Full Text Journal Articles by
Author Nathanael J Yates

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Inflammatory Mechanisms in Parkinson's Disease: From Pathogenesis to Targeted Therapies.

Stellina Y H Lee, Nathanael J Yates, Susannah J Tye,

Inflammation is a critical factor contributing to the progressive neurodegenerative process observed in Parkinson's disease (PD). Microglia, the immune cells of the central nervous system, are activated early in PD pathogenesis and can both trigger and propagate early disease processes via innate and adaptive immune mechanisms such as upregulated immune ... Read more >>

Neuroscientist (The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry)
[2021, :1073858421992265]

Cited: 0 times

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Ex Vivo MRI Analytical Methods and Brain Pathology in Preterm Lambs Treated with Postnatal Dexamethasone †.

Nathanael J Yates, Kirk W Feindel, Andrew Mehnert, Richard Beare, Sophia Quick, Dominique Blache, J Jane Pillow, Rod W Hunt,

Postnatal glucocorticoids such as dexamethasone are effective in promoting lung development in preterm infants, but are prescribed cautiously due to concerns of neurological harm. We developed an analysis pipeline for post-mortem magnetic resonance imaging (MRI) to assess brain development and hence the neurological safety profile of postnatal dexamethasone in preterm ... Read more >>

Brain Sci (Brain sciences)
[2020, 10(4):]

Cited: 1 time

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Physiological and anatomical investigation of the auditory brainstem in the Fat-tailed dunnart (Sminthopsis crassicaudata).

Andrew Garrett, Virginia Lannigan, Nathanael J Yates, Jennifer Rodger, Wilhelmina Mulders,

The fat-tailed dunnart (<i>Sminthopsis crassicaudata</i>) is a small (10-20 g) native marsupial endemic to the south west of Western Australia. Currently little is known about the auditory capabilities of the dunnart, and of marsupials in general. Consequently, this study sought to investigate several electrophysiological and anatomical properties of the dunnart ... Read more >>

PeerJ (PeerJ)
[2019, 7:e7773]

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Maternal vitamin D deficiency during rat gestation elicits a milder phenotype compared to the mouse model: Implications for the placental glucocorticoid barrier.

Rachael C Crew, Ana Rakonjac, Dijana Tesic, Michael W Clarke, Nathanael J Yates, Caitlin S Wyrwoll,

Maternal vitamin D deficiency disturbs fetal development and programmes neurodevelopmental complications in offspring, possibly through increased fetal glucocorticoid exposure. We aimed to determine whether prenatal exposure to excess glucocorticoids underlies our rat model of early-life vitamin D deficiency, leading to altered adult behaviours. Vitamin D deficiency reduced the expression of ... Read more >>

Placenta (Placenta)
[2019, 83:5-7]

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Differential responses to increasing numbers of mild traumatic brain injury in a rodent closed-head injury model.

Brooke Fehily, Carole A Bartlett, Stephen Lydiard, Michael Archer, Hannah Milbourn, Maimuna Majimbi, Jan M Hemmi, Sarah A Dunlop, Nathanael J Yates, Melinda Fitzgerald,

Following mild traumatic brain injury (mTBI), further mild impacts can exacerbate negative outcomes. To compare chronic damage and deficits following increasing numbers of repeated mTBIs, a closed-head weight-drop model of repeated mTBI was used to deliver 1, 2 or 3 mTBIs to adult female rats at 24 h intervals. Outcomes were ... Read more >>

J Neurochem (Journal of neurochemistry)
[2019, 149(5):660-678]

Cited: 1 time

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The Effects of a Combination of Ion Channel Inhibitors in Female Rats Following Repeated Mild Traumatic Brain Injury.

Yilin Mao, Anna M B Black, Hannah R Milbourn, Samra Krakonja, Michael Nesbit, Carole A Bartlett, Brooke Fehily, Ryu Takechi, Nathanael J Yates, Melinda Fitzgerald,

Following mild traumatic brain injury (mTBI), the ionic homeostasis of the central nervous system (CNS) becomes imbalanced. Excess Ca<sup>2+</sup> influx into cells triggers molecular cascades, which result in detrimental effects. The authors assessed the effects of a combination of ion channel inhibitors (ICI) following repeated mTBI (rmTBI). Adult female rats ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2018, 19(11):]

Cited: 5 times

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Vitamin D is crucial for maternal care and offspring social behaviour in rats.

