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Author Neda Nasheri

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Survival and Inactivation by Advanced Oxidative Process of Foodborne Viruses in Model Low-Moisture Foods

Neda Nasheri, Jennifer Harlow, Angela Chen, Forest Dussault, Nathalie Corneau, Sabah Bidawid,

Abstract Enteric viruses, such as human norovirus (NoV) and hepatitis A virus (HAV), are the major causes of foodborne illnesses worldwide. These viruses are shed in high numbers, have low infectious dose, and may remain infectious for weeks in the environment and food. While numerous viral survival studies have been ... Read more >>

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Evaluation of Bead-Based Assays for the Isolation of Foodborne Viruses from Low-Moisture Foods.

Neda Nasheri, Jennifer Harlow, Angela Chen, Nathalie Corneau, Sabah Bidawid,

ABSTRACT:Foodborne viruses such as norovirus and hepatitis A virus (HAV) are highly transmissible, persistent in the environment, and resistant to many conventional inactivation methods. Foods can become contaminated with these viruses either at the source of harvest or during food handling and processing. Multiple lines of evidence suggest that foodborne ... Read more >>

J. Food Prot. (Journal of food protection)
[2020, 83(3):388-396]

Cited: 0 times

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Evaluation of porcine gastric mucin assay for detection and quantification of human norovirus in fresh herbs and leafy vegetables

Menka Suresh, Jennifer Harlow, Neda Nasheri,

Leafy vegetables and fresh herbs are important parts of a healthy diet, however, they can be common vehicles of norovirus (NoV) infection and lead to serious health and economic concerns globally. NoV is highly infectious and persistent in the food and the environment, while being resistant to conventional food decontamination ... Read more >>

Food Microbiol. (Food microbiology)
[2019, 84:Not Available]

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Evaluation of porcine gastric mucin assay for detection and quantification of human norovirus in fresh herbs and leafy vegetables.

Menka Suresh, Jennifer Harlow, Neda Nasheri,

Leafy vegetables and fresh herbs are important parts of a healthy diet, however, they can be common vehicles of norovirus (NoV) infection and lead to serious health and economic concerns globally. NoV is highly infectious and persistent in the food and the environment, while being resistant to conventional food decontamination ... Read more >>

Food Microbiol. (Food microbiology)
[2019, 84:103254]

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Evaluation of High-Pressure Processing in Inactivation of the Hepatitis E Virus

Neda Nasheri, Tanushka Doctor, Angela Chen, Jennifer Harlow, Alexander Gill,

Hepatitis E virus (HEV) causes acute hepatitis with approximately 20 million cases per year globally. While HEV is endemic in certain regions of Asia, Africa and South America, it is considered an emerging foodborne pathogen in developed countries. Based on genetic diversity, HEV is classified into different genotypes, with genotype ... Read more >>

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Genetic characterization of norovirus GII.4 variants circulating in Canada using a metagenomic technique.

Nicholas Petronella, Jennifer Ronholm, Menka Suresh, Jennifer Harlow, Oksana Mykytczuk, Nathalie Corneau, Sabah Bidawid, Neda Nasheri,

BACKGROUND:Human norovirus is the leading cause of viral gastroenteritis globally, and the GII.4 has been the most predominant genotype for decades. This genotype has numerous variants that have caused repeated epidemics worldwide. However, the molecular evolutionary signatures among the GII.4 variants have not been elucidated throughout the viral genome. METHOD:A ... Read more >>

BMC Infect. Dis. (BMC infectious diseases)
[2018, 18(1):521]

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Characterization of the Genomic Diversity of Norovirus in Linked Patients Using a Metagenomic Deep Sequencing Approach.

