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Author Neil R Aggarwal

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Accelerating Coronavirus Disease 2019 Therapeutic Interventions and Vaccines-Selecting Compounds for Clinical Evaluation in Coronavirus Disease 2019 Clinical Trials.

Timothy G Buchman, Ruxandra Draghia-Akli, Stacey J Adam, Neil R Aggarwal, Joshua P Fessel, Elizabeth S Higgs, Joseph P Menetski, Sarah W Read, Eric A Hughes, ,

Given the urgent need for coronavirus disease 2019 therapeutics, early in the pandemic the Accelerating Coronavirus Disease 2019 Therapeutic Interventions and Vaccines (ACTIV) public-private partnership rapidly designed a unique therapeutic agent intake and assessment process for candidate treatments of coronavirus disease 2019. These treatments included antivirals, immune modulators, severe acute ... Read more >>

Crit Care Med (Critical care medicine)
[2021, 49(11):1963-1973]

Cited: 0 times

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Advancing precision medicine for acute respiratory distress syndrome.

Jeremy R Beitler, B Taylor Thompson, Rebecca M Baron, Julie A Bastarache, Loren C Denlinger, Laura Esserman, Michelle N Gong, Lisa M LaVange, Roger J Lewis, John C Marshall, Thomas R Martin, Daniel F McAuley, Nuala J Meyer, Marc Moss, Lora A Reineck, Eileen Rubin, Eric P Schmidt, Theodore J Standiford, Lorraine B Ware, Hector R Wong, Neil R Aggarwal, Carolyn S Calfee,

Acute respiratory distress syndrome (ARDS) is a heterogeneous clinical syndrome. Understanding of the complex pathways involved in lung injury pathogenesis, resolution, and repair has grown considerably in recent decades. Nevertheless, to date, only therapies targeting ventilation-induced lung injury have consistently proven beneficial, and despite these gains, ARDS morbidity and mortality ... Read more >>

Lancet Respir Med (The Lancet. Respiratory medicine)
[2021, :]

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Variation in Initial U.S. Hospital Responses to the Coronavirus Disease 2019 Pandemic.

Kusum S Mathews, Kevin P Seitz, Kelly C Vranas, Abhijit Duggal, Thomas S Valley, Bo Zhao, Stephanie Gundel, Michael O Harhay, Steven Y Chang, Catherine L Hough, ,

<h4>Objectives</h4>The coronavirus disease 2019 pandemic has strained many healthcare systems. In response, U.S. hospitals altered their care delivery systems, but there are few data regarding specific structural changes. Understanding these changes is important to guide interpretation of outcomes and inform pandemic preparedness. We sought to characterize emergency responses across hospitals ... Read more >>

Crit Care Med (Critical care medicine)
[2021, 49(7):1038-1048]

Cited: 1 time

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Diagnosis and Treatment of Right Heart Failure in Pulmonary Vascular Diseases: A National Heart, Lung, and Blood Institute Workshop.

Jane A Leopold, Steven M Kawut, Micheala A Aldred, Stephen L Archer, Ray L Benza, Michael R Bristow, Evan L Brittain, Naomi Chesler, Frances S DeMan, Serpil C Erzurum, Mark T Gladwin, Paul M Hassoun, Anna R Hemnes, Tim Lahm, Joao A C Lima, Joseph Loscalzo, Bradley A Maron, Laura Mercer Rosa, John H Newman, Susan Redline, Stuart Rich, Franz Rischard, Lissa Sugeng, W H Wilson Tang, Ryan J Tedford, Emily J Tsai, Corey E Ventetuolo, YouYang Zhou, Neil R Aggarwal, Lei Xiao,

Right ventricular dysfunction is a hallmark of advanced pulmonary vascular, lung parenchymal, and left heart disease, yet the underlying mechanisms that govern (mal)adaptation remain incompletely characterized. Owing to the knowledge gaps in our understanding of the right ventricle (RV) in health and disease, the National Heart, Lung, and Blood Institute ... Read more >>

Circ Heart Fail (Circulation. Heart failure)
[2021, 14(6):]

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NHLBI-CMREF Workshop Report on Pulmonary Vascular Disease Classification: JACC State-of-the-Art Review.

