Full Text Journal Articles by
Author Nicholas A Pullen

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Kefir Is a Viable Exercise Recovery Beverage for Cancer Survivors Enrolled in a Structured Exercise Program.

Peter Smoak, Nicholas Harman, Victoria Flores, Jacob Kisiolek, Nicholas A Pullen, Jonathan Lisano, Reid Hayward, Laura K Stewart,

<h4>Purpose</h4>This study investigated the effects of 12 wk of postexercise kefir consumption in cancer survivors who have undergone chemotherapy and/or radiation therapy.<h4>Methods</h4>All participants were enrolled in a structured exercise training program and separated into kefir (KEF) or control (CON) treatment groups. KEF consumed 8 oz. of kefir after exercise sessions ... Read more >>

Med Sci Sports Exerc (Medicine and science in sports and exercise)
[2021, 53(10):2045-2053]

Cited: 0 times

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Berberine Delays Onset of Collagen-Induced Arthritis through T Cell Suppression.

Alexandra A Vita, Hend Aljobaily, David O Lyons, Nicholas A Pullen,

There is evidence that berberine (BBR), a clinically relevant plant compound, ameliorates clinically apparent collagen-induced arthritis (CIA) in vivo. However, to date, there are no studies involving the use of BBR which explore its prophylactic potential in this model of rheumatoid arthritis (RA). The aim of this study was to ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(7):]

Cited: 0 times

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The Role of Innate and Adaptive Immune Cells in Skeletal Muscle Regeneration.

Natalia Ziemkiewicz, Genevieve Hilliard, Nicholas A Pullen, Koyal Garg,

Skeletal muscle regeneration is highly dependent on the inflammatory response. A wide variety of innate and adaptive immune cells orchestrate the complex process of muscle repair. This review provides information about the various types of immune cells and biomolecules that have been shown to mediate muscle regeneration following injury and ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(6):]

Cited: 1 time

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Physical activity delays accumulation of immunosuppressive myeloid-derived suppressor cells.

Jacob Garritson, Luke Krynski, Lea Haverbeck, James M Haughian, Nicholas A Pullen, Reid Hayward,

<h4>Background</h4>Myeloid-derived suppressor cells (MDSCs) are potent suppressors of immune function and may play a key role in the development and progression of metastatic cancers. Aerobic exercise has been shown to have anticancer effects, yet the mechanisms behind this protection are largely unknown. Therefore, we examined the effects of physical activity ... Read more >>

PLoS One (PloS one)
[2020, 15(6):e0234548]

Cited: 4 times

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Facilitating Growth through Frustration: Using Genomics Research in a Course-Based Undergraduate Research Experience.

David Lopatto, Anne G Rosenwald, Justin R DiAngelo, Amy T Hark, Matthew Skerritt, Matthew Wawersik, Anna K Allen, Consuelo Alvarez, Sara Anderson, Cindy Arrigo, Andrew Arsham, Daron Barnard, Christopher Bazinet, James E J Bedard, Indrani Bose, John M Braverman, Martin G Burg, Rebecca C Burgess, Paula Croonquist, Chunguang Du, Sondra Dubowsky, Heather Eisler, Matthew A Escobar, Michael Foulk, Emily Furbee, Thomas Giarla, Rivka L Glaser, Anya L Goodman, Yuying Gosser, Adam Haberman, Charles Hauser, Shan Hays, Carina E Howell, Jennifer Jemc, M Logan Johnson, Christopher J Jones, Lisa Kadlec, Jacob D Kagey, Kimberly L Keller, Jennifer Kennell, S Catherine Silver Key, Adam J Kleinschmit, Melissa Kleinschmit, Nighat P Kokan, Olga Ruiz Kopp, Meg M Laakso, Judith Leatherman, Lindsey J Long, Mollie Manier, Juan C Martinez-Cruzado, Luis F Matos, Amie Jo McClellan, Gerard McNeil, Evan Merkhofer, Vida Mingo, Hemlata Mistry, Elizabeth Mitchell, Nathan T Mortimer, Debaditya Mukhopadhyay, Jennifer Leigh Myka, Alexis Nagengast, Paul Overvoorde, Don Paetkau, Leocadia Paliulis, Susan Parrish, Mary Lai Preuss, James V Price, Nicholas A Pullen, Catherine Reinke, Dennis Revie, Srebrenka Robic, Jennifer A Roecklein-Canfield, Michael R Rubin, Takrima Sadikot, Jamie Siders Sanford, Maria Santisteban, Kenneth Saville, Stephanie Schroeder, Christopher D Shaffer, Karim A Sharif, Diane E Sklensky, Chiyedza Small, Mary Smith, Sheryl Smith, Rebecca Spokony, Aparna Sreenivasan, Joyce Stamm, Rachel Sterne-Marr, Katherine C Teeter, Justin Thackeray, Jeffrey S Thompson, Stephanie Toering Peters, Melanie Van Stry, Norma Velazquez-Ulloa, Cindy Wolfe, James Youngblom, Brian Yowler, Leming Zhou, Janie Brennan, Jeremy Buhler, Wilson Leung, Laura K Reed, Sarah C R Elgin,