Neda Nasheri, Nicholas Petronella, Jennifer Ronholm, Sabah Bidawid, Nathalie Corneau,

Norovirus (NoV) is the leading cause of gastroenteritis worldwide. A robust cell culture system does not exist for NoV and therefore detailed characterization of outbreak and sporadic strains relies on molecular techniques. In this study, we employed a metagenomic approach that uses non-specific amplification followed by next-generation sequencing to whole ... Read more >>

Front Microbiol (Frontiers in Microbiology)
[2017, 8:73]

Cited: 7 times

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Prevalence and Molecular Characterization of the Hepatitis E Virus in Retail Pork Products Marketed in Canada.

Oksana Mykytczuk, Jennifer Harlow, Sabah Bidawid, Nathalie Corneau, Neda Nasheri,

Infection with the hepatitis E virus (HEV) is very common worldwide. HEV causes acute viral hepatitis with approximately 20 million cases per year. While HEV genotypes 1 and 2 cause large waterborne and foodborne outbreaks with a significant mortality in developing countries, genotypes 3 and 4 are more prevalent in ... Read more >>

Food Environ Virol (Food and environmental virology)
[2017, 9(2):208-218]

Cited: 12 times

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Activity-based profiling of the proteasome pathway during hepatitis C virus infection.

Neda Nasheri, Zhibin Ning, Daniel Figeys, Shao Yao, Natalie K Goto, John Paul Pezacki,

Hepatitis C virus (HCV) infection often leads to chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma. The stability of the HCV proteins is controlled by ubiquitin-dependent and ubiquitin-independent proteasome pathways. Many viruses modulate proteasome function for their propagation. To examine the interrelationship between HCV and the proteasome pathways we employed a ... Read more >>

Proteomics (Proteomics)
[2015, 15(22):3815-3825]

Cited: 1 time

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Profiling Kinase Activity during Hepatitis C Virus Replication Using a Wortmannin Probe.

Geneviève F Desrochers, Allison R Sherratt, David R Blais, Neda Nasheri, Zhibin Ning, Daniel Figeys, Natalie K Goto, John Paul Pezacki,

To complete its life cycle, the hepatitis C virus (HCV) induces changes to numerous aspects of its host cell. As kinases act as regulators of many pathways utilized by HCV, they are likely enzyme targets for virally induced inhibition or activation. Herein, we used activity-based protein profiling (ABPP), which allows ... Read more >>

ACS Infect Dis (ACS infectious diseases)
[2015, 1(9):443-452]

Cited: 2 times

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Hydrophobic triaryl-substituted β-lactams as activity-based probes for profiling eukaryotic enzymes and host-pathogen interactions.

Neda Nasheri, Craig S McKay, Kelly Fulton, Susan Twine, Megan H Powdrill, Allison R Sherratt, John Paul Pezacki,

Chembiochem (Chembiochem : a European journal of chemical biology)
[2014, 15(15):2195-2200]

Cited: 3 times

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A new chemical probe for phosphatidylinositol kinase activity.

Allison R Sherratt, Neda Nasheri, Craig S McKay, Shifawn O'Hara, Ashley Hunt, Zhibin Ning, Daniel Figeys, Natalie K Goto, John Paul Pezacki,

Phosphatidylinositol kinases (PIKs) are key enzymatic regulators of membrane phospholipids and membrane environments that control many aspects of cellular function, from signal transduction to secretion, through the Golgi apparatus. Here, we have developed a photoreactive "clickable" probe, PIK-BPyne, to report the activity of PIKs. We investigated the selectivity and efficiency ... Read more >>

Chembiochem (Chembiochem : a European journal of chemical biology)
[2014, 15(9):1253-1256]

Cited: 4 times

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Hepatitis C virus induced up-regulation of microRNA-27: a novel mechanism for hepatic steatosis.

Ragunath Singaravelu, Ran Chen, Rodney K Lyn, Daniel M Jones, Shifawn O'Hara, Yanouchka Rouleau, Jenny Cheng, Prashanth Srinivasan, Neda Nasheri, Rodney S Russell, D Lorne Tyrrell, John Paul Pezacki,

MicroRNAs (miRNAs) are small RNAs that posttranscriptionally regulate gene expression. Their aberrant expression is commonly linked with diseased states, including hepatitis C virus (HCV) infection. Herein, we demonstrate that HCV replication induces the expression of miR-27 in cell culture and in vivo HCV infectious models. Overexpression of the HCV proteins ... Read more >>

Hepatology (Hepatology (Baltimore, Md.))
[2014, 59(1):98-108]

Cited: 50 times

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Modulation of fatty acid synthase enzyme activity and expression during hepatitis C virus replication.

