Full Text Journal Articles by
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Microvascular Disease in Patients With Diabetes With Heart Failure and Reduced Ejection Versus Preserved Ejection Fraction.

Jasper Tromp, Shir Lynn Lim, Wan Ting Tay, Tiew-Hwa Katherine Teng, Chanchal Chandramouli, Wouter Ouwerkerk, Gupreet S Wander, Jitendra P S Sawhney, Jonathan Yap, Michael R MacDonald, Lieng Hsi Ling, Naveed Sattar, John J V McMurray, A Mark Richards, Inder Anand, Carolyn S P Lam, ,

OBJECTIVE:Microvascular complications are common among patients with diabetes mellitus (DM). The presence of heart failure (HF) is presumed to be due to macrovascular disease (typically HF with reduced ejection fraction [HFrEF] following myocardial infarction). We hypothesized that HF with preserved ejection fraction (HFpEF) in patients with DM may be a ... Read more >>

Diabetes Care (Diabetes care)
[2019, :]

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Cardiometabolic comorbidities in RA and PsA: lessons learned and future directions.

Lyn D Ferguson, Stefan Siebert, Iain B McInnes, Naveed Sattar,

Cardiometabolic comorbidities present a considerable burden for patients with rheumatoid arthritis (RA) or psoriatic arthritis (PsA). Both RA and PsA are associated with an increased risk of cardiovascular disease (CVD). PsA more often exhibits an increased risk of metabolically linked comorbidities such as obesity, insulin resistance, type 2 diabetes mellitus ... Read more >>

Nat Rev Rheumatol (Nature reviews. Rheumatology)
[2019, :]

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Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.

