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Brain Function Differences in Children With Type 1 Diabetes: An fMRI Study of Working Memory.

Lara C Foland-Ross, Gabby Tong, Nelly Mauras, Allison Cato, Tandy Aye, Michael Tansey, Neil H White, Stuart A Weinzimer, Kimberly Englert, Hanyang Shen, Paul K Mazaika, Allan L Reiss, ,

Glucose is a primary fuel source to the brain, yet the influence of dysglycemia on neurodevelopment in children with type 1 diabetes remains unclear. We examined brain activation using functional MRI in 80 children with type 1 diabetes (mean age ± SD, 11.5±1.8 years; 46% female) and 47 children without ... Read more >>

Diabetes (Diabetes)
[2020, :]

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PrEvention of posttraumatic contractuRes with Ketotifen 2 (PERK 2) - protocol for a multicenter randomized clinical trial.

Ayoola Ademola, Kevin A Hildebrand, Prism S Schneider, Nicholas G H Mohtadi, Neil J White, Michael J Bosse, Alexandra Garven, Richard E A Walker, Tolulope T Sajobi,

BACKGROUND:Injuries and resulting stiffness around joints, especially the elbow, have huge psychological effects by reducing quality of life through interference with normal daily activities such as feeding, dressing, grooming, and reaching for objects. Over the last several years and through numerous research results, the myofibroblast-mast cell-neuropeptide axis of fibrosis had ... Read more >>

BMC Musculoskelet Disord (BMC musculoskeletal disorders)
[2020, 21(1):123]

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Parameter estimation for functional-structural plant models when data are scarce: using multiple patterns for rejecting unsuitable parameter sets.

Ming Wang, Neil White, Jim Hanan, Di He, Enli Wang, Bronwen Cribb, Darren J Kriticos, Dean Paini, Volker Grimm,

BACKGROUND AND AIMS:Functional-structural plant (FSP) models provide insights into the complex interactions between plant architecture and underlying developmental mechanisms. However, parameter estimation of FSP models remains challenging. We therefore used pattern-oriented modelling (POM) to test whether parameterisation of FSP models can be made more efficient, systematic and powerful. With POM, ... Read more >>

Ann. Bot. (Annals of botany)
[2020, :]

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Risk Factors for Diabetic Peripheral Neuropathy and Cardiovascular Autonomic Neuropathy in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study.

Barbara H Braffett, Rose A Gubitosi-Klug, James W Albers, Eva L Feldman, Catherine L Martin, Neil H White, Trevor J Orchard, Maria Lopes-Virella, John M Lachin, Rodica Pop-Busui, ,

The Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) study demonstrated that intensive glucose control reduced the risk of developing diabetic peripheral neuropathy (DPN) and cardiovascular autonomic neuropathy (CAN). We evaluated multiple risk factors and phenotypes associated with DPN and CAN in this large, well-characterized cohort of ... Read more >>

Diabetes (Diabetes)
[2020, 69(5):1000-1010]

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Accelerated surgery versus standard care in hip fracture (HIP ATTACK): an international, randomised, controlled trial.

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BACKGROUND:Observational studies have suggested that accelerated surgery is associated with improved outcomes in patients with a hip fracture. The HIP ATTACK trial assessed whether accelerated surgery could reduce mortality and major complications. METHODS:HIP ATTACK was an international, randomised, controlled trial done at 69 hospitals in 17 countries. Patients with a ... Read more >>

Lancet (Lancet (London, England))
[2020, 395(10225):698-708]

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Scapholunate Ligament Injury and the Effect of Scaphoid Lengthening.

Matthew J Furey, Neil J White, Gurpreet S Dhaliwal,

Objective  We hypothesized that lengthening the scaphoid in a model of scapholunate ligament injury (SLI) will result in correction of radiographic markers of dorsal intercalated segment instability (DISI) deformity. Materials and Methods  An SLI with DISI deformity was created by sectioning the SL ligament, the palmar radiocarpal ligaments, and scapho-trapezio-trapezoid ... Read more >>

J Wrist Surg (Journal of wrist surgery)
[2020, 9(1):76-80]

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Interaction Between Type 2 Diabetes Prevention Strategies and Genetic Determinants of Coronary Artery Disease on Cardiometabolic Risk Factors.

