratory tract infection.

Micaela Gal, Nicholas A Francis, Kerenza Hood, Jorge Villacian, Herman Goossens, Angela Watkins, Christopher C Butler, ,

BACKGROUND:Point of care tests (POCTs) are increasingly being promoted for guiding the primary medical care of community acquired lower respiratory tract infections (CA-LRTI). POCT development has seldom been guided by explicitly identified clinical need and requirements of the intended users. Approaches for identifying POCT priorities and developing target product profiles ... Read more >>

PLoS ONE (PloS one)
[2018, 13(8):e0200531]

Cited: 2 times

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Fc Effector Function Contributes to the Activity of Human Anti-CTLA-4 Antibodies.

Frederick Arce Vargas, Andrew J S Furness, Kevin Litchfield, Kroopa Joshi, Rachel Rosenthal, Ehsan Ghorani, Isabelle Solomon, Marta H Lesko, Nora Ruef, Claire Roddie, Jake Y Henry, Lavinia Spain, Assma Ben Aissa, Andrew Georgiou, Yien Ning Sophia Wong, Myles Smith, Dirk Strauss, Andrew Hayes, David Nicol, Tim O'Brien, Linda Mårtensson, Anne Ljungars, Ingrid Teige, Björn Frendéus, , , , Martin Pule, Teresa Marafioti, Martin Gore, James Larkin, Samra Turajlic, Charles Swanton, Karl S Peggs, Sergio A Quezada,

With the use of a mouse model expressing human Fc-gamma receptors (FcγRs), we demonstrated that antibodies with isotypes equivalent to ipilimumab and tremelimumab mediate intra-tumoral regulatory T (Treg) cell depletion in vivo, increasing the CD8+ to Treg cell ratio and promoting tumor rejection. Antibodies with improved FcγR binding profiles drove superior anti-tumor ... Read more >>

Cancer Cell (Cancer cell)
[2018, 33(4):649-663.e4]

Cited: 72 times

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An Erythematous Papular Rash on the Left Flank of a 31-year-old Woman: A Quiz.

Emily Rudd, Nicholas Francis, Luke Moore, Louise Fearfield,

Acta Derm. Venereol. (Acta dermato-venereologica)
[2018, 98(4):477-478]

Cited: 0 times

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Talking to the people that really matter about their participation in pandemic clinical research: A qualitative study in four European countries.

Nina H Gobat, Micaela Gal, Christopher C Butler, Steve A R Webb, Nicholas A Francis, Helen Stanton, Sibyl Anthierens, Hilde Bastiaens, Maciek Godycki-Ćwirko, Anna Kowalczyk, Mariona Pons-Vigués, Enriqueta Pujol-Ribera, Anna Berenguera, Angela Watkins, Prasanth Sukumar, Ronald G Moore, Kerenza Hood, Alistair Nichol,

BACKGROUND:Pandemics of new and emerging infectious diseases are unpredictable, recurrent events that rapidly threaten global health and security. We aimed to identify public views regarding provision of information and consent to participate in primary and critical care clinical research during a future influenza-like illness pandemic. METHODS:Descriptive-interpretive qualitative study, using focus ... Read more >>

Health Expect (Health expectations : an international journal of public participation in health care and health policy)
[2018, 21(1):387-395]

Cited: 3 times

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Immunosuppression-associated Kaposi sarcoma following stem cell transplantation.

Andrew J Innes, Matthew Lee, Nicholas Francis, Eduardo Olavarria,

Br. J. Haematol. (British journal of haematology)
[2017, 178(1):9]

Cited: 1 time

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A case of acquired reactive perforating collagenosis.

Jeremy Reid, Lorna Almond, Naomi Matthewman, Howard Stringer, Nicholas Francis, Mohammed Al Abadie,

Australas. J. Dermatol. (The Australasian journal of dermatology)
[2018, 59(1):e75-e76]

Cited: 0 times

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Fc-Optimized Anti-CD25 Depletes Tumor-Infiltrating Regulatory T Cells and Synergizes with PD-1 Blockade to Eradicate Established Tumors.

Frederick Arce Vargas, Andrew J S Furness, Isabelle Solomon, Kroopa Joshi, Leila Mekkaoui, Marta H Lesko, Enrique Miranda Rota, Rony Dahan, Andrew Georgiou, Anna Sledzinska, Assma Ben Aissa, Dafne Franz, Mariana Werner Sunderland, Yien Ning Sophia Wong, Jake Y Henry, Tim O'Brien, David Nicol, Ben Challacombe, Stephen A Beers, , , , Samra Turajlic, Martin Gore, James Larkin, Charles Swanton, Kerry A Chester, Martin Pule, Jeffrey V Ravetch, Teresa Marafioti, Karl S Peggs, Sergio A Quezada,

CD25 is expressed at high levels on regulatory T (Treg) cells and was initially proposed as a target for cancer immunotherapy. However, anti-CD25 antibodies have displayed limited activity against established tumors. We demonstrated that CD25 expression is largely restricted to tumor-infiltrating Treg cells in mice and humans. While existing anti-CD25 antibodies ... Read more >>

Immunity (Immunity)
[2017, 46(4):577-586]

Cited: 69 times

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Local chemokine profiling in eosinophilic esophagitis: The synthetic absorptive matrix test.

Eleanor Minshall, Harsita Patel, Nicholas Francis, Trevor T Hansel, John O Warner, Robert J Boyle, John Fell, Jenny Epstein,

Pediatr Allergy Immunol (Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology)
[2017, 28(1):100-102]

Cited: 0 times

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Rare Skin Adnexal and Melanocytic Tumors Arising in Ovarian Mature Cystic Teratomas: A Report of 3 Cases and Review of the Literature.