Valérie Turcot, Yingchang Lu, Heather M Highland, Claudia Schurmann, Anne E Justice, Rebecca S Fine, Jonathan P Bradfield, Tõnu Esko, Ayush Giri, Mariaelisa Graff, Xiuqing Guo, Audrey E Hendricks, Tugce Karaderi, Adelheid Lempradl, Adam E Locke, Anubha Mahajan, Eirini Marouli, Suthesh Sivapalaratnam, Kristin L Young, Tamuno Alfred, Mary F Feitosa, Nicholas G D Masca, Alisa K Manning, Carolina Medina-Gomez, Poorva Mudgal, Maggie C Y Ng, Alex P Reiner, Sailaja Vedantam, Sara M Willems, Thomas W Winkler, Gonçalo Abecasis, Katja K Aben, Dewan S Alam, Sameer E Alharthi, Matthew Allison, Philippe Amouyel, Folkert W Asselbergs, Paul L Auer, Beverley Balkau, Lia E Bang, Inês Barroso, Lisa Bastarache, Marianne Benn, Sven Bergmann, Lawrence F Bielak, Matthias Blüher, Michael Boehnke, Heiner Boeing, Eric Boerwinkle, Carsten A Böger, Jette Bork-Jensen, Michiel L Bots, Erwin P Bottinger, Donald W Bowden, Ivan Brandslund, Gerome Breen, Murray H Brilliant, Linda Broer, Marco Brumat, Amber A Burt, Adam S Butterworth, Peter T Campbell, Stefania Cappellani, David J Carey, Eulalia Catamo, Mark J Caulfield, John C Chambers, Daniel I Chasman, Yii-Der I Chen, Rajiv Chowdhury, Cramer Christensen, Audrey Y Chu, Massimiliano Cocca, Francis S Collins, James P Cook, Janie Corley, Jordi Corominas Galbany, Amanda J Cox, David S Crosslin, Gabriel Cuellar-Partida, Angela D'Eustacchio, John Danesh, Gail Davies, Paul I W Bakker, Mark C H Groot, Renée Mutsert, Ian J Deary, George Dedoussis, Ellen W Demerath, Martin Heijer, Anneke I Hollander, Hester M Ruijter, Joe G Dennis, Josh C Denny, Emanuele Di Angelantonio, Fotios Drenos, Mengmeng Du, Marie-Pierre Dubé, Alison M Dunning, Douglas F Easton, Todd L Edwards, David Ellinghaus, Patrick T Ellinor, Paul Elliott, Evangelos Evangelou, Aliki-Eleni Farmaki, I Sadaf Farooqi, Jessica D Faul, Sascha Fauser, Shuang Feng, Ele Ferrannini, Jean Ferrieres, Jose C Florez, Ian Ford, Myriam Fornage, Oscar H Franco, Andre Franke, Paul W Franks, Nele Friedrich, Ruth Frikke-Schmidt, Tessel E Galesloot, Wei Gan, Ilaria Gandin, Paolo Gasparini, Jane Gibson, Vilmantas Giedraitis, Anette P Gjesing, Penny Gordon-Larsen, Mathias Gorski, Hans-Jörgen Grabe, Struan F A Grant, Niels Grarup, Helen L Griffiths, Megan L Grove, Vilmundur Gudnason, Stefan Gustafsson, Jeff Haessler, Hakon Hakonarson, Anke R Hammerschlag, Torben Hansen, Kathleen Mullan Harris, Tamara B Harris, Andrew T Hattersley, Christian T Have, Caroline Hayward, Liang He, Nancy L Heard-Costa, Andrew C Heath, Iris M Heid, Øyvind Helgeland, Jussi Hernesniemi, Alex W Hewitt, Oddgeir L Holmen, G Kees Hovingh, Joanna M M Howson, Yao Hu, Paul L Huang, Jennifer E Huffman, M Arfan Ikram, Erik Ingelsson, Anne U Jackson, Jan-Håkan Jansson, Gail P Jarvik, Gorm B Jensen, Yucheng Jia, Stefan Johansson, Marit E Jørgensen, Torben Jørgensen, J Wouter Jukema, Bratati Kahali, René S Kahn, Mika Kähönen, Pia R Kamstrup, Stavroula Kanoni, Jaakko Kaprio, Maria Karaleftheri, Sharon L R Kardia, Fredrik Karpe, Sekar Kathiresan, Frank Kee, Lambertus A Kiemeney, Eric Kim, Hidetoshi Kitajima, Pirjo Komulainen, Jaspal S Kooner, Charles Kooperberg, Tellervo Korhonen, Peter Kovacs, Helena Kuivaniemi, Zoltán Kutalik, Kari Kuulasmaa, Johanna Kuusisto, Markku Laakso, Timo A Lakka, David Lamparter, Ethan M Lange, Leslie A Lange, Claudia Langenberg, Eric B Larson, Nanette R Lee, Terho