Jordi Merino, Kathleen A Jablonski, Josep M Mercader, Steven E Kahn, Ling Chen, Maegan Harden, Linda M Delahanty, Maria Rosario G Araneta, Geoffrey A Walford, Suzanne B R Jacobs, Uzoma N Ibebuogu, Paul W Franks, William C Knowler, Jose C Florez, ,

Coronary artery disease (CAD) is more frequent among individuals with dysglycemia. Preventive interventions for diabetes can improve cardiometabolic risk factors (CRFs), but it is unclear whether the benefits on CRFs are similar for individuals at different genetic risk for CAD. We built a 201-variant polygenic risk score (PRS) for CAD ... Read more >>

Diabetes (Diabetes)
[2020, 69(1):112-120]

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Antibiotic Impregnated Cement Dowel in a Tibial Stump to Salvage Infected Below-Knee Amputation in a Diabetic.

Sahil Prabhnoor Sidhu, Neil Jeffrey White,

Case:We describe the use of local antibiotics to salvage an infected below-knee amputation in a diabetic patient and prevent the need to convert to the above-knee level. After débridement, an antibiotic tibial "dowel" was fashioned and inserted into the intramedullary canal before closure. The wound was fully healed after four ... Read more >>

J Am Acad Orthop Surg Glob Res Rev (Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews)
[2019, 3(10):]

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Total Hip Arthroplasty or Hemiarthroplasty for Hip Fracture.

, Mohit Bhandari, Thomas A Einhorn, Gordon Guyatt, Emil H Schemitsch, Robert D Zura, Sheila Sprague, Frede Frihagen, Ernesto Guerra-Farfán, Ydo V Kleinlugtenbelt, Rudolf W Poolman, Amar Rangan, Sofia Bzovsky, Diane Heels-Ansdell, Lehana Thabane, Stephen D Walter, P J Devereaux,

BACKGROUND:Globally, hip fractures are among the top 10 causes of disability in adults. For displaced femoral neck fractures, there remains uncertainty regarding the effect of a total hip arthroplasty as compared with hemiarthroplasty. METHODS:We randomly assigned 1495 patients who were 50 years of age or older and had a displaced ... Read more >>

N. Engl. J. Med. (The New England journal of medicine)
[2019, 381(23):2199-2208]

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Metabolite Profiles of Incident Diabetes and Heterogeneity of Treatment Effect in the Diabetes Prevention Program.

Zsu-Zsu Chen, Jinxi Liu, Jordan Morningstar, Brandy M Heckman-Stoddard, Christine G Lee, Samuel Dagogo-Jack, Jane F Ferguson, Richard F Hamman, William C Knowler, Kieren J Mather, Leigh Perreault, Jose C Florez, Thomas J Wang, Clary Clish, Marinella Temprosa, Robert E Gerszten, ,

Novel biomarkers of type 2 diabetes (T2D) and response to preventative treatment in individuals with similar clinical risk may highlight metabolic pathways that are important in disease development. We profiled 331 metabolites in 2,015 baseline plasma samples from the Diabetes Prevention Program (DPP). Cox models were used to determine associations ... Read more >>

Diabetes (Diabetes)
[2019, 68(12):2337-2349]

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Heart Rate Variability and Cardiac Autonomic Dysfunction: Prevalence, Risk Factors, and Relationship to Arterial Stiffness in the Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) Study.

Amy S Shah, Laure El Ghormli, Mary Ellen Vajravelu, Fida Bacha, Ryan M Farrell, Samuel S Gidding, Lorraine E Levitt Katz, Jeanie B Tryggestad, Neil H White, Elaine M Urbina,

OBJECTIVE:To determine whether prior type 2 diabetes (T2D) treatment or glycemic control over time are independently associated with heart rate variability (HRV) and whether the presence of cardiac autonomic dysfunction is associated with arterial stiffness in young adults with youth-onset T2D enrolled in the Treatment Options for Type 2 Diabetes ... Read more >>

Diabetes Care (Diabetes care)
[2019, 42(11):2143-2150]

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Screening eye exams in youth with type 1 diabetes under 18 years of age: Once may be enough?

