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Author Naveed Akhtar

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Changes in Neuroendovascular Procedural Volume During the COVID-19 Pandemic: An International Multicenter Study.

Adnan I Qureshi, Samiat Agunbiade, Wei Huang, Iqra N Akhtar, Michael G Abraham, Naveed Akhtar, Fawaz Al-Mufti, Emrah Aytac, Ferhat Balgetir, Mikayel Grigoryan, Camilo R Gomez, Ameer E Hassan, Vishal Jani, Nazli A Janjua, Liqun Jiao, Rakesh Khatri, Jawad F Kirmani, Adam Kobayashi, Osman Kozak, Jun Lee, Iryna Lobanova, Ossama Yassin Mansour, Alberto Maud, Mikael Mazighi, Michel Piotin, Gustavo J Rodriguez, Farhan Siddiq, M Fareed K Suri, Wondwossen G Tekle,

BACKGROUND AND PURPOSE:The effect of coronavirus disease 2019 (COVID-19) pandemic on performance of neuroendovascular procedures has not been quantified. METHODS:We performed an audit of performance of neuroendovascular procedures at 18 institutions (seven countries) for two periods; January-April 2019 and 2020, to identify changes in various core procedures. We divided the ... Read more >>

J Neuroimaging (Journal of neuroimaging : official journal of the American Society of Neuroimaging)
[2020, :]

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Characteristics and Comparison of 32 COVID-19 and Non-COVID-19 Ischemic Strokes and Historical Stroke Patients.

Naveed Akhtar, Fatma Ben Abid, Saadat Kamran, Rajvir Singh, Yahia Imam, Salman AlJerdi, Muna AlMaslamani, Ashfaq Shuaib,

OBJECTIVES:The presence of COVID-19 infection may increase the risk of thrombotic events including ischemic strokes. Whilst a number of recent reports suggest that COVID-19 associated stroke tends to be severe, there is limited data on the effects of COVID-19 in prospective registries. MATERIAL AND METHODS:To determine how COVID-19 infection may ... Read more >>

J Stroke Cerebrovasc Dis (Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association)
[2020, 30(1):105435]

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The prevalence, mortality rate and functional outcome of intracerebral hemorrhage according to age sex and ethnic group in the state of Qatar.

Maher Saqqur, Abdul Salam, Ali Ayyad, Naveed Akhtar, Musab Ali, Adnan Khan, Yahya Imam, Sujatha Joseph, Salman Al Jerdi, Ashfaq Shuaib,

OBJECTIVE:To investigate the prevalence of intracerebral hemorrhage (ICH) using stroke database from the main tertiary hospital in Qatar (Hamad General Hospital) over the period of Dec 2013 to Oct 2017. METHODS:The prevalence of ICH was calculated based on age groups and ethnicity (Qatari nationals, non-Qatari Arab, South east Indian (SI) ... Read more >>

Clin Neurol Neurosurg (Clinical neurology and neurosurgery)
[2020, 199:106255]

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A difunctional Pluronic®127-based in situ formed injectable thermogels as prolonged and controlled curcumin depot, fabrication, in vitro characterization and in vivo safety evaluation.

Samiullah Khan, Naveed Akhtar, Muhammad Usman Minhas, Hassan Shah, Kifayat Ullah Khan, Raghu Raj Singh Thakur,

Curcumin has been reported to be used widely against many types of pathological conditions in clinics. However, due to its limitations such as poor solubility, poor oral absorption and low stability have limited its applications. In the current study, a series of novel chemically cross-linkable depot gel formulations were developed ... Read more >>

J Biomater Sci Polym Ed (Journal of biomaterials science. Polymer edition)
[2020, :1-39]

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Stroke in the adult Qatari population (Q-stroke) a hospital-based retrospective cohort study.

Yahia Z Imam, Saadat Kamran, Maher Saqqur, Faisal Ibrahim, Prem Chandra, Jon D Perkins, Rayaz A Malik, Naveed Akhtar, Salman Al-Jerdi, Dirk Deleu, Osama Elalamy, Yasir Osman, Gayane Malikyan, Hisham Elkhider, Suha Elmakki, Lubna ElSheikh, Noha Mhjob, Mohamed S Abdelmoneim, Nima Alkhawad, Ahmed Own, Ashfaq Shuaib,

BACKGROUND:Studies assessing the burden of stroke in Qataris are limited. We aim to study stroke in the Qatari population. METHODS:A retrospective review was undertaken of all Qatari adults presenting with stroke to Hamad Medical Corporation over a 5-year period. Descriptive statistics were used to summarize demographic and all other clinical ... Read more >>

PLoS One (PloS one)
[2020, 15(9):e0238865]

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Palynological investigation of selected species of family asteraceae using light and scanning electron microscopic techniques.