Lehtimäki, Cora E Lewis, Huaixing Li, Jin Li, Ruifang Li-Gao, Honghuang Lin, Keng-Hung Lin, Li-An Lin, Xu Lin, Lars Lind, Jaana Lindström, Allan Linneberg, Ching-Ti Liu, Dajiang J Liu, Yongmei Liu, Ken S Lo, Artitaya Lophatananon, Andrew J Lotery, Anu Loukola, Jian'an Luan, Steven A Lubitz, Leo-Pekka Lyytikäinen, Satu Männistö, Gaëlle Marenne, Angela L Mazul, Mark I McCarthy, Roberta McKean-Cowdin, Sarah E Medland, Karina Meidtner, Lili Milani, Vanisha Mistry, Paul Mitchell, Karen L Mohlke, Leena Moilanen, Marie Moitry, Grant W Montgomery, Dennis O Mook-Kanamori, Carmel Moore, Trevor A Mori, Andrew D Morris, Andrew P Morris, Martina Müller-Nurasyid, Patricia B Munroe, Mike A Nalls, Narisu Narisu, Christopher P Nelson, Matt Neville, Sune F Nielsen, Kjell Nikus, Pål R Njølstad, Børge G Nordestgaard, Dale R Nyholt, Jeffrey R O'Connel, Michelle L O'Donoghue, Loes M Olde Loohuis, Roel A Ophoff, Katharine R Owen, Chris J Packard, Sandosh Padmanabhan, Colin N A Palmer, Nicholette D Palmer, Gerard Pasterkamp, Aniruddh P Patel, Alison Pattie, Oluf Pedersen, Peggy L Peissig, Gina M Peloso, Craig E Pennell, Markus Perola, James A Perry, John R B Perry, Tune H Pers, Thomas N Person, Annette Peters, Eva R B Petersen, Patricia A Peyser, Ailith Pirie, Ozren Polasek, Tinca J Polderman, Hannu Puolijoki, Olli T Raitakari, Asif Rasheed, Rainer Rauramaa, Dermot F Reilly, Frida Renström, Myriam Rheinberger, Paul M Ridker, John D Rioux, Manuel A Rivas, David J Roberts, Neil R Robertson, Antonietta Robino, Olov Rolandsson, Igor Rudan, Katherine S Ruth, Danish Saleheen, Veikko Salomaa, Nilesh J Samani, Yadav Sapkota, Naveed Sattar, Robert E Schoen, Pamela J Schreiner, Matthias B Schulze, Robert A Scott, Marcelo P Segura-Lepe, Svati H Shah, Wayne H-H Sheu, Xueling Sim, Andrew J Slater, Kerrin S Small, Albert V Smith, Lorraine Southam, Timothy D Spector, Elizabeth K Speliotes, John M Starr, Kari Stefansson, Valgerdur Steinthorsdottir, Kathleen E Stirrups, Konstantin Strauch, Heather M Stringham, Michael Stumvoll, Liang Sun, Praveen Surendran, Amy J Swift, Hayato Tada, Katherine E Tansey, Jean-Claude Tardif, Kent D Taylor, Alexander Teumer, Deborah J Thompson, Gudmar Thorleifsson, Unnur Thorsteinsdottir, Betina H Thuesen, Anke Tönjes, Gerard Tromp, Stella Trompet, Emmanouil Tsafantakis, Jaakko Tuomilehto, Anne Tybjaerg-Hansen, Jonathan P Tyrer, Rudolf Uher, André G Uitterlinden, Matti Uusitupa, Sander W Laan, Cornelia M Duijn, Nienke Leeuwen, Jessica van Setten, Mauno Vanhala, Anette Varbo, Tibor V Varga, Rohit Varma, Digna R Velez Edwards, Sita H Vermeulen, Giovanni Veronesi, Henrik Vestergaard, Veronique Vitart, Thomas F Vogt, Uwe Völker, Dragana Vuckovic, Lynne E Wagenknecht, Mark Walker, Lars Wallentin, Feijie Wang, Carol A Wang, Shuai Wang, Yiqin Wang, Erin B Ware, Nicholas J Wareham, Helen R Warren, Dawn M Waterworth, Jennifer Wessel, Harvey D White, Cristen J Willer, James G Wilson, Daniel R Witte, Andrew R Wood, Ying Wu, Hanieh Yaghootkar, Jie Yao, Pang Yao, Laura M Yerges-Armstrong, Robin Young, Eleftheria Zeggini, Xiaowei Zhan, Weihua Zhang, Jing Hua Zhao, Wei Zhao, Wei Zhao, Wei Zhou, Krina T Zondervan, , , , , , , , , , , , Jerome I Rotter, John A Pospisilik, Fernando Rivadeneira, Ingrid B Borecki, Panos Deloukas, Timothy M Frayling, Guillaume Lettre, Kari E North, Cecilia M Lindgren, Joel N Hirschhorn, Ruth J F Loos,

