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Author Navil Sethna

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Efficacy and safety of pharmacological, physical, and psychological interventions for the management of chronic pain in children: a WHO systematic review and meta-analysis.

Emma Fisher, Gemma Villanueva, Nicholas Henschke, Sarah J Nevitt, William Zempsky, Katrin Probyn, Brian Buckley, Tess E Cooper, Navil Sethna, Christopher Eccleston,

<h4>Abstract</h4>Chronic pain in childhood is an international public health problem. We conducted a systematic review and meta-analysis to provide a summary of the published evidence of pharmacological, physical, and psychological therapies for children with chronic pain conditions. We searched CENTRAL, MEDLINE, EMBASE, and PsycINFO from inception to April 2020; clinical ... Read more >>

Pain (Pain)
[2021, :]

Cited: 0 times

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Pain stickiness in pediatric complex regional pain syndrome: A role for the nucleus accumbens.

Andrew M Youssef, Ke Peng, Pearl Kijoo Kim, Alyssa Lebel, Navil F Sethna, Corey Kronman, David Zurakowski, David Borsook, Laura E Simons,

Some individuals with chronic pain experience improvement in their pain with treatment, whereas others do not. The neurobiological reason is unclear, but an understanding of brain structure and functional patterns may provide insights into pain's responsivity to treatment. In this investigation, we used magnetic resonance imaging (MRI) techniques to determine ... Read more >>

Neurobiol Pain (Neurobiology of pain (Cambridge, Mass.))
[2021, 9:100062]

Cited: 0 times

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Antinociceptive effect of vapocoolant medium stream spray on hotplate latency in rat pups.

Navil F Sethna, Brenden Fish, Barak Yahalom, Birgitta Schmidt, David Zurakowski,

<h4>Background</h4>Heel sticks account for most blood tests performed in neonates without analgesia because topical local anesthetics are ineffective on heel glabrous skin. We investigated the antinociceptive effect of an alternative topical analgesic, a vapocoolant spray, on hind paw glabrous skin of rat pups. The spray was applied by two methods: ... Read more >>

Paediatr Anaesth (Paediatric anaesthesia)
[2021, 31(3):330-337]

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Offset analgesia identifies impaired endogenous pain modulation in pediatric chronic pain disorders.

Julie Shulman, David Zurakowski, Julie Keysor, Kelsey Jervis, Navil F Sethna,

Offset analgesia (OA), a psychophysical test of endogenous pain inhibition, is diminished in many adult chronic pain disorders but OA has not been investigated in youth with chronic pain disorders. This study assessed OA responses in 30 youth with chronic primary and secondary pain disorders and 32 healthy controls. The ... Read more >>

Pain (Pain)
[2020, 161(12):2852-2859]

Cited: 1 time

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Variation in pediatric local anesthetic dosing for peripheral nerve blocks: an analysis from the Pediatric Regional Anesthesia Network (PRAN).

Andreas H Taenzer, Michael Herrick, Matthew Hoyt, R J Ramamurthi, Benjamin Walker, Sean H Flack, Adrian Bosenberg, Andrew Franklin, David M Polaner, , ,

<h4>Background</h4>Variation of local anesthetic dosing has been reported for adult peripheral nerve blocks (PNBs) and infant caudal blocks. As higher doses of local anesthetics (LA) are potentially associated with increased risk of complications (eg, local anesthetic systemic toxicity), it is important to understand the source of LA dose variation. Using ... Read more >>

Reg Anesth Pain Med (Regional anesthesia and pain medicine)
[2020, 45(12):964-969]

Cited: 0 times

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Variation Between and Within Hospitals in Single Injection Caudal Local Anesthetic Dose: A Report From the Pediatric Regional Anesthesia Network.

Andreas H Taenzer, Matthew Hoyt, Elliot J Krane, Benjamin J Walker, Sean Flack, Adrian Bosenberg, Navil F Sethna, Andrew D Franklin, David M Polaner, ,

BACKGROUND:Given that variation exists in health care utilization, expenditure, and medical practice, there is a paucity of data on variation within the practice of anesthesia. The Pediatric Regional Anesthesia Network (PRAN) data lend itself to explore whether different medical practice patterns exist and if there are nerve blocks with more ... Read more >>

Anesth Analg (Anesthesia and analgesia)
[2020, 130(6):1693-1701]

Cited: 1 time

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Does intensive interdisciplinary pain treatment improve pediatric headache-related disability?