A hallmark of the research experience is encountering difficulty and working through those challenges to achieve success. This ability is essential to being a successful scientist, but replicating such challenges in a teaching setting can be difficult. The Genomics Education Partnership (GEP) is a consortium of faculty who engage their ... Read more >>

J Microbiol Biol Educ (Journal of microbiology & biology education)
[2020, 21(1):]

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Beyond IgE: Alternative Mast Cell Activation Across Different Disease States.

David O Lyons, Nicholas A Pullen,

Mast cells are often regarded through the lens of IgE-dependent reactions as a cell specialized only for anti-parasitic and type I hypersensitive responses. However, recently many researchers have begun to appreciate the expansive repertoire of stimuli that mast cells can respond to. After the characterization of the interleukin (IL)-33/suppression of ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(4):]

Cited: 11 times

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Nanoparticles and danger signals: Oral delivery vehicles as potential disruptors of intestinal barrier homeostasis.

Alexandra A Vita, Emily A Royse, Nicholas A Pullen,

Gut immune system homeostasis involves diverse structural interactions among resident microbiota, the protective mucus layer, and a variety of cells (intestinal epithelial, lymphoid, and myeloid). Due to the substantial surface area in direct contact with an "external" environment and the diversity of xenobiotic, abiotic, and self-interactions coordinating to maintain gut ... Read more >>

J Leukoc Biol (Journal of leukocyte biology)
[2019, 106(1):95-103]

Cited: 10 times

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Soluble transforming growth factor beta-1 enhances murine mast cell release of Interleukin 6 in IgE-independent and Interleukin 13 in IgE-dependent settings in vitro.

David O Lyons, Michele R Plewes, Nicholas A Pullen,

<h4>Introduction</h4>For immune cells transforming growth factor beta-1 (TGF-β1) can enhance or repress effector functions. Here, we characterize the effects of TGF-β1 on IgE-mediated and IL-33-mediated activation of primary murine mast cells derived from hematopoietic stem cells (bone marrow derived mast cells; BMMC). We also investigated potential interactions between TGF-β1 and ... Read more >>

PLoS One (PloS one)
[2018, 13(11):e0207704]

Cited: 3 times

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ADAM10 is required for SCF-induced mast cell migration.

Travis W Faber, Nicholas A Pullen, Josephine F A Fernando, Elizabeth Motunrayo Kolawole, Jamie J A McLeod, Marcela Taruselli, Kathryn L Williams, Kevin O Rivera, Brian O Barnstein, Daniel H Conrad, John J Ryan,

A Disintegrin and Metalloproteinase (ADAM)-10 plays critical roles in neuronal migration and distribution. Recently, ADAM10 deletion was shown to disrupt myelopoiesis. We found that inducible deletion of ADAM10 using Mx1-driven Cre recombinase for a period of three weeks resulted in mast cell hyperplasia in the skin, intestine and spleen. Mast ... Read more >>

Cell Immunol (Cellular immunology)
[2014, 290(1):80-88]

Cited: 10 times

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Myeloid-derived suppressor cells enhance IgE-mediated mast cell responses.

