Full Text Journal Articles by
Author Navil F Sethna

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Pain stickiness in pediatric complex regional pain syndrome: A role for the nucleus accumbens.

Andrew M Youssef, Ke Peng, Pearl Kijoo Kim, Alyssa Lebel, Navil F Sethna, Corey Kronman, David Zurakowski, David Borsook, Laura E Simons,

Some individuals with chronic pain experience improvement in their pain with treatment, whereas others do not. The neurobiological reason is unclear, but an understanding of brain structure and functional patterns may provide insights into pain's responsivity to treatment. In this investigation, we used magnetic resonance imaging (MRI) techniques to determine ... Read more >>

Neurobiol Pain (Neurobiology of pain (Cambridge, Mass.))
[2021, 9:100062]

Cited: 0 times

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Antinociceptive effect of vapocoolant medium stream spray on hotplate latency in rat pups.

Navil F Sethna, Brenden Fish, Barak Yahalom, Birgitta Schmidt, David Zurakowski,

<h4>Background</h4>Heel sticks account for most blood tests performed in neonates without analgesia because topical local anesthetics are ineffective on heel glabrous skin. We investigated the antinociceptive effect of an alternative topical analgesic, a vapocoolant spray, on hind paw glabrous skin of rat pups. The spray was applied by two methods: ... Read more >>

Paediatr Anaesth (Paediatric anaesthesia)
[2021, 31(3):330-337]

Cited: 0 times

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Offset analgesia identifies impaired endogenous pain modulation in pediatric chronic pain disorders.

Julie Shulman, David Zurakowski, Julie Keysor, Kelsey Jervis, Navil F Sethna,

Offset analgesia (OA), a psychophysical test of endogenous pain inhibition, is diminished in many adult chronic pain disorders but OA has not been investigated in youth with chronic pain disorders. This study assessed OA responses in 30 youth with chronic primary and secondary pain disorders and 32 healthy controls. The ... Read more >>

Pain (Pain)
[2020, 161(12):2852-2859]

Cited: 1 time

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Variation Between and Within Hospitals in Single Injection Caudal Local Anesthetic Dose: A Report From the Pediatric Regional Anesthesia Network.

Andreas H Taenzer, Matthew Hoyt, Elliot J Krane, Benjamin J Walker, Sean Flack, Adrian Bosenberg, Navil F Sethna, Andrew D Franklin, David M Polaner, ,

BACKGROUND:Given that variation exists in health care utilization, expenditure, and medical practice, there is a paucity of data on variation within the practice of anesthesia. The Pediatric Regional Anesthesia Network (PRAN) data lend itself to explore whether different medical practice patterns exist and if there are nerve blocks with more ... Read more >>

Anesth Analg (Anesthesia and analgesia)
[2020, 130(6):1693-1701]

Cited: 1 time

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Does intensive interdisciplinary pain treatment improve pediatric headache-related disability?

Julie Shulman, Caitlin Conroy, Anna Cybulski, Kelly R Smith, Kelsey Jervis, Hannah Johnson, David Zurakowski, Navil F Sethna,

Purpose: To examine the effectiveness of intensive interdisciplinary pain treatment for improving disability in children with chronic headache using the International Classification of Functioning, Disability and Health model as a conceptual framework for disability assessment.Materials and methods: Children with chronic headache (n = 50; ages 10-19 years; 62% female) attended an intensive interdisciplinary ... Read more >>

Disabil Rehabil (Disability and rehabilitation)
[2020, :1-8]

Cited: 1 time

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Pharmacological interventions for chronic pain in children: an overview of systematic reviews.

Christopher Eccleston, Emma Fisher, Tess E Cooper, Marie-Claude Grégoire, Lauren C Heathcote, Elliot Krane, Susan M Lord, Navil F Sethna, Anna-Karenia Anderson, Brian Anderson, Jacqueline Clinch, Andrew L Gray, Jeffrey I Gold, Richard F Howard, Gustaf Ljungman, R Andrew Moore, Neil Schechter, Philip J Wiffen, Nick M R Wilkinson, David G Williams, Chantal Wood, Miranda A L van Tilburg, Boris Zernikow,

We know little about the safety or efficacy of pharmacological medicines for children and adolescents with chronic pain, despite their common use. Our aim was to conduct an overview review of systematic reviews of pharmacological interventions that purport to reduce pain in children with chronic noncancer pain (CNCP) or chronic ... Read more >>

Pain (Pain)
[2019, 160(8):1698-1707]

Cited: 10 times

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Shifting brain circuits in pain chronicity.