Rose A Gubitosi-Klug, Ionut Bebu, Neil H White, John Malone, Ryan Miller, Gayle M Lorenzi, Dean P Hainsworth, Victoria R Trapani, John M Lachin, William V Tamborlane, ,

Case series and registry data suggest that diabetic retinopathy requiring treatment is rare in youth with type 1 diabetes (T1D) prior to 18 years of age. We evaluated this question in the standardized clinical trial setting by retrospectively reviewing diabetic retinopathy examinations from participants in the Diabetes Control and Complications ... Read more >>

Pediatr Diabetes (Pediatric diabetes)
[2019, 20(6):743-749]

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Regression From Prediabetes to Normal Glucose Regulation and Prevalence of Microvascular Disease in the Diabetes Prevention Program Outcomes Study (DPPOS).

Leigh Perreault, Qing Pan, Emily B Schroeder, Rita R Kalyani, George A Bray, Samuel Dagogo-Jack, Neil H White, Ronald B Goldberg, Steven E Kahn, William C Knowler, Nestoras Mathioudakis, Dana Dabelea, ,

OBJECTIVE:Regression from prediabetes to normal glucose regulation (NGR) was associated with reduced incidence of diabetes by 56% over 10 years in participants in the Diabetes Prevention Program Outcomes Study (DPPOS). In an observational analysis, we examined whether regression to NGR also reduced risk for microvascular disease (MVD). RESEARCH DESIGN AND ... Read more >>

Diabetes Care (Diabetes care)
[2019, 42(9):1809-1815]

Cited: 1 time

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Does diabetes prevention translate into reduced long-term vascular complications of diabetes?

David M Nathan, Peter H Bennett, Jill P Crandall, Sharon L Edelstein, Ronald B Goldberg, Steven E Kahn, William C Knowler, Kieren J Mather, Sunder Mudaliar, Trevor J Orchard, Marinella Temprosa, Neil H White, ,

The global epidemic of type 2 diabetes has prompted numerous studies and public health efforts to reduce its development. A variety of interventions, including lifestyle modifications and pharmacological agents directed at ameliorating the major risk factors for type 2 diabetes, are of proven efficacy in reducing the development of type ... Read more >>

Diabetologia (Diabetologia)
[2019, 62(8):1319-1328]

Cited: 4 times

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Changes in Visceral and Subcutaneous Fat in Youth With Type 2 Diabetes in the TODAY Study.

Ruban Dhaliwal, John A Shepherd, Laure El Ghormli, Kenneth C Copeland, Mitchell E Geffner, Janine Higgins, Lynne L Levitsky, Kristen J Nadeau, Ruth S Weinstock, Neil H White, ,

OBJECTIVE:In the Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) study, metformin plus rosiglitazone (M + R) maintained glycemic control better than metformin alone (M) or metformin plus lifestyle (M + L) in youth with type 2 diabetes (T2D). We hypothesized that changes in visceral adipose tissue ... Read more >>

Diabetes Care (Diabetes care)
[2019, 42(8):1549-1559]

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Long-term Effects of Metformin on Diabetes Prevention: Identification of Subgroups That Benefited Most in the Diabetes Prevention Program and Diabetes Prevention Program Outcomes Study.