Johanna K Morales, Sheinei J Saleem, Rebecca K Martin, Bryan L Saunders, Brian O Barnstein, Travis W Faber, Nicholas A Pullen, Elizabeth Motunrayo Kolawole, Keith B Brooks, Sarah K Norton, Jamie Sturgill, Laura Graham, Harry D Bear, Joseph F Urban, Chris S Lantz, Daniel H Conrad, John J Ryan,

Mast cells and MDSCs are increased by parasitic infection and tumor growth. We previously demonstrated that enhanced MDSC development in ADAM10 transgenic mice yielded resistance to Nb infection and that coculturing MDSCs and mast cells enhanced cytokine production. In the current work, we show that MDSC-mast cell coculture selectively enhances ... Read more >>

J Leukoc Biol (Journal of leukocyte biology)
[2014, 95(4):643-650]

Cited: 11 times

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Genotype-dependent effects of TGF-β1 on mast cell function: targeting the Stat5 pathway.

Josephine Fernando, Travis W Faber, Nicholas A Pullen, Yves T Falanga, Elizabeth Motunrayo Kolawole, Carole A Oskeritzian, Brian O Barnstein, Geethani Bandara, Geqiang Li, Lawrence B Schwartz, Sarah Spiegel, David B Straus, Daniel H Conrad, Kevin D Bunting, John J Ryan,

We previously demonstrated that TGF-β1 suppresses IgE-mediated signaling in human and mouse mast cells in vitro, an effect that correlated with decreased expression of the high-affinity IgE receptor, FcεRI. The in vivo effects of TGF-β1 and the means by which it suppresses mast cells have been less clear. This study ... Read more >>

J Immunol (Journal of immunology (Baltimore, Md. : 1950))
[2013, 191(9):4505-4513]

Cited: 21 times

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Macrophage functional polarization (M1/M2) in response to varying fiber and pore dimensions of electrospun scaffolds.

Koyal Garg, Nicholas A Pullen, Carole A Oskeritzian, John J Ryan, Gary L Bowlin,

In this study, we investigated the effect of fiber and pore size of an electrospun scaffold on the polarization of mouse bone marrow-derived macrophages (BMMΦs) towards regenerative (M2) or inflammatory (M1) phenotypes. BMMΦs were seeded on Polydioxanone (PDO) scaffolds electrospun from varying polymer concentrations (60, 100, and 140 mg/ml). Higher ... Read more >>

Biomaterials (Biomaterials)
[2013, 34(18):4439-4451]

Cited: 128 times

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Abstracts from the 2012 BNOS Conference