Andrew M Youssef, Monica Azqueta-Gavaldon, Katie E Silva, Nadia Barakat, Natalia Lopez, Farah Mahmud, Alyssa Lebel, Navil F Sethna, David Zurakowski, Laura E Simons, Eduard Kraft, David Borsook,

The evaluation of brain changes to a specific pain condition in pediatric and adult patients allows for insights into potential mechanisms of pain chronicity and possibly long-term brain changes. Here we focused on the primary somatosensory system (SS) involved in pain processing, namely the ventroposterolateral thalamus (VPL) and the primary ... Read more >>

Hum Brain Mapp (Human brain mapping)
[2019, 40(15):4381-4396]

Cited: 2 times

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Tranexamic Acid Is Efficacious at Decreasing the Rate of Blood Loss in Adolescent Scoliosis Surgery: A Randomized Placebo-Controlled Trial.

Susan M Goobie, David Zurakowski, Michael P Glotzbecker, Mary E McCann, Daniel Hedequist, Robert M Brustowicz, Navil F Sethna, Lawerence I Karlin, John B Emans, M Timothy Hresko,

<h4>Background</h4>Tranexamic acid (TXA) is an antifibrinolytic drug that reduces surgical blood loss. Evidence supporting its efficacy in surgery for adolescent idiopathic scoliosis is not robust. This trial was designed to validate the clinical efficacy of TXA in surgery for adolescent idiopathic scoliosis.<h4>Methods</h4>This institutional review board-approved prospective double-blinded trial involved 111 ... Read more >>

J Bone Joint Surg Am (The Journal of bone and joint surgery. American volume)
[2018, 100(23):2024-2032]

Cited: 10 times

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Complications in Pediatric Regional Anesthesia: An Analysis of More than 100,000 Blocks from the Pediatric Regional Anesthesia Network.

Benjamin J Walker, Justin B Long, Madhankumar Sathyamoorthy, Jennifer Birstler, Christine Wolf, Adrian T Bosenberg, Sean H Flack, Elliot J Krane, Navil F Sethna, Santhanam Suresh, Andreas H Taenzer, David M Polaner, Lynn Martin, Corrie Anderson, Rani Sunder, Trevor Adams, Lizabeth Martin, Martha Pankovich, Amod Sawardekar, Patrick Birmingham, Ryan Marcelino, R J Ramarmurthi, Peter Szmuk, Galit Kastner Ungar, Sara Lozano, Karen Boretsky, Ranu Jain, Maria Matuszczak, Timothy R Petersen, Jennifer Dillow, Robert Power, Kim Nguyen, Benjamin H Lee, Lisa Chan, Jorge Pineda, Jacob Hutchins, Kimberly Mendoza, Kristen Spisak, Aali Shah, Kathryn DelPizzo, Naomi Dong, Vidya Yalamanchili, Claudia Venable, Cassandra Armstead Williams, Reena Chaudahari, Susumu Ohkawa, Helga Usljebrka, Tarun Bhalla, Pedro Paulo Vanzillotta, Seza Apiliogullari, Andrew D Franklin, Akiko Ando, Sophie R Pestieau, Caroline Wright, Julia Rosenbloom, Tony Anderson, ,

<h4>What we already know about this topic</h4>WHAT THIS ARTICLE TELLS US THAT IS NEW: BACKGROUND:: Complications in pediatric regional anesthesia are rare, so a large sample size is necessary to quantify risk. The Pediatric Regional Anesthesia Network contains data on more than 100,000 blocks administered at more than 20 children's ... Read more >>

Anesthesiology (Anesthesiology)
[2018, 129(4):721-732]

Cited: 20 times

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Perioperative management of gastrostomy tube placement in Duchenne muscular dystrophy adolescent and young adult patients: A role for a perioperative surgical home.

Ariane Boivin, Richard Antonelli, Navil F Sethna,

BACKGROUND:In past decades, Duchenne muscular dystrophy patients have been living longer and as the disease advances, patients experience multisystemic deterioration. Older patients often require gastrostomy tube placement for nutritional support. For optimizing the perioperative care, a practice of multidisciplinary team can better anticipate, prevent, and manage possible complications and reduce ... Read more >>

Paediatr Anaesth (Paediatric anaesthesia)
[2018, 28(2):127-133]

Cited: 0 times

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Children With Chronic Pain: Response Trajectories After Intensive Pain Rehabilitation Treatment.

Laura E Simons, Christine B Sieberg, Caitlin Conroy, Edin T Randall, Julie Shulman, David Borsook, Charles Berde, Navil F Sethna, Deirdre E Logan,

Intensive pain rehabilitation programs for children with chronic pain are effective for many patients. However, characteristics associated with treatment response have not been well documented. In this article we report trajectories of pain and functional impairment in patients with chronic pain up to 1 year after intensive pain rehabilitation and ... Read more >>

J Pain (The journal of pain)
[2018, 19(2):207-218]

Cited: 16 times

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Anesthetic management of 877 pediatric patients undergoing muscle biopsy for neuromuscular disorders: a 20-year review.