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OBJECTIVE:We examined the effects of metformin on diabetes prevention and the subgroups that benefited most over 15 years in the Diabetes Prevention Program (DPP) and its follow-up, the Diabetes Prevention Program Outcomes Study (DPPOS). RESEARCH DESIGN AND METHODS:During the DPP (1996-2001), adults at high risk of developing diabetes were randomly ... Read more >>

Diabetes Care (Diabetes care)
[2019, 42(4):601-608]

Cited: 1 time

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Surgical outcomes of chronic isolated scapholunate interosseous ligament injuries: a systematic review of 805 wrists

Spencer J. Montgomery, Natalie J. Rollick, Jeremy F. Kubik, Alexander R. Meldrum, Neil J. White,

Background:Management of chronic isolated scapholunate interosseous ligament (SLIL) injuries has generated a substantial volume of low-quality literature with descriptions of multiple new surgical techniques, and the impact of instability pattern and the optimal surgical technique remain unclear. The primary goal of this review was to compare clinical, radiographic and patient-rated ... Read more >>

Can J Surg (Canadian journal of surgery. Journal canadien de chirurgie)
[2019, 62(3):1-12]

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Risk Factors for Kidney Disease in Type 1 Diabetes.

Bruce A Perkins, Ionut Bebu, Ian H de Boer, Mark Molitch, William Tamborlane, Gayle Lorenzi, William Herman, Neil H White, Rodica Pop-Busui, Andrew D Paterson, Trevor Orchard, Catherine Cowie, John M Lachin, ,

OBJECTIVE:In type 1 diabetes (T1D), the course of microalbuminuria is unpredictable and timing of glomerular filtration rate (GFR) loss is uncertain. Thus, there is a need to identify the risk factors associated with the development of more advanced stages of kidney disease through large, long-term systematic analysis. RESEARCH DESIGN AND ... Read more >>

Diabetes Care (Diabetes care)
[2019, 42(5):883-890]

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Risk Factors for Retinopathy in Type 1 Diabetes: The DCCT/EDIC Study.

Dean P Hainsworth, Ionut Bebu, Lloyd P Aiello, William Sivitz, Rose Gubitosi-Klug, John Malone, Neil H White, Ronald Danis, Amisha Wallia, Xiaoyu Gao, Andrew J Barkmeier, Arup Das, Shriji Patel, Thomas W Gardner, John M Lachin, ,

OBJECTIVE:The Diabetes Control and Complications Trial (DCCT) demonstrated that intensive therapy reduced the development and progression of retinopathy in type 1 diabetes (T1D) compared with conventional therapy. The Epidemiology of Diabetes Interventions and Complications (EDIC) study observational follow-up showed persistent benefits. In addition to glycemia, we now examine other potential ... Read more >>

Diabetes Care (Diabetes care)
[2019, 42(5):875-882]

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Impact of Early Diabetic Ketoacidosis on the Developing Brain.

Tandy Aye, Paul K Mazaika, Nelly Mauras, Matthew J Marzelli, Hanyang Shen, Tamara Hershey, Allison Cato, Stuart A Weinzimer, Neil H White, Eva Tsalikian, Booil Jo, Allan L Reiss, ,

OBJECTIVE:This study examined whether a history of diabetic ketoacidosis (DKA) is associated with changes in longitudinal cognitive and brain development in young children with type 1 diabetes. RESEARCH DESIGN AND METHODS:Cognitive and brain imaging data were analyzed from 144 children with type 1 diabetes, ages 4 to <10 years, who ... Read more >>

Diabetes Care (Diabetes care)
[2019, 42(3):443-449]

Cited: 1 time

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Evaluation and Management of Youth-Onset Type 2 Diabetes: A Position Statement by the American Diabetes Association.

Silva Arslanian, Fida Bacha, Margaret Grey, Marsha D Marcus, Neil H White, Philip Zeitler,

Diabetes Care (Diabetes care)
[2018, 41(12):2648-2668]

Cited: 4 times

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The Shape of the Glucose Response Curve During an Oral Glucose Tolerance Test: Forerunner of Heightened Glycemic Failure Rates and Accelerated Decline in β-Cell Function in TODAY.

Silva Arslanian, Laure El Ghormli, Joon Young Kim, Fida Bacha, Christine Chan, Heba M Ismail, Lorraine E Levitt Katz, Lynne Levitsky, Jeanie B Tryggestad, Neil H White, ,

OBJECTIVE:Obese youth without diabetes with monophasic oral glucose tolerance test (OGTT) glucose response curves have lower insulin sensitivity and impaired β-cell function compared with those with biphasic curves. The OGTT glucose response curve has not been studied in youth-onset type 2 diabetes. Here we test the hypothesis that the OGTT ... Read more >>

Diabetes Care (Diabetes care)
[2019, 42(1):164-172]

Cited: 1 time

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The 27 kDa Trypanosoma brucei Pentatricopeptide Repeat Protein is a G-tract Specific RNA Binding Protein.