William M Oldham, Anna R Hemnes, Micheala A Aldred, John Barnard, Evan L Brittain, Stephen Y Chan, Feixiong Cheng, Michael H Cho, Ankit A Desai, Joe G N Garcia, Mark W Geraci, Susan D Ghiassian, Kathryn T Hall, Evelyn M Horn, Mohit Jain, Rachel S Kelly, Jane A Leopold, Sara Lindstrom, Brian D Modena, William C Nichols, Christopher J Rhodes, Wei Sun, Andrew J Sweatt, Rebecca R Vanderpool, Martin R Wilkins, Beth Wilmot, Roham T Zamanian, Joshua P Fessel, Neil R Aggarwal, Joseph Loscalzo, Lei Xiao,

The National Heart, Lung, and Blood Institute and the Cardiovascular Medical Research and Education Fund held a workshop on the application of pulmonary vascular disease omics data to the understanding, prevention, and treatment of pulmonary vascular disease. Experts in pulmonary vascular disease, omics, and data analytics met to identify knowledge ... Read more >>

J Am Coll Cardiol (Journal of the American College of Cardiology)
[2021, 77(16):2040-2052]

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A Neutralizing Monoclonal Antibody for Hospitalized Patients with Covid-19.

, Jens D Lundgren, Birgit Grund, Christina E Barkauskas, Thomas L Holland, Robert L Gottlieb, Uriel Sandkovsky, Samuel M Brown, Kirk U Knowlton, Wesley H Self, D Clark Files, Mamta K Jain, Thomas Benfield, Michael E Bowdish, Bradley G Leshnower, Jason V Baker, Jens-Ulrik Jensen, Edward M Gardner, Adit A Ginde, Estelle S Harris, Isik S Johansen, Norman Markowitz, Michael A Matthay, Lars Østergaard, Christina C Chang, Victoria J Davey, Anna Goodman, Elizabeth S Higgs, Daniel D Murray, Thomas A Murray, Roger Paredes, Mahesh K B Parmar, Andrew N Phillips, Cavan Reilly, Shweta Sharma, Robin L Dewar, Marc Teitelbaum, Deborah Wentworth, Huyen Cao, Paul Klekotka, Abdel G Babiker, Annetine C Gelijns, Virginia L Kan, Mark N Polizzotto, B Taylor Thompson, H Clifford Lane, James D Neaton,

<h4>Background</h4>LY-CoV555, a neutralizing monoclonal antibody, has been associated with a decrease in viral load and the frequency of hospitalizations or emergency department visits among outpatients with coronavirus disease 2019 (Covid-19). Data are needed on the effect of this antibody in patients who are hospitalized with Covid-19.<h4>Methods</h4>In this platform trial of ... Read more >>

N Engl J Med (The New England journal of medicine)
[2021, 384(10):905-914]

Cited: 76 times

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Rationale and Design of ORCHID: A Randomized Placebo-controlled Clinical Trial of Hydroxychloroquine for Adults Hospitalized with COVID-19.

Jonathan D Casey, Nicholas J Johnson, Matthew W Semler, Sean P Collins, Neil R Aggarwal, Roy G Brower, Steven Y Chang, John Eppensteiner, Michael Filbin, Kevin W Gibbs, Adit A Ginde, Michelle N Gong, Frank Harrell, Douglas L Hayden, Catherine L Hough, Akram Khan, Lindsay M Leither, Marc Moss, Cathryn F Oldmixon, Pauline K Park, Lora A Reineck, Nancy J Ringwood, Bryce R H Robinson, David A Schoenfeld, Nathan I Shapiro, Jay S Steingrub, Donna K Torr, Alexandra Weissman, Christopher J Lindsell, Todd W Rice, B Taylor Thompson, Samuel M Brown, Wesley H Self,