Julie Shulman, Caitlin Conroy, Anna Cybulski, Kelly R Smith, Kelsey Jervis, Hannah Johnson, David Zurakowski, Navil F Sethna,

Purpose: To examine the effectiveness of intensive interdisciplinary pain treatment for improving disability in children with chronic headache using the International Classification of Functioning, Disability and Health model as a conceptual framework for disability assessment.Materials and methods: Children with chronic headache (n = 50; ages 10-19 years; 62% female) attended an intensive interdisciplinary ... Read more >>

Disabil Rehabil (Disability and rehabilitation)
[2020, :1-8]

Cited: 1 time

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Pain Stickiness in Complex Regional Pain Syndrome: A role for the Nucleus Accumbens

Andrew Youssef, Ke Peng, Pearl Kijoo Kim, Alyssa Lebel, Navil Sethna, Corey Kronman, David Zurakowski, David Borsook, Laura Simons,

Some individuals with chronic pain experience improvement in their pain with treatment, whereas others do not. The neurobiological reason is unclear, but an understanding of brain structure and functional patterns may provide insights into pain’s responsivity to treatment. In this investigation, we used magnetic resonance imaging (MRI) techniques to determine ... Read more >>

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Pharmacological interventions for chronic pain in children: an overview of systematic reviews.

Christopher Eccleston, Emma Fisher, Tess E Cooper, Marie-Claude Grégoire, Lauren C Heathcote, Elliot Krane, Susan M Lord, Navil F Sethna, Anna-Karenia Anderson, Brian Anderson, Jacqueline Clinch, Andrew L Gray, Jeffrey I Gold, Richard F Howard, Gustaf Ljungman, R Andrew Moore, Neil Schechter, Philip J Wiffen, Nick M R Wilkinson, David G Williams, Chantal Wood, Miranda A L van Tilburg, Boris Zernikow,

We know little about the safety or efficacy of pharmacological medicines for children and adolescents with chronic pain, despite their common use. Our aim was to conduct an overview review of systematic reviews of pharmacological interventions that purport to reduce pain in children with chronic noncancer pain (CNCP) or chronic ... Read more >>

Pain (Pain)
[2019, 160(8):1698-1707]

Cited: 7 times

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Sleep deficiency and chronic pain: potential underlying mechanisms and clinical implications.

Monika Haack, Norah Simpson, Navil Sethna, Satvinder Kaur, Janet Mullington,

Pain can be both a cause and a consequence of sleep deficiency. This bidirectional relationship between sleep and pain has important implications for clinical management of patients, but also for chronic pain prevention and public health more broadly. The review that follows will provide an overview of the neurobiological evidence ... Read more >>

Neuropsychopharmacology (Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology)
[2020, 45(1):205-216]

Cited: 17 times

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Shifting brain circuits in pain chronicity.

Andrew M Youssef, Monica Azqueta-Gavaldon, Katie E Silva, Nadia Barakat, Natalia Lopez, Farah Mahmud, Alyssa Lebel, Navil F Sethna, David Zurakowski, Laura E Simons, Eduard Kraft, David Borsook,

The evaluation of brain changes to a specific pain condition in pediatric and adult patients allows for insights into potential mechanisms of pain chronicity and possibly long-term brain changes. Here we focused on the primary somatosensory system (SS) involved in pain processing, namely the ventroposterolateral thalamus (VPL) and the primary ... Read more >>

Hum Brain Mapp (Human brain mapping)
[2019, 40(15):4381-4396]

Cited: 2 times

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The Society for Pediatric Anesthesia recommendations for the use of opioids in children during the perioperative period.

