Full Text Journal Articles by
Author Naveen Parmar

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LSD1 represses a neonatal/reparative gene program in adult intestinal epithelium.

Rosalie T Zwiggelaar, Håvard T Lindholm, Madeleine Fosslie, Marianne Terndrup Pedersen, Yuki Ohta, Alberto Díez-Sánchez, Mara Martín-Alonso, Jenny Ostrop, Mami Matano, Naveen Parmar, Emilie Kvaløy, Roos R Spanjers, Kamran Nazmi, Morten Rye, Finn Drabløs, Cheryl Arrowsmith, John Arne Dahl, Kim B Jensen, Toshiro Sato, Menno J Oudhoff,

Intestinal epithelial homeostasis is maintained by adult intestinal stem cells, which, alongside Paneth cells, appear after birth in the neonatal period. We aimed to identify regulators of neonatal intestinal epithelial development by testing a small library of epigenetic modifier inhibitors in Paneth cell-skewed organoid cultures. We found that lysine-specific demethylase ... Read more >>

Sci Adv (Science advances)
[2020, 6(37):]

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A semi-automated organoid screening method demonstrates epigenetic control of intestinal epithelial maturation

Jenny Ostrop, Rosalie Zwiggelaar, Marianne Terndrup Pedersen, François Gerbe, Korbinian Bösl, Håvard Lindholm, Alberto Díez-Sánchez, Naveen Parmar, Silke Radetzki, Jens Peter von Kries, Philippe Jay, Kim Jensen, Cheryl Arrowsmith, Menno Oudhoff,

Abstract Intestinal organoids are an excellent model to study epithelial biology. Yet, the selection of analytical tools to accurately quantify heterogeneous organoid cultures remains limited. Here, we developed a semi-automated organoid screening method, which we applied to a library of highly specific chemical probes to identify epigenetic regulators of intestinal ... Read more >>

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Intestinal-epithelial LSD1 controls cytoskeletal-mediated cell identity including goblet cell effector responses required for gut inflammatory and infectious diseases

Naveen Parmar, Kyle Burrows, Håvard Lindholm, Rosalie Zwiggelaar, Mara Martín-Alonso, Madeleine Fosslie, Bruce Vallance, John Arne Dahl, Colby Zaph, Menno Oudhoff,

ABSTRACT Infectious and inflammatory diseases in the intestine remain a serious threat for patients world-wide. Reprogramming of the intestinal epithelium towards a protective effector state is important to manage inflammation and immunity. The role of epigenetic regulatory enzymes within these processes is not yet defined. Here, we use a mouse ... Read more >>

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Developmental pathways regulate cytokine-driven effector and feedback responses in the intestinal epithelium

Håvard Lindholm, Naveen Parmar, Claire Drurey, Jenny Ostrop, Alberto Díez-Sanchez, Rick Maizels, Menno Oudhoff,

Abstract The intestinal tract is a common site for infection, and it relies on an appropriate immune response to defend against pathogens. The intestinal epithelium has an important role in effector responses, which is coordinated by immune-type specific cytokines. It is incompletely understood how cytokines drive epithelial responses. Here, using ... Read more >>

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Corrigendum to 'Protection against filarial infection by 45-49 kDa molecules of Brugia malayi via IFN-γ-mediated iNOS induction' [Vaccine 33 (2015) 527-534].

Shiv K Verma, Sujith K Joseph, Richa Verma, Vikas Kushwaha, Naveen Parmar, Pawan K Yadav, Jagadeshwar Reddy Thota, Susanta Kar, P Kalpana Murthy,

Vaccine (Vaccine)
[2020, 38(32):5076]

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Leishmania donovani Subverts Host Immune Response by Epigenetic Reprogramming of Macrophage M(Lipopolysaccharides + IFN-γ)/M(IL-10) Polarization.

Naveen Parmar, Pragya Chandrakar, Susanta Kar,

Reciprocal changes in histone lysine methylation/demethylation of M(LPS + IFN-γ)/M(IL-10) genes is one of the factors that direct macrophage polarization and contribute to host defense/susceptibility toward infection. Although, histone lysine methyltransferases and lysine demethylases orchestrate these events, their role remains elusive in visceral leishmaniasis, a disease associated with macrophage M(IL-10) ... Read more >>

J Immunol (Journal of immunology (Baltimore, Md. : 1950))
[2020, 204(10):2762-2778]

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LSD1 represses a neonatal/reparative gene program in adult intestinal epithelium

Rosalie Zwiggelaar, Håvard Lindholm, Madeleine Fosslie, Marianne Pedersen, Yuki Ohta, Alberto Díez-Sánchez, Mara Martín-Alonso, Jenny Ostrop, Mami Matano, Naveen Parmar, Emilie Kvaløy, Roos Spanjers, Kamran Nazmi, Morten Rye, Finn Drabløs, Cheryl Arrowsmith, John Arne Dahl, Kim Jensen, Toshiro Sato, Menno Oudhoff,

ABSTRACT Intestinal epithelial homeostasis is maintained by adult intestinal stem cells, which, alongside Paneth cells, appear after birth in the neonatal period. We aimed to identify new regulators of neonatal intestinal epithelial development by testing a small library of epigenetic modifier inhibitors in Paneth cell-skewed organoid cultures. We found that ... Read more >>

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β-Amino acid derivatives as mitochondrial complex III inhibitors of L. donovani: A promising chemotype targeting visceral leishmaniasis.