Nadia Ali, Naveed Akhtar, Shafqat Ali Khan, Noor Ul Uza,

Palynological study on 11 species of family asteraceae, that is, Sonchus asper L., Gazania rigens L., Helianthus annus L., Dahlia pinnata Cav., Zinnia peruviana L., Tagetes erectus L., Glebionis coronaria L., Calendula officinale L., Osteospermum ecklonis L., Centaurea cyanus L. and Cosmos sulphureus Cav. was carried out in Islamia College ... Read more >>

Microsc Res Tech (Microscopy research and technique)
[2020, :e23583]

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Left Heart Factors in Embolic Stroke of Undetermined Source in a Multiethnic Asian and North African Cohort.

Saadat Kamran, Rajvir Singh, Naveed Akhtar, Pooja George, Abdul Salam, Blessy Babu, Ahmed Own, Tahir Hamid, Jonathan D Perkins,

Background Cardiac features diverge in Asians; however, it is not known how these differences relate to embolic stroke of unknown source (ESUS) in Southeast Asian and Eastern Mediterranean regions. Methods and Results A retrospective analysis of prospectively collected acute ischemic stroke data from 2014 to 2018 was performed. Stroke subtypes ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2020, 9(15):e016534]

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Prospective study to optimize the health of patients with TIAS (transient ischemic attack) and stroke admitted to the Hamad General Hospital.

Yahia Z Imam, Mouhand F H Mohamed, Mohamed S Abdelmoneim, Mark Santos, Nima Alkhawad, Abdul Salam, Numan Amir, Maher Saqqur, Ahmad Muhammad, Ahmed Elsoutohy, Saadat Kamran, Naveed Akhtar, Abdul Salim Kiliyanni, Ahmed Own, Dirk Deleu, Ashfaq Shuaib,

INTRODUCTION:Recurrent ischemic strokes (IS) make up to one-third of all strokes. Nine out of 10 strokes are due to modifiable risk factors. Thus, it seems that standard management strategies of modifiable risk factors are yet to improve. Hence, we planned a randomized controlled trial assessing nurses or pharmacists-led aggressive control ... Read more >>

Medicine (Madr) (Medicine)
[2020, 99(28):e20694]

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Stroke Mimics: A five-year follow-up study from the Qatar Stroke Database.

Naveed Akhtar, Zain Bhutta, Saadat Kamran, Blessy Babu, Namitha Jose, Sujatha Joseph, Deborah Morgan, Reny Francis, Ahmed Own, Ashfaq Shuaib,

BACKGROUND AND PURPOSE:Mimics comprise a third of patients presenting with an acute stroke. There is limited information on their natural history. METHODS:We evaluate long term major cardiovascular events (MACE) in stroke mimics in a prospective database from Qatar. RESULTS:Between Feb 2014 and Jan 2019, 481 patients (male: 238; female: 243) ... Read more >>

J Stroke Cerebrovasc Dis (Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association)
[2020, 29(10):105110]

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Foliar epidermal micromorphology and its taxonomic significance in Polygonatum (Asparagaceae) using scanning electron microscopy.

Maroof Ali, Saraj Bahadur, Abrar Hussain, Sara Saeed, Izaz Khuram, Manzoor Ullah, Jian-Wen Shao, Naveed Akhtar,

In the current investigation, 16 samples of six species of the genus Polygonatum were collected from different geographical regions in China. Leaf micromorphological traits were studied in detail using scanning electron microscopy. About five-leaf samples were used for each species collected from different geographical regions. A significant variation was found ... Read more >>

Microsc Res Tech (Microscopy research and technique)
[2020, :]

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Sex-Specific Differences in Short-Term and Long-Term Outcomes in Acute Stroke Patients from Qatar.