Neda Nasheri, Michael Joyce, Yanouchka Rouleau, Pengyu Yang, Shao Yao, D Lorne Tyrrell, John Paul Pezacki,

The hepatitis C virus (HCV) induces alterations of host cells to facilitate its life cycle. Fatty acid synthase (FASN) is a multidomain enzyme that plays a key role in the biosynthesis of fatty acids and is upregulated during HCV infection. Herein, we applied activity-based protein profiling (ABPP) that allows for ... Read more >>

Chem. Biol. (Chemistry & biology)
[2013, 20(4):570-582]

Cited: 37 times

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Systems biology methods help develop a better understanding of hepatitis C virus-induced liver injury.

Ragunath Singaravelu, Neda Nasheri, Allison Sherratt, John Paul Pezacki,

Hepatology (Hepatology (Baltimore, Md.))
[2012, 56(1):1-4]

Cited: 3 times

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An enzyme-linked assay for the rapid quantification of microRNAs based on the viral suppressor of RNA silencing protein p19.

Neda Nasheri, Jenny Cheng, Ragunath Singaravelu, Peng Wu, Mark T McDermott, John Paul Pezacki,

MicroRNAs (miRNAs) are endogenous posttranscriptional regulators found in all metazoa and play crucial roles in virtually all cellular processes. Their aberrant expression has been linked to several diseased states; therefore, techniques capable of sensitive and specific profiling of the miRNA milieu will have significant application in prognostics, diagnostics, and therapeutics. ... Read more >>

Anal. Biochem. (Analytical biochemistry)
[2011, 412(2):165-172]

Cited: 17 times

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Enhanced specificity of the viral suppressor of RNA silencing protein p19 toward sequestering of human microRNA-122.

Jenny Cheng, Dana C Danielson, Neda Nasheri, Ragunath Singaravelu, John Paul Pezacki,

Tombusviruses express a 19 kDa protein (p19) that, as a dimeric protein, suppresses the RNAs silencing pathway during infection by binding short-interfering RNA (siRNA) and preventing their association with the RNA-induced silencing complex (RISC). The p19 protein can bind to both endogenous and synthetic siRNAs with a high degree of ... Read more >>

Biochemistry (Biochemistry)
[2011, 50(36):7745-7755]

Cited: 7 times

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The efficacy of siRNAs against hepatitis C virus is strongly influenced by structure and target site accessibility.

Selena M Sagan, Neda Nasheri, Christian Luebbert, John Paul Pezacki,

Hepatitis C virus (HCV) is a global health problem. Designing therapeutic agents that target HCV's RNA genome remains challenging. HCV genomic RNA is large and highly structured with long-range genome-scale ordered RNA structures. Predicting the secondary- and tertiary-structure elements that reveal the accessibility of target sites within HCV RNA is ... Read more >>

Chem. Biol. (Chemistry & biology)
[2010, 17(5):515-527]

Cited: 12 times

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Competing roles of microRNA-122 recognition elements in hepatitis C virus RNA.

Neda Nasheri, Ragunath Singaravelu, Matthew Goodmurphy, Rodney K Lyn, John Paul Pezacki,

MicroRNA-122 positively modulates hepatitis C virus (HCV) through direct interactions with viral RNA. Three microRNA-122 recognition elements (MREs) have been previously identified: two in the 5'UTR and one in the 3'UTR. Herein, we report the relative affinity of microRNA-122 to these sites using viral RNA-coated magnetic beads, with mutagenesis and ... Read more >>

Virology (Virology)
[2011, 410(2):336-344]

Cited: 21 times

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