Pragya Chandrakar, Naresh Gunaganti, Naveen Parmar, Ashok Kumar, Sandeep Kumar Singh, Mamunur Rashid, M Wahajuddin, Kalyan Mitra, Tadigopula Narender, Susanta Kar,

β-amino acids and their analogues are gathering increased attention not only because of their antibacterial and antifungal activity, but also for their use in designing peptidomimetics with increased oral bioavailability and resistance to metabolic degradation. In this study, a series of α-phenyl substituted chalcones, α-phenyl, β-amino substituted dihydrochalcones and β-amino ... Read more >>

Eur J Med Chem (European journal of medicinal chemistry)
[2019, 182:111632]

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Differential Induction of SOCS Isoforms by Leishmania donovani Impairs Macrophage-T Cell Cross-Talk and Host Defense.

Pragya Chandrakar, Naveen Parmar, Albert Descoteaux, Susanta Kar,

Immune evasion strategies adopted by Leishmania donovani involve the exploitation of suppressor of cytokine signaling (SOCS) proteins that are well-known negative regulators of the JAK/STAT pathway. However, the cellular mechanism underpinning the induction of SOCS isoforms and their role in breaching the multilevel regulatory circuit connecting the innate and adaptive ... Read more >>

J Immunol (Journal of immunology (Baltimore, Md. : 1950))
[2020, 204(3):596-610]

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Reciprocal changes in CD11c+CD11b+ and CD11c+CD8α+ dendritic cell subsets determine protective or permissive immune response in murine experimental VL.

Pawan Kumar Yadav, Pragya Chandrakar, Pankaj Sharma, Preeti Vishwakarma, Naveen Parmar, Mrigank Srivastava, Susanta Kar,

CD11c+CD8α+ and CD11c+CD11b+ dendritic cells are two major subsets of murine splenic CD11c+ DCs which play a crucial role in T cell priming and shaping Th1/Th2 responses, but their role in the context of experimental visceral leishmaniasis (VL) is poorly understood. Herein, we showed that L. donovani infection in Balb/c ... Read more >>

Vaccine (Vaccine)
[2020, 38(2):355-365]

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Synthesis, Biological Evaluation, Structure-Activity Relationship, and Mechanism of Action Studies of Quinoline-Metronidazole Derivatives Against Experimental Visceral Leishmaniasis.

Akanksha Upadhyay, Pragya Chandrakar, Sampa Gupta, Naveen Parmar, Sandeep Kumar Singh, Mamunur Rashid, Pragati Kushwaha, Muhammad Wahajuddin, Koneni V Sashidhara, Susanta Kar,

In our efforts to identify novel chemical scaffolds for the development of antileishmanial agents, a series of quinoline-metronidazole hybrid compounds was synthesized and tested against the murine model of visceral leishmaniasis. Among all synthesized derivatives, 15b and 15i showed significant antileishmanial efficacy against both extracellular promastigote (IC50 9.54 and 5.42 ... Read more >>

J Med Chem (Journal of medicinal chemistry)
[2019, 62(11):5655-5671]

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Leishmania donovani molecules recognized by sera of filaria infected host facilitate filarial infection.

Richa Verma, Vikas Kushwaha, Smriti Pandey, Jagadeshwar Reddy Thota, Preeti Vishwakarma, Naveen Parmar, Pawan Kumar Yadav, Prachi Tewari, Susanta Kar, Praveen Kumar Shukla, Puvvada Kalpana Murthy,

We earlier found that F6 fraction of human filaria Brugia malayi cross-reacted with sera of Leishmania donovani infected hamsters and immunization with F6 inhibited both filarial and leishmanial infections. In the present study, we identified a 52.9-93.6 kDa fraction (Ld1) of L. donovani that cross-reacted with sera of B. malayi ... Read more >>

Parasitol. Res. (Parasitology research)
[2018, 117(9):2901-2912]

Cited: 1 time

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Leishmania donovani Exploits Tollip, a Multitasking Protein, To Impair TLR/IL-1R Signaling for Its Survival in the Host.