Alexandra A Moulla, Nesreen Magdy, Nicholas Francis, Janis Taube, Brigitte M Ronnett, Mona El-Bahrawy,

Mature teratoma of the ovary is the most common primary ovarian tumor accounting for 15% (10%-20%) of all ovarian neoplasms. Skin and skin adnexal structures are the most common elements identified in mature teratomas. Benign and malignant skin tumors can arise in ovarian teratomas, the most common being epithelial tumors. ... Read more >>

Int. J. Gynecol. Pathol. (International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists)
[2016, 35(5):448-455]

Cited: 0 times

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Subcutaneous Phaeohyphomycosis Cyst Associated with Medicopsis romeroi in an Immunocompromised Host.

Alireza Abdolrasouli, Ximena Gonzalo, Anita Jatan, Gordon J McArthur, Nicholas Francis, Berge S Azadian, Andrew M Borman, Elizabeth M Johnson,

An 88-year-old man, receiving prednisolone for sarcoidosis, presented with a discrete keratotic lesion on the dorsum of his right hand following the placement of an intravenous cannula a month prior to its appearance. Medicopsis romeroi was isolated from the tissue and identified by sequencing the internal transcribed spacer region ITS-1 ... Read more >>

Mycopathologia (Mycopathologia)
[2016, 181(9-10):717-721]

Cited: 5 times

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Oral steroids for the resolution of otitis media with effusion (OME) in children (OSTRICH): study protocol for a randomised controlled trial.

Cherry-Ann Waldron, Emma Thomas-Jones, Rebecca Cannings-John, Kerenza Hood, Colin Powell, Amanda Roberts, Alun Tomkinson, Deborah Fitzsimmons, Micaela Gal, Debbie Harris, Victoria Shepherd, Christopher C Butler, Nicholas Francis,

BACKGROUND:Otitis media with effusion (OME) is an accumulation of fluid in the middle ear affecting about 80 % of children by the age of 4 years. While OME usually resolves spontaneously, it can affect speech, behaviour and development. Children with persistent hearing loss associated with OME are usually offered hearing ... Read more >>

Trials (Trials)
[2016, 17(1):115]

Cited: 1 time

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Influenza Vaccination as a Novel Trigger of Wells Syndrome in a Child.

Jacqueline K Simpson, Rakesh Patalay, Nicholas Francis, Nerys Roberts,

Wells syndrome is a rare disorder of unknown etiology. Precipitants include insect bites, infections, medications, malignancies, and vaccinations. Possible mechanisms include hypersensitivity reactions to antigens. There are four reports in the literature of Wells syndrome precipitated by vaccinations (hepatitis B vaccine, tetanus vaccine, tetanus-diptheria vaccine and triple antigen vaccine). We ... Read more >>

Pediatr Dermatol (Pediatric dermatology)
[2015, 32(4):e171-2]

Cited: 1 time

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Unilateral eruption of painful papules: a quiz. Type 1 segmental cutaneous leiomyomatosis.

Annabel D Scott, Nicholas Francis, Sarita Singh,

Acta Derm. Venereol. (Acta dermato-venereologica)
[2014, 94(5):619-622]

Cited: 1 time

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High-resolution anoscopy screening of HIV-positive MSM: longitudinal results from a pilot study.

Alessia Dalla Pria, Maryam Alfa-Wali, Paul Fox, Paul Holmes, Justin Weir, Nicholas Francis, Mark Bower,

BACKGROUND: The ability to detect and treat pre-malignant anal lesions suggests screening may prevent anal cancer. The incidence of anal cancer in men who have sex with men (MSM) living with HIV exceeds that of cervical cancer before screening was introduced. METHODS: High-resolution anoscopy (HRA) with intervention for high-grade squamous ... Read more >>

AIDS (AIDS (London, England))
[2014, 28(6):861-867]

Cited: 29 times

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Urticarial vasculitis associated with essential thrombocythaemia.

Annabel D Scott, Nicholas Francis, Helen Yarranton, Sarita Singh,

Acta Derm. Venereol. (Acta dermato-venereologica)
[2014, 94(2):244-245]

Cited: 1 time

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A segmental rash in a young male: a quiz. Naevoid urticaria pigmentosa.

Eirini E Merika, Christopher B Bunker, Nicholas Francis, Sarita Singh,

Acta Derm. Venereol. (Acta dermato-venereologica)
[2014, 94(2):253-254]

Cited: 1 time

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Asthma prevalence and humoral immune response in Somali immigrants in the US: implications for the hygiene hypothesis.

Christopher C Butler, Nick A Francis,

Prim Care Respir J (Primary care respiratory journal : journal of the General Practice Airways Group)
[2013, 22(3):262-264]

Cited: 0 times

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Nonmelanoma skin cancers among HIV-infected persons in the HAART era.

Elisa Garlassi, Victoria Harding, Justin Weir, Nicholas Francis, Mark Nelson, Tom Newsom-Davis, Mark Bower,

J. Acquir. Immune Defic. Syndr. (Journal of acquired immune deficiency syndromes (1999))
[2012, 60(2):e63-5]

Cited: 1 time

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Atypical fibroxanthoma in an HIV-infected individual.

Conal M Perrett, Chrystalla Macedo, Nicholas Francis, Lucian Ion, Christopher B Bunker,

Atypical fibroxanthoma is a neoplasm primarily occurring in older patients, with a predilection for photo-damaged skin of the head and neck. Compared to the immunocompetent population, patients infected with HIV have a higher risk of certain malignancies including non-Hodgkin lymphoma, Kaposi's sarcoma and skin cancer. Although atypical fibroxanthoma has been ... Read more >>

J. Cutan. Pathol. (Journal of cutaneous pathology)
[2011, 38(4):357-359]

Cited: 2 times

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