Joseph P Cravero, Rita Agarwal, Charles Berde, Patrick Birmingham, Charles J Coté, Jeffrey Galinkin, Lisa Isaac, Sabine Kost-Byerly, David Krodel, Lynne Maxwell, Terri Voepel-Lewis, Navil Sethna, Robert Wilder,

Opioids have long held a prominent role in the management of perioperative pain in adults and children. Published reports concerning the appropriate, and inappropriate, use of these medications in pediatric patients have appeared in various publications over the last 50 years. For this document, the Society for Pediatric Anesthesia appointed a ... Read more >>

Paediatr Anaesth (Paediatric anaesthesia)
[2019, 29(6):547-571]

Cited: 3 times

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Youth With Chronic Pain and a History of Adverse Childhood Experiences in the Context of Multidisciplinary Pain Rehabilitation.

Sarah Nelson, Kelly Smith, Navil Sethna, Deirdre Logan,

OBJECTIVES:Previous research has shown that youth with chronic pain who presented for a multidisciplinary evaluation report a history of adverse childhood experiences (ACEs) (eg, abuse, neglect, parent/guardian separation or divorce) at a high rate (over 80%) and that those with pain and ACEs experience increased psychosocial impairment. Outside of chronic ... Read more >>

Clin J Pain (The Clinical journal of pain)
[2019, 35(5):420-427]

Cited: 3 times

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Physical Therapy Outcome Measures for Assessment of Lower Extremity Chronic Pain-Related Function in Pediatrics.

Elizabeth Mirek, Deirdre Logan, Kimberly Boullard, Amber M Hall, Steven J Staffa, Navil Sethna,

<h4>Purpose</h4>To assess the clinical utility of 5 physical therapy (PT) outcome measures in quantifying functional changes in pediatric lower extremity chronic pain treated at a hospital-based interdisciplinary rehabilitation center.<h4>Design</h4>This was a cross-sectional study with retrospective review of 173 individuals, 8 to 18 years old, treated from June 2008 to 2013.<h4>Methods</h4>The ... Read more >>

Pediatr Phys Ther (Pediatric physical therapy : the official publication of the Section on Pediatrics of the American Physical Therapy Association)
[2019, 31(2):200-207]

Cited: 2 times

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Neurodevelopmental outcome at 5 years of age after general anaesthesia or awake-regional anaesthesia in infancy (GAS): an international, multicentre, randomised, controlled equivalence trial.

Mary Ellen McCann, Jurgen C de Graaff, Liam Dorris, Nicola Disma, Davinia Withington, Graham Bell, Anneke Grobler, Robyn Stargatt, Rodney W Hunt, Suzette J Sheppard, Jacki Marmor, Gaia Giribaldi, David C Bellinger, Penelope L Hartmann, Pollyanna Hardy, Geoff Frawley, Francesca Izzo, Britta S von Ungern Sternberg, Anne Lynn, Niall Wilton, Martin Mueller, David M Polaner, Anthony R Absalom, Peter Szmuk, Neil Morton, Charles Berde, Sulpicio Soriano, Andrew J Davidson, ,

<h4>Background</h4>In laboratory animals, exposure to most general anaesthetics leads to neurotoxicity manifested by neuronal cell death and abnormal behaviour and cognition. Some large human cohort studies have shown an association between general anaesthesia at a young age and subsequent neurodevelopmental deficits, but these studies are prone to bias. Others have ... Read more >>

Lancet (Lancet (London, England))
[2019, 393(10172):664-677]

Cited: 62 times

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Tranexamic Acid Is Efficacious at Decreasing the Rate of Blood Loss in Adolescent Scoliosis Surgery: A Randomized Placebo-Controlled Trial.

Susan M Goobie, David Zurakowski, Michael P Glotzbecker, Mary E McCann, Daniel Hedequist, Robert M Brustowicz, Navil F Sethna, Lawerence I Karlin, John B Emans, M Timothy Hresko,

<h4>Background</h4>Tranexamic acid (TXA) is an antifibrinolytic drug that reduces surgical blood loss. Evidence supporting its efficacy in surgery for adolescent idiopathic scoliosis is not robust. This trial was designed to validate the clinical efficacy of TXA in surgery for adolescent idiopathic scoliosis.<h4>Methods</h4>This institutional review board-approved prospective double-blinded trial involved 111 ... Read more >>

J Bone Joint Surg Am (The Journal of bone and joint surgery. American volume)
[2018, 100(23):2024-2032]

Cited: 10 times

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Complications in Pediatric Regional Anesthesia: An Analysis of More than 100,000 Blocks from the Pediatric Regional Anesthesia Network.