An amendment to this paper has been published and can be accessed via a link at the top of the paper. ... Read more >>

Nat. Genet. (Nature genetics)
[2019, 51(7):1191-1192]

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What Do Older People Do When Sitting and Why? Implications for Decreasing Sedentary Behavior.

Victoria J Palmer, Cindy M Gray, Claire F Fitzsimons, Nanette Mutrie, Sally Wyke, Ian J Deary, Geoff Der, Sebastien F M Chastin, Dawn A Skelton, ,

BACKGROUND AND OBJECTIVES:Sitting less can reduce older adults' risk of ill health and disability. Effective sedentary behavior interventions require greater understanding of what older adults do when sitting (and not sitting), and why. This study compares the types, context, and role of sitting activities in the daily lives of older ... Read more >>

Gerontologist (The Gerontologist)
[2019, 59(4):686-697]

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Publisher Correction: Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes.

Rainer Malik, Ganesh Chauhan, Matthew Traylor, Muralidharan Sargurupremraj, Yukinori Okada, Aniket Mishra, Loes Rutten-Jacobs, Anne-Katrin Giese, Sander W van der Laan, Solveig Gretarsdottir, Christopher D Anderson, Michael Chong, Hieab H H Adams, Tetsuro Ago, Peter Almgren, Philippe Amouyel, Hakan Ay, Traci M Bartz, Oscar R Benavente, Steve Bevan, Giorgio B Boncoraglio, Robert D Brown, Adam S Butterworth, Caty Carrera, Cara L Carty, Daniel I Chasman, Wei-Min Chen, John W Cole, Adolfo Correa, Ioana Cotlarciuc, Carlos Cruchaga, John Danesh, Paul I W de Bakker, Anita L DeStefano, Marcel den Hoed, Qing Duan, Stefan T Engelter, Guido J Falcone, Rebecca F Gottesman, Raji P Grewal, Vilmundur Gudnason, Stefan Gustafsson, Jeffrey Haessler, Tamara B Harris, Ahamad Hassan, Aki S Havulinna, Susan R Heckbert, Elizabeth G Holliday, George Howard, Fang-Chi Hsu, Hyacinth I Hyacinth, M Arfan Ikram, Erik Ingelsson, Marguerite R Irvin, Xueqiu Jian, Jordi Jiménez-Conde, Julie A Johnson, J Wouter Jukema, Masahiro Kanai, Keith L Keene, Brett M Kissela, Dawn O Kleindorfer, Charles Kooperberg, Michiaki Kubo, Leslie A Lange, Carl D Langefeld, Claudia Langenberg, Lenore J Launer, Jin-Moo Lee, Robin Lemmens, Didier Leys, Cathryn M Lewis, Wei-Yu Lin, Arne G Lindgren, Erik Lorentzen, Patrik K Magnusson, Jane Maguire, Ani Manichaikul, Patrick F McArdle, James F Meschia, Braxton D Mitchell, Thomas H Mosley, Michael A Nalls, Toshiharu Ninomiya, Martin J O'Donnell, Bruce M Psaty, Sara L Pulit, Kristiina Rannikmäe, Alexander P Reiner, Kathryn M Rexrode, Kenneth Rice, Stephen S Rich, Paul M Ridker, Natalia S Rost, Peter M Rothwell, Jerome I Rotter, Tatjana Rundek, Ralph L Sacco, Saori Sakaue, Michele M Sale, Veikko Salomaa, Bishwa R Sapkota, Reinhold Schmidt, Carsten O Schmidt, Ulf Schminke, Pankaj Sharma, Agnieszka Slowik, Cathie L M Sudlow, Christian Tanislav, Turgut Tatlisumak, Kent D Taylor, Vincent N S Thijs, Gudmar Thorleifsson, Unnur Thorsteinsdottir, Steffen Tiedt, Stella Trompet, Christophe Tzourio, Cornelia M van Duijn, Matthew Walters, Nicholas J Wareham, Sylvia Wassertheil-Smoller, James G Wilson, Kerri L Wiggins, Qiong Yang, Salim Yusuf, , , , , , Joshua C Bis, Tomi Pastinen, Arno Ruusalepp, Eric E Schadt, Simon Koplev, Johan L M Björkegren, Veronica Codoni, Mete Civelek, Nicholas L Smith, David A Trégouët, Ingrid E Christophersen, Carolina Roselli, Steven A Lubitz, Patrick T Ellinor, E Shyong Tai, Jaspal S Kooner, Norihiro Kato, Jiang He, Pim van der Harst, Paul Elliott, John C Chambers, Fumihiko Takeuchi, Andrew D Johnson, , , , , , , , , , , Dharambir K Sanghera, Olle Melander, Christina Jern, Daniel Strbian, Israel Fernandez-Cadenas, W T Longstreth, Arndt Rolfs, Jun Hata, Daniel Woo, Jonathan Rosand, Guillaume Pare, Jemma C Hopewell, Danish Saleheen, Kari Stefansson, Bradford B Worrall, Steven J Kittner, Sudha Seshadri, Myriam Fornage, Hugh S Markus, Joanna M M Howson, Yoichiro Kamatani, Stephanie Debette, Martin Dichgans,

An amendment to this paper has been published and can be accessed via a link at the top of the paper. ... Read more >>

Nat. Genet. (Nature genetics)
[2019, 51(7):1192-1193]

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Diabetes management gains: teaching old dogs new tricks.

Naveed Sattar,

In the world of diabetes management there is a lot be thankful for. Over the past three decades, excess mortality rates in people with diabetes relative to the general population have declined substantially in high-income countries such that those with diabetes are living longer than ever. That said, the gap ... Read more >>

Diabet. Med. (Diabetic medicine : a journal of the British Diabetic Association)
[2019, :]

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Response by Welsh et al to Letter Regarding Article "Urinary Sodium Excretion, Blood Pressure, and Risk of Future Cardiovascular Disease and Mortality in Subjects Without Prior Cardiovascular Disease".

Claire E Welsh, Paul Welsh, Pardeep Jhund, Naveed Sattar, Patrick B Mark,

Hypertension (Hypertension (Dallas, Tex. : 1979))
[2019, 74(2):e27-e28]

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Effects of dietary and physical activity interventions on the risk of type 2 diabetes in South Asians: meta-analysis of individual participant data from randomised controlled trials.