Suzanne Birks, Melis Altinkaya, Ali Altinkaya, Geoff Pilkington, Kathreena M Kurian, Charlene Crosby, Kirsten Hopkins, Maggie Williams, Laura Donovan, Suzanne Birks, Amy Eason, Viktoria Bosak, Geoffrey Pilkington, Suzanne Birks, Jonathon Holliday, Ivason Corbett, Geoffrey Pilkington, Melanie Keeling, Jacki Bambrough, Jane Simpson, Samantha Higgins, Harjot Dogra, Geoffrey Pilkington, Kathreena M Kurian, Yuening Zhang, Marcus Bradley, Claudia Schmidberger, Sassan Hafizi, Imran Noorani, Stephen Price, Aurore Dubocq, Tomasz Jaunky, Clémence Chatelain, Luke Evans, Tanja Gaißmaier, Geoffrey J Pilkington, Qian An, V Hurwitz, J Logan, R Bhangoo, K Ashkan, A Gullan, R Beaney, L Brazil, S Kokkinos, R Blake, A Singleton, Abigail Shaw, Venkat Iyer, Kathreena M Kurian, Jennie N Jeyapalan, Isabel CF Morley, Alfred A Hill, Muhammad A Mumin, Ruth G Tatevossian, Ibrahim Qaddoumi, David W Ellison, Denise Sheer, A Frary, S Price, S Jefferies, F Harris, N Burnet, R Jena, C Watts, Brian Haylock, Sophie Leow-Dyke, Nitika Rathi, Helen Wong, Julie Dunn, Atik Baborie, Daniel Crooks, David Husband, Adi Shenoy, Andrew Brodbelt, Carol Walker, A Bahl, JJ Larsen, I Craven, P Metherall, FM McKevitt, CAJ Romanowski, N Hoggard, D A Jellinek, S Bell, E Murray, R Muirhead, A James, Z Hanzely, R Jackson, W Stewart, A O'Brien, A Young, S Bell, Z Hanzely, W Stewart, SC Shepherd, D Cavers, LM Wallace, B Hacking, SE Scott, DJ Bowyer, Ashraf Elmahdi, Amy J Frary, Dominic G O'Donovan, Stephen J Price, Azadeh Kia, Justyna M Przystal, Nastasia Nianiaris, Nicholas D Mazarakis, Paul J Mintz, Amin Hajitou, K Karakoula, KP Phipps, W Harkness, R Hayward, D Thompson, TS Jacques, B Harding, J Darling, T Warr, Sophie Leow-Dyke, Nitika Rathi, Brain Haylock, Daniel Crooks, Michael Jenkinson, Carol Walker, Andrew Brodbelt, Lu Zhou, Emanuela Ercolano, Sylwia Ammoun, M Caroline Schmid, Magdalena Barczyk, C Oliver Hanemann, FB Rowther, T Dawson, K Ashton, J Darling, T Warr, Zaynah Maherally, Kathryn E Hatherell, Karolin Kroese, Sassan Hafizi, Geoffrey J Pilkington, P Singh, S McQuaid, S Al-Rashid, K Prise, B Herron, E Healy, A Shoakazemi, M Donnelly, R McConnell, J Harney, D Conkey, E McGrath, LD Lunsford, D Kondziolka, A Niranjan, H Kano, R Hamilton, T Flannery, Yvonne Majani, Stuart Smith, Richard Grundy, Ruman Rahman, Sarvinder Saini, Gregory Hall, Charles Davis, FB Rowther, T Lawson, K Ashton, N Potter, E Goessl, J Darling, T Warr, Andrew Brodbelt, Michael Jenkinson, Carol Walker, Sophie Leow-Dyke, Brian Haylock, Julie Dunn, Simone Wilkins, Trevor Smith, V Petinou, ID Nicholl, J Singh, RW Lea, PJ Welsby, Inma Spiteri, Andrea Sottoriva, Nicholas Marko, Simon Tavare, Peter Collins, Stephen J Price, Colin Watts, ZJ Su, A Gerhard, R Hinz, F Roncaroli, D Coope, G Thompson, K Karabatsou, A Sofat, J Leggate, D du Plessis, F Turkheimer, A Jackson, A Brodbelt, MD Jenkinson, K Das, D Crooks, K Herholz, Stephen J Price, Ian R Whittle, Keyoumars Ashkan, Paul Grundy, Garth Cruickshank, VL Berry, DJE Elder, V Iyer, K Hopkins, NR Cohen, JM Tavaré, Georgios Zilidis, Priyanka Tibarewal, Laura Spinelli, Nick R Leslie, David John Coope, Konstantina Karabatsou, Sophie Green, Gemma Wall, Jacki Bambrough, PM Brennan, J Baily, M Diaz, J Ironside, O Sansom, V Brunton, M Frame, AMH Young, OM Thomas, LA Mohsen, AJ Frary, VC Lupson, MA McLean, SJ Price, Mohit Arora, Lisa Shaw, Clare Lawrence, Jane Alder, Tim Dawson, Greg Hall, Lavdie Rada, Ke Chen, A Shivane, S Ammoun, DB Parkinson, CO Hanemann, Rajendra P Pangeni, Tracy J Warr, Mark R Morris, Mairi Mackinnon, Aoife Williamson, Allan James, Anthony Chalmers, VL Beckett, AJ Joannides, R Brock, K McCarthy, SJ Price, A Singh, K Karakoula, T Dawson, K Ashton, J Darling, T Warr, H Kardooni, M Morris, F Rowther, J Darling, T Warr, Colin Watts, N Syed, F Roncaroli, K Janczar, P Singh, K O'Neil, C Lo Nigro, L Lattanzio, HM Coley, E Hatzimichael, J Bomalaski, P Szlosarek, T Crook, Nicholas A Pullen, Monika Anand, Suzanne Birks, Timothy Van Meter, Nicholas A Pullen, Monika Anand, Shante Williams, Marjorie Boissinot, Lynette Steele, Shante Williams, E Antonio Chiocca, Sean Lawler, Shahnaz T Al Rashid, Stephanie Mashal, Laura Taggart, Ellen Clarke, Thomas Flannery, Kevin M Prise,