Naveed Akhtar, Mahesh Kate, Saadat Kamran, Rajvir Singh, Zain Bhutta, Maher Saqqur, Abdel-Naser Elzouki, Blessy Babu, Paula Bourke, Deborah Morgan, Sujatha Joseph, Namitha Jose, Reny Francis, Yahia Imam, Numan Amir, Ahmed Own, Ashfaq Shuaib,

BACKGROUND:Sex differences may determine presentation, utility of treatment, rehabilitation, and occurrences of major adverse cardiovascular events (MACEs) in acute stroke (AS). OBJECTIVE:The purpose of the study was to evaluate the short-term prognosis and long-term outcomes in MACEs in Qatari nationals admitted with AS. METHODS:All AS patients admitted between January 2014 ... Read more >>

Eur Neurol (European neurology)
[2020, 83(2):154-161]

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Progression of stroke deficits in patients presenting with mild symptoms: The underlying etiology determines outcome.

Naveed Akhtar, Saadat Kamran, Hisham Elkhider, Soha Al-Makki, Noha Mhjob, Lubna ElShiekh, Hassan AlHussain, Musab Ali, Rola Khodair, Faisal Wadiwala, Abdul Salam, Dirk Deleu, Reny Francis, Ashfaq Shuaib,

BACKGROUND AND PURPOSE:Patients with acute stroke and mild or rapidly improving symptoms frequently show progression. The role of reperfusion treatment in such patients is not clear. We hypothesized that progression was most likely in patients with cortical localization and such patients may benefit from thrombolysis. MATERIAL AND METHODS:We interrogated Hamad ... Read more >>

PLoS One (PloS one)
[2020, 15(4):e0231448]

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Corneal confocal microscopy identifies greater corneal nerve damage in patients with a recurrent compared to first ischemic stroke.

Adnan Khan, Naveed Akhtar, Saadat Kamran, Hamad Almuhannadi, Georgios Ponirakis, Ioannis N Petropoulos, Blessy Babu, Namitha R Jose, Rumissa G Ibrahim, Hoda Gad, Paula Bourke, Maher Saqqur, Ashfaq Shuaib, Rayaz A Malik,

OBJECTIVES:Corneal nerve damage may be a surrogate marker for the risk of ischemic stroke. This study was undertaken to determine if there is greater corneal nerve damage in patients with recurrent ischemic stroke. METHODS:Corneal confocal microscopy (CCM) was used to quantify corneal nerve fiber density (CNFD), corneal nerve branch density ... Read more >>

PLoS One (PloS one)
[2020, 15(4):e0231987]

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An increase in AMPK/e-NOS signaling and attenuation of MMP-9 may contribute to remote ischemic perconditioning associated neuroprotection in rat model of focal ischemia.

Aijaz Parray, Yongli Ma, Mustafa Alam, Naveed Akhtar, Abdul Salam, Fayaz Mir, Shahnaz Qadri, Sajitha V Pananchikkal, Ruth Priyanka, Saadat Kamran, Ian R Winship, Ashfaq Shuaib,

Remote ischemic perconditioning (RIPerC) results in collateral enhancement and a reduction in middle cerebral artery occlusion (MCAO) induced ischemia. RIPerC likely activates multiple metabolic protective mechanisms, including effects on matrix metalloproteinases (MMPs) and protein kinases. Here we explore if RIPerC improves neuroprotection and collateral flow by modifying the activities of ... Read more >>

Brain Res (Brain research)
[2020, 1740:146860]

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Spherical Kernel for Efficient Graph Convolution on 3D Point Clouds.

Huan Lei, Naveed Akhtar, Ajmal Mian,

We propose a spherical kernel for efficient graph convolution of 3D point clouds. Our metric-based kernels systematically quantize the local 3D space to identify distinctive geometric relationships in the data. Similar to the regular grid CNN kernels, the spherical kernel maintains translation-invariance and asymmetry properties, where the former guarantees weight ... Read more >>

IEEE Trans Pattern Anal Mach Intell (IEEE transactions on pattern analysis and machine intelligence)
[2020, PP:]

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Management of Coronary Disease in Patients with Advanced Kidney Disease.