Anne Karen Jenum, Idunn Brekke, Ibrahimu Mdala, Mirthe Muilwijk, Ambady Ramachandran, Marte Kjøllesdal, Eivind Andersen, Kåre R Richardsen, Anne Douglas, Genevieve Cezard, Aziz Sheikh, Carlos A Celis-Morales, Jason M R Gill, Naveed Sattar, Raj S Bhopal, Erik Beune, Karien Stronks, Per Olav Vandvik, Irene G M van Valkengoed,

AIMS/HYPOTHESIS:Individuals of South Asian origin have a high risk of type 2 diabetes and of dying from a diabetes-attributable cause. Lifestyle modification intervention trials to prevent type 2 diabetes in high-risk South Asian adults have suggested more modest effects than in European-origin populations. The strength of the evidence of individual ... Read more >>

Diabetologia (Diabetologia)
[2019, 62(8):1337-1348]

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Comparison of Conventional Lipoprotein Tests and Apolipoproteins in the Prediction of Cardiovascular Disease: Data from UK Biobank.

Claire Welsh, Carlos A Celis-Morales, Rosemary Brown, Daniel F Mackay, James Lewsey, Patrick B Mark, Stuart R Gray, Lyn D Ferguson, Jana J Anderson, Donald M Lyall, John G Cleland, Pardeep S Jhund, Jason M R Gill, Jill P Pell, Naveed Sattar, Paul Welsh,

BACKGROUND:Total cholesterol and HDL-C measurements are central to CVD risk assessment, but there is continuing debate around the utility of other lipids for risk prediction. METHODS:Participants from UK Biobank without baseline CVD and not taking statins, with relevant lipid measurements (n=346,686), were included in the primary analysis. An incident fatal ... Read more >>

Circulation (Circulation)
[2019, :]

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The association of grip strength with health outcomes does not differ if grip strength is used in absolute or relative terms: a prospective cohort study.

Frederick K W Ho, Carlos A Celis-Morales, Fanny Petermann-Rocha, Anne Sillars, Paul Welsh, Claire Welsh, Jana Anderson, Donald M Lyall, Daniel F Mackay, Naveed Sattar, Jason M R Gill, Jill P Pell, Stuart R Gray,

BACKGROUND:higher grip strength is associated with better health outcomes. The optimal way to report grip strength (i.e. absolute vs. relative) for prediction, however, remains to be established. METHODS:in participants (aged 37-73 at baseline) from the UK Biobank, we examined the associations of grip strength, expressed in absolute terms (kilograms) and ... Read more >>

Age Ageing (Age and ageing)
[2019, :]

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Genome-wide association study provides new insights into the genetic architecture and pathogenesis of heart failure

Sonia Shah, Albert Henry, Carolina Roselli, Honghuang Lin, Garðar Sveinbjörnsson, Ghazaleh Fatemifar, Åsa Hedman, Jemma Wilk, Michael Morley, Mark Chaffin, Anna Helgadottir, Niek Verweij, Abbas Dehghan, Peter Almgren, Charlotte Anderson, Krishna Aragam, Johan Ärnlöv, Joshua Backman, Mary Biggs, Heather Bloom, Jeffrey Brandimarto, Michael Brown, Leonard Buckbinder, David Carey, Daniel Chasman, Xing Chen, Xu Chen, Jonathan Chung, William Chutkow, James Cook, Graciela Delgado, Spiros Denaxas, Alexander Doney, Marcus Dörr, Samuel Dudley, Michael Dunn, Gunnar Engström, Tõnu Esko, Stephan Felix, Chris Finan, Ian Ford, Mohsen Ghanbari, Sahar Ghasemi, Vilmantas Giedraitis, Franco Giulianini, John Gottdiener, Stefan Gross, Daníel Guðbjartsson, Rebecca Gutmann, Christopher Haggerty, Pim van der Harst, Harry Hemingway, Craig Hyde, Erik Ingelsson, Wouter Jukema, Maryam Kavousi, Kay-Tee Khaw, Marcus Kleber, Lars Køber, Andrea Koekemoer, Claudia Langenberg, Lars Lind, Cecilia Lindgren, Barry London, Luca Lotta, Ruth Lovering, Jian'an Luan, Patrik Magnusson, Anubha Mahajan, Kenneth Margulies, Winfried März, Olle Melander, Ify Mordi, Thomas Morgan, Andrew Morris, Andrew Morris, Alanna Morrison, Michael Nagle, Christopher Nelson, Alexander Niessner, Teemu Niiranen, Michelle O'Donoghue, Anjali Owens, Colin Palmer, Helen Parry, Markus Perola, Eliana Portilla-Fernandez, Bruce Psaty, Kenneth Rice, Paul Ridker, Simon Romaine, Jerome Rotter, Perttu Salo, Veikko Salomaa, Jessica van Setten, Alaa Shalaby, Diane Smelser, Nicholas Smith, Steen Stender, David Stott, Per Svensson, Mari-Liis Tammesoo, Kent Taylor, Maris Teder-Laving, Alexander Teumer, Guðmundur Thorgeirsson, Unnur Thorsteinsdottir, Christian Torp-Pedersen, Stella Trompet, Benoit Tyl, Andre Uitterlinden, Abirami Veluchamy, Uwe Völker, Adriaan Voors, Xiaosong Wang, Nicholas Wareham, Dawn Waterworth, Peter Weeke, Raul Weiss, Kerri Wiggins, Heming Xing, Laura Yerges-Armstrong, Bing Yu, Faiez Zannad, Jing Hua Zhao, Nilesh Samani, John McMurray, Jian Yang, Peter Visscher, Christopher Newton-Cheh, Anders Malarstig, Hilma Holm, Steven Lubitz, Naveed Sattar, Michael Holmes, Thomas Cappola, Folkert Asselbergs, Aroon Dinesh Hingorani, Karoline Kuchenbaecker, Patrick Ellinor, Chim Lang, Kari Stefansson, Gustav Smith, Ramachandran Vasan, Daniel Swerdlow, Thomas Lumbers, , , ,