The ORCHID (Outcomes Related to COVID-19 treated with Hydroxychloroquine among In-patients with symptomatic Disease) trial is a multicenter, blinded, randomized trial of hydroxychloroquine versus placebo for the treatment of adults hospitalized with coronavirus disease (COVID-19). This document provides the rationale and background for the trial and highlights key design features. ... Read more >>

Ann Am Thorac Soc (Annals of the American Thoracic Society)
[2020, 17(9):1144-1153]

Cited: 6 times

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Identifying Clinical Research Priorities in Adult Pulmonary and Critical Care: NHLBI Working Group Report.

Matthew W Semler, Gordon R Bernard, Shawn D Aaron, Derek C Angus, Michelle H Biros, Roy G Brower, Carolyn S Calfee, Elizabeth A Colantuoni, Niall D Ferguson, Michelle N Gong, Ramona O Hopkins, Catherine L Hough, Theodore J Iwashyna, Bruce D Levy, Thomas R Martin, Michael A Matthay, Joseph P Mizgerd, Marc Moss, Dale M Needham, Wesley H Self, Christopher W Seymour, Renee D Stapleton, B Taylor Thompson, Richard G Wunderink, Neil R Aggarwal, Lora A Reineck,

Preventing, treating, and promoting recovery from critical illness due to pulmonary disease are foundational goals of the critical care community and the National Heart, Lung, and Blood Institute. Decades of clinical research in acute respiratory distress syndrome, acute respiratory failure, pneumonia, and sepsis have yielded improvements in supportive care, which ... Read more >>

Am J Respir Crit Care Med (American journal of respiratory and critical care medicine)
[2020, :]

Cited: 10 times

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A Perspective: Division of Lung Diseases at Fifty.

Gail G Weinmann, Thomas L Croxton, Neil R Aggarwal, Michael J Twery, James P Kiley, ,

Am J Respir Crit Care Med (American journal of respiratory and critical care medicine)
[2019, 200(12):1466-1471]

Cited: 1 time

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Rare Lung Disease Research: National Heart, Lung, and Blood Institute's Commitment to Partnership and Progress.

Louis J Vuga, Neil R Aggarwal, Lora A Reineck, Roya Kalantari, Koyeli Banerjee, James Kiley,

Chest (Chest)
[2019, 156(3):438-444]

Cited: 0 times

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Validation of a Host Response Assay, SeptiCyte LAB, for Discriminating Sepsis from Systemic Inflammatory Response Syndrome in the ICU.

Russell R Miller, Bert K Lopansri, John P Burke, Mitchell Levy, Steven Opal, Richard E Rothman, Franco R D'Alessio, Venkataramana K Sidhaye, Neil R Aggarwal, Robert Balk, Jared A Greenberg, Mark Yoder, Gourang Patel, Emily Gilbert, Majid Afshar, Jorge P Parada, Greg S Martin, Annette M Esper, Jordan A Kempker, Mangala Narasimhan, Adey Tsegaye, Stella Hahn, Paul Mayo, Tom van der Poll, Marcus J Schultz, Brendon P Scicluna, Peter Klein Klouwenberg, Antony Rapisarda, Therese A Seldon, Leo C McHugh, Thomas D Yager, Silvia Cermelli, Dayle Sampson, Victoria Rothwell, Richard Newman, Shruti Bhide, Brian A Fox, James T Kirk, Krupa Navalkar, Roy F Davis, Roslyn A Brandon, Richard B Brandon,

RATIONALE:A molecular test to distinguish between sepsis and systemic inflammation of noninfectious etiology could potentially have clinical utility. OBJECTIVES:This study evaluated the diagnostic performance of a molecular host response assay (SeptiCyte LAB) designed to distinguish between sepsis and noninfectious systemic inflammation in critically ill adults. METHODS:The study employed a prospective, ... Read more >>

Am J Respir Crit Care Med (American journal of respiratory and critical care medicine)
[2018, 198(7):903-913]

Cited: 19 times

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National Heart, Lung, and Blood Institute and American Association for Thoracic Surgery Workshop Report: Identifying collaborative clinical research priorities in lung transplantation.