Sripal Bangalore, David J Maron, Sean M O'Brien, Jerome L Fleg, Evgeny I Kretov, Carlo Briguori, Upendra Kaul, Harmony R Reynolds, Tomasz Mazurek, Mandeep S Sidhu, Jeffrey S Berger, Roy O Mathew, Olga Bockeria, Samuel Broderick, Radoslaw Pracon, Charles A Herzog, Zhen Huang, Gregg W Stone, William E Boden, Jonathan D Newman, Ziad A Ali, Daniel B Mark, John A Spertus, Karen P Alexander, Bernard R Chaitman, Glenn M Chertow, Judith S Hochman, ,

BACKGROUND:Clinical trials that have assessed the effect of revascularization in patients with stable coronary disease have routinely excluded those with advanced chronic kidney disease. METHODS:We randomly assigned 777 patients with advanced kidney disease and moderate or severe ischemia on stress testing to be treated with an initial invasive strategy consisting ... Read more >>

N Engl J Med (The New England journal of medicine)
[2020, 382(17):1608-1618]

Cited: 6 times

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Health Status after Invasive or Conservative Care in Coronary and Advanced Kidney Disease.

John A Spertus, Philip G Jones, David J Maron, Daniel B Mark, Sean M O'Brien, Jerome L Fleg, Harmony R Reynolds, Gregg W Stone, Mandeep S Sidhu, Bernard R Chaitman, Glenn M Chertow, Judith S Hochman, Sripal Bangalore, ,

BACKGROUND:In the ISCHEMIA-CKD trial, the primary analysis showed no significant difference in the risk of death or myocardial infarction with initial angiography and revascularization plus guideline-based medical therapy (invasive strategy) as compared with guideline-based medical therapy alone (conservative strategy) in participants with stable ischemic heart disease, moderate or severe ischemia, ... Read more >>

N Engl J Med (The New England journal of medicine)
[2020, 382(17):1619-1628]

Cited: 1 time

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Prevalence, Characteristics and Risk Factors for Embolic Stroke of Undetermined Source in West and South Asia and North African Population Residing in Qatar.

Jon D Perkins, Naveed Akhtar, Pooja George, Abdul Salam, Heba Bandey, Blessy Babu, Paula J Bourke, Saadat Kamran,

BACKGROUND AND PURPOSE:Embolic stroke of undetermined source (ESUS) is an important contributor to stroke worldwide. Little is known about ESUS in developing parts of the world such as South Asia, West Asia and North Africa despite the high stroke burden in these areas. The purpose of the study was to ... Read more >>

J Stroke Cerebrovasc Dis (Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association)
[2020, 29(5):104666]

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Formulation of Phaseolus vulgaris L. cream and its characterization.

Muhammad Tahir Khan, Muhammad Usman, Hafiz Awais Nawaz, Huma Rasheed, Rizwan Rasul Khan, Syed Muhammad Muneeb Anjum, Muhammad Imran Khokhar, Naveed Akhtar,

Red kidney beans have antioxidant effect and thereby can help in skin smoothening, moisturizing, whitening and have anti-wrinkles effect. The study was based on the formulation of a stable w/o emulsion possessing extract of Phaseolus vulgaris L. seeds, using paraffin oil with the aim to investigate its effect on various ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2020, 33(2(Supplementary)):815-820]

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The improvement on the skin surface by a new type of dermocosmetic loaded plant extract: A split face skin topographic study.

Atif Ali, Naveed Akhtar, Hira Khan, Muhammad Hassham Hassan Bin Asad, Zia Ahmad,

Various extrinsic and intrinsic origins slant skins and pledge evident vicissitudes of the skin surface. We explored the effects of dermocosmetic loaded medical Cannabis seed extract and evaluate the improvement on the skin surface in Asian and male volunteers in a split face topographic study. Dermocosmetic and base (without extract) ... Read more >>

Pak J Pharm Sci (Pakistan journal of pharmaceutical sciences)
[2020, 33(2):531-535]

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Effect of an Al/Mg Hydroxide Antacid and Food on the Pharmacokinetics of Dexibuprofen.

M Ahsan Shaker, Naveed Akhtar, Muhammad Usman Minhas, Kifayat Ullah Khan, Muhammad Imad-Ud-Din Zangi, Abubakar Munir,

OBJECTIVES:In this communication we report an important findings, the effect of Al/Mg hydroxide antacid and food on the pharmacokinetics of dexibuprofen when administered concomitantly. METHODS:Subjects were divided into four groups, each containing 6 subjects, to evaluate the effect of antacid and food on pharmacokinetic of dexibuprofen. A new HPLC method ... Read more >>

Drug Res (Stuttg) (Drug research)
[2020, 70(4):158-164]

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Efficacy and safety of nerinetide for the treatment of acute ischaemic stroke (ESCAPE-NA1): a multicentre, double-blind, randomised controlled trial.