Nathanael J Yates, Dijana Tesic, Kirk W Feindel, Jeremy T Smith, Michael W Clarke, Celeste Wale, Rachael C Crew, Michaela D Wharfe, Andrew J O Whitehouse, Caitlin S Wyrwoll,

Early life vitamin D plays a prominent role in neurodevelopment and subsequent brain function, including schizophrenic-like outcomes and increasing evidence for an association with autism spectrum disorder (ASD). Here, we investigate how early life vitamin D deficiency during rat pregnancy and lactation alters maternal care and influences neurodevelopment and affective, ... Read more >>

J Endocrinol (The Journal of endocrinology)
[2018, 237(2):73-85]

Cited: 10 times

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Specific ion channels contribute to key elements of pathology during secondary degeneration following neurotrauma.

Ryan L O'Hare Doig, Wissam Chiha, Marcus K Giacci, Nathanael J Yates, Carole A Bartlett, Nicole M Smith, Stuart I Hodgetts, Alan R Harvey, Melinda Fitzgerald,

<h4>Background</h4>Following partial injury to the central nervous system, cells beyond the initial injury site undergo secondary degeneration, exacerbating loss of neurons, compact myelin and function. Changes in Ca<sup>2+</sup> flux are associated with metabolic and structural changes, but it is not yet clear how flux through specific ion channels contributes to ... Read more >>

BMC Neurosci (BMC neuroscience)
[2017, 18(1):62]

Cited: 10 times

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Repeated mild traumatic brain injury in female rats increases lipid peroxidation in neurons.

Nathanael J Yates, Stephen Lydiard, Brooke Fehily, Gillian Weir, Aaron Chin, Carole A Bartlett, Jacqueline Alderson, Melinda Fitzgerald,

Negative outcomes of mild traumatic brain injury (mTBI) can be exacerbated by repeated insult. Animal models of repeated closed-head mTBI provide the opportunity to define acute pathological mechanisms as the number of mTBI increases. Furthermore, little is known about the effects of mTBI impact site, and how this may affect ... Read more >>

Exp Brain Res (Experimental brain research)
[2017, 235(7):2133-2149]

Cited: 8 times

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Delayed treatment of secondary degeneration following acute optic nerve transection using a combination of ion channel inhibitors.

Nathanael J Yates, Marcus K Giacci, Ryan L O'Hare Doig, Wissam Chiha, Bethany E Ashworth, Jade Kenna, Carole A Bartlett, Melinda Fitzgerald,

Studies have shown that a combined application of several ion channel inhibitors immediately after central nervous system injury can inhibit secondary degeneration. However, for clinical use, it is necessary to determine how long after injury the combined treatment of several ion channel inhibitors can be delayed and efficacy maintained. In ... Read more >>

Neural Regen Res (Neural regeneration research)
[2017, 12(2):307-316]

Cited: 2 times

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Effects of Neonatal Dexamethasone Exposure on Adult Neuropsychiatric Traits in Rats.

Nathanael J Yates, Donald Robertson, Jennifer Rodger, Mathew T Martin-Iverson,

The effects of early life stress in utero or in neonates has long-term consequences on hypothalamic-pituitary-adrenal (HPA) stress axis function and neurodevelopment. These effects extend into adulthood and may underpin a variety of mental illnesses and be related to various developmental and cognitive changes. We examined the potential role of ... Read more >>

PLoS One (PloS one)
[2016, 11(12):e0167220]

Cited: 0 times

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The role of ephrin-A2 and ephrin-A5 in sensorimotor control and gating.

Nathanael J Yates, Mathew T Martin-Iverson, Jennifer Rodger,

Many factors influence neurodevelopment. However, their contribution to adult neural function is often unclear. This is often due to complex expression profiles, cell signalling, neuroanatomy, and a lack of effective tests to assess the function of neural circuits in vivo. Ephrin-A2 and ephrin-A5 are cell surface proteins implicated in multiple ... Read more >>

Behav Brain Res (Behavioural brain research)
[2014, 275:225-233]

Cited: 4 times

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