Michael S Mulligan, David Weill, R Duane Davis, Jason D Christie, Farhood Farjah, Jonathan P Singer, Matthew Hartwig, Pablo G Sanchez, Daniel Kreisel, Lorraine B Ware, Christian Bermudez, Ramsey R Hachem, Michael J Weyant, Cynthia Gries, Jeremiah W Awori Hayanga, Bartley P Griffith, Laurie D Snyder, Jonah Odim, J Matthew Craig, Neil R Aggarwal, Lora A Reineck,

J Thorac Cardiovasc Surg (The Journal of thoracic and cardiovascular surgery)
[2018, 156(6):2355-2365]

Cited: 1 time

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Oxygen Exposure Resulting in Arterial Oxygen Tensions Above the Protocol Goal Was Associated With Worse Clinical Outcomes in Acute Respiratory Distress Syndrome.

Neil R Aggarwal, Roy G Brower, David N Hager, B Taylor Thompson, Giora Netzer, Carl Shanholtz, Adrian Lagakos, William Checkley, ,

<h4>Objectives</h4>High fractions of inspired oxygen may augment lung damage to exacerbate lung injury in patients with acute respiratory distress syndrome. Participants enrolled in Acute Respiratory Distress Syndrome Network trials had a goal partial pressure of oxygen in arterial blood range of 55-80 mm Hg, yet the effect of oxygen exposure ... Read more >>

Crit Care Med (Critical care medicine)
[2018, 46(4):517-524]

Cited: 16 times

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Correction: Immunological Priming Requires Regulatory T Cells and IL-10-Producing Macrophages To Accelerate Resolution from Severe Lung Inflammation.

Neil R Aggarwal, Kenji Tsushima, Yoshiki Eto, Ashutosh Tripathi, Pooja Mandke, Jason R Mock, Brian T Garibaldi, Benjamin D Singer, Venkataramana K Sidhaye, Maureen R Horton, Landon S King, Franco R D'Alessio,

J Immunol (Journal of immunology (Baltimore, Md. : 1950))
[2016, 196(9):3963-3965]

Cited: 0 times

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Flow-cytometric method for simultaneous analysis of mouse lung epithelial, endothelial, and hematopoietic lineage cells.

Benjamin D Singer, Jason R Mock, Franco R D'Alessio, Neil R Aggarwal, Pooja Mandke, Laura Johnston, Mahendra Damarla,

Flow cytometry is a powerful tool capable of simultaneously analyzing multiple parameters on a cell-by-cell basis. Lung tissue preparation for flow cytometry requires creation of a single-cell suspension, which often employs enzymatic and mechanical dissociation techniques. These practices may damage cells and cause cell death that is unrelated to the ... Read more >>

Am J Physiol Lung Cell Mol Physiol (American journal of physiology. Lung cellular and molecular physiology)
[2016, 310(9):L796-801]

Cited: 29 times

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Searching for the Source: Bacteremia with Marked Cerebrospinal Fluid Pleocytosis.

Souvik Chatterjee, Alan N Baer, Marinos Kontzialis, Neil R Aggarwal, Allan C Gelber,

Am J Med (The American journal of medicine)
[2016, 129(1):44-47]

Cited: 0 times

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Regulatory T cell DNA methyltransferase inhibition accelerates resolution of lung inflammation.