Frederic Shapiro, Umeshkumar Athiraman, David J Clendenin, Monica Hoagland, Navil F Sethna,

<h4>Background</h4>The objectives are to review the anesthetic management and anesthetic-related adverse events in patients undergoing muscle biopsy for a broad spectrum of neuromuscular disorders (NMD).<h4>Aim</h4>The study aims to assess the hypothesis that perceived awareness of potential anesthesia-induced hyperkalemia and MH in patients with NMD reduces the frequency of such events.<h4>Methods</h4>A ... Read more >>

Paediatr Anaesth (Paediatric anaesthesia)
[2016, 26(7):710-721]

Cited: 7 times

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Fear and Reward Circuit Alterations in Pediatric CRPS.

Laura E Simons, Nathalie Erpelding, Jessica M Hernandez, Paul Serrano, Kunyu Zhang, Alyssa A Lebel, Navil F Sethna, Charles B Berde, Sanjay P Prabhu, Lino Becerra, David Borsook,

In chronic pain, a number of brain regions involved in emotion (e.g., amygdala, hippocampus, nucleus accumbens, insula, anterior cingulate, and prefrontal cortex) show significant functional and morphometric changes. One phenotypic manifestation of these changes is pain-related fear (PRF). PRF is associated with profoundly altered behavioral adaptations to chronic pain. For ... Read more >>

Front Hum Neurosci (Frontiers in human neuroscience)
[2015, 9:703]

Cited: 8 times

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Sensory and Thermal Quantitative Testing in Children With Sickle Cell Disease.

Eufemia Jacob, Victoria Wong Chan, Christopher Hodge, Lonnie Zeltzer, David Zurakowski, Navil F Sethna,

Very little is known about pain processing in sickle cell disease (SCD). We examined the mechanical and thermal sensory patterns in children with SCD. Children ages 10 to 17 years (n = 48; mean 13.7 ± 2.0 y; 22 females) participated in quantitative sensory testing (QST) procedures and completed a ... Read more >>

J Pediatr Hematol Oncol (Journal of pediatric hematology/oncology)
[2015, 37(3):185-189]

Cited: 27 times

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Pain management following major intracranial surgery in pediatric patients: a prospective cohort study in three academic children's hospitals.

Lynne G Maxwell, George M Buckley, Sapna R Kudchadkar, Elizabeth Ely, Emily L Stebbins, Christine Dube, Athir Morad, Ebaa A Jastaniah, Navil F Sethna, Myron Yaster,

<h4>Introduction</h4>Pain management following major intracranial surgery is often limited by a presumed lack of need and a concern that opioids will adversely affect postoperative outcome and interfere with the neurologic examination. Nevertheless, evidence in adults is accumulating that these patients suffer moderate to severe pain, and this pain is often ... Read more >>

Paediatr Anaesth (Paediatric anaesthesia)
[2014, 24(11):1132-1140]

Cited: 7 times

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The analgesic effect of a vapocoolant stream spray in reducing heat nociception on the glabrous skin of rat pups.

Navil F Sethna, Barak Yahalom, Birgitta Schmidt, Amber M Hall, David Zurakowski,

<h4>Background</h4>Blood sampling is a common screening and diagnostic test in newborn infants in the neonatal intensive care unit, and heel lancing accounts for two-thirds of these tests. Heel lancing causes acute pain and distress, and most infants rarely receive analgesics because of fear of respiratory depression from opioids and lack ... Read more >>

Anesth Analg (Anesthesia and analgesia)
[2014, 119(6):1367-1372]

Cited: 0 times

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Pain hypersensitivity in juvenile idiopathic arthritis: a quantitative sensory testing study.

Laura Cornelissen, Carolina Donado, Joseph Kim, Laura Chiel, David Zurakowski, Deirdre E Logan, Petra Meier, Navil F Sethna, Markus Blankenburg, Boris Zernikow, Robert P Sundel, Charles B Berde,

<h4>Background</h4>Juvenile Idiopathic Arthritis (JIA) is the most common cause of non-infectious joint inflammation in children. Synovial inflammation results in pain, swelling and stiffness. Animal and adult human studies indicate that localized joint-associated inflammation may produce generalized changes in pain sensitivity. The aim was to characterize pain sensitivity in children with ... Read more >>

Pediatr Rheumatol Online J (Pediatric rheumatology online journal)
[2014, 12:39]

Cited: 16 times

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Review of outcomes in pediatric patients undergoing anterior cruciate ligament repairs with regional nerve blocks.