INTRODUCTION: Boswellia derivatives possess pro-apoptotic potential towards glioblastoma in vitro and inhibit cell growth. We investigated whether combining boswellic acid with either clomipramine or temozolomide has synergistic therapeutic potential and whether this would reduce viability of the cancer stem cell (CSC) population. METHOD: Standard and CSC enriched human glioblastoma cell ... Read more >>

Neuro Oncol (Neuro-oncology)
[2012, 14(Suppl 2):ii1-ii12]

Cited: 0 times

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The Fyn-STAT5 Pathway: A New Frontier in IgE- and IgG-Mediated Mast Cell Signaling.

Nicholas A Pullen, Yves T Falanga, Johanna K Morales, John J Ryan,

Mast cells are central players in immune surveillance and activation, positioned at the host-environment interface. Understanding the signaling events controlling mast cell function, especially those that maintain host homeostasis, is an important and still less understood area of mast cell-mediated disease. With respect to allergic disease, it is well established ... Read more >>

Front Immunol (Frontiers in immunology)
[2012, 3:117]

Cited: 17 times

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Lyn but not Fyn kinase controls IgG-mediated systemic anaphylaxis.

Yves T Falanga, Natalia S Chaimowitz, Nicolas Charles, Fred D Finkelman, Nicholas A Pullen, Suzanne Barbour, Kevin Dholaria, Travis Faber, Motunrayo Kolawole, Bernice Huang, Sandra Odom, Juan Rivera, Jason Carlyon, Daniel H Conrad, Sarah Spiegel, Carole A Oskeritzian, John J Ryan,

Anaphylaxis is a rapid, life-threatening hypersensitivity reaction. Until recently, it was mainly attributed to histamine released by mast cells activated by allergen crosslinking (XL) of FcεRI-bound allergen-specific IgE. However, recent reports established that anaphylaxis could also be triggered by basophil, macrophage, and neutrophil secretion of platelet-activating factor subsequent to FcγR ... Read more >>

J Immunol (Journal of immunology (Baltimore, Md. : 1950))
[2012, 188(9):4360-4368]

Cited: 21 times

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Matrix metalloproteinase-1 expression enhances tumorigenicity as well as tumor-related angiogenesis and is inversely associated with TIMP-4 expression in a model of glioblastoma.

Nicholas A Pullen, Monika Anand, Patricia S Cooper, Helen L Fillmore,

Herein we continue the study of matrix metalloproteinase-1 (MMP-1) with respect to glioblastoma multiforme (GBM) cell tumorigenicity and angiogenesis. A model of tumorigenicity with cells stably altered to over-express or knock-down MMP-1 revealed that it significantly increases tumor incidence and size. Organized endothelial growth in human umbilical vein endothelial cell ... Read more >>

J Neurooncol (Journal of neuro-oncology)
[2012, 106(3):461-471]

Cited: 11 times

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Induction of matrix metalloproteinase-1 and glioma cell motility by nitric oxide.

Nicholas A Pullen, Helen L Fillmore,

High grade gliomas invariably recur due in a large part to tumor cells permeating normal brain in an inaccessible, diffuse manner. Previous work demonstrates that the expression of matrix metalloproteinases (MMP) contributes to this characteristic. Not only can MMPs assist a cell in traversing its environment by clearing extracellular matrix ... Read more >>

J Neurooncol (Journal of neuro-oncology)
[2010, 96(2):201-209]

Cited: 11 times

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