Benjamin D Singer, Jason R Mock, Neil R Aggarwal, Brian T Garibaldi, Venkataramana K Sidhaye, Marcus A Florez, Eric Chau, Kevin W Gibbs, Pooja Mandke, Ashutosh Tripathi, Srinivasan Yegnasubramanian, Landon S King, Franco R D'Alessio,

Acute respiratory distress syndrome (ARDS) is a common and often fatal inflammatory lung condition without effective targeted therapies. Regulatory T cells (Tregs) resolve lung inflammation, but mechanisms that enhance Tregs to promote resolution of established damage remain unknown. DNA demethylation at the forkhead box protein 3 (Foxp3) locus and other ... Read more >>

Am J Respir Cell Mol Biol (American journal of respiratory cell and molecular biology)
[2015, 52(5):641-652]

Cited: 47 times

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Targeting normoxemia in acute respiratory distress syndrome may cause worse short-term outcomes because of oxygen toxicity.

Neil R Aggarwal, Roy G Brower,

It was suggested that targeting normoxemia (PaO2 85-110 mm Hg) in patients with acute respiratory distress syndrome (ARDS) might prevent neurocognitive dysfunction in survivors. However, targeting normoxemia may cause detrimental effects to the lungs from oxygen toxicity. Some have suggested that oxygen is not harmful to the lungs at FiO2 ... Read more >>

Ann Am Thorac Soc (Annals of the American Thoracic Society)
[2014, 11(9):1449-1453]

Cited: 13 times

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Therapeutic exercise attenuates neutrophilic lung injury and skeletal muscle wasting.

D Clark Files, Chun Liu, Andrea Pereyra, Zhong-Min Wang, Neil R Aggarwal, Franco R D'Alessio, Brian T Garibaldi, Jason R Mock, Benjamin D Singer, Xin Feng, Raghunatha R Yammani, Tan Zhang, Amy L Lee, Sydney Philpott, Stephanie Lussier, Lina Purcell, Jeff Chou, Michael Seeds, Landon S King, Peter E Morris, Osvaldo Delbono,

Early mobilization of critically ill patients with the acute respiratory distress syndrome (ARDS) has emerged as a therapeutic strategy that improves patient outcomes, such as the duration of mechanical ventilation and muscle strength. Despite the apparent efficacy of early mobility programs, their use in clinical practice is limited outside of ... Read more >>

Sci Transl Med (Science translational medicine)
[2015, 7(278):278ra32]

Cited: 20 times

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Immunological priming requires regulatory T cells and IL-10-producing macrophages to accelerate resolution from severe lung inflammation.

Neil R Aggarwal, Kenji Tsushima, Yoshiki Eto, Ashutosh Tripathi, Pooja Mandke, Jason R Mock, Brian T Garibaldi, Benjamin D Singer, Venkataramana K Sidhaye, Maureen R Horton, Landon S King, Franco R D'Alessio,

Overwhelming lung inflammation frequently occurs following exposure to both direct infectious and noninfectious agents and is a leading cause of mortality worldwide. In that context, immunomodulatory strategies may be used to limit severity of impending organ damage. We sought to determine whether priming the lung by activating the immune system, ... Read more >>

J Immunol (Journal of immunology (Baltimore, Md. : 1950))
[2014, 192(9):4453-4464]

Cited: 24 times

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Aquaporin 5 regulates cigarette smoke induced emphysema by modulating barrier and immune properties of the epithelium.

Neil R Aggarwal, Eric Chau, Brian T Garibaldi, Jason R Mock, Thomas Sussan, Keshav Rao, Kaavya Rao, Anil G Menon, Franco R D'Alessio, Mahendra Damarla, Shyam Biswal, Landon S King, Venkataramana K Sidhaye,

Chronic obstructive pulmonary disease (COPD) causes significant morbidity and mortality. Cigarette smoke, the most common risk factor for COPD, induces airway and alveolar epithelial barrier permeability and initiates an innate immune response. Changes in abundance of aquaporin 5 (AQP5), a water channel, can affect epithelial permeability and immune response after ... Read more >>

Tissue Barriers (Tissue barriers)
[2013, 1(4):e25248]

Cited: 13 times

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Macrophage A2A adenosinergic receptor modulates oxygen-induced augmentation of murine lung injury.