Rosella A Micalizzi, Lee Ann Williams, Shelly Pignataro, Navil F Sethna, David Zurakowski,

<h4>Purpose</h4>This article compared the outcomes of pediatric patients undergoing ACL repairs receiving intravenous opioids versus regional nerve blocks for pain management. It was hypothesized that compared to intravenous opioids the use of regional nerve blocks would decrease pain, opioid consumption, and opioid-related side effects.<h4>Method</h4>A random retrospective chart review was conducted ... Read more >>

J Pediatr Nurs (Journal of pediatric nursing)
[2014, 29(6):670-678]

Cited: 2 times

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Population pharmacokinetics of tranexamic acid in paediatric patients undergoing craniosynostosis surgery.

Susan M Goobie, Petra M Meier, Navil F Sethna, Sulpicio G Soriano, David Zurakowski, Snehal Samant, Luis M Pereira,

<h4>Background</h4>Tranexamic acid (TXA) effectively reduces blood loss and transfusion requirements during craniofacial surgery. The pharmacokinetics of TXA have not been fully characterized in paediatric patients and dosing regimens remain diverse in practice. A mixed-effects population analysis would characterize patient variability and guide dosing practices.<h4>Objective</h4>The objective of this study was to ... Read more >>

Clin Pharmacokinet (Clinical pharmacokinetics)
[2013, 52(4):267-276]

Cited: 25 times

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Hemodynamic changes during spinal anesthesia in premature infants with congenital heart disease undergoing inguinal hernia correction.

Ze'ev Shenkman, Victor M Johnson, David Zurakowski, Shmuel Arnon, Navil F Sethna,

<h4>Introduction</h4>There are conflicting reports on the effects of spinal anesthesia (SA) on hemodynamics. Data on the hemodynamic effects of SA in infants with congenital heart disease (CHD) are limited.<h4>Methods</h4>We reviewed our experience with 44 unsupplemented SA with 1 mg·kg(-1) of either hyperbaric tetracaine or bupivacaine in premature and former premature ... Read more >>

Paediatr Anaesth (Paediatric anaesthesia)
[2012, 22(9):865-870]

Cited: 9 times

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Unilateral hemiparesis with thoracic epidural in an adolescent.

Rosalie F Tassone, Christian Seefelder, Navil F Sethna,

Objective. Unilateral sensory and motor blockade is known to occur with epidural anesthesia but is rarely reported in children. The differential diagnosis should include the presence of a midline epidural septum. Case Report. We describe a case of a 16-year-old adolescent who developed repeated complete unilateral extensive epidural sensory and ... Read more >>

Case Rep Anesthesiol (Case reports in anesthesiology)
[2012, 2012:732584]

Cited: 2 times

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Sympathetic nerve blocks, pragmatic trials, and responder analysis.

Navil F Sethna, Charles B Berde,

Anesthesiology (Anesthesiology)
[2012, 116(1):12-14]

Cited: 2 times

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Efficacy of tranexamic acid in pediatric craniosynostosis surgery: a double-blind, placebo-controlled trial.

Susan M Goobie, Petra M Meier, Luis M Pereira, Francis X McGowan, Randy P Prescilla, Laurie A Scharp, Gary F Rogers, Mark R Proctor, John G Meara, Sulpicio G Soriano, David Zurakowski, Navil F Sethna,

<h4>Background</h4>Extensive blood loss is common in pediatric craniosynostosis reconstruction surgery. Tranexamic acid (TXA) is increasingly used to reduce perioperative blood loss in various settings, but data on its efficacy are limited in children. The purpose of this randomized, double-blind, placebo-controlled, parallel trial was to evaluate the efficacy of TXA in ... Read more >>

Anesthesiology (Anesthesiology)
[2011, 114(4):862-871]

Cited: 100 times

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Incidence of epidural catheter-associated infections after continuous epidural analgesia in children.

Navil F Sethna, David Clendenin, Umeshkumar Athiraman, Jean Solodiuk, Diana P Rodriguez, David Zurakowski,

Clinical observation suggests that the number of serious epidural catheter-associated infections have increased recently in children. This increase is likely attributed to an increase in reporting and in frequency of epidural analgesia usage. Estimates of infection rates are difficult to determine primarily because of insufficient study of large pediatric populations. ... Read more >>

Anesthesiology (Anesthesiology)
[2010, 113(1):224-232]

Cited: 24 times

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Successful resuscitation after inadvertent intravenous injection of bupivacaine in an adolescent.

Gennadiy Fuzaylov, Binyu Ying, Yanfeng Tang, Navil F Sethna,

Paediatr Anaesth (Paediatric anaesthesia)
[2010, 20(10):958-959]

Cited: 3 times

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