Pakoyo F Kamba, David A Dickson, Neil A White, Jennifer L Ekstrom, Donna J Koslowsky, Charles G Hoogstraten,

Pentatricopeptide repeat (PPR) proteins, a helical repeat family of organellar RNA binding proteins, play essential roles in post-transcriptional RNA processing. In Trypanosoma brucei, an expanded family of PPR proteins localize to the parasite's single mitochondrion, where they are believed to perform important roles in both RNA processing and translation. We ... Read more >>

Sci Rep (Scientific reports)
[2018, 8(1):16989]

Cited: 1 time

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Coupling between conformational dynamics and catalytic function at the active site of the lead-dependent ribozyme.

Neil A White, Minako Sumita, Victor E Marquez, Charles G Hoogstraten,

In common with other self-cleaving RNAs, the lead-dependent ribozyme (leadzyme) undergoes dynamic fluctuations to a chemically activated conformation. We explored the connection between conformational dynamics and self-cleavage function in the leadzyme using a combination of NMR spin-relaxation analysis of ribose groups and conformational restriction via chemical modification. The functional studies ... Read more >>

RNA (RNA (New York, N.Y.))
[2018, 24(11):1542-1554]

Cited: 1 time

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A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes.

Natalie R van Zuydam, Emma Ahlqvist, Niina Sandholm, Harshal Deshmukh, N William Rayner, Moustafa Abdalla, Claes Ladenvall, Daniel Ziemek, Eric Fauman, Neil R Robertson, Paul M McKeigue, Erkka Valo, Carol Forsblom, Valma Harjutsalo, , Annalisa Perna, Erica Rurali, M Loredana Marcovecchio, Robert P Igo, Rany M Salem, Norberto Perico, Maria Lajer, Annemari Käräjämäki, Minako Imamura, Michiaki Kubo, Atsushi Takahashi, Xueling Sim, Jianjun Liu, Rob M van Dam, Guozhi Jiang, Claudia H T Tam, Andrea O Y Luk, Heung Man Lee, Cadmon K P Lim, Cheuk Chun Szeto, Wing Yee So, Juliana C N Chan, , Su Fen Ang, Rajkumar Dorajoo, Ling Wang, Tan Si Hua Clara, Amy-Jayne McKnight, Seamus Duffy, , Marcus G Pezzolesi, , Michel Marre, Beata Gyorgy, Samy Hadjadj, Linda T Hiraki, , Tarunveer S Ahluwalia, Peter Almgren, Christina-Alexandra Schulz, Marju Orho-Melander, Allan Linneberg, Cramer Christensen, Daniel R Witte, Niels Grarup, Ivan Brandslund, Olle Melander, Andrew D Paterson, David Tregouet, Alexander P Maxwell, Su Chi Lim, Ronald C W Ma, E Shyong Tai, Shiro Maeda, Valeriya Lyssenko, Tiinamaija Tuomi, Andrzej S Krolewski, Stephen S Rich, Joel N Hirschhorn, Jose C Florez, David Dunger, Oluf Pedersen, Torben Hansen, Peter Rossing, Giuseppe Remuzzi, , Mary Julia Brosnan, Colin N A Palmer, Per-Henrik Groop, Helen M Colhoun, Leif C Groop, Mark I McCarthy,

Identification of sequence variants robustly associated with predisposition to diabetic kidney disease (DKD) has the potential to provide insights into the pathophysiological mechanisms responsible. We conducted a genome-wide association study (GWAS) of DKD in type 2 diabetes (T2D) using eight complementary dichotomous and quantitative DKD phenotypes: the principal dichotomous analysis ... Read more >>

Diabetes (Diabetes)
[2018, 67(7):1414-1427]

Cited: 17 times

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