Benjamin J Walker, Justin B Long, Madhankumar Sathyamoorthy, Jennifer Birstler, Christine Wolf, Adrian T Bosenberg, Sean H Flack, Elliot J Krane, Navil F Sethna, Santhanam Suresh, Andreas H Taenzer, David M Polaner, Lynn Martin, Corrie Anderson, Rani Sunder, Trevor Adams, Lizabeth Martin, Martha Pankovich, Amod Sawardekar, Patrick Birmingham, Ryan Marcelino, R J Ramarmurthi, Peter Szmuk, Galit Kastner Ungar, Sara Lozano, Karen Boretsky, Ranu Jain, Maria Matuszczak, Timothy R Petersen, Jennifer Dillow, Robert Power, Kim Nguyen, Benjamin H Lee, Lisa Chan, Jorge Pineda, Jacob Hutchins, Kimberly Mendoza, Kristen Spisak, Aali Shah, Kathryn DelPizzo, Naomi Dong, Vidya Yalamanchili, Claudia Venable, Cassandra Armstead Williams, Reena Chaudahari, Susumu Ohkawa, Helga Usljebrka, Tarun Bhalla, Pedro Paulo Vanzillotta, Seza Apiliogullari, Andrew D Franklin, Akiko Ando, Sophie R Pestieau, Caroline Wright, Julia Rosenbloom, Tony Anderson, ,

<h4>What we already know about this topic</h4>WHAT THIS ARTICLE TELLS US THAT IS NEW: BACKGROUND:: Complications in pediatric regional anesthesia are rare, so a large sample size is necessary to quantify risk. The Pediatric Regional Anesthesia Network contains data on more than 100,000 blocks administered at more than 20 children's ... Read more >>

Anesthesiology (Anesthesiology)
[2018, 129(4):721-732]

Cited: 18 times

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Back to Living: Long-term Functional Status of Pediatric Patients Who Completed Intensive Interdisciplinary Pain Treatment.

Edin T Randall, Kelly R Smith, Caitlin Conroy, Allison M Smith, Navil Sethna, Deirdre E Logan,

<h4>Objectives</h4>To provide a descriptive account of long-term functioning (≥5 y posttreatment) among youth who completed intensive interdisciplinary pain treatment (IIPT) for pediatric chronic pain conditions.<h4>Materials and methods</h4>A total of 95 patients (mean age at follow-up=20.0 y) treated at least 5 years previously at a single IIPT program completed questionnaires assessing pain, functional ... Read more >>

Clin J Pain (The Clinical journal of pain)
[2018, 34(10):890-899]

Cited: 2 times

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Nusinersen versus Sham Control in Later-Onset Spinal Muscular Atrophy.

Eugenio Mercuri, Basil T Darras, Claudia A Chiriboga, John W Day, Craig Campbell, Anne M Connolly, Susan T Iannaccone, Janbernd Kirschner, Nancy L Kuntz, Kayoko Saito, Perry B Shieh, Már Tulinius, Elena S Mazzone, Jacqueline Montes, Kathie M Bishop, Qingqing Yang, Richard Foster, Sarah Gheuens, C Frank Bennett, Wildon Farwell, Eugene Schneider, Darryl C De Vivo, Richard S Finkel, ,

BACKGROUND:Nusinersen is an antisense oligonucleotide drug that modulates pre-messenger RNA splicing of the survival motor neuron 2 ( SMN2) gene. It has been developed for the treatment of spinal muscular atrophy (SMA). METHODS:We conducted a multicenter, double-blind, sham-controlled, phase 3 trial of nusinersen in 126 children with SMA who had ... Read more >>

N Engl J Med (The New England journal of medicine)
[2018, 378(7):625-635]

Cited: 242 times

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Chronic exposure to insufficient sleep alters processes of pain habituation and sensitization.