Neil R Aggarwal, Franco R D'Alessio, Yoshiki Eto, Eric Chau, Claudia Avalos, Adam T Waickman, Brian T Garibaldi, Jason R Mock, Daniel C Files, Venkataramana Sidhaye, Vsevolod Y Polotsky, Jonathan Powell, Maureen Horton, Landon S King,

Acute respiratory distress syndrome (ARDS) causes significant morbidity and mortality. Exacerbating factors increasing the risk of ARDS remain unknown. Supplemental oxygen is often necessary in both mild and severe lung disease. The potential effects of supplemental oxygen may include augmentation of lung inflammation by inhibiting anti-inflammatory pathways in alveolar macrophages. ... Read more >>

Am J Respir Cell Mol Biol (American journal of respiratory cell and molecular biology)
[2013, 48(5):635-646]

Cited: 15 times

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Regulatory T cells reduce acute lung injury fibroproliferation by decreasing fibrocyte recruitment.

Brian T Garibaldi, Franco R D'Alessio, Jason R Mock, D Clark Files, Eric Chau, Yoshiki Eto, M Bradley Drummond, Neil R Aggarwal, Venkataramana Sidhaye, Landon S King,

Acute lung injury (ALI) causes significant morbidity and mortality. Fibroproliferation in ALI results in worse outcomes, but the mechanisms governing fibroproliferation remain poorly understood. Regulatory T cells (Tregs) are important in lung injury resolution. Their role in fibroproliferation is unknown. We sought to identify the role of Tregs in ALI ... Read more >>

Am J Respir Cell Mol Biol (American journal of respiratory cell and molecular biology)
[2013, 48(1):35-43]

Cited: 79 times

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Effect of chronic intermittent hypoxia on triglyceride uptake in different tissues.

Qiaoling Yao, Mi-Kyung Shin, Jonathan C Jun, Karen L Hernandez, Neil R Aggarwal, Jason R Mock, Jason Gay, Luciano F Drager, Vsevolod Y Polotsky,

Chronic intermittent hypoxia (CIH) inhibits plasma lipoprotein clearance and adipose lipoprotein lipase (LPL) activity in association with upregulation of an LPL inhibitor angiopoietin-like protein 4 (Angptl4). We hypothesize that CIH inhibits triglyceride (TG) uptake via Angptl4 and that an anti-Angptl4-neutralizing antibody would abolish the effects of CIH. Male C57BL/6J mice ... Read more >>

J Lipid Res (Journal of lipid research)
[2013, 54(4):1058-1065]

Cited: 31 times

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A critical role for muscle ring finger-1 in acute lung injury-associated skeletal muscle wasting.

D Clark Files, Franco R D'Alessio, Laura F Johnston, Priya Kesari, Neil R Aggarwal, Brian T Garibaldi, Jason R Mock, Jessica L Simmers, Antonio DeGorordo, Jared Murdoch, Monte S Willis, Cam Patterson, Clarke G Tankersley, Maria L Messi, Chun Liu, Osvaldo Delbono, J David Furlow, Sue C Bodine, Ronald D Cohn, Landon S King, Michael T Crow,

<h4>Rationale</h4>Acute lung injury (ALI) is a debilitating condition associated with severe skeletal muscle weakness that persists in humans long after lung injury has resolved. The molecular mechanisms underlying this condition are unknown.<h4>Objectives</h4>To identify the muscle-specific molecular mechanisms responsible for muscle wasting in a mouse model of ALI.<h4>Methods</h4>Changes in skeletal muscle ... Read more >>

Am J Respir Crit Care Med (American journal of respiratory and critical care medicine)
[2012, 185(8):825-834]

Cited: 53 times

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