Michael D Hill, Mayank Goyal, Bijoy K Menon, Raul G Nogueira, Ryan A McTaggart, Andrew M Demchuk, Alexandre Y Poppe, Brian H Buck, Thalia S Field, Dar Dowlatshahi, Brian A van Adel, Richard H Swartz, Ruchir A Shah, Eric Sauvageau, Charlotte Zerna, Johanna M Ospel, Manish Joshi, Mohammed A Almekhlafi, Karla J Ryckborst, Mark W Lowerison, Kathy Heard, David Garman, Diogo Haussen, Shawna M Cutting, Shelagh B Coutts, Daniel Roy, Jeremy L Rempel, Axel Cr Rohr, Daniela Iancu, Demetrios J Sahlas, Amy Y X Yu, Thomas G Devlin, Ricardo A Hanel, Volker Puetz, Frank L Silver, Bruce C V Campbell, René Chapot, Jeanne Teitelbaum, Jennifer L Mandzia, Timothy J Kleinig, David Turkel-Parrella, Donald Heck, Michael E Kelly, Aditya Bharatha, Oh Young Bang, Ashutosh Jadhav, Rishi Gupta, Donald F Frei, Jason W Tarpley, Cameron G McDougall, Staffan Holmin, Joung-Ho Rha, Ajit S Puri, Marie-Christine Camden, Götz Thomalla, Hana Choe, Stephen J Phillips, Joseph L Schindler, John Thornton, Simon Nagel, Ji Hoe Heo, Sung-Il Sohn, Marios-Nikos Psychogios, Ronald F Budzik, Sidney Starkman, Coleman O Martin, Paul A Burns, Seán Murphy, George A Lopez, Joey English, Michael Tymianski, ,

BACKGROUND:Nerinetide, an eicosapeptide that interferes with post-synaptic density protein 95, is a neuroprotectant that is effective in preclinical stroke models of ischaemia-reperfusion. In this trial, we assessed the efficacy and safety of nerinetide in human ischaemia-reperfusion that occurs with rapid endovascular thrombectomy in patients who had an acute ischaemic stroke. ... Read more >>

Lancet (Lancet (London, England))
[2020, 395(10227):878-887]

Cited: 9 times

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The incidence rate, mortality rate, and functional outcome of intracerebral hemorrhage according to age, sex, and ethnic group in the state of Qatar.

Maher Saqqur, Abdul Salam, Naveed Akhtar, Musab Ali, Sujatha Joseph, Adnan Khan, Ahmed ElSotouhy, Paula Bourke, Atlantic D'Souza, Ashfaq Shuaib,

Int J Stroke (International journal of stroke : official journal of the International Stroke Society)
[2020, 15(2):NP3]

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Cornea: A Window to White Matter Changes in Stroke; Corneal Confocal Microscopy a Surrogate Marker for the Presence and Severity of White Matter Hyperintensities in Ischemic Stroke.

Saadat Kamran, Adnan Khan, Abdul Salam, Naveed Akhtar, Ioannis Petropoulos, Georgios Ponirakis, Blessy Babu, Pooja George, Ashfaq Shuaib, Rayaz A Malik,

PURPOSE:The presence of white matter hyperintensities (WMH) on MRI imaging confers an increased risk of stroke, dementia, and death. Corneal confocal microscopy (CCM) can detect nerve injury non-invasively and may be a useful surrogate marker for WMH. The objective is to determine whether corneal nerve pathology identified using CCM is ... Read more >>

J Stroke Cerebrovasc Dis (Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association)
[2020, 29(3):104543]

Cited: 1 time

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Anti-pollution cosmetic-based one-step formation of w/o/w multiple emulsion containing D-biotin for skin protection: fabrication and in vitro and in vivo evaluation.

Atif Ali, Sajid Iqbal, Aqsa Ilyas, Hira Khan, Muhammad Hassham Hassan Bin Asad, Nighat Fatima, Naveed Akhtar,

Continuous contact of air pollutants on human skin has produced early ageing and led to roughness, dryness, poor elasticity, increased wrinkling and irregular pigmentation of the skin. The present study was carried out to fabricate an anti-pollution cosmetic-based w/o/w multiple emulsion containing D-biotin, prepared by a one-step formation as protection ... Read more >>

Drug Deliv Transl Res (Drug delivery and translational research)
[2019, 9(6):1117-1132]

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