Naveen Parmar, Pragya Chandrakar, Preeti Vishwakarma, Kavita Singh, Kalyan Mitra, Susanta Kar,

IL-1R/TLR signaling plays a significant role in sensing harmful foreign pathogens and mounting effective innate and adaptive immune responses. However, the precise mechanism by which Leishmania donovani, an obligate intramacrophagic pathogen, breaches IL-1R/TLR signaling and host-protective immunity remains obscure. In this study, we report the novel biphasic role of Toll-interacting ... Read more >>

J. Immunol. (Journal of immunology (Baltimore, Md. : 1950))
[2018, 201(3):957-970]

Cited: 4 times

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Ammonium trichloro [1,2-ethanediolato-O,O']-tellurate cures experimental visceral leishmaniasis by redox modulation of Leishmania donovani trypanothione reductase and inhibiting host integrin linked PI3K/Akt pathway.

Preeti Vishwakarma, Naveen Parmar, Pragya Chandrakar, Tanuj Sharma, Manoj Kathuria, Pramod K Agnihotri, Mohammad Imran Siddiqi, Kalyan Mitra, Susanta Kar,

In an endeavor to search for affordable and safer therapeutics against debilitating visceral leishmaniasis, we examined antileishmanial potential of ammonium trichloro [1,2-ethanediolato-O,O']-tellurate (AS101); a tellurium based non toxic immunomodulator. AS101 showed significant in vitro efficacy against both Leishmania donovani promastigotes and amastigotes at sub-micromolar concentrations. AS101 could also completely eliminate ... Read more >>

Cell Mol Life Sci (Cellular and molecular life sciences : CMLS)
[2018, 75(3):563-588]

Cited: 6 times

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Antileishmanial Activity of Pyrazolopyridine Derivatives and Their Potential as an Adjunct Therapy with Miltefosine.

Devireddy Anand, Pawan Kumar Yadav, Om P S Patel, Naveen Parmar, Rahul K Maurya, Preeti Vishwakarma, Kanumuri S R Raju, Isha Taneja, M Wahajuddin, Susanta Kar, Prem P Yadav,

A series of pyrazolo(dihydro)pyridines was synthesized and evaluated for antileishmanial efficacy against experimental visceral leishmaniasis (VL). Among all compounds, 6d and 6j exhibited better activity than miltefosine against intracellular amastigotes. Compound 6j (50 mg/kg/day) was further studied against Leishmania donovani/BALB/c mice via the intraperitoneal route for 5 days and displayed ... Read more >>

J Med Chem (Journal of medicinal chemistry)
[2017, 60(3):1041-1059]

Cited: 6 times

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15d-Prostaglandin J2 induced reactive oxygen species-mediated apoptosis during experimental visceral leishmaniasis.

Preeti Vishwakarma, Naveen Parmar, Pawan Kumar Yadav, Pragya Chandrakar, Susanta Kar,

15-Deoxy-delta (12,14)-prostaglandin J2 (15d-PgJ2) is a potent bioactive lipid mediator, known to possess several roles in cell regulation and differentiation along with antimicrobial efficacy against different bacterial and viral infections. In the present study, we investigated the therapeutic efficacy and mechanism of action of 15d-PgJ2 in vitro in Leishmania donovani ... Read more >>

J Mol Med (Berl) (Journal of molecular medicine (Berlin, Germany))
[2016, 94(6):695-710]

Cited: 5 times

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Protection against filarial infection by 45-49 kDa molecules of Brugia malayi via IFN-γ-mediated iNOS induction.

Shiv K Verma, Sujith K Joseph, Richa Verma, Vikas Kushwaha, Naveen Parmar, Pawan K Yadav, Jagadeshwar Reddy Thota, Susanta Kar, P Kalpana Murthy,

Nitric oxide (NO) mediated mechanisms have been implicated in killing of some life-stages of Brugia malayi/Wuchereria bancrofti and protect the host through type 1 responses and IFN-γ stimulated toxic mediators' release. However, the identity of NO stimulating molecules of the parasites is not known. Three predominantly NO-stimulating SDS-PAGE resolved fractions ... Read more >>

Vaccine (Vaccine)
[2015, 33(4):527-534]

Cited: 4 times

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Combination of liposomal CpG oligodeoxynucleotide 2006 and miltefosine induces strong cell-mediated immunity during experimental visceral leishmaniasis.

Rahul Shivahare, Preeti Vishwakarma, Naveen Parmar, Pawan Kumar Yadav, Wahajul Haq, Mrigank Srivastava, Suman Gupta, Susanta Kar,

Immuno-modulators in combination with antileishmanial drug miltefosine is a better therapeutic approach for treatment of Visceral Leishmaniasis (VL) as it not only reduces the dose of miltefosine but also shortens the treatment regimen. However, immunological mechanisms behind the perceived benefits of this combination therapy have not been investigated in detail. ... Read more >>

PLoS One (PloS one)
[2014, 9(4):e94596]

Cited: 23 times

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