Heart failure (HF) is a leading cause of morbidity and mortality worldwide. A small proportion of HF cases are attributable to monogenic cardiomyopathies and existing genome-wide association studies (GWAS) have yielded only limited insights, leaving the observed heritability of HF largely unexplained. We report the largest GWAS meta-analysis of HF ... Read more >>

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Research digest: SGLT2 inhibition in kidney and liver disease.

David Preiss, Naveed Sattar,

Lancet Diabetes Endocrinol (The lancet. Diabetes & endocrinology)
[2019, 7(6):427]

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Higher Body Mass Index in Adolescence Predicts Cardiomyopathy Risk in Midlife.

Josefina Robertson, Maria Schaufelberger, Martin Lindgren, Martin Adiels, Linus Schiöler, Kjell Torén, John McMurray, Naveed Sattar, Maria Åberg, Annika Rosengren,

BACKGROUND:Modifiable lifestyle factors in relation to risk for cardiomyopathy, a common and increasing cause of heart failure in the young, have not been widely studied. We sought to investigate a potential link between obesity, a recognized predictor of early heart failure, in adolescence and being diagnosed with cardiomyopathy in adulthood. ... Read more >>

Circulation (Circulation)
[2019, 140(2):117-125]

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Do physical activity, commuting mode, cardiorespiratory fitness and sedentary behaviours modify the genetic predisposition to higher BMI? Findings from a UK Biobank study.

Carlos A Celis-Morales, Donald M Lyall, Fanny Petermann, Jana Anderson, Joey Ward, Stamatina Iliodromiti, Daniel F Mackay, Paul Welsh, Mark E S Bailey, Jill Pell, Naveed Sattar, Jason M R Gill, Stuart R Gray,

To investigate whether the association between a genetic profile risk score for obesity (GPRS-obesity) (based on 93 SNPs) and body mass index (BMI) was modified by physical activity (PA), cardiorespiratory fitness, commuting mode, walking pace and sedentary behaviours. For the analyses we used cross-sectional baseline data from 310,652 participants in ... Read more >>

Int J Obes (Lond) (International journal of obesity (2005))
[2019, :]

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GDF15 and the beneficial actions of metformin in pre-diabetes

Anthony Coll, Michael Chen, Pranali Taskar, Debra Rimmington, Satish Patel, John Tadross, Irene Cimino, Ming Yang, Paul Welsh, Samuel Virtue, Deborah Goldspink, Emily Miedzybrodzka, Loraine Tung, Sergio Rodriguez-Cuenca, Rute Tomaz, Heather Harding, Audrey Melvin, Giles S.H. Yeo, David Preiss, Antonio Vidal-Puig, Ludovic Vallier, David Ron, Fiona Gribble, Frank Reimann, Naveed Sattar, David Savage, Bernard Allan, Stephen O’Rahilly,

Summary Metformin, the world’s most prescribed anti-diabetic drug, is also effective in preventing Type 2 diabetes in people at high risk, by lowering body weight, fat mass and circulating insulin levels through mechanisms that are incompletely understood. Recent observational studies reporting the association of metformin use and circulating levels of ... Read more >>

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Urinary Sodium Excretion, Blood Pressure, and Risk of Future Cardiovascular Disease and Mortality in Subjects Without Prior Cardiovascular Disease.