Norah S Simpson, Jennifer Scott-Sutherland, Shiva Gautam, Navil Sethna, Monika Haack,

Chronic pain conditions are highly comorbid with insufficient sleep. While the mechanistic relationships between the 2 are not understood, chronic insufficient sleep may be 1 pathway through which central pain-modulatory circuits deteriorate, thereby contributing to chronic pain vulnerability over time. To test this hypothesis, an in-laboratory model of 3 weeks ... Read more >>

Pain (Pain)
[2018, 159(1):33-40]

Cited: 16 times

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Perioperative management of gastrostomy tube placement in Duchenne muscular dystrophy adolescent and young adult patients: A role for a perioperative surgical home.

Ariane Boivin, Richard Antonelli, Navil F Sethna,

BACKGROUND:In past decades, Duchenne muscular dystrophy patients have been living longer and as the disease advances, patients experience multisystemic deterioration. Older patients often require gastrostomy tube placement for nutritional support. For optimizing the perioperative care, a practice of multidisciplinary team can better anticipate, prevent, and manage possible complications and reduce ... Read more >>

Paediatr Anaesth (Paediatric anaesthesia)
[2018, 28(2):127-133]

Cited: 0 times

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Children With Chronic Pain: Response Trajectories After Intensive Pain Rehabilitation Treatment.

Laura E Simons, Christine B Sieberg, Caitlin Conroy, Edin T Randall, Julie Shulman, David Borsook, Charles Berde, Navil F Sethna, Deirdre E Logan,

Intensive pain rehabilitation programs for children with chronic pain are effective for many patients. However, characteristics associated with treatment response have not been well documented. In this article we report trajectories of pain and functional impairment in patients with chronic pain up to 1 year after intensive pain rehabilitation and ... Read more >>

J Pain (The journal of pain)
[2018, 19(2):207-218]

Cited: 16 times

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Nusinersen versus Sham Control in Infantile-Onset Spinal Muscular Atrophy.

Richard S Finkel, Eugenio Mercuri, Basil T Darras, Anne M Connolly, Nancy L Kuntz, Janbernd Kirschner, Claudia A Chiriboga, Kayoko Saito, Laurent Servais, Eduardo Tizzano, Haluk Topaloglu, Már Tulinius, Jacqueline Montes, Allan M Glanzman, Kathie Bishop, Z John Zhong, Sarah Gheuens, C Frank Bennett, Eugene Schneider, Wildon Farwell, Darryl C De Vivo, ,

<h4>Background</h4>Spinal muscular atrophy is an autosomal recessive neuromuscular disorder that is caused by an insufficient level of survival motor neuron (SMN) protein. Nusinersen is an antisense oligonucleotide drug that modifies pre-messenger RNA splicing of the SMN2 gene and thus promotes increased production of full-length SMN protein.<h4>Methods</h4>We conducted a randomized, double-blind, ... Read more >>

N Engl J Med (The New England journal of medicine)
[2017, 377(18):1723-1732]

Cited: 381 times

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Opioids for chronic non-cancer pain in children and adolescents.

Tess E Cooper, Emma Fisher, Andrew L Gray, Elliot Krane, Navil Sethna, Miranda Al van Tilburg, Boris Zernikow, Philip J Wiffen,

<h4>Background</h4>Pain is a common feature of childhood and adolescence around the world, and for many young people, that pain is chronic. The World Health Organization guidelines for pharmacological treatments for children's persisting pain acknowledge that pain in children is a major public health concern of high significance in most parts ... Read more >>

Cochrane Database Syst Rev (The Cochrane database of systematic reviews)
[2017, 7:CD012538]

Cited: 18 times

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Antiepileptic drugs for chronic non-cancer pain in children and adolescents.

Tess E Cooper, Philip J Wiffen, Lauren C Heathcote, Jacqui Clinch, Richard Howard, Elliot Krane, Susan M Lord, Navil Sethna, Neil Schechter, Chantal Wood,

<h4>Background</h4>Pain is a common feature of childhood and adolescence around the world, and for many young people, that pain is chronic. The World Health Organization (WHO) guidelines for pharmacological treatments for children's persisting pain acknowledge that pain in children is a major public health concern of high significance in most ... Read more >>

Cochrane Database Syst Rev (The Cochrane database of systematic reviews)
[2017, 8:CD012536]

Cited: 16 times

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