C E Welsh, Paul Welsh, Pardeep Jhund, Christian Delles, C Celis-Morales, J D Lewsey, S Gray, D Lyall, S Iliodromiti, J M R Gill, Naveed Sattar, Patrick B Mark,

Hypertension is a risk factor for cardiovascular disease. Increased urinary sodium excretion, representing dietary sodium intake, is associated with hypertension. Low sodium intake has been associated with increased mortality in observational studies. Further studies should assess whether confounding relationships explain associations between sodium intake and outcomes. We studied UK Biobank ... Read more >>

Hypertension (Hypertension (Dallas, Tex. : 1979))
[2019, 73(6):1202-1209]

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Glycaemic control trends in people with type 1 diabetes in Scotland 2004-2016.

Colette Mair, Wahyu Wulaningsih, Anita Jeyam, Stuart McGurnaghan, Luke Blackbourn, Brian Kennon, Graham Leese, Robert Lindsay, Rory J McCrimmon, John McKnight, John R Petrie, Naveed Sattar, Sarah H Wild, Nicholas Conway, Ian Craigie, Kenneth Robertson, Louise Bath, Paul M McKeigue, Helen M Colhoun, ,

AIMS/HYPOTHESIS:The aim of this work was to examine whether glycaemic control has improved in those with type 1 diabetes in Scotland between 2004 and 2016, and whether any trends differed by sociodemographic factors. METHODS:We analysed records from 30,717 people with type 1 diabetes, registered anytime between 2004 and 2016 in ... Read more >>

Diabetologia (Diabetologia)
[2019, 62(8):1375-1384]

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Association of central adiposity with psoriasis, psoriatic arthritis and rheumatoid arthritis: a cross-sectional study of the UK Biobank.

Lyn D Ferguson, Rosemary Brown, Carlos Celis-Morales, Paul Welsh, Donald M Lyall, Jill P Pell, Iain B McInnes, Stefan Siebert, Naveed Sattar,

OBJECTIVES:To determine the independent association of central adiposity, assessed by waist circumference, with odds of psoriasis, PsA and RA prevalence after controlling for general adiposity (BMI). METHODS:A cross-sectional study of UK Biobank participants aged 40-70 years was performed. Logistic regression was used to calculate the odds of psoriasis, PsA and ... Read more >>

Rheumatology (Oxford) (Rheumatology (Oxford, England))
[2019, :]

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Association between fat mass through adolescence and arterial stiffness: a population-based study from The Avon Longitudinal Study of Parents and Children.

Frida Dangardt, Marietta Charakida, Georgios Georgiopoulos, Scott T Chiesa, Alicja Rapala, Kaitlin H Wade, Alun D Hughes, Nicholas J Timpson, Konstantinos Pateras, Nick Finer, Naveed Sattar, George Davey Smith, Debbie A Lawlor, John E Deanfield,

BACKGROUND:The link between adiposity, metabolic abnormalities, and arterial disease progression in children and adolescents remains poorly defined. We aimed to assess whether persistent high adiposity levels are associated with increased arterial stiffness in adolescence and any mediation effects by common metabolic risk factors. METHODS:We included participants from the Avon Longitudinal ... Read more >>

Lancet Child Adolesc Health (The Lancet. Child & adolescent health)
[2019, 3(7):474-481]

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Risks and clinical predictors of cirrhosis and hepatocellular carcinoma diagnoses in adults with diagnosed NAFLD: real-world study of 18 million patients in four European cohorts.

Myriam Alexander, A Katrina Loomis, Johan van der Lei, Talita Duarte-Salles, Daniel Prieto-Alhambra, David Ansell, Alessandro Pasqua, Francesco Lapi, Peter Rijnbeek, Mees Mosseveld, Dawn M Waterworth, Stuart Kendrick, Naveed Sattar, William Alazawi,

BACKGROUND:Non-alcoholic fatty liver disease (NAFLD) is a common condition that progresses in some patients to steatohepatitis (NASH), cirrhosis and hepatocellular carcinoma (HCC). Here we used healthcare records of 18 million adults to estimate risk of acquiring advanced liver disease diagnoses in patients with NAFLD or NASH compared to individually matched ... Read more >>

BMC Med (BMC medicine)
[2019, 17(1):95]

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Epidemiology, risk factors, and opportunities for prevention of cardiovascular disease in individuals of South Asian ethnicity living in Europe.

Miguel Cainzos-Achirica, Ugo Fedeli, Naveed Sattar, Charles Agyemang, Anne K Jenum, John W McEvoy, Jack D Murphy, Carlos Brotons, Roberto Elosua, Usama Bilal, Alka M Kanaya, Namratha R Kandula, Pablo Martinez-Amezcua, Josep Comin-Colet, Xavier Pinto,

South Asian (SA) individuals represent a large, growing population in a number of European countries. These individuals, particularly first-generation SA immigrants, are at higher risk of developing type 2 diabetes, atherogenic dyslipidaemia, and coronary heart disease than most other racial/ethnic groups living in Europe. SAs also have an increased risk ... Read more >>

Atherosclerosis (Atherosclerosis)
[2019, 286:105-113]

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BMI, Mortality, and Cardiovascular Outcomes in Type 1 Diabetes: Findings Against an Obesity Paradox.

Jon Edqvist, Araz Rawshani, Martin Adiels, Lena Björck, Marcus Lind, Ann-Marie Svensson, Sofia Gudbjörnsdottir, Naveed Sattar, Annika Rosengren,

OBJECTIVE:Low weight has been associated with increased mortality risks in type 1 diabetes. We aimed to investigate the importance of weight and weight gain/loss in the Swedish population diagnosed with type 1 diabetes. RESEARCH DESIGN AND METHODS:Patients with type 1 diabetes (n = 26,125; mean age 33.3 years; 45% women) ... Read more >>

Diabetes Care (Diabetes care)
[2019, 42(7):1297-1304]

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Understanding the mechanisms of reversal of type 2 diabetes.

Roy Taylor, Ahmad Al-Mrabeh, Naveed Sattar,

Clinical and pathophysiological studies have shown type 2 diabetes to be a condition mainly caused by excess, yet reversible, fat accumulation in the liver and pancreas. Within the liver, excess fat worsens hepatic responsiveness to insulin, leading to increased glucose production. Within the pancreas, the β cell seems to enter ... Read more >>

Lancet Diabetes Endocrinol (The lancet. Diabetes & endocrinology)
[2019, :]

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Mendelian randomization evaluation of causal effects of fibrinogen on incident coronary heart disease.

Cavin K Ward-Caviness, Paul S de Vries, Kerri L Wiggins, Jennifer E Huffman, Lisa R Yanek, Lawrence F Bielak, Franco Giulianini, Xiuqing Guo, Marcus E Kleber, Tim Kacprowski, Stefan Groß, Astrid Petersman, George Davey Smith, Fernando P Hartwig, Jack Bowden, Gibran Hemani, Martina Müller-Nuraysid, Konstantin Strauch, Wolfgang Koenig, Melanie Waldenberger, Thomas Meitinger, Nathan Pankratz, Eric Boerwinkle, Weihong Tang, Yi-Ping Fu, Andrew D Johnson, Ci Song, Moniek P M de Maat, André G Uitterlinden, Oscar H Franco, Jennifer A Brody, Barbara McKnight, Yii-Der Ida Chen, Bruce M Psaty, Rasika A Mathias, Diane M Becker, Patricia A Peyser, Jennifer A Smith, Suzette J Bielinski, Paul M Ridker, Kent D Taylor, Jie Yao, Russell Tracy, Graciela Delgado, Stella Trompet, Naveed Sattar, J Wouter Jukema, Lewis C Becker, Sharon L R Kardia, Jerome I Rotter, Winfried März, Marcus Dörr, Daniel I Chasman, Abbas Dehghan, Christopher J O'Donnell, Nicholas L Smith, Annette Peters, Alanna C Morrison,

BACKGROUND:Fibrinogen is an essential hemostatic factor and cardiovascular disease risk factor. Early attempts at evaluating the causal effect of fibrinogen on coronary heart disease (CHD) and myocardial infraction (MI) using Mendelian randomization (MR) used single variant approaches, and did not take advantage of recent genome-wide association studies (GWAS) or multi-variant, ... Read more >>

PLoS ONE (PloS one)
[2019, 14(5):e0216222]

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Da Qing 30 years on: more reasons to extend diabetes prevention.

Michael E J Lean, Naveed Sattar,

Lancet Diabetes Endocrinol (The lancet. Diabetes & endocrinology)
[2019, 7(6):417-419]

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